PubRank

Gavril W Pasternak

Author PubWeight™ 57.18‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain 2009 9.36
2 Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects. Proc Natl Acad Sci U S A 2011 1.39
3 Genetic dissociation of opiate tolerance and physical dependence in delta-opioid receptor-1 and preproenkephalin knock-out mice. J Neurosci 2002 1.37
4 Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions. Proc Natl Acad Sci U S A 2009 1.35
5 Functional analysis of MOR-1 splice variants of the mouse mu opioid receptor gene Oprm. Synapse 2004 1.27
6 Identification of four novel exon 5 splice variants of the mouse mu-opioid receptor gene: functional consequences of C-terminal splicing. Mol Pharmacol 2005 1.20
7 Sigma 1 receptor modulation of G-protein-coupled receptor signaling: potentiation of opioid transduction independent from receptor binding. Mol Pharmacol 2010 1.15
8 Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy. J Neurochem 2004 1.12
9 Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X. Biochem Biophys Res Commun 2003 1.11
10 Synergy between mu opioid ligands: evidence for functional interactions among mu opioid receptor subtypes. J Pharmacol Exp Ther 2002 1.10
11 Sigma1 receptor modulation of opioid analgesia in the mouse. J Pharmacol Exp Ther 2002 1.09
12 Historical review: Opioid receptors. Trends Pharmacol Sci 2003 1.07
13 Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene. J Neurochem 2008 1.07
14 Generation of novel radiolabeled opiates through site-selective iodination. Bioorg Med Chem Lett 2011 1.02
15 Dimerization of morphine and orphanin FQ/nociceptin receptors: generation of a novel opioid receptor subtype. Biochem Biophys Res Commun 2002 1.01
16 Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants. J Med Chem 2012 1.00
17 Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action. J Biol Chem 2013 0.99
18 Modulation of brainstem opiate analgesia in the rat by sigma 1 receptors: a microinjection study. J Pharmacol Exp Ther 2007 0.96
19 Identification and characterization of seven new exon 11-associated splice variants of the rat μ opioid receptor gene, OPRM1. Mol Pain 2011 0.95
20 High-affinity mu opioid receptor ligands discovered by the screening of an exhaustively stereodiversified library of 1,5-enediols. J Am Chem Soc 2002 0.92
21 Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions. Biochemistry 2014 0.91
22 Improved brain uptake and pharmacological activity of dalargin using a peptide-vector-mediated strategy. J Pharmacol Exp Ther 2003 0.90
23 Mediation of opioid analgesia by a truncated 6-transmembrane GPCR. J Clin Invest 2015 0.88
24 14-Methoxymetopon, a very potent mu-opioid receptor-selective analgesic with an unusual pharmacological profile. Eur J Pharmacol 2003 0.88
25 Characterization of the binding of [3H][Dmt1]H-Dmt-D-Arg-Phe-Lys-NH2, a highly potent opioid peptide. J Pharmacol Exp Ther 2003 0.87
26 Selective potentiation of opioid analgesia by nonsteroidal anti-inflammatory drugs. Brain Res 2005 0.87
27 Immunohistochemical labeling of the mu opioid receptor carboxy terminal splice variant mMOR-1B4 in the mouse central nervous system. Brain Res 2006 0.86
28 The peripheral-type benzodiazepine receptor and tumorigenicity: isoquinoline binding protein (IBP) antisense knockdown in the C6 glioma cell line. Biochemistry 2005 0.86
29 The synergistic analgesic interactions between hydrocodone and ibuprofen. Anesth Analg 2003 0.85
30 Isolating and characterizing three alternatively spliced mu opioid receptor variants: mMOR-1A, mMOR-1O, and mMOR-1P. Synapse 2014 0.85
31 Feeding induced by food deprivation is differentially reduced by G-protein alpha-subunit antisense probes in rats. Brain Res 2002 0.85
32 Dynorphin A(1-17)-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats. J Pharmacol Exp Ther 2002 0.83
33 Pharmacological characterization of dihydromorphine, 6-acetyldihydromorphine and dihydroheroin analgesia and their differentiation from morphine. Eur J Pharmacol 2004 0.83
34 Novel 6β-acylaminomorphinans with analgesic activity. Eur J Med Chem 2013 0.82
35 Morphine regulates expression of μ-opioid receptor MOR-1A, an intron-retention carboxyl terminal splice variant of the μ-opioid receptor (OPRM1) gene via miR-103/miR-107. Mol Pharmacol 2013 0.81
36 Analgesic synergy between topical morphine and butamben in mice. Anesth Analg 2003 0.81
37 The role of multidrug resistance-associated protein in the blood-brain barrier and opioid analgesia. Synapse 2013 0.81
38 Methadone-induced hypoglycemia. Cell Mol Neurobiol 2013 0.81
39 Opposing actions of neuronal nitric oxide synthase isoforms in formalin-induced pain in mice. Brain Res 2009 0.80
40 Differential sensitivities of mouse strains to morphine and [Dmt1]DALDA analgesia. Brain Res 2003 0.80
41 Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun 2012 0.80
42 Affinity labeling mu opioid receptors with novel radioligands. Cell Mol Neurobiol 2005 0.79
43 Topical methadone and meperidine analgesic synergy in the mouse. Eur J Pharmacol 2010 0.79
44 Separation of binding affinity and intrinsic activity of the potent mu-opioid 14-methoxymetopon. J Pharmacol Exp Ther 2006 0.79
45 Sequential cytoprotective responses to Sigma1 ligand-induced endoplasmic reticulum stress. Mol Pharmacol 2013 0.79
46 Systemically and topically active antinociceptive neurotensin compounds. J Pharmacol Exp Ther 2010 0.78
47 Three-component coupling approach for the synthesis of diverse heterocycles utilizing reactive nitrilium trapping. Org Lett 2014 0.77
48 Sandmeyer reaction repurposed for the site-selective, non-oxidizing radioiodination of fully-deprotected peptides: studies on the endogenous opioid peptide α-neoendorphin. Bioorg Med Chem Lett 2013 0.77
49 Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine. J Clin Invest 2017 0.77
50 Characterization of rat prepro-orphanin FQ/nociceptin((154-181)): nociceptive processing in supraspinal sites. J Pharmacol Exp Ther 2002 0.77
51 Feeling pain? Who's your daddy.... Nat Med 2006 0.76
52 Changes in mouse mu opioid receptor Exon 7/8-like immunoreactivity following food restriction and food deprivation in rats. Synapse 2009 0.76
53 2,6-Dimethyltyrosine analogues of a stereodiversified ligand library: highly potent, selective, non-peptidic mu opioid receptor agonists. J Med Chem 2003 0.75
54 Codeine and 6-acetylcodeine analgesia in mice. Cell Mol Neurobiol 2006 0.75
55 Radioligand Binding Assay for an Exon 11-Associated Mu Opioid Receptor Target. Methods Mol Biol 2015 0.75
56 Pharmacological characterization of beta-endorphin- and dynorphin A(1-17)-induced feeding using G-protein alpha-subunit antisense probes in rats. Peptides 2002 0.75
57 Truncated μ-Opioid Receptors With 6 Transmembrane Domains Are Essential for Opioid Analgesia. Anesth Analg 2017 0.75