Published in Biochem Biophys Res Commun on October 11, 2002
Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis. Mol Pharmacol (2009) 1.56
What do drug transporters really do? Nat Rev Drug Discov (2014) 1.41
The organic anion transporter (OAT) family: a systems biology perspective. Physiol Rev (2015) 1.01
The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. J Biol Chem (2009) 0.99
Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Physiol Genomics (2009) 0.93
A genome-wide association study of bronchodilator response in Latinos implicates rare variants. J Allergy Clin Immunol (2013) 0.93
Transporters at CNS barrier sites: obstacles or opportunities for drug delivery? Curr Pharm Des (2014) 0.88
Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs. PLoS One (2015) 0.87
Are organic cation transporters capable of transporting prostaglandins? Naunyn Schmiedebergs Arch Pharmacol (2005) 0.83
Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus. Am J Med Genet B Neuropsychiatr Genet (2010) 0.83
Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways. Drug Metab Dispos (2013) 0.83
Wide tolerance to amino acids substitutions in the OCTN1 ergothioneine transporter. Biochim Biophys Acta (2016) 0.76
Phylogenetic, syntenic, and tissue expression analysis of slc22 genes in zebrafish (Danio rerio). BMC Genomics (2016) 0.75
Organic anion transporter 5 renal expression and urinary excretion in rats with vascular calcification. Biomed Res Int (2013) 0.75
Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature (2003) 3.72
Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. J Biol Chem (2005) 2.07
Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem (2002) 1.87
Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy. Nat Med (2009) 1.86
TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud. Dev Biol (2004) 1.59
Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis. Mol Pharmacol (2009) 1.56
Branching morphogenesis and kidney disease. Development (2004) 1.54
Multiple organic anion transporters contribute to net renal excretion of uric acid. Physiol Genomics (2008) 1.53
Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney. Dev Biol (2004) 1.49
Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease. J Am Soc Nephrol (2013) 1.49
Adult kidney tubular cell population showing phenotypic plasticity, tubulogenic capacity, and integration capability into developing kidney. J Am Soc Nephrol (2005) 1.46
Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination. J Biol Chem (2008) 1.38
The molecular pharmacology of organic anion transporters: from DNA to FDA? Mol Pharmacol (2004) 1.25
Changes in gene expression patterns in the ureteric bud and metanephric mesenchyme in models of kidney development. Kidney Int (2003) 1.23
Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. Biochem Biophys Res Commun (2004) 1.22
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem (2007) 1.22
Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1). J Proteome Res (2011) 1.18
Remote communication through solute carriers and ATP binding cassette drug transporter pathways: an update on the remote sensing and signaling hypothesis. Mol Pharmacol (2011) 1.16
Glial cell-derived neurotrophic factor independent ureteric bud outgrowth from the Wolffian duct. J Am Soc Nephrol (2007) 1.14
Organic anion transporter 3 contributes to the regulation of blood pressure. J Am Soc Nephrol (2008) 1.14
Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics. Am J Physiol Renal Physiol (2008) 1.10
Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Physiol Genomics (2004) 1.10
Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development. Differentiation (2006) 1.08
Beta1-integrin is required for kidney collecting duct morphogenesis and maintenance of renal function. Am J Physiol Renal Physiol (2009) 1.07
Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling. J Biol Chem (2010) 1.06
Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions. Biochem Biophys Res Commun (2006) 1.06
Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney. Dev Biol (2004) 1.05
Toward an etiological classification of developmental disorders of the kidney and upper urinary tract. Kidney Int (2002) 1.04
Analysis of metagene portraits reveals distinct transitions during kidney organogenesis. Sci Signal (2008) 1.03
A role for the organic anion transporter OAT3 in renal creatinine secretion in mice. Am J Physiol Renal Physiol (2012) 1.02
Implications of gene networks for understanding resilience and vulnerability in the kidney branching program. Physiology (Bethesda) (2004) 1.01
Interaction of organic cations with organic anion transporters. J Biol Chem (2009) 1.01
Organic anion and cation transporters occur in pairs of similar and similarly expressed genes. Biochem Biophys Res Commun (2003) 1.01
Organic anion transport in choroid plexus from wild-type and organic anion transporter 3 (Slc22a8)-null mice. Am J Physiol Renal Physiol (2003) 0.99
A strategy for in vitro propagation of rat nephrons. Kidney Int (2002) 0.96
Constructing kidney-like tissues from cells based on programs for organ development: toward a method of in vitro tissue engineering of the kidney. Tissue Eng Part A (2010) 0.95
Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev Biol (2006) 0.95
MAPAS: a tool for predicting membrane-contacting protein surfaces. Nat Methods (2008) 0.94
Hs2st mediated kidney mesenchyme induction regulates early ureteric bud branching. Dev Biol (2010) 0.94
Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Physiol Genomics (2009) 0.93
Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling. Dev Biol (2011) 0.93
Heregulin induces glial cell line-derived neurotrophic growth factor-independent, non-branching growth and differentiation of ureteric bud epithelia. J Biol Chem (2005) 0.93
Developmental approaches to kidney tissue engineering. Am J Physiol Renal Physiol (2004) 0.93
The effect of hyaluronic acid size and concentration on branching morphogenesis and tubule differentiation in developing kidney culture systems: potential applications to engineering of renal tissues. Biomaterials (2007) 0.93
The developmental nephrome: systems biology in the developing kidney. Curr Opin Nephrol Hypertens (2007) 0.92
Novel aspects of renal organic anion transporters. Curr Opin Nephrol Hypertens (2003) 0.91
Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]. Kidney Int (2005) 0.91
Linkage of organic anion transporter-1 to metabolic pathways through integrated "omics"-driven network and functional analysis. J Biol Chem (2011) 0.91
Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice. PLoS One (2010) 0.90
The instructive role of metanephric mesenchyme in ureteric bud patterning, sculpting, and maturation and its potential ability to buffer ureteric bud branching defects. Am J Physiol Renal Physiol (2009) 0.90
Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney. Mol Pharmacol (2011) 0.89
Growth factor-dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan sulfate. Dev Biol (2011) 0.88
Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury. J Biol Chem (2011) 0.88
Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting system. Dev Biol (2006) 0.88
A protein kinase A and Wnt-dependent network regulating an intermediate stage in epithelial tubulogenesis during kidney development. Dev Biol (2012) 0.88
Hepatocyte nuclear factors 4α and 1α regulate kidney developmental expression of drug-metabolizing enzymes and drug transporters. Mol Pharmacol (2013) 0.85
Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue. Neurosci Lett (2012) 0.84
Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule. PLoS One (2012) 0.84
Relevance of ureteric bud development and branching to tissue engineering, regeneration and repair in acute and chronic kidney disease. Curr Opin Organ Transplant (2014) 0.83
Biochemical processing of E-cadherin under cellular stress. Biochem Biophys Res Commun (2003) 0.83
Protein kinase A regulates GDNF/RET-dependent but not GDNF/Ret-independent ureteric bud outgrowth from the Wolffian duct. Dev Biol (2010) 0.83
Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways. Drug Metab Dispos (2013) 0.83
Modeling of glycerol-3-phosphate transporter suggests a potential 'tilt' mechanism involved in its function. J Bioinform Comput Biol (2008) 0.82
Neuropeptide Y functions as a facilitator of GDNF-induced budding of the Wolffian duct. Development (2009) 0.81
Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1). Bioorg Med Chem (2011) 0.80
Tunicamycin preserves intercellular junctions, cytoarchitecture, and cell-substratum interactions in ATP-depleted epithelial cells. Biochem Biophys Res Commun (2004) 0.80
N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland. J Biol Chem (2012) 0.80
Analyses of 5' regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3). J Hum Genet (2006) 0.79
Cellular and developmental strategies aimed at kidney tissue engineering. Nephron Exp Nephrol (2014) 0.79
Conformational changes of the multispecific transporter organic anion transporter 1 (OAT1/SLC22A6) suggests a molecular mechanism for initial stages of drug and metabolite transport. Cell Biochem Biophys (2011) 0.79
In vitro culture of embryonic kidney rudiments and isolated ureteric buds. Methods Mol Biol (2012) 0.78
From the ureteric bud to the penome. Kidney Int (2003) 0.78
Complex dynamics of chaperone-protein interactions under cellular stress. Cell Biochem Biophys (2004) 0.77
Debt91, a putative zinc finger protein differentially expressed during epithelial morphogenesis. Biochem Biophys Res Commun (2003) 0.77
GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling. Biol Open (2013) 0.76
Branching morphogenesis: from individual molecules to a systems biology approach: commentary on "Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney" by Perälä et al. Differentiation (2010) 0.75