Published in Hepatology on November 01, 2002
Hepatic encephalopathy: effects of liver failure on brain function. Nat Rev Neurosci (2013) 1.27
Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests. World J Gastroenterol (2014) 0.81
Pharmacological manipulation of cyclic GMP levels in brain restores learning ability in animal models of hepatic encephalopathy: therapeutic implications. Neuropsychiatr Dis Treat (2006) 0.81
Restoring soluble guanylyl cyclase expression and function blocks the aggressive course of glioma. Mol Pharmacol (2011) 0.81
Contribution of altered signal transduction associated to glutamate receptors in brain to the neurological alterations of hepatic encephalopathy. World J Gastroenterol (2006) 0.79
Changes of the thioredoxin system, glutathione peroxidase activity and total antioxidant capacity in rat brain cortex during acute liver failure: modulation by L-histidine. Neurochem Res (2014) 0.76
Role of Bioflavonoid Quercetin on Expression of Urea Cycle Enzymes, Astrocytic and Inflammatory Markers in Hyperammonemic Rats. Indian J Clin Biochem (2016) 0.75
Intravenous scAAV9 delivery of a codon-optimized SMN1 sequence rescues SMA mice. Hum Mol Genet (2010) 2.26
Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat. J Neurochem (2008) 1.88
Neurobiology of ammonia. Prog Neurobiol (2002) 1.84
Brain edema and inflammatory activation in bile duct ligated rats with diet-induced hyperammonemia: A model of hepatic encephalopathy in cirrhosis. Hepatology (2006) 1.83
Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts. Hepatology (2007) 1.81
Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study. Gastroenterology (2003) 1.60
Alterations in expression of genes coding for proteins of the neurovascular unit in ischemic liver failure. Neurochem Int (2009) 1.55
Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study. Crit Care Med (2006) 1.50
A 1H nuclear magnetic resonance-based metabonomic approach for grading hepatic encephalopathy and monitoring the effects of therapeutic hypothermia in rats. Liver Int (2008) 1.50
Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence. CNS Drugs (2014) 1.49
Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients. J Mol Med (Berl) (2007) 1.49
Experimental models of hepatic encephalopathy: ISHEN guidelines. Liver Int (2009) 1.48
Increased brain serotonin turnover correlates with the degree of shunting and hyperammonemia in rats following variable portal vein stenosis. J Hepatol (2004) 1.44
Value of the critical flicker frequency in patients with minimal hepatic encephalopathy. Hepatology (2007) 1.41
Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy. Gastroenterology (2010) 1.21
Characterization of functional heme domains from soluble guanylate cyclase. Biochemistry (2005) 1.21
Update of cell damage mechanisms in thiamine deficiency: focus on oxidative stress, excitotoxicity and inflammation. Alcohol Alcohol (2009) 1.11
New strategies to optimize kidney recovery and preservation in transplantation. Nat Rev Nephrol (2012) 1.11
Activation of NMDA receptors induces protein kinase A-mediated phosphorylation and degradation of matrin 3. Blocking these effects prevents NMDA-induced neuronal death. J Neurochem (2005) 1.11
Cerebral inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline. J Neurochem (2009) 1.08
Neurobiological characterization of an azoxymethane mouse model of acute liver failure. Neurochem Int (2006) 1.07
Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes. FASEB J (2002) 1.07
IL-6 and IL-18 in blood may discriminate cirrhotic patients with and without minimal hepatic encephalopathy. J Clin Gastroenterol (2009) 1.07
Direct evidence for central proinflammatory mechanisms in rats with experimental acute liver failure: protective effect of hypothermia. J Cereb Blood Flow Metab (2009) 1.06
Long-term potentiation in hippocampus involves sequential activation of soluble guanylate cyclase, cGMP-dependent protein kinase, and cGMP-degrading phosphodiesterase. J Neurosci (2002) 1.04
Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity. Gastroenterology (2006) 1.04
Oral administration of sildenafil restores learning ability in rats with hyperammonemia and with portacaval shunts. Hepatology (2005) 1.03
IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure. Neurochem Int (2009) 1.01
Glutamine synthetase activity and glutamine content in brain: modulation by NMDA receptors and nitric oxide. Neurochem Int (2003) 1.01
N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms. Metab Brain Dis (2010) 1.00
A functional domain of the alpha1 subunit of soluble guanylyl cyclase is necessary for activation of the enzyme by nitric oxide and YC-1 but is not involved in heme binding. J Biol Chem (2003) 0.99
Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: ibuprofen restores its motor activity. J Neurosci Res (2009) 0.98
Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure. J Hepatol (2006) 0.97
Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms. Neurochem Int (2005) 0.97
Downregulation of nNOS and synthesis of PGs associated with endotoxin-induced delay in gastric emptying. Am J Physiol Gastrointest Liver Physiol (2002) 0.95
Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy. Metab Brain Dis (2008) 0.95
p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts. Gut (2011) 0.95
Hyperammonemia increases GABAergic tone in the cerebellum but decreases it in the rat cortex. Gastroenterology (2008) 0.95
Serum metabolic signature of minimal hepatic encephalopathy by (1)H-nuclear magnetic resonance. J Proteome Res (2010) 0.94
Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats. Gastroenterology (2010) 0.93
Pathogenesis of hepatic encephalopathy: new insights from neuroimaging and molecular studies. J Hepatol (2003) 0.93
Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study. Hepatology (2003) 0.93
[Normality tables in the Spanish population for psychometric tests used in the diagnosis of minimal hepatic encephalopathy]. Med Clin (Barc) (2006) 0.92
Role of mitochondrial dysfunction and oxidative stress in the pathogenesis of selective neuronal loss in Wernicke's encephalopathy. Mol Neurobiol (2005) 0.92
Mitochondrial dysfunction in acute hyperammonemia. Neurochem Int (2002) 0.92
The neurosteroid system: implication in the pathophysiology of hepatic encephalopathy. Neurochem Int (2007) 0.91
Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined. Neurochem Int (2012) 0.91
Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications. PLoS One (2012) 0.91
Modulation of NMDA receptors in the cerebellum. 1. Properties of the NMDA receptor that modulate its function. Cerebellum (2005) 0.91
Acute liver failure: a critical appraisal of available animal models. Metab Brain Dis (2005) 0.90
Modulation of NMDA receptors in the cerebellum. II. Signaling pathways and physiological modulators regulating NMDA receptor function. Cerebellum (2005) 0.90
A new method for measuring motor evoked potentials in the awake rat: effects of anesthetics. J Neurotrauma (2008) 0.88
Species differences in the localization of cGMP-producing and NO-responsive elements in the mouse and rat hippocampus using cGMP immunocytochemistry. Eur J Neurosci (2004) 0.88
Chronic liver failure in rats impairs glutamatergic synaptic transmission and long-term potentiation in hippocampus and learning ability. Eur J Neurosci (2007) 0.88
Sources of oxygen radicals in brain in acute ammonia intoxication in vivo. Brain Res (2003) 0.88
BAY 41-2272 activates two isoforms of nitric oxide-sensitive guanylyl cyclase. Biochem Biophys Res Commun (2002) 0.88
Increased brain endothelial nitric oxide synthase expression in thiamine deficiency: relationship to selective vulnerability. Neurochem Int (2004) 0.87
Liver-brain proinflammatory signalling in acute liver failure: role in the pathogenesis of hepatic encephalopathy and brain edema. Metab Brain Dis (2012) 0.87
Loss of expression of glial fibrillary acidic protein in acute hyperammonemia. Neurochem Int (2002) 0.87
Molecular mechanism of acute ammonia toxicity: role of NMDA receptors. Neurochem Int (2002) 0.87
Brain cholinergic impairment in liver failure. Brain (2008) 0.87
Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide. Metab Brain Dis (2005) 0.87
Restoration of learning ability in hyperammonemic rats by increasing extracellular cGMP in brain. Brain Res (2005) 0.87
Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects. Metab Brain Dis (2002) 0.86
Differential long-term effects of developmental exposure to polychlorinated biphenyls 52, 138 or 180 on motor activity and neurotransmission. Gender dependence and mechanisms involved. Neurochem Int (2010) 0.86
Keeping cool in acute liver failure: rationale for the use of mild hypothermia. J Hepatol (2005) 0.86
Altered expression of tight junction proteins and matrix metalloproteinases in thiamine-deficient mouse brain. Neurochem Int (2009) 0.86
Encapsulation of glutamine synthetase in mouse erythrocytes: a new procedure for ammonia detoxification. Biochem Cell Biol (2008) 0.86
Changes in liver and plasma acetylcholinesterase in rats with cirrhosis induced by bile duct ligation. Hepatology (2006) 0.86
Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure. Metab Brain Dis (2010) 0.86
Focal cortical damage parallels cognitive impairment in minimal hepatic encephalopathy. Neuroimage (2012) 0.86
The brain glutamate system in liver failure. J Neurochem (2006) 0.85
Hypolocomotion in rats with chronic liver failure is due to increased glutamate and activation of metabotropic glutamate receptors in substantia nigra. J Hepatol (2006) 0.85
Chronic hyperammonemia reduces the activity of neuronal nitric oxide synthase in cerebellum by altering its localization and increasing its phosphorylation by calcium-calmodulin kinase II. J Neurochem (2008) 0.85
3-nitro-tyrosine as a peripheral biomarker of minimal hepatic encephalopathy in patients with liver cirrhosis. Am J Gastroenterol (2011) 0.85
Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat. Neurochem Int (2005) 0.85
Minocycline attenuates oxidative/nitrosative stress and cerebral complications of acute liver failure in rats. Neurochem Int (2009) 0.85
Molecular mechanisms of the alterations in NMDA receptor-dependent long-term potentiation in hyperammonemia. Metab Brain Dis (2005) 0.85
Proteome analysis of primary neurons and astrocytes from rat cerebellum. J Proteome Res (2005) 0.84
Manganese distribution in the brain and neurobehavioral changes following inhalation exposure of rats to three chemical forms of manganese. Neurotoxicology (2004) 0.84
Normal coupling of brain benzodiazepine and neurosteroid modulatory sites on the GABA-A receptor complex in human hepatic encephalopathy. Neurochem Int (2003) 0.84
Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma. Neurochem Int (2006) 0.84
Nitric oxide activation of guanylate cyclase pushes the α1 signaling helix and the β1 heme-binding domain closer to the substrate-binding site. J Biol Chem (2013) 0.84
Modulation of NMDA receptors by AKT kinase. Neurochem Int (2006) 0.84
Lipopolysaccharide precipitates hepatic encephalopathy and increases blood-brain barrier permeability in mice with acute liver failure. Liver Int (2013) 0.83
Ebselen prevents chronic alcohol-induced rat hippocampal stress and functional impairment. Alcohol Clin Exp Res (2007) 0.83
Potentiation of the transient receptor potential vanilloid 1 channel contributes to pruritogenesis in a rat model of liver disease. J Biol Chem (2013) 0.83
Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy: effect of nimesulide. Metab Brain Dis (2008) 0.83
Increased Na, K-ATPase alpha2 isoform gene expression by ammonia in astrocytes and in brain in vivo. Neurochem Int (2010) 0.83
Region-selective alterations of glucose oxidation and amino acid synthesis in the thiamine-deficient rat brain: a re-evaluation using 1H/13C nuclear magnetic resonance spectroscopy. J Neurochem (2008) 0.83
Increasing the function of the glutamate-nitric oxide-cyclic guanosine monophosphate pathway increases the ability to learn a Y-maze task. J Neurosci Res (2009) 0.83
Effects of hyperammonemia and liver failure on glutamatergic neurotransmission. Metab Brain Dis (2002) 0.83
Increased brain concentrations of a neuroinhibitory steroid in human hepatic encephalopathy. Ann Neurol (2005) 0.83
Antioxidant and anti-inflammatory effects of mild hypothermia in the attenuation of liver injury due to azoxymethane toxicity in the mouse. Metab Brain Dis (2010) 0.83
Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia. Brain Res (2004) 0.83