Published in Brain Res on October 11, 2002
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36
Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling. Proc Natl Acad Sci U S A (2003) 2.28
High plasma erythropoietin levels are associated with prolonged coma duration and increased mortality in children with cerebral malaria. Clin Infect Dis (2014) 2.02
Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo. Proc Natl Acad Sci U S A (2003) 1.88
Erythropoietin both protects from and reverses experimental diabetic neuropathy. Proc Natl Acad Sci U S A (2004) 1.65
Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli. Blood (2009) 1.55
The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier--implications for the pathogenesis of diabetic retinopathy. J Biomed Biotechnol (2010) 1.52
Erythropoietin Receptor-Mediated Molecular Crosstalk Promotes T Cell Immunoregulation and Transplant Survival. J Am Soc Nephrol (2017) 1.38
Therapeutic potential of erythropoietin and its structural or functional variants in the nervous system. Neurotherapeutics (2009) 1.36
Post-ischemic treatment with erythropoietin or carbamylated erythropoietin reduces infarction and improves neurological outcome in a rat model of focal cerebral ischemia. Br J Pharmacol (2007) 1.35
Erythropoietin sustains cognitive function and brain volume after neonatal stroke. Dev Neurosci (2009) 1.26
Nonhematopoietic erythropoietin derivatives prevent motoneuron degeneration in vitro and in vivo. Mol Med (2006) 1.21
Current status of the immunomodulation and immunomediated therapeutic strategies for multiple sclerosis. Clin Dev Immunol (2011) 1.18
Erythropoietin: a potent inducer of peripheral immuno/inflammatory modulation in autoimmune EAE. PLoS One (2008) 1.18
TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury. Proc Natl Acad Sci U S A (2008) 1.17
Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion. Child Neuropsychol (2011) 1.15
Erythropoietin: a multimodal neuroprotective agent. Exp Transl Stroke Med (2009) 1.14
Chronic progressive multiple sclerosis - pathogenesis of neurodegeneration and therapeutic strategies. Curr Neuropharmacol (2010) 1.10
Animal models of multiple sclerosis for the development and validation of novel therapies - potential and limitations. J Neurol (2008) 1.08
Science review: recombinant human erythropoietin in critical illness: a role beyond anemia? Crit Care (2004) 1.07
Neuroprotective properties of chitosan and its derivatives. Mar Drugs (2010) 1.06
Long-term outcome of brain structure in premature infants: effects of liberal vs restricted red blood cell transfusions. Arch Pediatr Adolesc Med (2011) 1.03
Effects of erythropoietin on the bone microenvironment. Growth Factors (2011) 1.00
The pleiotropic effects of erythropoietin in infection and inflammation. Microbes Infect (2011) 0.99
Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS. J Drug Target (2010) 0.99
The effect of erythropoietin on normal and neoplastic cells. Biologics (2012) 0.98
Recent trends in erythropoietin-mediated neuroprotection. Int J Dev Neurosci (2007) 0.97
Erythropoietin, a novel versatile player regulating energy metabolism beyond the erythroid system. Int J Biol Sci (2014) 0.96
Do non-hemopoietic effects of erythropoietin play a beneficial role in heart failure? Heart Fail Rev (2008) 0.95
Erythropoietin in spinal cord injury. Eur Spine J (2008) 0.95
Erythropoietin enhances endogenous haem oxygenase-1 and represses immune responses to ameliorate experimental autoimmune encephalomyelitis. Clin Exp Immunol (2010) 0.94
Growth factors in ischemic stroke. J Cell Mol Med (2009) 0.94
Novel serum biomarkers for erythropoietin use in humans: a proteomic approach. J Appl Physiol (1985) (2010) 0.94
A molecular characterization of the choroid plexus and stress-induced gene regulation. Transl Psychiatry (2012) 0.93
Promises and pitfalls in erythopoietin-mediated tissue protection: are nonerythropoietic derivatives a way forward? J Investig Med (2011) 0.92
A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury. Exp Neurol (2008) 0.91
Erythropoietin: still on the neuroprotection road. Ther Adv Neurol Disord (2012) 0.90
Myelin basic protein induces inflammatory mediators from primary human endothelial cells and blood-brain barrier disruption: implications for the pathogenesis of multiple sclerosis. Neuropathol Appl Neurobiol (2013) 0.90
Erythropoietin: a candidate treatment for mood symptoms and memory dysfunction in depression. Psychopharmacology (Berl) (2011) 0.89
Erythropoietin attenuates brain injury, subventricular zone expansion, and sensorimotor deficits in hypoxic-ischemic neonatal rats. J Korean Med Sci (2008) 0.89
Erythropoietin and hypothermia for hypoxic-ischemic encephalopathy. Pediatr Neurol (2014) 0.89
Erythropoietin (EPO) increases myelin gene expression in CG4 oligodendrocyte cells through the classical EPO receptor. Mol Med (2013) 0.88
A randomized, masked study of weekly erythropoietin dosing in preterm infants. J Pediatr (2011) 0.87
Erythropoietin in brain development and beyond. Anat Res Int (2012) 0.86
A double-blind, placebo-controlled trial of adding erythropoietin to intravenous methylprednisolone for the treatment of unilateral acute optic neuritis of unknown or demyelinative origin. Graefes Arch Clin Exp Ophthalmol (2015) 0.85
Erythropoietin attenuates neurological and histological consequences of toxic demyelination in mice. Mol Med (2012) 0.85
Erythropoietin attenuates hyperoxia-induced lung injury by down-modulating inflammation in neonatal rats. J Korean Med Sci (2007) 0.84
Erythropoietin ameliorates rat experimental autoimmune neuritis by inducing transforming growth factor-β in macrophages. PLoS One (2011) 0.84
Cytoprotective effect of recombinant human erythropoietin produced in transgenic tobacco plants. PLoS One (2013) 0.84
The neurobiology of erythropoietin. Cell Mol Neurobiol (2011) 0.84
Suppression of coronary atherosclerosis by helix B surface Peptide, a nonerythropoietic, tissue-protective compound derived from erythropoietin. Mol Med (2013) 0.83
Non-erythroid effects of erythropoietin. Haematologica (2010) 0.83
A trifluoromethyl analogue of celecoxib exerts beneficial effects in neuroinflammation. PLoS One (2013) 0.83
Recombinant Human Erythropoietin: Novel Strategies for Neuroprotective/Neuro-regenerative Treatment of Multiple Sclerosis. Ther Adv Neurol Disord (2008) 0.82
Erythropoietin protects against murine cerebral malaria through actions on host cellular immunity. Infect Immun (2013) 0.82
Pretreatment with darbepoetin attenuates renal injury in a rat model of cisplatin-induced nephrotoxicity. Korean J Intern Med (2009) 0.81
Effect of erythropoietin-stimulating agent on uremic inflammation. J Inflamm (Lond) (2012) 0.81
Erythropoietin modulates neural and cognitive processing of emotional information in biomarker models of antidepressant drug action in depressed patients. Psychopharmacology (Berl) (2010) 0.81
Early sustained injections of erythropoietin improve angiogenesis and restoration of perfusion in the ischemic mouse hindlimb. J Korean Med Sci (2012) 0.81
Does erythropoietin protect the preterm brain? Arch Dis Child Fetal Neonatal Ed (2004) 0.80
Expression of erythropoietin in the spinal cord of lewis rats with experimental autoimmune encephalomyelitis. J Clin Neurol (2009) 0.80
Recombinant human erythropoietin in amyotrophic lateral sclerosis: a pilot study of safety and feasibility. J Clin Neurol (2014) 0.79
Recombinant human erythropoietin reduces plasminogen activator inhibitor and ameliorates pro-inflammatory responses following trauma. Daru (2011) 0.79
Erythropoietin Pathway: A Potential Target for the Treatment of Depression. Int J Mol Sci (2016) 0.79
Elevated endogenous erythropoietin concentrations are associated with increased risk of brain damage in extremely preterm neonates. PLoS One (2015) 0.79
Experimental studies of erythropoietin protection following traumatic brain injury in rats. Exp Ther Med (2012) 0.78
Two-step purification procedure for recombinant human asialoerythropoietin expressed in transgenic plants. Int J Biol Macromol (2014) 0.78
Erythropoietin and autoimmune neuroinflammation: lessons from experimental autoimmune encephalomyelitis and experimental autoimmune neuritis. Anat Cell Biol (2012) 0.78
Erythropoietin Protects Rat Brain Injury from Carbon Monoxide Poisoning by Inhibiting Toll-Like Receptor 4/NF-kappa B-Dependent Inflammatory Responses. Inflammation (2016) 0.77
Revisiting the role of erythropoietin for treatment of ocular disorders. Eye (Lond) (2016) 0.77
Carbamylated Erythropoietin Outperforms Erythropoietin in the Treatment of AKI-on-CKD and Other AKI Models. J Am Soc Nephrol (2016) 0.76
Neonatal Encephalopathy: Update on Therapeutic Hypothermia and Other Novel Therapeutics. Clin Perinatol (2016) 0.75
Effect of Erythropoietin on Serum Brain-derived Biomarkers after Carbon Monoxide Poisoning in Rats. Iran J Basic Med Sci (2012) 0.75
Are high cumulative doses of erythropoietin neuroprotective in preterm infants? A two year follow-up report. Ital J Pediatr (2015) 0.75
Epobis is a Nonerythropoietic and Neuroprotective Agonist of the Erythropoietin Receptor with Anti-Inflammatory and Memory Enhancing Effects. Mediators Inflamm (2016) 0.75
Grafted Neural Precursors Integrate Into Mouse Striatum, Differentiate and Promote Recovery of Function Through Release of Erythropoietin in MPTP-Treated Mice. ASN Neuro (2016) 0.75
An Overview of the Protective Effects of Chitosan and Acetylated Chitosan Oligosaccharides against Neuronal Disorders. Mar Drugs (2017) 0.75
Evaluation of the role of erythropoietin and methotrexate in multiple sclerosis. Indian J Pharmacol (2011) 0.75
Dose effect evaluation and therapeutic window of the neuro-EPO nasal application for the treatment of the focal ischemia model in the Mongolian gerbil. ScientificWorldJournal (2012) 0.75
Interplay between endothelin and erythropoietin in astroglia: the role in protection against hypoxia. Int J Mol Sci (2014) 0.75
Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis. Sci Rep (2017) 0.75
Erythropoietin reduces experimental autoimmune encephalomyelitis severity via neuroprotective mechanisms. J Neuroinflammation (2017) 0.75
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med (2007) 5.28
Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science (2004) 4.09
Erythropoietin therapy for acute stroke is both safe and beneficial. Mol Med (2002) 3.87
Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor. Proc Natl Acad Sci U S A (2004) 3.40
Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB. Proc Natl Acad Sci U S A (2009) 3.01
Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. J Exp Med (2003) 2.37
Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes. Proc Natl Acad Sci U S A (2002) 2.35
Emerging biological roles for erythropoietin in the nervous system. Nat Rev Neurosci (2005) 2.32
Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling. Proc Natl Acad Sci U S A (2003) 2.28
Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin. Proc Natl Acad Sci U S A (2008) 2.21
Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury. Proc Natl Acad Sci U S A (2002) 2.16
Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2002) 2.08
Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage. Proc Natl Acad Sci U S A (2011) 2.07
Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc Natl Acad Sci U S A (2004) 2.06
Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems. Proc Natl Acad Sci U S A (2002) 2.00
Human umbilical cord blood mesenchymal stem cells protect mice brain after trauma. Crit Care Med (2011) 1.95
Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo. Proc Natl Acad Sci U S A (2003) 1.88
IL-1 family nomenclature. Nat Immunol (2010) 1.79
Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma. Proc Natl Acad Sci U S A (2002) 1.66
Erythropoietin both protects from and reverses experimental diabetic neuropathy. Proc Natl Acad Sci U S A (2004) 1.65
Gene expression profiling reveals a signaling role of glutathione in redox regulation. Proc Natl Acad Sci U S A (2005) 1.57
Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1. Eur J Pharmacol (2007) 1.41
Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats. J Mol Cell Cardiol (2004) 1.40
Erythropoietin attenuates acute kidney dysfunction in murine experimental sepsis by activation of the β-common receptor. Kidney Int (2013) 1.37
Safety and efficacy of ARA 290 in sarcoidosis patients with symptoms of small fiber neuropathy: a randomized, double-blind pilot study. Mol Med (2012) 1.33
Identification of proteins undergoing glutathionylation in oxidatively stressed hepatocytes and hepatoma cells. Proteomics (2003) 1.31
CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents. J Neurosci (2011) 1.29
Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis. J Neuroimmunol (2005) 1.26
Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors. J Med Chem (2003) 1.24
A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2005) 1.24
Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands. J Med Chem (2008) 1.23
Nonhematopoietic erythropoietin derivatives prevent motoneuron degeneration in vitro and in vivo. Mol Med (2006) 1.21
Reduced functional deficits, neuroinflammation, and secondary tissue damage after treatment of stroke by nonerythropoietic erythropoietin derivatives. J Cereb Blood Flow Metab (2006) 1.21
HMGB-1, a DNA-binding protein with cytokine activity, induces brain TNF and IL-6 production, and mediates anorexia and taste aversion. Cytokine (2002) 1.19
The receptor that tames the innate immune response. Mol Med (2012) 1.19
Erythropoietin and erythropoietin receptor expression after experimental spinal cord injury encourages therapy by exogenous erythropoietin. Neurosurgery (2005) 1.18
Early administration of low-dose aspirin for the prevention of severe and mild preeclampsia: a systematic review and meta-analysis. Am J Perinatol (2012) 1.18
Erythropoietin as a tissue-protective cytokine in brain injury: what do we know and where do we go? Neuroscientist (2004) 1.18
TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury. Proc Natl Acad Sci U S A (2008) 1.17
Recognition of citrullinated and carbamylated proteins by human antibodies: specificity, cross-reactivity and the 'AMC-Senshu' method. Ann Rheum Dis (2012) 1.16
Early administration of low-dose aspirin for the prevention of preterm and term preeclampsia: a systematic review and meta-analysis. Fetal Diagn Ther (2012) 1.16
Neuroprotection with the CXCL8 inhibitor repertaxin in transient brain ischemia. Cytokine (2005) 1.15
Protective effect of erythropoietin and its carbamylated derivative in experimental Cisplatin peripheral neurotoxicity. Clin Cancer Res (2006) 1.15
Cardioprotection by a nonerythropoietic, tissue-protective peptide mimicking the 3D structure of erythropoietin. Proc Natl Acad Sci U S A (2010) 1.14
Erythropoietin protects primary hippocampal neurons increasing the expression of brain-derived neurotrophic factor. J Neurochem (2005) 1.13
ARA290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain: an experimental study in rats and β-common receptor knockout mice. Anesthesiology (2011) 1.11
Redox regulation of surface protein thiols: identification of integrin alpha-4 as a molecular target by using redox proteomics. Proc Natl Acad Sci U S A (2003) 1.11
The interleukin-8 (IL-8/CXCL8) receptor inhibitor reparixin improves neurological deficits and reduces long-term inflammation in permanent and transient cerebral ischemia in rats. Mol Med (2007) 1.11
Amelioration of spinal cord compressive injury by pharmacological preconditioning with erythropoietin and a nonerythropoietic erythropoietin derivative. J Neurosurg Spine (2006) 1.09
Methylprednisolone neutralizes the beneficial effects of erythropoietin in experimental spinal cord injury. Proc Natl Acad Sci U S A (2005) 1.07
Intervention with an erythropoietin-derived peptide protects against neuroglial and vascular degeneration during diabetic retinopathy. Diabetes (2011) 1.06
Cardiovascular oxidative stress is reduced by an ACE inhibitor in a rat model of streptozotocin-induced diabetes. Life Sci (2006) 1.05
Cytoprotective doses of erythropoietin or carbamylated erythropoietin have markedly different procoagulant and vasoactive activities. Proc Natl Acad Sci U S A (2006) 1.05
Antiepileptic effects of botulinum neurotoxin E. J Neurosci (2005) 1.03
Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia. Circulation (2012) 1.03
Erythropoietin-induced changes in brain gene expression reveal induction of synaptic plasticity genes in experimental stroke. Proc Natl Acad Sci U S A (2012) 1.02
A small nonerythropoietic helix B surface peptide based upon erythropoietin structure is cardioprotective against ischemic myocardial damage. Mol Med (2010) 1.02
Synthesis and binding properties of novel selective 5-HT3 receptor ligands. Bioorg Med Chem (2004) 1.00
Nonerythropoietic tissue protective compounds are highly effective facilitators of wound healing. Mol Med (2009) 1.00
Erythropoietin modulation of astrocyte water permeability as a component of neuroprotection. Proc Natl Acad Sci U S A (2009) 1.00
Glutathione protects mice from lethal sepsis by limiting inflammation and potentiating host defense. J Infect Dis (2002) 0.98
Riluzole, unlike the AMPA antagonist RPR119990, reduces motor impairment and partially prevents motoneuron death in the wobbler mouse, a model of neurodegenerative disease. Exp Neurol (2006) 0.98
ARA 290 for treatment of small fiber neuropathy in sarcoidosis. Expert Opin Investig Drugs (2014) 0.97
The heterogeneity of amyotrophic lateral sclerosis: a possible explanation of treatment failure. Curr Med Chem (2007) 0.96
Redox proteomics: identification and functional role of glutathionylated proteins. Expert Rev Proteomics (2004) 0.95
A nonerythropoietic peptide that mimics the 3D structure of erythropoietin reduces organ injury/dysfunction and inflammation in experimental hemorrhagic shock. Mol Med (2011) 0.94
Neuroprotective effects of toll-like receptor 4 antagonism in spinal cord cultures and in a mouse model of motor neuron degeneration. Mol Med (2012) 0.94