Published in Proc Natl Acad Sci U S A on December 28, 2009
Hypertrophic and dilated cardiomyopathy: four decades of basic research on muscle lead to potential therapeutic approaches to these devastating genetic diseases. Biophys J (2014) 1.44
Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function. Proc Natl Acad Sci U S A (2013) 1.42
Identification of functional differences between recombinant human α and β cardiac myosin motors. Cell Mol Life Sci (2012) 1.06
Erratum to: Identification of functional differences between recombinant human α and β cardiac myosin motors. Cell Mol Life Sci (2012) 1.01
The embryonic myosin R672C mutation that underlies Freeman-Sheldon syndrome impairs cross-bridge detachment and cycling in adult skeletal muscle. Hum Mol Genet (2015) 0.96
The role of mechanics in biological and bio-inspired systems. Nat Commun (2015) 0.95
IIb or not IIb? Regulation of myosin heavy chain gene expression in mice and men. Skelet Muscle (2011) 0.93
Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin. PLoS One (2013) 0.92
Developmental myosins: expression patterns and functional significance. Skelet Muscle (2015) 0.91
Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector. Cell Rep (2015) 0.90
The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosin. J Biol Chem (2013) 0.89
Transgenic mouse α- and β-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences. J Biol Chem (2013) 0.89
Contractility and kinetics of human fetal and human adult skeletal muscle. J Physiol (2013) 0.88
The myosin-binding UCS domain but not the Hsp90-binding TPR domain of the UNC-45 chaperone is essential for function in Caenorhabditis elegans. J Cell Sci (2011) 0.88
Mechanical coordination in motor ensembles revealed using engineered artificial myosin filaments. Nat Nanotechnol (2015) 0.86
The genetic pleiotropy of musculoskeletal aging. Front Physiol (2012) 0.85
Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function. Sci Adv (2015) 0.85
Pitx2 regulates myosin heavy chain isoform expression and multi-innervation in extraocular muscle. J Physiol (2011) 0.84
Emergent systems energy laws for predicting myosin ensemble processivity. PLoS Comput Biol (2015) 0.83
The superfast human extraocular myosin is kinetically distinct from the fast skeletal IIa, IIb, and IId isoforms. J Biol Chem (2013) 0.82
The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury. PLoS One (2014) 0.82
Sex-based differences in skeletal muscle kinetics and fiber-type composition. Physiology (Bethesda) (2015) 0.81
Mechanistic heterogeneity in contractile properties of α-tropomyosin (TPM1) mutants associated with inherited cardiomyopathies. J Biol Chem (2014) 0.81
Poorly understood aspects of striated muscle contraction. Biomed Res Int (2015) 0.78
Transgenic expression and purification of myosin isoforms using the Drosophila melanogaster indirect flight muscle system. Methods (2011) 0.77
Piperine's mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle. Proc Natl Acad Sci U S A (2016) 0.76
Estrogen receptor profiling and activity in cardiac myocytes. Mol Cell Endocrinol (2016) 0.76
Modeling the Actin.myosin ATPase Cross-Bridge Cycle for Skeletal and Cardiac Muscle Myosin Isoforms. Biophys J (2017) 0.75
The Most Prevalent Freeman-Sheldon Syndrome Mutations in the Embryonic Myosin Motor Share Functional Defects. J Biol Chem (2016) 0.75
Robust mechanobiological behavior emerges in heterogeneous myosin systems. Proc Natl Acad Sci U S A (2017) 0.75
Measuring the Kinetic and Mechanical Properties of Non-processive Myosins Using Optical Tweezers. Methods Mol Biol (2017) 0.75
A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A (1998) 24.58
The isometric responses of mammalian muscles. J Physiol (1930) 19.26
Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle. Nature (1978) 11.49
Purification of muscle actin. Methods Enzymol (1982) 9.11
Separation of subfragment-1 isoenzymes from rabbit skeletal muscle myosin. Nature (1975) 7.09
Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev (1996) 5.47
A myogenic cell line with altered serum requirements for differentiation. Differentiation (1977) 5.30
The kinetic mechanism of myosin V. Proc Natl Acad Sci U S A (1999) 4.56
Mutation of perinatal myosin heavy chain associated with a Carney complex variant. N Engl J Med (2004) 4.22
Myosin VI is a processive motor with a large step size. Proc Natl Acad Sci U S A (2001) 3.95
Mutations in embryonic myosin heavy chain (MYH3) cause Freeman-Sheldon syndrome and Sheldon-Hall syndrome. Nat Genet (2006) 3.94
Myosin subfragment-1 is sufficient to move actin filaments in vitro. Nature (1987) 3.44
Kinetic tuning of myosin via a flexible loop adjacent to the nucleotide binding pocket. J Biol Chem (1998) 2.62
Skeletal muscle myosin light chains are essential for physiological speeds of shortening. Nature (1993) 2.29
Mammalian skeletal muscle fiber type transitions. Int Rev Cytol (1997) 2.28
Force-velocity relations and myosin heavy chain isoform compositions of skinned fibres from rat skeletal muscle. J Physiol (1991) 2.25
Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin. Science (2002) 2.22
The mammalian myosin heavy chain gene family. Annu Rev Cell Dev Biol (1996) 2.20
Shortening velocity in single fibers from adult rabbit soleus muscles is correlated with myosin heavy chain composition. J Biol Chem (1985) 2.17
Myosin isoforms in mammalian skeletal muscle. J Appl Physiol (1985) (1994) 1.92
Co-expression of multiple myosin heavy chain genes, in addition to a tissue-specific one, in extraocular musculature. J Cell Biol (1985) 1.90
The expression of myosin genes in developing skeletal muscle in the mouse embryo. J Cell Biol (1990) 1.90
Myosin heavy chain isoforms in postnatal muscle development of mice. Biol Cell (2003) 1.78
Unc-45 mutations in Caenorhabditis elegans implicate a CRO1/She4p-like domain in myosin assembly. J Cell Biol (1998) 1.78
Heterologous expression of a cardiomyopathic myosin that is defective in its actin interaction. J Biol Chem (1994) 1.77
Chaperone-mediated folding and assembly of myosin in striated muscle. J Cell Sci (2004) 1.68
Unloaded shortening velocity and myosin heavy chain and alkali light chain isoform composition in rat skeletal muscle fibres. J Physiol (1994) 1.64
A 7-amino-acid insert in the heavy chain nucleotide binding loop alters the kinetics of smooth muscle myosin in the laser trap. J Muscle Res Cell Motil (1998) 1.61
Myofibrillar ATPase activity in skinned human skeletal muscle fibres: fibre type and temperature dependence. J Physiol (1996) 1.60
Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions. J Cell Sci (2002) 1.58
The essential light chain is required for full force production by skeletal muscle myosin. Proc Natl Acad Sci U S A (1994) 1.52
A myosin II mutation uncouples ATPase activity from motility and shortens step size. Nat Cell Biol (2001) 1.52
Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity. J Mol Biol (1999) 1.52
Function of skeletal muscle myosin heavy and light chain isoforms by an in vitro motility assay. J Biol Chem (1993) 1.47
Dynamic properties of inferior rectus muscle of the rat. J Physiol (1974) 1.40
Different pathways regulate expression of the skeletal myosin heavy chain genes. J Biol Chem (2001) 1.38
Whole-muscle and single-fibre contractile properties and myosin heavy chain isoforms in humans. Pflugers Arch (1996) 1.37
Myosin II folding is mediated by a molecular chaperonin. J Biol Chem (1999) 1.36
Myofibrillar ATPase activity during isometric contraction and isomyosin composition in rat single skinned muscle fibres. J Physiol (1994) 1.35
What limits the velocity of fast-skeletal muscle contraction in mammals? J Mol Biol (2005) 1.35
Maximum velocity of shortening related to myosin isoform composition in frog skeletal muscle fibres. J Physiol (1988) 1.29
Differing ADP release rates from myosin heavy chain isoforms define the shortening velocity of skeletal muscle fibers. J Biol Chem (2001) 1.23
Growth and muscle defects in mice lacking adult myosin heavy chain genes. J Cell Biol (1997) 1.18
Biochemical studies of myosin. Methods (2000) 1.16
The sequence of the myosin 50-20K loop affects Myosin's affinity for actin throughout the actin-myosin ATPase cycle and its maximum ATPase activity. Biochemistry (1999) 1.16
Chimeric substitutions of the actin-binding loop activate dephosphorylated but not phosphorylated smooth muscle heavy meromyosin. J Biol Chem (1995) 1.16
Clinical phenotypes and molecular genetic mechanisms of Carney complex. Lancet Oncol (2005) 1.14
Fibre types in extraocular muscles: a new myosin isoform in the fast fibres. J Muscle Res Cell Motil (1987) 1.13
Chemo-mechanical energy transduction in relation to myosin isoform composition in skeletal muscle fibres of the rat. J Physiol (1997) 1.12
Cold-sensitive mutants G680V and G691C of Dictyostelium myosin II confer dramatically different biochemical defects. J Biol Chem (1997) 1.11
MyoD, Myf5, and the calcineurin pathway activate the developmental myosin heavy chain genes. Dev Biol (2006) 1.09
Folding of the striated muscle myosin motor domain. J Biol Chem (2002) 1.08
Postnatal myosin heavy chain isoform expression in normal mice and mice null for IIb or IId myosin heavy chains. Dev Biol (2001) 1.08
Adult human masseter muscle fibers express myosin isozymes characteristic of development. Muscle Nerve (1988) 1.06
Spatial and temporal patterns of myosin heavy chain expression in developing rat extraocular muscle. J Muscle Res Cell Motil (1996) 1.04
Maximum shortening velocity and coexistence of myosin heavy chain isoforms in single skinned fast fibres of rat skeletal muscle. J Muscle Res Cell Motil (1994) 1.02
Expression of extraocular myosin heavy chain in rabbit laryngeal muscle. J Muscle Res Cell Motil (1995) 0.98
Mismatch between myosin heavy chain mRNA and protein distribution in human skeletal muscle fibers. Am J Physiol (1997) 0.97
A flash photolysis fluorescence/light scattering apparatus for use with sub microgram quantities of muscle proteins. J Muscle Res Cell Motil (2000) 0.96
Sarcomeric Myosin Isoforms: Fine Tuning of a Molecular Motor. News Physiol Sci (2000) 0.96
Unloaded shortening velocity and myosin heavy chain variations in human laryngeal muscle fibers. Ann Otol Rhinol Laryngol (2002) 0.95
Inactivation of myosin heavy chain genes in the mouse: diverse and unexpected phenotypes. Microsc Res Tech (2000) 0.94
ATP consumption rate per cross bridge depends on myosin heavy chain isoform. J Appl Physiol (1985) (2003) 0.94
Nonuniform myosin expression along single fibers of chronically stimulated and contralateral rabbit tibialis anterior muscles. Pflugers Arch (1987) 0.93
Variable surface loops and myosin activity: accessories to a motor. J Muscle Res Cell Motil (2000) 0.92
Quantitative analyses of myosin heavy-chain mRNA and protein isoforms in single fibers reveal a pronounced fiber heterogeneity in normal rabbit muscles. Eur J Biochem (1997) 0.88
Continued expression of neonatal myosin heavy chain in adult dystrophic skeletal muscle. Science (1985) 0.86
Development of a mammalian fast muscle: dynamic and biochemical properties correlated. J Physiol (1973) 0.86
Comparison of myosins from the masseter muscle of adult rat, mouse and guinea-pig. Persistence of neonatal-type isoforms in the murine muscle. Eur J Biochem (1986) 0.85
Differential expression of equine myosin heavy-chain mRNA and protein isoforms in a limb muscle. J Histochem Cytochem (2003) 0.83
Diversity of myosin-based motility: multiple genes and functions. Soc Gen Physiol Ser (1994) 0.78
Optimized localization analysis for single-molecule tracking and super-resolution microscopy. Nat Methods (2010) 5.09
Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure. Circulation (2006) 4.69
Single molecule high-resolution colocalization of Cy3 and Cy5 attached to macromolecules measures intramolecular distances through time. Proc Natl Acad Sci U S A (2005) 3.98
The mechanism of myosin VI translocation and its load-induced anchoring. Cell (2004) 3.85
Role of the lever arm in the processive stepping of myosin V. Proc Natl Acad Sci U S A (2002) 2.86
Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological extracellular matrix remodeling in heart valve disease. Circ Res (2004) 2.45
A force-dependent state controls the coordination of processive myosin V. Proc Natl Acad Sci U S A (2005) 2.39
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell (2012) 2.35
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature (2012) 2.33
Myosin VI walks hand-over-hand along actin. Nat Struct Mol Biol (2004) 2.19
Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav Immun (2009) 2.19
Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains. J Appl Physiol (1985) (2002) 2.15
Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy. Circ Res (2006) 2.09
Dynamics of the unbound head during myosin V processive translocation. Nat Struct Mol Biol (2007) 2.04
Long single alpha-helical tail domains bridge the gap between structure and function of myosin VI. Nat Struct Mol Biol (2008) 1.88
Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. PLoS Genet (2006) 1.84
Optical traps to study properties of molecular motors. Cold Spring Harb Protoc (2011) 1.79
A flexible domain is essential for the large step size and processivity of myosin VI. Mol Cell (2005) 1.78
Mechanics and regulation of cytokinesis. Curr Opin Cell Biol (2004) 1.76
Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med (2002) 1.76
Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis. Proc Natl Acad Sci U S A (2005) 1.73
Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10. Eur J Neurosci (2005) 1.73
The power stroke of myosin VI and the basis of reverse directionality. Proc Natl Acad Sci U S A (2006) 1.72
Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats. Brain Behav Immun (2006) 1.67
Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10. Mol Pain (2005) 1.66
Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain (2006) 1.66
Colocalization of fluorescent probes: accurate and precise registration with nanometer resolution. Cold Spring Harb Protoc (2012) 1.62
A non-Gaussian distribution quantifies distances measured with fluorescence localization techniques. Biophys J (2005) 1.57
The cell biology of disease: cellular mechanisms of cardiomyopathy. J Cell Biol (2011) 1.54
Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization. Exp Neurol (2013) 1.52
Crosslinked hyaluronan scaffolds as a biologically active carrier for valvular interstitial cells. Biomaterials (2005) 1.51
Dynamic charge interactions create surprising rigidity in the ER/K alpha-helical protein motif. Proc Natl Acad Sci U S A (2008) 1.50
Competencies: a cure for pre-med curriculum. Science (2011) 1.47
Quantitation of the distribution and flux of myosin-II during cytokinesis. BMC Cell Biol (2002) 1.44
Designing scaffolds for valvular interstitial cells: cell adhesion and function on naturally derived materials. J Biomed Mater Res A (2004) 1.43
Uncoupling of expression of an intronic microRNA and its myosin host gene by exon skipping. Mol Cell Biol (2010) 1.43
Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function. Proc Natl Acad Sci U S A (2013) 1.42
Redirecting valvular myofibroblasts into dormant fibroblasts through light-mediated reduction in substrate modulus. PLoS One (2012) 1.41
Principles of unconventional myosin function and targeting. Annu Rev Cell Dev Biol (2011) 1.30
The optical trapping dumbbell assay for nonprocessive motors or motors that turn around filaments. Cold Spring Harb Protoc (2011) 1.30
Fatty acids identified in the Burmese python promote beneficial cardiac growth. Science (2011) 1.30
Cancer causes cardiac atrophy and autophagy in a sexually dimorphic manner. Cancer Res (2010) 1.30
How does ATP hydrolysis control actin's associations? Proc Natl Acad Sci U S A (2002) 1.29
Soy diet worsens heart disease in mice. J Clin Invest (2006) 1.29
Rho kinase's role in myosin recruitment to the equatorial cortex of mitotic Drosophila S2 cells is for myosin regulatory light chain phosphorylation. PLoS One (2006) 1.28
The myosin superfamily at a glance. J Cell Sci (2012) 1.23
Loaded wheel running and muscle adaptation in the mouse. Am J Physiol Heart Circ Physiol (2005) 1.23
Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway. Proc Natl Acad Sci U S A (2013) 1.20
Contribution of the myosin VI tail domain to processive stepping and intramolecular tension sensing. Proc Natl Acad Sci U S A (2010) 1.20
Bioinformatics assessment of beta-myosin mutations reveals myosin's high sensitivity to mutations. Trends Cardiovasc Med (2008) 1.20
Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension. J Mol Cell Cardiol (2011) 1.19
Sex modifies exercise and cardiac adaptation in mice. Am J Physiol Heart Circ Physiol (2004) 1.18
Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain. Neuron Glia Biol (2006) 1.18
Attachment of anti-GFP antibodies to microspheres for optical trapping experiments. Cold Spring Harb Protoc (2011) 1.18
Precise positioning of myosin VI on endocytic vesicles in vivo. PLoS Biol (2007) 1.17
Statins block calcific nodule formation of valvular interstitial cells by inhibiting alpha-smooth muscle actin expression. Arterioscler Thromb Vasc Biol (2009) 1.16
Identification of a minimal myosin Va binding site within an intrinsically unstructured domain of melanophilin. J Biol Chem (2007) 1.15
Velocity, processivity, and individual steps of single myosin V molecules in live cells. Biophys J (2009) 1.15
Engineered myosin VI motors reveal minimal structural determinants of directionality and processivity. J Mol Biol (2009) 1.13
Sex-based cardiac physiology. Annu Rev Physiol (2009) 1.13
Determinants of myosin II cortical localization during cytokinesis. Curr Biol (2010) 1.13
Building and using optical traps to study properties of molecular motors. Methods Enzymol (2003) 1.12
Pregnancy as a cardiac stress model. Cardiovasc Res (2014) 1.11
Systematic control of protein interaction using a modular ER/K α-helix linker. Proc Natl Acad Sci U S A (2011) 1.10
Predicting allosteric communication in myosin via a pathway of conserved residues. J Mol Biol (2007) 1.10
MyoD, Myf5, and the calcineurin pathway activate the developmental myosin heavy chain genes. Dev Biol (2006) 1.09
Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells. J Cell Biol (2009) 1.08
Robust mechanosensing and tension generation by myosin VI. J Mol Biol (2010) 1.08
The effects of biological sex and diet on the development of heart failure. Circulation (2007) 1.07
Dictyostelium myosin bipolar thick filament formation: importance of charge and specific domains of the myosin rod. PLoS Biol (2004) 1.07
Intracellular calcium and myosin isoform transitions. Calcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter. J Biol Chem (2002) 1.07
Identification of functional differences between recombinant human α and β cardiac myosin motors. Cell Mol Life Sci (2012) 1.06
Restoration of CREB function is linked to completion and stabilization of adaptive cardiac hypertrophy in response to exercise. Am J Physiol Heart Circ Physiol (2007) 1.06
Coupled myosin VI motors facilitate unidirectional movement on an F-actin network. J Cell Biol (2009) 1.06
Integrin-linked kinase production prevents anoikis in human mesenchymal stem cells. J Biomed Mater Res A (2007) 1.05
Skeletal myosin heavy chain function in cultured lung myofibroblasts. J Cell Biol (2003) 1.05
Dynacortin is a novel actin bundling protein that localizes to dynamic actin structures. J Biol Chem (2002) 1.04
Single-molecule fluorescence imaging of processive myosin with enhanced background suppression using linear zero-mode waveguides (ZMWs) and convex lens induced confinement (CLIC). Opt Express (2013) 1.01
Erratum to: Identification of functional differences between recombinant human α and β cardiac myosin motors. Cell Mol Life Sci (2012) 1.01
Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins. Proc Natl Acad Sci U S A (2011) 1.01
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. J Biol Chem (2005) 1.01
Detailed tuning of structure and intramolecular communication are dispensable for processive motion of myosin VI. Biophys J (2011) 1.00
Hypertrophy, fibrosis, and sudden cardiac death in response to pathological stimuli in mice with mutations in cardiac troponin T. Circulation (2004) 0.99
The localization of inner centromeric protein (INCENP) at the cleavage furrow is dependent on Kif12 and involves interactions of the N terminus of INCENP with the actin cytoskeleton. Mol Biol Cell (2007) 0.99
Morphological and functional alterations in ventricular myocytes from male transgenic mice with hypertrophic cardiomyopathy. Circ Res (2003) 0.98
Mutations in the beta-myosin rod cause myosin storage myopathy via multiple mechanisms. Proc Natl Acad Sci U S A (2009) 0.98
Akt and MAPK signaling mediate pregnancy-induced cardiac adaptation. J Appl Physiol (1985) (2012) 0.97
Expression of cardiac troponin T with COOH-terminal truncation accelerates cross-bridge interaction kinetics in mouse myocardium. Am J Physiol Heart Circ Physiol (2004) 0.97
Whole transcriptome analysis of the fasting and fed Burmese python heart: insights into extreme physiological cardiac adaptation. Physiol Genomics (2010) 0.95
Mutations at the same amino acid in myosin that cause either skeletal or cardiac myopathy have distinct molecular phenotypes. J Mol Cell Cardiol (2009) 0.94
Single-molecule dual-beam optical trap analysis of protein structure and function. Methods Enzymol (2010) 0.94
Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy. EMBO Mol Med (2012) 0.94
IIb or not IIb? Regulation of myosin heavy chain gene expression in mice and men. Skelet Muscle (2011) 0.93
Loss of desmin leads to impaired voluntary wheel running and treadmill exercise performance. J Appl Physiol (1985) (2003) 0.93