Published in Br J Clin Pharmacol on February 01, 1975
Age as a determinant of sensitivity to warfarin. Br J Clin Pharmacol (1977) 1.90
The effect of ageing on the hepatic clearance of propranolol. Br J Clin Pharmacol (1979) 1.45
Prazosin disposition in young and elderly subjects. Br J Clin Pharmacol (1981) 1.24
Plasma protein binding of phenytoin in 100 epileptic patients. Br J Clin Pharmacol (1982) 1.14
The influence of age on the response to anticoagulants. Br J Clin Pharmacol (1977) 1.07
Modification of phenytoin clearance by valproic acid in normal subjects. Br J Clin Pharmacol (1979) 0.99
Disposition of sodium valproate in epileptic patients. Br J Clin Pharmacol (1978) 0.98
Factors affecting drug binding in plasma of elderly patients. Br J Clin Pharmacol (1976) 0.95
The influence of age, smoking and hyperthyroidism on plasma propranolol steady state concentration. Br J Clin Pharmacol (1981) 0.94
Drugs in the elderly. Br J Clin Pharmacol (1975) 0.85
The pharmacokinetics of doxazosin in elderly normotensives. Br J Clin Pharmacol (1986) 0.84
Changes in the plasma clearance and protein binding of carbenoxolone with age, and their possible relationship with adverse drug effects. Gut (1977) 0.82
Plasma protein binding of phenytoin in the aged: in vivo studies. Br J Clin Pharmacol (1982) 0.81
The 'apparent clearance' of free phenytoin in elderly vs. younger adults. Br J Clin Pharmacol (2010) 0.78
Population pharmacokinetics of dolutegravir in HIV-infected treatment-naive patients. Br J Clin Pharmacol (2015) 0.76
Editorial: drug metabolism and increasing age. Br Med J (1975) 0.75
How to Choose In Vitro Systems to Predict In Vivo Drug Clearance: A System Pharmacology Perspective. Biomed Res Int (2015) 0.75
Medical management of epileptic seizures: challenges and solutions. Neuropsychiatr Dis Treat (2016) 0.75
Intravenous Vancomycin Dosing in the Elderly: A Focus on Clinical Issues and Practical Application. Drugs Aging (2016) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Effect of age and sex on human drug metabolism. Br Med J (1971) 5.19
A graphic method for the determination and presentation of binding parameters in a complex system. Anal Biochem (1967) 4.32
Plasma protein binding of diphenylhydantoin in man. Interaction with other drugs and the effect of temperature and plasma dilution. Clin Pharmacol Ther (1971) 2.45
Rapid determination of diphenylhydantoin in blood plasma by gas-liquid chromatography. Anal Chem (1970) 2.41
The rate of decline of diphenylhydantoin in human plasma. Clin Pharmacol Ther (1970) 2.23
Studies on the coumarin anticoagulant drugs: interaction of human plasma albumin and warfarin sodium. J Clin Invest (1967) 1.67
Serum protein binding of thyroxine and diphenylhydantoin. J Clin Endocrinol Metab (1966) 1.20
The determination of human serum albumin by its specific binding of the anionic dye, 2-(4'-hydroxybenzeneazo)-benzoic acid. Clin Chim Acta (1965) 1.10
The metabolic fate of diphenylhydantoin in the dog, rat and man. J Pharmacol Exp Ther (1960) 1.04
Review of company postmarketing surveillance studies. BMJ (1992) 6.21
Use of anti-inflammatory drugs by patients admitted with small or large bowel perforations and haemorrhage. Br Med J (Clin Res Ed) (1985) 4.30
Uses of barium meal examination in dyspeptic patients under 50. Br Med J (1977) 3.82
Treatment of gastric ulcer with carbenoxolone: antagonistic effect of spironolactone. Gut (1968) 3.46
Towards estimation and confidence intervals. Br Med J (Clin Res Ed) (1986) 3.22
Omeprazole versus placebo for acute upper gastrointestinal bleeding: randomised double blind controlled trial. BMJ (1992) 3.17
20 years of hospital admissions for peptic ulcer in England and Wales. Lancet (1981) 3.06
Changing patterns in epidemiology of Crohn's disease. Lancet (1974) 2.99
Postmarketing surveillance of the safety of cimetidine: 12 month mortality report. Br Med J (Clin Res Ed) (1983) 2.90
Effect of different operation policies on mortality from bleeding peptic ulcer. Lancet (1979) 2.74
Aspirin, paracetamol, and haematemesis and melaena. Gut (1982) 2.55
Epidemiological evidence for the association of aspirin and acute gastrointestinal bleeding. Gut (1970) 2.55
Trial of early nifedipine in acute myocardial infarction: the Trent study. Br Med J (Clin Res Ed) (1986) 2.55
Childhood factors in ulcerative colitis and Crohn's disease. An international cooperative study. Scand J Gastroenterol (1987) 2.54
Double-blind trial of linoleate supplementation of the diet in multiple sclerosis. Br Med J (1973) 2.53
Cimetidine and gastric cancer: preliminary report from post-marketing surveillance study. Br Med J (Clin Res Ed) (1982) 2.40
A new method for measuring power output in a single leg extension: feasibility, reliability and validity. Eur J Appl Physiol Occup Physiol (1990) 2.32
Smoking and Crohn's disease. Br Med J (Clin Res Ed) (1984) 2.17
A flow-sensitive apparatus for studying the responses of the constrictor muscles of perfused tubular organs [proceedings]. J Physiol (1978) 2.14
ABO blood group and secretor status in relation to clinical characteristics of peptic ulcers. Gut (1965) 2.11
Gastric and duodenal ulcer and their associated diseases. Lancet (1976) 2.10
Cimetidine and ranitidine: comparison of effects on hepatic drug metabolism. Br Med J (1980) 2.09
Post-marketing surveillance of the safety of cimetidine: twelve-month morbidity report. Q J Med (1985) 2.07
Smoking and ulcerative colitis. Br Med J (Clin Res Ed) (1984) 2.05
Cigarette smoking and inflammatory bowel disease. Gastroenterology (1987) 2.04
Aspirin and bleeding peptic ulcers in the elderly. BMJ (1988) 2.00
Acute taurine depletion and maximal rates of hepatic conjugation and secretion of cholic acid in the dog. J Physiol (1965) 1.97
Factors determining the maximal rate of organic anion secretion by the liver and further evidence on the hepatic site of action of the hormone secretin. J Physiol (1966) 1.91
Controlled trial of maintenance cimetidine treatment in healed duodenal ulcer: short and long-term effects. Gut (1979) 1.90
Comparison of surgical and medical management of bleeding peptic ulcers. Br Med J (Clin Res Ed) (1982) 1.90
Epidemiology of cancer of the large intestine. Proc R Soc Med (1966) 1.83
A prospective, randomised study of endoscopy and radiology in acute upper-gastrointestinal-tract bleeding. Lancet (1977) 1.81
Postmarketing surveillance of the safety of cimetidine: mortality during second, third, and fourth years of follow up. Br Med J (Clin Res Ed) (1985) 1.78
Faecal stasis in proctocolitis. Gut (1962) 1.71
The late results of medical and surgical treatment for bleeding duodenal ulcer. Q J Med (1970) 1.70
What is happening to peptic ulcer? Br Med J (Clin Res Ed) (1982) 1.70
Peptic ulcer bleeding: accessory risk factors and interactions with non-steroidal anti-inflammatory drugs. Gut (2000) 1.69
Audit of mortality in upper gastrointestinal bleeding. Postgrad Med J (1989) 1.68
Cimetidine and ranitidine in duodenal ulcer. Br Med J (1980) 1.63
The demographic and social characteristics of patients with Crohn's disease in the Nottingham area. Scand J Gastroenterol (1976) 1.54
Blood pressure reduction in elderly: a randomised controlled trial of methyldopa. Br Med J (Clin Res Ed) (1981) 1.52
Coincident salmonella infections and ulcerative colitis: problems of recognition and management. Br Med J (1974) 1.51
Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man. Clin Sci (Lond) (1993) 1.50
Changes in drug metabolism with increasing age: 1. warfarin binding and plasma proteins. Br J Clin Pharmacol (1975) 1.46
Outcome of endoscopy and barium radiography for acute upper gastrointestinal bleeding: controlled trial in 1037 patients. Br Med J (Clin Res Ed) (1982) 1.46
Effect of long-term beta2-agonist dosing on human cardiac beta-adrenoceptor expression in vivo: comparison with changes in lung and mononuclear leukocyte beta-receptors. J Nucl Cardiol (1998) 1.45
Influence of diet on the "intestinal" component of serum alkaline phosphatase in people of different ABO blood groups and secretor status. Nature (1966) 1.44
Treatment of gastric ulcer with oestrogens. Gut (1968) 1.44
Upper gastrointestinal bleeding: the trials of trials. Gut (1985) 1.42
Cimetidine maintenance: How long? Lancet (1978) 1.40
Somatostatin in treatment of haematemesis and melaena. Lancet (1985) 1.39
The influence of conjugation of cholic acid on its uptake and secretion: hepatic extraction of taurocholate and cholate in the dog. J Physiol (1967) 1.35
Relation of sub-acute combined degeneration of the cord to vitamin B 12 deficiency. Nature (1966) 1.34
Rising death rate from non-malignant disease of the oesophagus (NMOD) in England and Wales. Gut (1995) 1.32
Screening for gastric cancer after gastric surgery. Lancet (1983) 1.32
Intravenous omeprazole rapidly raises intragastric pH. Gut (1985) 1.31
Hospital admissions for peptic ulcer during 1958-72. Br Med J (1976) 1.31
Isolation and structural identification of 1,25-dihydroxyvitamin D3 produced by cultured alveolar macrophages in sarcoidosis. J Clin Endocrinol Metab (1985) 1.30
Comparison of mobilization after two and nine days in uncomplicated myocardial infarction. Br Med J (1974) 1.27
Carbenoxolone sodium. Gut (1968) 1.27
The [14C]-aminopyrine breath test. A comparison of different forms of analysis. Br J Clin Pharmacol (1979) 1.26
Duodenal ulcer and refined carbohydrate intake: a case-control study assessing dietary fibre and refined sugar intake. Gut (1990) 1.22
Postmarketing surveillance of the safety of cimetidine: 10 year mortality report. Gut (1992) 1.20
Antisecretory drugs and gastric cancer. Br Med J (Clin Res Ed) (1985) 1.20
ABO and Lewis blood-groups and serum-cholesterol. Lancet (1969) 1.20
Comparative trial of sulphasalazine and oral sodium cromoglycate in the maintenance of remission in ulcerative colitis. Gut (1978) 1.19
Alzheimer's disease in antacid users. Lancet (1989) 1.17
The hepatocellular uptake of glucose, galactose and fructose in conscious sheep. J Physiol (1977) 1.16
HLA-A and -B antigens in inflammatory bowel disease. Gut (1986) 1.16
Oral phenytoin pharmacokinetics during omeprazole therapy. Br J Clin Pharmacol (1987) 1.13
Gas chromatography-mass spectrometry characteristics of methylated perfluoroacyl derivatives of cytosine and 5-methylcytosine. J Chromatogr (1984) 1.11
ABO blood group and secretor status in stomal ulcer. Gut (1967) 1.10
ABO blood groups, secretor status, salivary protein, and serum and salivary immunoglobulin concentrations. Gut (1971) 1.09
Antibacterial activity in serum and urine following oral administration in man of DL473 (a cyclopentyl derivative of rifampicin) [proceedings]. Br J Clin Pharmacol (1978) 1.09
Controlled trial of active immunotherapy in management of stage IIB malignant melanoma. Br Med J (1977) 1.08
Loss of estrogen inactivation in colonic cancer. J Clin Endocrinol Metab (1999) 1.06
Treatment of chronic gastric ulcer with carbenoxolone and gefarnate: a comparative trial. Br Med J (1973) 1.06
Ranitidine and cimetidine for duodenal ulcer. Scand J Gastroenterol Suppl (1981) 1.06
Epidemiological features of ruptured dissecting and saccular aortic aneurysms. Postgrad Med J (1972) 1.05
Did the drug do it? Br Med J (Clin Res Ed) (1986) 1.05
Cell-mediated and humoral immune reactions to human tumours. Int J Cancer (1973) 1.05
Colitis associated with non-steroidal anti-inflammatory drugs. Br Med J (Clin Res Ed) (1984) 1.03
Adverse effects of anti-ulcer drugs. Drugs (1981) 1.03
Observations on the elimination rates of single injections of taurocholate and cholate in the dog. Q J Exp Physiol Cogn Med Sci (1969) 1.03
Differential expression of oestrogen receptor and oestrogen inducible genes in gastric mucosa and cancer. Gut (1997) 1.02
Antiproliferative responses to two human colon cancer cell lines to vitamin D3 are differently modified by 9-cis-retinoic acid. Cancer Res (1996) 1.02
Post-cimetidine surveillance for up to ten years: incidence of carcinoma of the stomach and oesophagus. Q J Med (1991) 1.01
Differential growth response to oestrogen of premalignant and malignant colonic cell lines. Anticancer Res (1994) 1.01
Clinical trial of a new carbenoxolone analogue (BX24), zinc sulphate, and vitamin A in the treatment of gastric ulcer. Gut (1972) 1.01
Late mortality in elderly patients surviving acute peptic ulcer bleeding. Gut (1995) 1.00
Changing patterns of coeliac disease frequency: an analysis of Coeliac Society membership records. Gut (1985) 1.00
Pre- and post-operative symptoms of patients with stomal ulcers. Gut (1967) 0.99
Large bowel cancer: causation and management. Gut (1975) 0.99
Sulphadoxine-pyrimethamine therapy in Crohn's disease. Digestion (1982) 0.99
Sex differences in the incidence of colorectal cancer: an exploration of oestrogen and progesterone receptors. Gut (1993) 0.98
Controlled trial of hydroxocobalamin and riboflavine in Nigerian ataxic neuropathy. J Neurol Neurosurg Psychiatry (1970) 0.97
Review: post-marketing surveillance of the safety of cimetidine--the problems of data interpretation. Aliment Pharmacol Ther (1987) 0.97