Published in J Biol Chem on September 25, 2002
Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. J Cell Biol (2006) 2.76
HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO J (2006) 2.52
Mislocalization to the nuclear envelope: an effect of the dystonia-causing torsinA mutation. Proc Natl Acad Sci U S A (2004) 2.19
Distinct roles for the AAA ATPases NSF and p97 in the secretory pathway. Mol Biol Cell (2003) 2.09
Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr Opin Cell Biol (2004) 1.90
Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis. Mol Cell Biol (2003) 1.68
The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover. Mol Biol Cell (2010) 1.65
VCP associated inclusion body myopathy and paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease. PLoS One (2010) 1.34
The role of the N-domain in the ATPase activity of the mammalian AAA ATPase p97/VCP. J Biol Chem (2012) 1.32
p97 functions as an auxiliary factor to facilitate TM domain extraction during CFTR ER-associated degradation. EMBO J (2006) 1.24
Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity. Proc Natl Acad Sci U S A (2012) 1.23
The complexities of p97 function in health and disease. Mol Biosyst (2010) 1.17
Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1. Development (2011) 1.15
The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins. EMBO J (2012) 1.15
Regulation of ubiquitin-proteasome system mediated degradation by cytosolic stress. Mol Biol Cell (2007) 1.14
TorsinA and torsion dystonia: Unraveling the architecture of the nuclear envelope. Proc Natl Acad Sci U S A (2004) 1.14
Involvement of the p97-Ufd1-Npl4 complex in the regulated endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors. J Biol Chem (2005) 1.13
The slow Wallerian degeneration protein, WldS, binds directly to VCP/p97 and partially redistributes it within the nucleus. Mol Biol Cell (2005) 1.13
Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A. J Biol Chem (2010) 0.97
Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation. Mol Biol Cell (2009) 0.96
A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse. Muscle Nerve (2012) 0.96
Mass spectrometric analysis of type 1 inositol 1,4,5-trisphosphate receptor ubiquitination. J Biol Chem (2008) 0.95
Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model. PLoS Genet (2011) 0.94
Positive cooperativity of the p97 AAA ATPase is critical for essential functions. J Biol Chem (2011) 0.94
ATP-binding sites in brain p97/VCP (valosin-containing protein), a multifunctional AAA ATPase. Biochem J (2003) 0.93
Novel VCP modulators mitigate major pathologies of rd10, a mouse model of retinitis pigmentosa. Sci Rep (2014) 0.92
Valosin-containing protein (VCP/p97) is required for poliovirus replication and is involved in cellular protein secretion pathway in poliovirus infection. J Virol (2012) 0.91
Valosin containing protein associated fronto-temporal lobar degeneration: clinical presentation, pathologic features and pathogenesis. Curr Alzheimer Res (2011) 0.91
Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth. Am J Pathol (2007) 0.91
Structural and functional deviations in disease-associated p97 mutants. J Struct Biol (2012) 0.90
The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism. Mol Pharmacol (2013) 0.88
Liver cytochrome P450 3A endoplasmic reticulum-associated degradation: a major role for the p97 AAA ATPase in cytochrome P450 3A extraction into the cytosol. J Biol Chem (2010) 0.86
Endoplasmic Reticulum Stress and Associated ROS. Int J Mol Sci (2016) 0.86
Valosin-containing protein (VCP) in novel feedback machinery between abnormal protein accumulation and transcriptional suppression. J Biol Chem (2010) 0.86
VCP/p97 AAA-ATPase does not interact with the endogenous wild-type cystic fibrosis transmembrane conductance regulator. Am J Respir Cell Mol Biol (2007) 0.83
Valosin-containing protein gene mutations: cellular phenotypes relevant to neurodegeneration. J Mol Neurosci (2011) 0.83
Myofibril breakdown during atrophy is a delayed response requiring the transcription factor PAX4 and desmin depolymerization. Proc Natl Acad Sci U S A (2017) 0.80
VCP Is an integral component of a novel feedback mechanism that controls intracellular localization of catalase and H2O2 Levels. PLoS One (2013) 0.80
Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa. PLoS One (2015) 0.79
The valosin-containing protein promotes cardiac survival through the inducible isoform of nitric oxide synthase. Cardiovasc Res (2013) 0.79
Down regulation effect of Rosmarinus officinalis polyphenols on cellular stress proteins in rat pheochromocytoma PC12 cells. Cytotechnology (2011) 0.79
Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice. Am J Pathol (2013) 0.79
Protective role of cell division cycle 48 (CDC48) protein against neurodegeneration via ubiquitin-proteasome system dysfunction during zebrafish development. J Biol Chem (2012) 0.79
Ataxin-3 is a multivalent ligand for the parkin Ubl domain. Biochemistry (2013) 0.78
Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation. Biochem J (2014) 0.78
Unveiling the degradative route of the V247M α-sarcoglycan mutant responsible for LGMD-2D. Hum Mol Genet (2014) 0.78
Role of p97/Valosin-containing protein (VCP) and Jab1/CSN5 in testicular ischaemia-reperfusion injury. J Mol Histol (2016) 0.76
A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase. Front Mol Biosci (2017) 0.75
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev (2002) 6.44
Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell (2009) 3.45
Local calcium signaling in neurons. Neuron (2003) 3.33
Listeria monocytogenes ActA-mediated escape from autophagic recognition. Nat Cell Biol (2009) 3.05
PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity. Proc Natl Acad Sci U S A (2003) 2.89
The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology. Curr Biol (2005) 2.53
Does secondhand smoke affect the development of dental caries in children? A systematic review. Int J Environ Res Public Health (2011) 2.25
Genetic and antigenic diversity among noroviruses. J Gen Virol (2006) 1.91
Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. J Neurosci (2009) 1.85
Causal assessment of smoking and tooth loss: a systematic review of observational studies. BMC Public Health (2011) 1.80
Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome. Proc Natl Acad Sci U S A (2011) 1.80
An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasis. Cell (2009) 1.78
Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis. Hum Mol Genet (2005) 1.70
Molecular clearance of ataxin-3 is regulated by a mammalian E4. EMBO J (2004) 1.57
Genetic changes of coxsackievirus A16 and enterovirus 71 isolated from hand, foot, and mouth disease patients in Toyama, Japan between 1981 and 2007. Jpn J Infect Dis (2009) 1.52
A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration. J Neurosci (2004) 1.45
Involvement of valosin-containing protein (VCP)/p97 in the formation and clearance of abnormal protein aggregates. Genes Cells (2007) 1.44
Alpha,beta-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor gamma. J Biol Chem (2005) 1.43
Botulinum toxin A injections improve apraxia of eyelid opening without overt blepharospasm associated with neurodegenerative diseases. Mov Disord (2007) 1.38
Clinical features of neuromyelitis optica in a large Japanese cohort: comparison between phenotypes. J Neurol Neurosurg Psychiatry (2011) 1.32
Molecular determinants for subcellular localization of hepatitis C virus core protein. J Virol (2005) 1.31
Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells. Nat Neurosci (2010) 1.26
Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders. J Biol Chem (2004) 1.23
Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice. Carcinogenesis (2002) 1.21
Astrocytic necrosis is induced by anti-aquaporin-4 antibody-positive serum. Neuroreport (2009) 1.19
Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia. Genes Cells (2010) 1.18
Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan. J Neurol Sci (2010) 1.18
Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL/6J mice of arylhydrocarbon receptor gene. Toxicol Appl Pharmacol (2003) 1.18
Interferon-beta(1b) treatment in neuromyelitis optica. Eur Neurol (2009) 1.16
Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features. BMC Psychiatry (2012) 1.16
Vacuole-creating protein in neurodegenerative diseases in humans. Neurosci Lett (2003) 1.15
Suppression of synaptic plasticity by cerebrospinal fluid from anti-NMDA receptor encephalitis patients. Neurobiol Dis (2011) 1.13
Activation of μ-opioid receptors in the dorsal striatum is necessary for adult social attachment in monogamous prairie voles. Neuropsychopharmacology (2011) 1.13
p180 is involved in the interaction between the endoplasmic reticulum and microtubules through a novel microtubule-binding and bundling domain. Mol Biol Cell (2007) 1.13
Relationship between NMO-antibody and anti-MOG antibody in optic neuritis. J Neuroophthalmol (2012) 1.12
Dietary patterns during pregnancy and the risk of postpartum depression in Japan: the Osaka Maternal and Child Health Study. Br J Nutr (2010) 1.12
Fish and fat intake and prevalence of depressive symptoms during pregnancy in Japan: baseline data from the Kyushu Okinawa Maternal and Child Health Study. J Psychiatr Res (2013) 1.11
Association of melanin pigmentation in the gingiva of children with parents who smoke. Pediatrics (2005) 1.11
Sensitive and rapid detection of cholera toxin-producing Vibrio cholerae using a loop-mediated isothermal amplification. BMC Microbiol (2008) 1.10
Cigarette smoking and tooth loss experience among young adults: a national record linkage study. BMC Public Health (2007) 1.10
Dietary folate, riboflavin, vitamin B-6, and vitamin B-12 and depressive symptoms in early adolescence: the Ryukyus Child Health Study. Psychosom Med (2010) 1.10
Association of total tooth loss with smoking, drinking alcohol and nutrition in elderly Japanese: analysis of national database. Gerodontology (2007) 1.08
Mutational analysis of human papillomavirus type 16 major capsid protein L1: the cysteines affecting the intermolecular bonding and structure of L1-capsids. Virology (2003) 1.08
ATPase activity of p97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif. J Biol Chem (2005) 1.08
Education, but not occupation or household income, is positively related to favorable dietary intake patterns in pregnant Japanese women: the Osaka Maternal and Child Health Study. Nutr Res (2009) 1.06
Nutritional adequacy of three dietary patterns defined by cluster analysis in 997 pregnant Japanese women: the Osaka Maternal and Child Health Study. Public Health Nutr (2010) 1.06
Cellular localization of P2X7 receptor mRNA in the rat brain. Brain Res (2007) 1.05
Development and evaluation of a loop-mediated isothermal amplification assay for rapid and simple detection of Campylobacter jejuni and Campylobacter coli. J Med Microbiol (2008) 1.04
Toxigenic Corynebacterium ulcerans isolated from the domestic dog for the first time in Japan. Jpn J Infect Dis (2009) 1.04
Steroid-responsive limbic encephalitis. Intern Med (2003) 1.04
Human papillomavirus 16 minor capsid protein L2 helps capsomeres assemble independently of intercapsomeric disulfide bonding. Virus Genes (2005) 1.04
Unequal crossing-over in unique PABP2 mutations in Japanese patients: a possible cause of oculopharyngeal muscular dystrophy. Arch Neurol (2002) 1.04
Plasma corticosterone activates SGK1 and induces morphological changes in oligodendrocytes in corpus callosum. PLoS One (2011) 1.03
Longitudinal and simultaneous imaging of retinal ganglion cells and inner retinal layers in a mouse model of glaucoma induced by N-methyl-D-aspartate. Invest Ophthalmol Vis Sci (2011) 1.03
Maternal dietary patterns in pregnancy and fetal growth in Japan: the Osaka Maternal and Child Health Study. Br J Nutr (2011) 1.03
Antibodies to N-methyl-D-aspartate glutamate receptors in Creutzfeldt-Jakob disease patients. J Neuroimmunol (2012) 1.03
Dietary folate and vitamins B12, B6, and B2 intake and the risk of postpartum depression in Japan: the Osaka Maternal and Child Health Study. J Affect Disord (2006) 1.02
Hyperactivation of midbrain dopaminergic system in schizophrenia could be attributed to the down-regulation of dysbindin. Biochem Biophys Res Commun (2006) 1.01
Home environment and suspected atopic eczema in Japanese infants: the Osaka Maternal and Child Health Study. Pediatr Allergy Immunol (2007) 1.00
Dietary glycemic index and load and the risk of postpartum depression in Japan: the Osaka Maternal and Child Health Study. J Affect Disord (2008) 0.99
[Anti-NMDA receptor antibody encephalitis with recurrent optic neuritis and epilepsy]. Rinsho Shinkeigaku (2010) 0.99
P2X(2)- and P2X(3)-positive fibers in fungiform papillae originate from the chorda tympani but not the trigeminal nerve in rats and mice. J Comp Neurol (2009) 0.99
Increased prevalence, incidence, and female predominance of multiple sclerosis in northern Japan. J Neurol Sci (2012) 0.99
Relationship between smoking status and tooth loss: findings from national databases in Japan. J Epidemiol (2007) 0.99
Daytime hypoxemia, sleep-disordered breathing, and laryngopharyngeal findings in multiple system atrophy. Arch Neurol (2007) 0.98
Regulatory T cells in paraneoplastic neurological syndromes. J Neuroimmunol (2008) 0.98
Dental caries in 3-year-old children and smoking status of parents. Paediatr Perinat Epidemiol (2008) 0.97
Genetic susceptibility to atopic dermatitis. Allergol Int (2008) 0.96
Glucosamine induces autophagy via an mTOR-independent pathway. Biochem Biophys Res Commun (2010) 0.96
Acoustic radiation force impulse elastography of the kidneys: is shear wave velocity affected by tissue fibrosis or renal blood flow? J Ultrasound Med (2014) 0.96
Risk of postpartum depression in relation to dietary fish and fat intake in Japan: the Osaka Maternal and Child Health Study. Psychol Med (2006) 0.96
Heterozygous UDP-GlcNAc 2-epimerase and N-acetylmannosamine kinase domain mutations in the GNE gene result in a less severe GNE myopathy phenotype compared to homozygous N-acetylmannosamine kinase domain mutations. J Neurol Sci (2012) 0.95
Mechanism of cytotoxicity of paraquat. Environ Health Prev Med (2002) 0.95
Fish and n-3 polyunsaturated fatty acid intake and depressive symptoms: Ryukyus Child Health Study. Pediatrics (2010) 0.94
Cytotoxic T cell activity against peptides of Hu protein in anti-Hu syndrome. J Neurol Sci (2002) 0.94
Residential proximity to main roads during pregnancy and the risk of allergic disorders in Japanese infants: the Osaka Maternal and Child Health Study. Pediatr Allergy Immunol (2009) 0.94
Development of a loop-mediated isothermal amplification assay for sensitive and rapid detection of Vibrio parahaemolyticus. BMC Microbiol (2008) 0.94
p97/valosin-containing protein (VCP) is highly modulated by phosphorylation and acetylation. Genes Cells (2009) 0.94
Fezf1 is required for penetration of the basal lamina by olfactory axons to promote olfactory development. J Comp Neurol (2009) 0.93
In vitro modeling of paraxial mesodermal progenitors derived from induced pluripotent stem cells. PLoS One (2012) 0.92
Inhibition of nuclear entry of HPV16 pseudovirus-packaged DNA by an anti-HPV16 L2 neutralizing antibody. Virology (2010) 0.92
In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia. J Exp Med (2006) 0.92
A novel mutation in the GNE gene and a linkage disequilibrium in Japanese pedigrees. Ann Neurol (2002) 0.92
Employment, income, and education and risk of postpartum depression: the Osaka Maternal and Child Health Study. J Affect Disord (2010) 0.92
Real-time imaging of rabbit retina with retinal degeneration by using spectral-domain optical coherence tomography. PLoS One (2012) 0.92
Synthesis and evaluation of C-11, F-18 and I-125 small molecule radioligands for detecting oxytocin receptors. Bioorg Med Chem (2012) 0.91
Tumor necrosis factor receptor-associated protein 1 regulates cell adhesion and synaptic morphology via modulation of N-cadherin expression. J Neurochem (2009) 0.91
Gene polymorphisms of the mu opioid receptor in methamphetamine abusers. Ann N Y Acad Sci (2004) 0.90
Employment, income, and education and prevalence of depressive symptoms during pregnancy: the Kyushu Okinawa Maternal and Child Health Study. BMC Psychiatry (2012) 0.89
Dominant-negative effect of mutant valosin-containing protein in aggresome formation. FEBS Lett (2005) 0.89
Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease: a case-control study in Japan. Br J Nutr (2010) 0.89
Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan. J Neurol Sci (2009) 0.89
Ambient formaldehyde levels and allergic disorders among Japanese pregnant women: baseline data from the Osaka maternal and child health study. Ann Epidemiol (2008) 0.89
Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL. Neurobiol Dis (2005) 0.89
Phylogenetic Clades 6 and 8 of Enterohemorrhagic Escherichia coli O157:H7 With Particular stx Subtypes are More Frequently Found in Isolates From Hemolytic Uremic Syndrome Patients Than From Asymptomatic Carriers. Open Forum Infect Dis (2014) 0.89
Details of treatment-related difficulties in men with anti-N-methyl-D-aspartate receptor encephalitis. Eur Neurol (2012) 0.89
Intermittent intravenous immunoglobulin successfully prevents relapses of neuromyelitis optica. Intern Med (2007) 0.89
A case of neuromyelitis optica developing into myelitis 25 years after optic neuritis. Jpn J Ophthalmol (2010) 0.89
Development and evaluation of immunochromatographic assay for simple and rapid detection of Campylobacter jejuni and Campylobacter coli in human stool specimens. J Clin Microbiol (2008) 0.88