Published in J Infect Dis on September 09, 2002
Antibiotic selection pressure and resistance in Streptococcus pneumoniae and Streptococcus pyogenes. Emerg Infect Dis (2004) 2.35
Variable recombination dynamics during the emergence, transmission and 'disarming' of a multidrug-resistant pneumococcal clone. BMC Biol (2014) 1.03
Biochemical characterization of Streptococcus pneumoniae penicillin-binding protein 2b and its implication in beta-lactam resistance. Antimicrob Agents Chemother (2004) 0.98
Properties of novel international drug-resistant pneumococcal clones identified in day-care centers of Lisbon, Portugal. J Clin Microbiol (2005) 0.97
Unique variations of pbp2b sequences in penicillin-nonsusceptible Streptococcus pneumoniae isolates from Korea. J Clin Microbiol (2004) 0.97
An internationally spread clone of Streptococcus pneumoniae evolves from low-level to higher-level penicillin resistance by uptake of penicillin-binding protein gene fragments from nonencapsulated pneumococci. Antimicrob Agents Chemother (2004) 0.95
Genome sequencing in microfabricated high-density picolitre reactors. Nature (2005) 150.21
Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2002) 15.11
Evolution of MRSA during hospital transmission and intercontinental spread. Science (2010) 13.34
Rapid pneumococcal evolution in response to clinical interventions. Science (2011) 9.09
Secrets of success of a human pathogen: molecular evolution of pandemic clones of meticillin-resistant Staphylococcus aureus. Lancet Infect Dis (2002) 6.18
Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing. Proc Natl Acad Sci U S A (2007) 6.14
Update to the multiplex PCR strategy for assignment of mec element types in Staphylococcus aureus. Antimicrob Agents Chemother (2007) 3.96
Tackling antibiotic resistance. Nat Rev Microbiol (2011) 3.95
Multiplex PCR strategy for subtyping the staphylococcal cassette chromosome mec type IV in methicillin-resistant Staphylococcus aureus: 'SCCmec IV multiplex'. J Antimicrob Chemother (2007) 3.43
Temporal and geographic stability of the serogroup-specific invasive disease potential of Streptococcus pneumoniae in children. J Infect Dis (2004) 3.31
Redefining a structural variant of staphylococcal cassette chromosome mec, SCCmec type VI. Antimicrob Agents Chemother (2006) 2.78
Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences. Proc Natl Acad Sci U S A (2014) 2.63
Overexpression of genes of the cell wall stimulon in clinical isolates of Staphylococcus aureus exhibiting vancomycin-intermediate- S. aureus-type resistance to vancomycin. J Bacteriol (2006) 2.32
Assessment of allelic variation in the ccrAB locus in methicillin-resistant Staphylococcus aureus clones. J Antimicrob Chemother (2006) 2.28
Epidemiology of emerging methicillin-resistant Staphylococcus aureus (MRSA) in Denmark: a nationwide study in a country with low prevalence of MRSA infection. J Clin Microbiol (2005) 2.23
Alternative mutational pathways to intermediate resistance to vancomycin in methicillin-resistant Staphylococcus aureus. J Infect Dis (2013) 2.19
Bridges from hospitals to the laboratory: genetic portraits of methicillin-resistant Staphylococcus aureus clones. FEMS Immunol Med Microbiol (2004) 1.94
International clones of methicillin-resistant Staphylococcus aureus in two hospitals in Miami, Florida. J Clin Microbiol (2004) 1.94
Antibiotic resistant Staphylococcus aureus: a paradigm of adaptive power. Curr Opin Microbiol (2007) 1.93
Role of penicillin-binding protein 2 (PBP2) in the antibiotic susceptibility and cell wall cross-linking of Staphylococcus aureus: evidence for the cooperative functioning of PBP2, PBP4, and PBP2A. J Bacteriol (2005) 1.83
Analysis of typing methods for epidemiological surveillance of both methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains. J Clin Microbiol (2007) 1.80
Wide geographic distribution of a unique methicillin-resistant Staphylococcus aureus clone in Hungarian hospitals. Clin Microbiol Infect (1997) 1.65
Properties of a novel PBP2A protein homolog from Staphylococcus aureus strain LGA251 and its contribution to the β-lactam-resistant phenotype. J Biol Chem (2012) 1.59
Temporal trends and molecular epidemiology of recently described serotype 6C of Streptococcus pneumoniae. J Clin Microbiol (2008) 1.57
Staphylococcus aureus bacteraemia--Nationwide assessment of treatment adequacy and outcome. J Infect (2011) 1.54
Guidelines for reporting novel mecA gene homologues. Antimicrob Agents Chemother (2012) 1.54
High genetic diversity among community-associated Staphylococcus aureus in Europe: results from a multicenter study. PLoS One (2012) 1.53
Peptidoglycan N-acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae. Infect Immun (2002) 1.52
Changing patterns in frequency of recovery of five methicillin-resistant Staphylococcus aureus clones in Portuguese hospitals: surveillance over a 16-year period. J Clin Microbiol (2008) 1.51
[Quinolone resistance in Gram negative rods in Iceland and association with antibiotic use]. Laeknabladid (2008) 1.51
Inactivation of the srtA gene affects localization of surface proteins and decreases adhesion of Streptococcus pneumoniae to human pharyngeal cells in vitro. Infect Immun (2003) 1.51
Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300. PLoS Pathog (2012) 1.44
Lessons from the past: familial aggregation analysis of fatal pandemic influenza (Spanish flu) in Iceland in 1918. Proc Natl Acad Sci U S A (2008) 1.44
Effect of the seven-valent conjugate pneumococcal vaccine on carriage and drug resistance of Streptococcus pneumoniae in healthy children attending day-care centers in Lisbon. Pediatr Infect Dis J (2005) 1.43
Pneumococcal capsular switching: a historical perspective. J Infect Dis (2012) 1.43
High level oxacillin and vancomycin resistance and altered cell wall composition in Staphylococcus aureus carrying the staphylococcal mecA and the enterococcal vanA gene complex. J Biol Chem (2003) 1.42
[Prevalence of Streptococcus pyogenes and methicillin-resistant Staphylococcus aureus in the pharynx of healthy children in the town of Gardabaer]. Laeknabladid (2008) 1.39
Trends of penicillin and erythromycin resistance among invasive Streptococcus pneumoniae in Europe. J Antimicrob Chemother (2004) 1.34
Development of methicillin resistance in clinical isolates of Staphylococcus sciuri by transcriptional activation of the mecA homologue native to s. J Bacteriol (2003) 1.32
Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan. J Biol Chem (2007) 1.31
Requirements of peptidoglycan structure that allow detection by the Drosophila Toll pathway. EMBO Rep (2005) 1.30
A molecular trigger for intercontinental epidemics of group A Streptococcus. J Clin Invest (2015) 1.29
Identification, prevalence and population structure of non-typable Streptococcus pneumoniae in carriage samples isolated from preschoolers attending day-care centres. Microbiology (2006) 1.27
Attenuation of penicillin resistance in a peptidoglycan O-acetyl transferase mutant of Streptococcus pneumoniae. Mol Microbiol (2006) 1.26
Large screening of CA-MRSA among Staphylococcus aureus colonizing healthy young children living in two areas (urban and rural) of Portugal. BMC Infect Dis (2010) 1.26
Analysis of invasiveness of pneumococcal serotypes and clones circulating in Portugal before widespread use of conjugate vaccines reveals heterogeneous behavior of clones expressing the same serotype. J Clin Microbiol (2011) 1.26
Molecular characterization of methicillin-resistant Staphylococcus epidermidis clones: evidence of geographic dissemination. J Clin Microbiol (2002) 1.26
The role of antimicrobial use in the epidemiology of resistant pneumococci: A 10-year follow up. Microb Drug Resist (2006) 1.25
Extensive and genome-wide changes in the transcription profile of Staphylococcus aureus induced by modulating the transcription of the cell wall synthesis gene murF. J Bacteriol (2006) 1.23
Characterization of Staphylococcus aureus isolates from buffalo, bovine, ovine, and caprine milk samples collected in Rio de Janeiro State, Brazil. Appl Environ Microbiol (2007) 1.22
Clonal spread of resistant pneumococci despite diminished antimicrobial use. Microb Drug Resist (2002) 1.19
Cocrystal structures of diaminopimelate decarboxylase: mechanism, evolution, and inhibition of an antibiotic resistance accessory factor. Structure (2002) 1.18
Penicillin-binding protein 2 is essential for expression of high-level vancomycin resistance and cell wall synthesis in vancomycin-resistant Staphylococcus aureus carrying the enterococcal vanA gene complex. Antimicrob Agents Chemother (2004) 1.18
Inhibition of the autolytic system by vancomycin causes mimicry of vancomycin-intermediate Staphylococcus aureus-type resistance, cell concentration dependence of the MIC, and antibiotic tolerance in vancomycin-susceptible S. aureus. Antimicrob Agents Chemother (2006) 1.18
Mechanisms of vancomycin resistance in Staphylococcus aureus. J Clin Invest (2014) 1.15
Denmark14-230 clone as an increasing cause of pneumococcal infection in Portugal within a background of diverse serotype 19A lineages. J Clin Microbiol (2009) 1.15
The anti-repressor MecR2 promotes the proteolysis of the mecA repressor and enables optimal expression of β-lactam resistance in MRSA. PLoS Pathog (2012) 1.14
Fluorescence ratio imaging microscopy shows decreased access of vancomycin to cell wall synthetic sites in vancomycin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2007) 1.14
Whole-genome sequencing reveals a link between β-lactam resistance and synthetases of the alarmone (p)ppGpp in Staphylococcus aureus. Microb Drug Resist (2013) 1.14
Molecular epidemiology and risk factors for nasal carriage of staphylococcus aureus and methicillin-resistant S. aureus in infants attending day care centers in Brazil. J Clin Microbiol (2009) 1.13
The murMN operon: a functional link between antibiotic resistance and antibiotic tolerance in Streptococcuspneumoniae. Proc Natl Acad Sci U S A (2002) 1.12
Isolation and analysis of cell wall components from Streptococcus pneumoniae. Anal Biochem (2011) 1.10
Soft antimicrobial agents: synthesis and activity of labile environmentally friendly long chain quaternary ammonium compounds. J Med Chem (2003) 1.08
Drastic reduction in the virulence of Streptococcus pneumoniae expressing type 2 capsular polysaccharide but lacking choline residues in the cell wall. Mol Microbiol (2006) 1.07
Identification of genetic determinants and enzymes involved with the amidation of glutamic acid residues in the peptidoglycan of Staphylococcus aureus. PLoS Pathog (2012) 1.06
Pilot study of the genetic diversity of the pneumococcal nasopharyngeal flora among children attending day care centers. J Clin Microbiol (2002) 1.06
A link in transcription between the native pbpB and the acquired mecA gene in a strain of Staphylococcus aureus. Microbiology (2006) 1.05
High prevalence of EMRSA-15 in Portuguese public buses: a worrisome finding. PLoS One (2011) 1.05
Variable recombination dynamics during the emergence, transmission and 'disarming' of a multidrug-resistant pneumococcal clone. BMC Biol (2014) 1.03
Methicillin-resistance in Staphylococcus aureus is not affected by the overexpression in trans of the mecA gene repressor: a surprising observation. PLoS One (2011) 1.03
Deep sternal wound infections following open heart surgery in Iceland: a population-based study. Scand Cardiovasc J (2008) 1.03
Strategies of adaptation of Staphylococcus epidermidis to hospital and community: amplification and diversification of SCCmec. J Antimicrob Chemother (2012) 1.02
Impact of a single dose of the 7-valent pneumococcal conjugate vaccine on colonization. Vaccine (2010) 1.02
The multidrug-resistant PMEN1 pneumococcus is a paradigm for genetic success. Genome Biol (2012) 1.01
Evidence for a dual role of PBP1 in the cell division and cell separation of Staphylococcus aureus. Mol Microbiol (2009) 1.00
Perturbation of cell wall synthesis suppresses autolysis in Staphylococcus aureus: evidence for coregulation of cell wall synthetic and hydrolytic enzymes. J Bacteriol (2007) 0.99
Optochin resistance among Streptococcus pneumoniae strains colonizing healthy children in Portugal. J Clin Microbiol (2007) 0.98
Penicillin-binding proteins and cell wall composition in beta-lactam-sensitive and -resistant strains of Staphylococcus sciuri. J Bacteriol (2007) 0.98
Clonal evolution leading to maintenance of antibiotic resistance rates among colonizing Pneumococci in the PCV7 era in Portugal. J Clin Microbiol (2011) 0.98
Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole. Antimicrob Agents Chemother (2008) 0.97
Properties of novel international drug-resistant pneumococcal clones identified in day-care centers of Lisbon, Portugal. J Clin Microbiol (2005) 0.97
In vivo capsular switch in Streptococcus pneumoniae--analysis by whole genome sequencing. PLoS One (2012) 0.95
Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene. Antimicrob Agents Chemother (2008) 0.95
Extensive dissemination of methicillin-resistant Staphylococcus aureus (MRSA) between the hospital and the community in a country with a high prevalence of nosocomial MRSA. PLoS One (2013) 0.95
Selection of resistant Streptococcus pneumoniae during penicillin treatment in vitro and in three animal models. Antimicrob Agents Chemother (2003) 0.94
The challenge of antibiotic resistant bacterial pathogens: the medical need, the market and prospects for new antimicrobial agents. Curr Opin Microbiol (2004) 0.94
The essential tacF gene is responsible for the choline-dependent growth phenotype of Streptococcus pneumoniae. J Bacteriol (2007) 0.94
Diagnosing infections: a qualitative view on prescription decisions in general practice over time. Pharm World Sci (2010) 0.91