Published in J Cell Sci on November 01, 2002
UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II. J Cell Biol (2004) 1.98
Valosin-containing protein disease: inclusion body myopathy with Paget's disease of the bone and fronto-temporal dementia. Neuromuscul Disord (2009) 1.94
The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans. J Cell Biol (2007) 1.49
Heat-shock protein 90alpha1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos. Proc Natl Acad Sci U S A (2008) 1.44
Build it up-Tear it down: protein quality control in the cardiac sarcomere. Cardiovasc Res (2008) 1.42
Still Heart Encodes a Structural HMT, SMYD1b, with Chaperone-Like Function during Fast Muscle Sarcomere Assembly. PLoS One (2015) 1.41
Shuttling of the chaperones Unc45b and Hsp90a between the A band and the Z line of the myofibril. J Cell Biol (2008) 1.24
Unc45 activates Hsp90-dependent folding of the myosin motor domain. J Biol Chem (2008) 1.23
Microtubule-dependent transport and organization of sarcomeric myosin during skeletal muscle differentiation. EMBO J (2005) 1.18
Functional diversity among a family of human skeletal muscle myosin motors. Proc Natl Acad Sci U S A (2009) 1.18
Loss of unc45a precipitates arteriovenous shunting in the aortic arches. Dev Biol (2008) 1.17
GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. Mol Cell Biol (2006) 1.17
Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain. PLoS One (2008) 1.13
Knockdown and overexpression of Unc-45b result in defective myofibril organization in skeletal muscles of zebrafish embryos. BMC Cell Biol (2010) 1.05
Paralysis and delayed Z-disc formation in the Xenopus tropicalis unc45b mutant dicky ticker. BMC Dev Biol (2010) 1.00
The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Cell (2013) 0.98
Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein trafficking. Proc Natl Acad Sci U S A (2014) 0.97
The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model. PLoS One (2011) 0.97
Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility. Am J Pathol (2007) 0.96
GCUNC45 is the first Hsp90 co-chaperone to show alpha/beta isoform specificity. J Biol Chem (2008) 0.96
Drosophila UNC-45 prevents heat-induced aggregation of skeletal muscle myosin and facilitates refolding of citrate synthase. Biochem Biophys Res Commun (2010) 0.95
Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability. J Cell Sci (2011) 0.89
X-ray crystal structure of the UCS domain-containing UNC-45 myosin chaperone from Drosophila melanogaster. Structure (2011) 0.89
Myosin assembly, maintenance and degradation in muscle: Role of the chaperone UNC-45 in myosin thick filament dynamics. Int J Mol Sci (2008) 0.89
Tracking UNC-45 chaperone-myosin interaction with a titin mechanical reporter. Biophys J (2012) 0.88
The myosin-binding UCS domain but not the Hsp90-binding TPR domain of the UNC-45 chaperone is essential for function in Caenorhabditis elegans. J Cell Sci (2011) 0.88
Myosin chaperones. Curr Opin Struct Biol (2013) 0.87
Lack of developmental redundancy between Unc45 proteins in zebrafish muscle development. PLoS One (2012) 0.85
At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis. Biochem Res Int (2012) 0.85
UNC-45B chaperone: the role of its domains in the interaction with the myosin motor domain. Biophys J (2014) 0.83
The UNC-45 myosin chaperone: from worms to flies to vertebrates. Int Rev Cell Mol Biol (2014) 0.82
A Toxoplasma gondii class XIV myosin, expressed in Sf9 cells with a parasite co-chaperone, requires two light chains for fast motility. J Biol Chem (2014) 0.82
Overexpression of smooth muscle myosin heavy chain leads to activation of the unfolded protein response and autophagic turnover of thick filament-associated proteins in vascular smooth muscle cells. J Biol Chem (2014) 0.82
The myosin chaperone UNC45B is involved in lens development and autosomal dominant juvenile cataract. Eur J Hum Genet (2014) 0.80
Dual function of the UNC-45b chaperone with myosin and GATA4 in cardiac development. J Cell Sci (2012) 0.78
Getting folded: chaperone proteins in muscle development, maintenance and disease. Anat Rec (Hoboken) (2014) 0.78
A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells. PLoS One (2011) 0.77
Altered myofilament stoichiometry in response to heart failure in a cardioprotective α-myosin heavy chain transgenic rabbit model. Proteomics Clin Appl (2011) 0.76
Chaperoning myosin assembly in muscle formation and aging. Worm (2013) 0.76
A Remodeled Hsp90 Molecular Chaperone Ensemble with the Novel Cochaperone Aarsd1 Is Required for Muscle Differentiation. Mol Cell Biol (2016) 0.76
Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70. PLoS One (2017) 0.75
UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation. Cancer Lett (2014) 0.75
Shaping proteostasis at the cellular, tissue, and organismal level. J Cell Biol (2017) 0.75
Mutation of the Ser18 phosphorylation site on the sole Saccharomyces cerevisiae UCS protein, She4, can compromise high-temperature survival. Cell Stress Chaperones (2016) 0.75
UNC-45A Is a Nonmuscle Myosin IIA Chaperone Required for NK Cell Cytotoxicity via Control of Lytic Granule Secretion. J Immunol (2015) 0.75
UNC-45A is Required for Neurite Extension via Controlling NMII activation. Mol Biol Cell (2017) 0.75
Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans. Cell (2004) 2.26
Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin. Science (2002) 2.22
Non-optimal codon usage affects expression, structure and function of clock protein FRQ. Nature (2013) 2.15
The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans. J Cell Biol (2007) 1.49
The UCS family of myosin chaperones. J Cell Sci (2002) 1.37
UNC-98 links an integrin-associated complex to thick filaments in Caenorhabditis elegans muscle. J Cell Biol (2006) 1.11
Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein. J Biol Chem (2011) 1.11
Comprehensive next-generation sequence analyses of the entire mitochondrial genome reveal new insights into the molecular diagnosis of mitochondrial DNA disorders. Genet Med (2013) 1.07
The sacsin repeating region (SRR): a novel Hsp90-related supra-domain associated with neurodegeneration. J Mol Biol (2010) 0.95
Novel phosphorylation target in the serum response factor MADS box regulates alpha-actin transcription. Biochemistry (2003) 0.90
Caenorhabditis elegans muscle: a genetic and molecular model for protein interactions in the heart. Circ Res (2011) 0.90
Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability. J Cell Sci (2011) 0.89
The myosin-binding UCS domain but not the Hsp90-binding TPR domain of the UNC-45 chaperone is essential for function in Caenorhabditis elegans. J Cell Sci (2011) 0.88
Tracking UNC-45 chaperone-myosin interaction with a titin mechanical reporter. Biophys J (2012) 0.88
Differential turnover of myosin chaperone UNC-45A isoforms increases in metastatic human breast cancer. J Mol Biol (2011) 0.84
Requirement of inositol 1,4,5-trisphosphate receptors for tumor-mediated lymphocyte apoptosis. J Biol Chem (2008) 0.84
An integrated approach for classifying mitochondrial DNA variants: one clinical diagnostic laboratory's experience. Genet Med (2012) 0.82
Homodimerization through coiled-coil regions enhances activity of the myotonic dystrophy protein kinase. FEBS Lett (2003) 0.81
Orthostatic tremor, progressive external ophthalmoplegia, and Twinkle. JAMA Neurol (2013) 0.79
Dual function of the UNC-45b chaperone with myosin and GATA4 in cardiac development. J Cell Sci (2012) 0.78
A role for myotonic dystrophy protein kinase in synaptic plasticity. J Neurophysiol (2002) 0.76
Atypical presentation of Leigh syndrome associated with a Leber hereditary optic neuropathy primary mitochondrial DNA mutation. Mol Genet Metab (2011) 0.76