Published in Am J Physiol Cell Physiol on November 01, 2002
Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels. J Clin Invest (2006) 2.47
Cellular stress failure in ventilator-injured lungs. Am J Respir Crit Care Med (2005) 1.44
Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras. Proc Natl Acad Sci U S A (2006) 1.39
Role of shear-stress-induced VEGF expression in endothelial cell survival. J Cell Sci (2012) 1.21
Cooperation between VEGF and beta3 integrin during cardiac vascular development. Blood (2006) 1.17
Shear stress-initiated signaling and its regulation of endothelial function. Arterioscler Thromb Vasc Biol (2014) 1.12
Participation of caveolae in beta1 integrin-mediated mechanotransduction. Biochem Biophys Res Commun (2007) 1.06
Tyrosine residues direct the ubiquitination and degradation of the NY-1 hantavirus G1 cytoplasmic tail. J Virol (2003) 1.02
Selective adapter recruitment and differential signaling networks by VEGF vs. shear stress. Proc Natl Acad Sci U S A (2007) 1.00
Shear stress during early embryonic stem cell differentiation promotes hematopoietic and endothelial phenotypes. Biotechnol Bioeng (2013) 1.00
Two distinct phases of calcium signalling under flow. Cardiovasc Res (2011) 0.94
p190 RhoGTPase-activating protein links the β1 integrin/caveolin-1 mechanosignaling complex to RhoA and actin remodeling. Arterioscler Thromb Vasc Biol (2010) 0.93
Mechanical signals activate vascular endothelial growth factor receptor-2 to upregulate endothelial cell proliferation during inflammation. J Immunol (2010) 0.92
Poly-N-acetyl glucosamine nanofibers regulate endothelial cell movement and angiogenesis: dependency on integrin activation of Ets1. J Vasc Res (2007) 0.91
Lung ischemia: a model for endothelial mechanotransduction. Cell Biochem Biophys (2008) 0.91
Differential effects of cyclic and static stretch on coronary microvascular endothelial cell receptors and vasculogenic/angiogenic responses. Am J Physiol Heart Circ Physiol (2008) 0.89
Blood flow patterns spatially associated with platelet aggregates in murine colitis. Anat Rec (Hoboken) (2009) 0.88
Activation of integrin α5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells. Proc Natl Acad Sci U S A (2016) 0.87
Shear Stress Regulates the Flk-1/Cbl/PI3K/NF-κB Pathway Via Actin and Tyrosine Kinases. Cell Mol Bioeng (2009) 0.85
Live cell imaging of mechanotransduction. J R Soc Interface (2010) 0.83
Computational flow dynamics in a geometric model of intussusceptive angiogenesis. Microvasc Res (2009) 0.82
Periodontal ligament cells cultured under steady-flow environments demonstrate potential for use in heart valve tissue engineering. Tissue Eng Part A (2012) 0.82
Heparanase-induced shedding of syndecan-1/CD138 in myeloma and endothelial cells activates VEGFR2 and an invasive phenotype: prevention by novel synstatins. Oncogenesis (2016) 0.81
Shear Stress Activates eNOS at the Endothelial Apical Surface Through β1 Containing Integrins and Caveolae. Cell Mol Bioeng (2013) 0.81
Caveolae: A Role in Endothelial Inflammation and Mechanotransduction? Front Physiol (2016) 0.78
Mechanotransduction at focal adhesions: from physiology to cancer development. J Cell Mol Med (2013) 0.77
Expression of the VEGF receptor-3 in osteoarthritic chondrocytes: stimulation by interleukin-1 beta and association with beta 1-integrins. Histochem Cell Biol (2003) 0.76
The role of mechanical tension on lipid raft dependent PDGF-induced TRPC6 activation. Biomaterials (2014) 0.76
Shear stress-induced angiogenesis in mouse muscle is independent of the vasodilator mechanism and quickly reversible. Acta Physiol (Oxf) (2016) 0.75
Genome sequence of Aedes aegypti, a major arbovirus vector. Science (2007) 9.19
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada. J Natl Cancer Inst (2006) 6.73
Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiol Rev (2011) 5.51
Visualizing the mechanical activation of Src. Nature (2005) 4.63
An extracellular matrix microarray for probing cellular differentiation. Nat Methods (2005) 4.35
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab (2011) 3.98
Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81
Molecular basis of the effects of shear stress on vascular endothelial cells. J Biomech (2005) 3.77
Stem cell fate dictated solely by altered nanotube dimension. Proc Natl Acad Sci U S A (2009) 3.73
Role of integrins in endothelial mechanosensing of shear stress. Circ Res (2002) 2.85
Cooperative effects of Rho and mechanical stretch on stress fiber organization. Proc Natl Acad Sci U S A (2005) 2.78
The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proc Natl Acad Sci U S A (2009) 2.55
Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression. EMBO J (2002) 2.46
A positive feedback mechanism governs the polarity and motion of motile cilia. Nature (2007) 2.44
Anisotropic mechanosensing by mesenchymal stem cells. Proc Natl Acad Sci U S A (2006) 2.43
Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. Gastroenterology (2007) 2.43
AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633. Circ Res (2009) 2.38
Anisamide-targeted stealth liposomes: a potent carrier for targeting doxorubicin to human prostate cancer cells. Int J Cancer (2004) 2.31
Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a. Circulation (2011) 2.29
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet (2013) 2.24
Effects of cell tension on the small GTPase Rac. J Cell Biol (2002) 2.24
Frequencies of BRCA1 and BRCA2 mutations among 1,342 unselected patients with invasive ovarian cancer. Gynecol Oncol (2011) 2.19
Fluorescence proteins, live-cell imaging, and mechanobiology: seeing is believing. Annu Rev Biomed Eng (2008) 2.16
Peroxisome proliferator-activated receptor-γ ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor. Hypertension (2012) 2.16
The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proc Natl Acad Sci U S A (2005) 2.10
Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Mol Cell (2003) 2.09
Biochemistry and biomechanics of cell motility. Annu Rev Biomed Eng (2005) 2.08
Boolean network simulations for life scientists. Source Code Biol Med (2008) 2.05
Differential effects of equiaxial and uniaxial strain on mesenchymal stem cells. Biotechnol Bioeng (2004) 2.05
Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress. Circ Res (2013) 2.04
Molecular basis of the effects of mechanical stretch on vascular smooth muscle cells. J Biomech (2006) 2.02
The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells. Proc Natl Acad Sci U S A (2002) 2.01
The prevalence of BRCA1 mutations among young women with triple-negative breast cancer. BMC Cancer (2009) 2.01
Antithrombogenic property of bone marrow mesenchymal stem cells in nanofibrous vascular grafts. Proc Natl Acad Sci U S A (2007) 2.01
Myotube assembly on nanofibrous and micropatterned polymers. Nano Lett (2006) 2.00
Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR). Cardiovasc Res (2005) 1.99
Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors. Proc Natl Acad Sci U S A (2008) 1.97
Klotho is a target gene of PPAR-gamma. Kidney Int (2008) 1.96
Proteomic profiling of bone marrow mesenchymal stem cells upon transforming growth factor beta1 stimulation. J Biol Chem (2004) 1.96
The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β. Biomaterials (2011) 1.93
EPHA2 is associated with age-related cortical cataract in mice and humans. PLoS Genet (2009) 1.82
Bioactive nanofibers: synergistic effects of nanotopography and chemical signaling on cell guidance. Nano Lett (2007) 1.81
MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells. Proc Natl Acad Sci U S A (2010) 1.80
Live Cells Exert 3-Dimensional Traction Forces on Their Substrata. Cell Mol Bioeng (2009) 1.80
miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4. Cancer Res (2012) 1.77
Rho mediates the shear-enhancement of endothelial cell migration and traction force generation. Biophys J (2004) 1.77
MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci U S A (2011) 1.77
Combinatorial signaling microenvironments for studying stem cell fate. Stem Cells Dev (2008) 1.76
Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow. Proc Natl Acad Sci U S A (2009) 1.74
Transforming growth factor-beta and notch signaling mediate stem cell differentiation into smooth muscle cells. Stem Cells (2010) 1.74
Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proc Natl Acad Sci U S A (2010) 1.73
AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress. Arterioscler Thromb Vasc Biol (2006) 1.68
Shear stress, SIRT1, and vascular homeostasis. Proc Natl Acad Sci U S A (2010) 1.68
Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats. J Hepatol (2010) 1.67
Differentiation of multipotent vascular stem cells contributes to vascular diseases. Nat Commun (2012) 1.66
Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin. Cancer Res (2006) 1.64
Regulation of vascular smooth muscle cells by micropatterning. Biochem Biophys Res Commun (2003) 1.63
Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proc Natl Acad Sci U S A (2007) 1.60
Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis. Circulation (2013) 1.60
Shear stress regulation of Krüppel-like factor 2 expression is flow pattern-specific. Biochem Biophys Res Commun (2006) 1.57
Statins activate AMP-activated protein kinase in vitro and in vivo. Circulation (2006) 1.55
Biophysical regulation of epigenetic state and cell reprogramming. Nat Mater (2013) 1.55
Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection. Circulation (2004) 1.52
Cationic lipids enhance siRNA-mediated interferon response in mice. Biochem Biophys Res Commun (2005) 1.50
Ability to predict breast cancer in Asian women using a polygenic susceptibility model. Breast Cancer Res Treat (2010) 1.50
Intervertebral disc degeneration: the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload. Am J Pathol (2004) 1.49
Regulation of endothelial cell cycle by laminar versus oscillatory flow: distinct modes of interactions of AMP-activated protein kinase and Akt pathways. Circ Res (2007) 1.48
Sporadic onset of erythermalgia: a gain-of-function mutation in Nav1.7. Ann Neurol (2006) 1.48
Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice. Proc Natl Acad Sci U S A (2008) 1.48
Defining long-term maintenance conditions of human embryonic stem cells with arrayed cellular microenvironment technology. Stem Cells Dev (2009) 1.46
Injectable biopolymers enhance angiogenesis after myocardial infarction. Tissue Eng (2006) 1.46
Shear stress increases ICAM-1 and decreases VCAM-1 and E-selectin expressions induced by tumor necrosis factor-[alpha] in endothelial cells. Arterioscler Thromb Vasc Biol (2003) 1.45
Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells. Arterioscler Thromb Vasc Biol (2007) 1.45
microRNA: a master regulator of cellular processes for bioengineering systems. Annu Rev Biomed Eng (2010) 1.44
PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proc Natl Acad Sci U S A (2004) 1.42
Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. Biomaterials (2010) 1.42
Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex. EMBO Rep (2009) 1.42
Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. Proc Natl Acad Sci U S A (2009) 1.40
Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras. Proc Natl Acad Sci U S A (2006) 1.39
Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls. Hum Mol Genet (2013) 1.38
Effects of flow patterns on the localization and expression of VE-cadherin at vascular endothelial cell junctions: in vivo and in vitro investigations. J Vasc Res (2005) 1.37