Published in J Med Chem on October 10, 2002
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De novo sequencing of Hypericum perforatum transcriptome to identify potential genes involved in the biosynthesis of active metabolites. PLoS One (2012) 0.96
Taxonomy and Chemotaxonomy of the Genus Hypericum. Med Aromat Plant Sci Biotechnol (2011) 0.90
Hyperforin accumulates in the translucent glands of Hypericum perforatum. Ann Bot (2007) 0.90
Anti-inflammatory phloroglucinol derivatives from Hypericum empetrifolium. Phytochem Lett (2008) 0.86
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Progress towards the synthesis of Papuaforin A: Selective formation of α-bromoenones from silyl enol ethers. Tetrahedron Lett (2008) 0.76
Biosynthesis of phlorisovalerophenone and 4-hydroxy-6-isobutyl-2-pyrone in Escherichia coli from glucose. Microb Cell Fact (2016) 0.75
A dicarboxylate/4-hydroxybutyrate autotrophic carbon assimilation cycle in the hyperthermophilic Archaeum Ignicoccus hospitalis. Proc Natl Acad Sci U S A (2008) 2.23
Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. Proc Natl Acad Sci U S A (2002) 2.14
The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: studies on the mechanisms of the reactions catalyzed by IspG and IspH protein. Proc Natl Acad Sci U S A (2003) 1.80
Probing the reaction mechanism of IspH protein by x-ray structure analysis. Proc Natl Acad Sci U S A (2009) 1.68
Nuphar lutea thioalkaloids inhibit the nuclear factor kappaB pathway, potentiate apoptosis and are synergistic with cisplatin and etoposide. Cancer Biol Ther (2009) 1.62
Biosynthesis of flavocoenzymes. Nat Prod Rep (2005) 1.52
Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction. Angew Chem Int Ed Engl (2009) 1.49
Nanoarchaeum equitans and Ignicoccus hospitalis: new insights into a unique, intimate association of two archaea. J Bacteriol (2007) 1.47
Carbon metabolism of Listeria monocytogenes growing inside macrophages. Mol Microbiol (2008) 1.47
Diagnosis of Toxoplasma gondii infection after allogeneic stem cell transplant can be difficult and requires intensive scrutiny. Leuk Lymphoma (2010) 1.45
Insights into the autotrophic CO2 fixation pathway of the archaeon Ignicoccus hospitalis: comprehensive analysis of the central carbon metabolism. J Bacteriol (2007) 1.43
IspH protein of Escherichia coli: studies on iron-sulfur cluster implementation and catalysis. J Am Chem Soc (2004) 1.41
Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development. J Biol Chem (2003) 1.40
Pathogenomics of Listeria spp. Int J Med Microbiol (2007) 1.39
Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase. Proc Natl Acad Sci U S A (2002) 1.38
Magnetic-field effect on the photoactivation reaction of Escherichia coli DNA photolyase. Proc Natl Acad Sci U S A (2008) 1.35
Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Eur J Biochem (2003) 1.35
A bicyclic autotrophic CO2 fixation pathway in Chloroflexus aurantiacus. J Biol Chem (2002) 1.34
Perspectives in anti-infective drug design. The late steps in the biosynthesis of the universal terpenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate. Bioorg Chem (2004) 1.27
A possible primordial peptide cycle. Science (2003) 1.25
The carotenase AtCCD1 from Arabidopsis thaliana is a dioxygenase. J Biol Chem (2006) 1.22
Vitamin B1 biosynthesis in plants requires the essential iron sulfur cluster protein, THIC. Proc Natl Acad Sci U S A (2007) 1.22
13C isotopologue perturbation studies of Listeria monocytogenes carbon metabolism and its modulation by the virulence regulator PrfA. Proc Natl Acad Sci U S A (2006) 1.21
Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways. Eur J Biochem (2004) 1.20
On the reaction mechanism of adduct formation in LOV domains of the plant blue-light receptor phototropin. J Am Chem Soc (2004) 1.18
Biosynthesis of isoprenoids: crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase. Proc Natl Acad Sci U S A (2003) 1.18
New enzymes involved in aerobic benzoate metabolism in Azoarcus evansii. Mol Microbiol (2004) 1.15
Blue light perception in plants. Detection and characterization of a light-induced neutral flavin radical in a C450A mutant of phototropin. J Biol Chem (2003) 1.14
Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis. J Mol Biol (2003) 1.13
Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors. Biochemistry (2005) 1.12
Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids. J Mol Biol (2002) 1.11
Carbon metabolism of enterobacterial human pathogens growing in epithelial colorectal adenocarcinoma (Caco-2) cells. PLoS One (2010) 1.10
Metabolic adaptation of human pathogenic and related nonpathogenic bacteria to extra- and intracellular habitats. FEMS Microbiol Rev (2011) 1.08
Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. Phytochemistry (2009) 1.08
Crystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysis. J Mol Biol (2011) 1.08
Isotopologue profiling of Legionella pneumophila: role of serine and glucose as carbon substrates. J Biol Chem (2010) 1.08
Reductive dehydroxylation of allyl alcohols by IspH protein. Angew Chem Int Ed Engl (2010) 1.07
Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I. J Mol Biol (2003) 1.06
Pyruvate carboxylase plays a crucial role in carbon metabolism of extra- and intracellularly replicating Listeria monocytogenes. J Bacteriol (2010) 1.06
Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG. J Mol Biol (2010) 1.05
Laticifer-specific cis-prenyltransferase silencing affects the rubber, triterpene, and inulin content of Taraxacum brevicorniculatum. Plant Physiol (2012) 1.03
How the intestinal peptide transporter PEPT-1 contributes to an obesity phenotype in Caenorhabditits elegans. PLoS One (2009) 1.02
Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation. J Am Chem Soc (2012) 1.02
Aerobic benzoyl-CoA catabolic pathway in Azoarcus evansii: studies on the non-oxygenolytic ring cleavage enzyme. Mol Microbiol (2005) 1.02
A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus. J Mol Biol (2003) 1.02
Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis. J Biol Chem (2004) 1.02
Biosynthesis of vitamin B2: Structure and mechanism of riboflavin synthase. Arch Biochem Biophys (2008) 1.02
Studies on the reaction mechanism of riboflavin synthase: X-ray crystal structure of a complex with 6-carboxyethyl-7-oxo-8-ribityllumazine. Structure (2002) 1.01
A metastable prerequisite for the growth of lumazine synthase crystals. J Am Chem Soc (2005) 1.01
Characterization of rubber particles and rubber chain elongation in Taraxacum koksaghyz. BMC Biochem (2010) 1.00
Biosynthesis of isoprenoids: a bifunctional IspDF enzyme from Campylobacter jejuni. Eur J Biochem (2004) 0.99
The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase. J Mol Biol (2002) 0.99
Folate synthesis in plants: the first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I. Proc Natl Acad Sci U S A (2002) 0.98
Evolution of vitamin B2 biosynthesis: structural and functional similarity between pyrimidine deaminases of eubacterial and plant origin. J Biol Chem (2004) 0.97
Characterization of central carbon metabolism of Streptococcus pneumoniae by isotopologue profiling. J Biol Chem (2011) 0.96
Transcriptional regulation by antitermination. Interaction of RNA with NusB protein and NusB/NusE protein complex of Escherichia coli. J Mol Biol (2002) 0.96
Robustness of central carbohydrate metabolism in developing maize kernels. Phytochemistry (2006) 0.96
13CO2 as a universal metabolic tracer in isotopologue perturbation experiments. Phytochemistry (2007) 0.95
Crystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding fold. J Mol Biol (2003) 0.95
Labeling and enzyme studies of the central carbon metabolism in Metallosphaera sedula. J Bacteriol (2010) 0.95
Mechanistic insights on riboflavin synthase inspired by selective binding of the 6,7-dimethyl-8-ribityllumazine exomethylene anion. J Am Chem Soc (2010) 0.95
Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods. J Org Chem (2006) 0.95
Enzyme catalysis via control of activation entropy: site-directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase. J Mol Biol (2003) 0.94