Published in J Pharmacol Exp Ther on November 01, 2002
Mu opioids and their receptors: evolution of a concept. Pharmacol Rev (2013) 1.66
Interactions between drugs and occupied receptors. Pharmacol Ther (2006) 1.53
Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions. Proc Natl Acad Sci U S A (2009) 1.35
Molecular insights into mu opioid pharmacology: From the clinic to the bench. Clin J Pain (2010) 1.10
Synaptic mechanism for functional synergism between delta- and mu-opioid receptors. J Neurosci (2010) 1.06
The determination and application of fixed-dose analgesic combinations for treating multimodal pain. J Pain (2010) 0.89
Preclinical pharmacology and opioid combinations. Pain Med (2012) 0.85
The successful use of parenteral methadone in a patient with a prolonged QTc interval. J Pain Symptom Manage (2007) 0.83
The role of methadone in opioid rotation-a Polish experience. Support Care Cancer (2008) 0.82
Synergism between fentanyl and tramadol in tonic inflammatory pain: the orofacial formalin test. Inflammation (2012) 0.82
Methadone-induced hypoglycemia. Cell Mol Neurobiol (2013) 0.81
Oxycodone combinations for pain relief. Drugs Today (Barc) (2010) 0.79
Topical methadone and meperidine analgesic synergy in the mouse. Eur J Pharmacol (2010) 0.79
Look before leaping: combined opioids may not be the rave. Support Care Cancer (2005) 0.75
Promoting science in a pragmatic world: not (yet) time for partial opioid rotation. Support Care Cancer (2005) 0.75
Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain (2009) 9.36
Isobolographic analysis for combinations of a full and partial agonist: curved isoboles. J Pharmacol Exp Ther (2004) 2.27
Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects. Proc Natl Acad Sci U S A (2011) 1.39
Genetic dissociation of opiate tolerance and physical dependence in delta-opioid receptor-1 and preproenkephalin knock-out mice. J Neurosci (2002) 1.37
Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions. Proc Natl Acad Sci U S A (2009) 1.35
Functional analysis of MOR-1 splice variants of the mouse mu opioid receptor gene Oprm. Synapse (2004) 1.27
Identification of four novel exon 5 splice variants of the mouse mu-opioid receptor gene: functional consequences of C-terminal splicing. Mol Pharmacol (2005) 1.20
Sigma 1 receptor modulation of G-protein-coupled receptor signaling: potentiation of opioid transduction independent from receptor binding. Mol Pharmacol (2010) 1.15
Combinations of cocaine with other dopamine uptake inhibitors: assessment of additivity. J Pharmacol Exp Ther (2009) 1.13
Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy. J Neurochem (2004) 1.12
Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X. Biochem Biophys Res Commun (2003) 1.11
Sigma1 receptor modulation of opioid analgesia in the mouse. J Pharmacol Exp Ther (2002) 1.09
Cocaine-induced hyperactivity and sensitization are dependent on GSK3. Neuropharmacology (2009) 1.08
Historical review: Opioid receptors. Trends Pharmacol Sci (2003) 1.07
Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene. J Neurochem (2008) 1.07
Generation of novel radiolabeled opiates through site-selective iodination. Bioorg Med Chem Lett (2011) 1.02
Dimerization of morphine and orphanin FQ/nociceptin receptors: generation of a novel opioid receptor subtype. Biochem Biophys Res Commun (2002) 1.01
Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants. J Med Chem (2012) 1.00
Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action. J Biol Chem (2013) 0.99
Quantitation of the contractile response mediated by two receptors: M2 and M3 muscarinic receptor-mediated contractions of human gastroesophageal smooth muscle. J Pharmacol Exp Ther (2009) 0.97
Interaction between muscarinic receptor subtype signal transduction pathways mediating bladder contraction. Am J Physiol Regul Integr Comp Physiol (2002) 0.97
Modulation of brainstem opiate analgesia in the rat by sigma 1 receptors: a microinjection study. J Pharmacol Exp Ther (2007) 0.96
Midazolam enhances the analgesic properties of dexmedetomidine in the rat. Vet Anaesth Analg (2010) 0.96
Identification and characterization of seven new exon 11-associated splice variants of the rat μ opioid receptor gene, OPRM1. Mol Pain (2011) 0.95
Intra-VTA CART 55-102 reduces the locomotor effect of systemic cocaine in rats: an isobolographic analysis. Neuropeptides (2007) 0.94
Effects of a Cannabinoid1 receptor antagonist and Serotonin2C receptor agonist alone and in combination on motivation for palatable food: a dose-addition analysis study in mice. J Pharmacol Exp Ther (2008) 0.92
A novel role of cannabinoids: implication in the fever induced by bacterial lipopolysaccharide. J Pharmacol Exp Ther (2006) 0.92
High-affinity mu opioid receptor ligands discovered by the screening of an exhaustively stereodiversified library of 1,5-enediols. J Am Chem Soc (2002) 0.92
Combination strategies for pain management. Expert Opin Pharmacother (2003) 0.91
Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions. Biochemistry (2014) 0.91
Improved brain uptake and pharmacological activity of dalargin using a peptide-vector-mediated strategy. J Pharmacol Exp Ther (2003) 0.90
Inhibition of GSK3 attenuates dopamine D1 receptor agonist-induced hyperactivity in mice. Brain Res Bull (2010) 0.90
The determination and application of fixed-dose analgesic combinations for treating multimodal pain. J Pain (2010) 0.89
Mediation of opioid analgesia by a truncated 6-transmembrane GPCR. J Clin Invest (2015) 0.88
Tramadol and several anticonvulsants synergize in attenuating nerve injury-induced allodynia. Pain (2007) 0.88
14-Methoxymetopon, a very potent mu-opioid receptor-selective analgesic with an unusual pharmacological profile. Eur J Pharmacol (2003) 0.88
The use of occupation isoboles for analysis of a response mediated by two receptors: M2 and M3 muscarinic receptor subtype-induced mouse stomach contractions. J Pharmacol Exp Ther (2008) 0.88
Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells. Life Sci (2011) 0.87
Characterization of the binding of [3H][Dmt1]H-Dmt-D-Arg-Phe-Lys-NH2, a highly potent opioid peptide. J Pharmacol Exp Ther (2003) 0.87
Selective potentiation of opioid analgesia by nonsteroidal anti-inflammatory drugs. Brain Res (2005) 0.87
The peripheral-type benzodiazepine receptor and tumorigenicity: isoquinoline binding protein (IBP) antisense knockdown in the C6 glioma cell line. Biochemistry (2005) 0.86
Gabapentin and the neurokinin(1) receptor antagonist CI-1021 act synergistically in two rat models of neuropathic pain. J Pharmacol Exp Ther (2002) 0.86
Immunohistochemical labeling of the mu opioid receptor carboxy terminal splice variant mMOR-1B4 in the mouse central nervous system. Brain Res (2006) 0.86
The synergistic analgesic interactions between hydrocodone and ibuprofen. Anesth Analg (2003) 0.85
Subadditive withdrawal from cocaine/kappa-opioid agonist combinations in Planaria. Brain Res (2006) 0.85
Feeding induced by food deprivation is differentially reduced by G-protein alpha-subunit antisense probes in rats. Brain Res (2002) 0.85
The dynamic relationship between mu and kappa opioid receptors in body temperature regulation. Life Sci (2005) 0.85
Isolating and characterizing three alternatively spliced mu opioid receptor variants: mMOR-1A, mMOR-1O, and mMOR-1P. Synapse (2014) 0.85
Fixed-dose combinations for emerging treatment of pain. Expert Opin Pharmacother (2012) 0.84
Dynorphin A(1-17)-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats. J Pharmacol Exp Ther (2002) 0.83
A quantitative study to assess synergistic interactions between urotensin II and angiotensin II. Eur J Pharmacol (2008) 0.83
Pharmacological characterization of dihydromorphine, 6-acetyldihydromorphine and dihydroheroin analgesia and their differentiation from morphine. Eur J Pharmacol (2004) 0.83
Novel 6β-acylaminomorphinans with analgesic activity. Eur J Med Chem (2013) 0.82
Methadone-induced hypoglycemia. Cell Mol Neurobiol (2013) 0.81
Analgesic synergy between topical morphine and butamben in mice. Anesth Analg (2003) 0.81
Nonlinear isobologram and superadditive withdrawal from cocaine: cannabinoid combinations in planarians. Eur J Pharmacol (2006) 0.81
Morphine regulates expression of μ-opioid receptor MOR-1A, an intron-retention carboxyl terminal splice variant of the μ-opioid receptor (OPRM1) gene via miR-103/miR-107. Mol Pharmacol (2013) 0.81
The role of multidrug resistance-associated protein in the blood-brain barrier and opioid analgesia. Synapse (2013) 0.81
Comparison of human and porcine gastric clasp and sling fiber contraction by M2 and M3 muscarinic receptors. Am J Physiol Gastrointest Liver Physiol (2010) 0.80
Differential sensitivities of mouse strains to morphine and [Dmt1]DALDA analgesia. Brain Res (2003) 0.80
Opposing actions of neuronal nitric oxide synthase isoforms in formalin-induced pain in mice. Brain Res (2009) 0.80
Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun (2012) 0.80
Synergistic antihypersensitive effects of pregabalin and tapentadol in a rat model of neuropathic pain. Eur J Pharmacol (2011) 0.80
On the quantitation of an agonist with dual but opposing components of action: application to vascular endothelial relaxation. Eur J Pharmacol (2011) 0.80
Affinity labeling mu opioid receptors with novel radioligands. Cell Mol Neurobiol (2005) 0.79
Sequential cytoprotective responses to Sigma1 ligand-induced endoplasmic reticulum stress. Mol Pharmacol (2013) 0.79
Spinal-supraspinal and intrinsic μ-opioid receptor agonist-norepinephrine reuptake inhibitor (MOR-NRI) synergy of tapentadol in diabetic heat hyperalgesia in mice. J Pharmacol Exp Ther (2013) 0.79
Topical methadone and meperidine analgesic synergy in the mouse. Eur J Pharmacol (2010) 0.79
Separation of binding affinity and intrinsic activity of the potent mu-opioid 14-methoxymetopon. J Pharmacol Exp Ther (2006) 0.79
Methylphenidate and impulsivity: a comparison of effects of methylphenidate enantiomers on delay discounting in rats. Psychopharmacology (Berl) (2013) 0.79
Systemically and topically active antinociceptive neurotensin compounds. J Pharmacol Exp Ther (2010) 0.78
Effects of drug combinations on smooth muscle cell proliferation: an isobolographic analysis. Eur J Pharmacol (2006) 0.78
Changes in aorta alpha1-adrenoceptor number and affinity during one year of streptozotocin-induced diabetes in rats. Pharmacology (2005) 0.78
Distinct interactions of cannabidiol and morphine in three nociceptive behavioral models in mice. Behav Pharmacol (2015) 0.77
Characterization of rat prepro-orphanin FQ/nociceptin((154-181)): nociceptive processing in supraspinal sites. J Pharmacol Exp Ther (2002) 0.77
Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine. J Clin Invest (2017) 0.77
Chemo fog: cancer chemotherapy-related cognitive impairment. Preface. Adv Exp Med Biol (2010) 0.77
Sandmeyer reaction repurposed for the site-selective, non-oxidizing radioiodination of fully-deprotected peptides: studies on the endogenous opioid peptide α-neoendorphin. Bioorg Med Chem Lett (2013) 0.77
Three-component coupling approach for the synthesis of diverse heterocycles utilizing reactive nitrilium trapping. Org Lett (2014) 0.77
Agmatine and a cannabinoid agonist, WIN 55212-2, interact to produce a hypothermic synergy. Eur J Pharmacol (2006) 0.77
Feeling pain? Who's your daddy.... Nat Med (2006) 0.76
Pronounced hypothermic synergy between systemic baclofen and NOS inhibitor. Eur J Pharmacol (2004) 0.76
Combining opioid and adrenergic mechanisms for chronic pain. Postgrad Med (2014) 0.76
Schild (apparent pA2) analysis of a kappa-opioid antagonist in Planaria. Eur J Pharmacol (2006) 0.76
Baclofen and NOS inhibitors interact to evoke synergistic hypothermia in rats. Life Sci (2005) 0.76
Changes in mouse mu opioid receptor Exon 7/8-like immunoreactivity following food restriction and food deprivation in rats. Synapse (2009) 0.76
2,6-Dimethyltyrosine analogues of a stereodiversified ligand library: highly potent, selective, non-peptidic mu opioid receptor agonists. J Med Chem (2003) 0.75
Modified 'Joyce model' of opioid dependence/withdrawal. Eur J Pharmacol (2006) 0.75
Cocaine synergism with α agonists in rat aorta: computational analysis reveals an action beyond reuptake inhibition. Drug Alcohol Depend (2012) 0.75
Codeine and 6-acetylcodeine analgesia in mice. Cell Mol Neurobiol (2006) 0.75
Truncated μ-Opioid Receptors With 6 Transmembrane Domains Are Essential for Opioid Analgesia. Anesth Analg (2017) 0.75
Future directions. Adv Exp Med Biol (2010) 0.75
Pharmacological characterization of beta-endorphin- and dynorphin A(1-17)-induced feeding using G-protein alpha-subunit antisense probes in rats. Peptides (2002) 0.75
Morphine potentiates dextromethorphan-induced vasodilation in rat superior mesenteric artery. Eur J Pharmacol (2004) 0.75
Radioligand Binding Assay for an Exon 11-Associated Mu Opioid Receptor Target. Methods Mol Biol (2015) 0.75