Published in J Biol Chem on October 23, 2002
Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity. Nat Neurosci (2014) 1.99
Acid-sensing ion channels in pain and disease. Nat Rev Neurosci (2013) 1.93
Heteromeric acid-sensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal death. J Neurosci (2011) 1.69
Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels. Mol Biol Cell (2007) 1.69
Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala. Proc Natl Acad Sci U S A (2014) 1.49
Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proc Natl Acad Sci U S A (2007) 1.38
ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95. J Neurosci (2009) 1.33
Membrane localization is critical for activation of the PICK1 BAR domain. Traffic (2008) 1.25
The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a. J Physiol (2005) 1.24
A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a. J Biol Chem (2007) 1.13
cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1. Proc Natl Acad Sci U S A (2003) 1.13
Acid-sensing ion channels: trafficking and synaptic function. Mol Brain (2013) 1.11
Protein kinase C in pain: involvement of multiple isoforms. Pharmacol Res (2007) 1.09
A stomatin dimer modulates the activity of acid-sensing ion channels. EMBO J (2012) 1.01
Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1. Eur J Neurosci (2008) 1.00
Modulation of acid-sensing ion channels: molecular mechanisms and therapeutic potential. Int J Physiol Pathophysiol Pharmacol (2011) 0.96
PDZ binding to the BAR domain of PICK1 is elucidated by coarse-grained molecular dynamics. J Mol Biol (2010) 0.91
ENaCs and ASICs as therapeutic targets. Am J Physiol Cell Physiol (2012) 0.91
Two PKC consensus sites on human acid-sensing ion channel 1b differentially regulate its function. Am J Physiol Cell Physiol (2008) 0.91
PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor. Cell Res (2012) 0.91
PICK1 regulates the trafficking of ASIC1a and acidotoxicity in a BAR domain lipid binding-dependent manner. Mol Brain (2010) 0.90
Extracellular acidosis activates ASIC-like channels in freshly isolated cerebral artery smooth muscle cells. Am J Physiol Cell Physiol (2010) 0.88
Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands. J Biol Chem (2014) 0.86
Neuropathic Nav1.3-mediated sensitization to P2X activation is regulated by protein kinase C. Mol Pain (2011) 0.85
Regulation of TGF-β Signal Transduction. Scientifica (Cairo) (2014) 0.84
ASIC2 subunits facilitate expression at the cell surface and confer regulation by PSD-95. PLoS One (2014) 0.84
Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding. Biochemistry (2012) 0.82
Functional modulation of the glutamate transporter variant GLT1b by the PDZ domain protein PICK1. J Biol Chem (2013) 0.81
Prokineticin 2 potentiates acid-sensing ion channel activity in rat dorsal root ganglion neurons. J Neuroinflammation (2012) 0.81
Acid-sensing ion channels are tuned to follow high-frequency stimuli. J Physiol (2016) 0.80
Nociceptors in cardiovascular functions: complex interplay as a result of cyclooxygenase inhibition. Mol Pain (2006) 0.79
Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1. Org Biomol Chem (2010) 0.78
Syntabulin regulates the trafficking of PICK1-containing vesicles in neurons. Sci Rep (2016) 0.77
PICK1/calcineurin suppress ASIC1-mediated Ca2+ entry in rat pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol (2015) 0.76
Down-regulation of ASICs current and the calcium transients by disrupting PICK1 protects primary cultured mouse cortical neurons from OGD-Rep insults. Int J Clin Exp Pathol (2015) 0.75
Acid-sensing ion channels: trafficking and pathophysiology. Channels (Austin) (2014) 0.75
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev (2005) 3.50
Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype. Nat Neurosci (2006) 2.75
Black mamba venom peptides target acid-sensing ion channels to abolish pain. Nature (2012) 2.28
ASIC3, a sensor of acidic and primary inflammatory pain. EMBO J (2008) 2.18
Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2. J Biol Chem (2002) 2.08
A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons. EMBO J (2004) 2.07
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev (2003) 2.05
TREK-1, a K+ channel involved in polymodal pain perception. EMBO J (2006) 2.02
Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel. Circ Res (2007) 2.02
The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception. EMBO J (2009) 1.98
A phospholipid sensor controls mechanogating of the K+ channel TREK-1. EMBO J (2004) 1.98
Acid-sensing ion channels (ASICs): pharmacology and implication in pain. Pharmacol Ther (2010) 1.92
Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels. J Neurosci (2002) 1.91
ASIC-like, proton-activated currents in rat hippocampal neurons. J Physiol (2002) 1.82
Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels. EMBO J (2003) 1.65
An intracellular proton sensor commands lipid- and mechano-gating of the K(+) channel TREK-1. EMBO J (2002) 1.63
International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol Rev (2005) 1.63
K+-dependent cerebellar granule neuron apoptosis. Role of task leak K+ channels. J Biol Chem (2003) 1.56
Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. EMBO Mol Med (2011) 1.50
A tarantula peptide against pain via ASIC1a channels and opioid mechanisms. Nat Neurosci (2007) 1.49
Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies. Mol Pharmacol (2002) 1.42
Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton. EMBO Rep (2005) 1.41
p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1. EMBO J (2002) 1.38
ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6. EMBO Rep (2004) 1.37
Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing. J Physiol (2004) 1.32
Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Mol Pharmacol (2005) 1.31
Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue. Proc Natl Acad Sci U S A (2009) 1.31
Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration. J Neurosci (2004) 1.29
The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a. J Physiol (2005) 1.24
AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels. EMBO J (2006) 1.24
Acid-sensing ion channels in postoperative pain. J Neurosci (2011) 1.23
Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels. Protein Sci (2003) 1.23
Lysophosphatidic acid-operated K+ channels. J Biol Chem (2004) 1.19
Acid sensing ion channels in dorsal spinal cord neurons. J Neurosci (2008) 1.17
Altered acetylcholine, bradykinin and cutaneous pressure-induced vasodilation in mice lacking the TREK1 potassium channel: the endothelial link. EMBO Rep (2007) 1.17
Molecular basis of the voltage-dependent gating of TREK-1, a mechano-sensitive K(+) channel. Biochem Biophys Res Commun (2002) 1.15
Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol (2010) 1.15
Mtap2 is a constituent of the protein network that regulates twik-related K+ channel expression and trafficking. J Neurosci (2008) 1.12
ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1. J Biol Chem (2004) 1.11
A potent protective role of lysophospholipids against global cerebral ischemia and glutamate excitotoxicity in neuronal cultures. J Cereb Blood Flow Metab (2002) 1.10
Does sumoylation control K2P1/TWIK1 background K+ channels? Cell (2007) 1.10
The 2P-domain K+ channels: role in apoptosis and tumorigenesis. Pflugers Arch (2004) 1.08
Structural elements for the generation of sustained currents by the acid pain sensor ASIC3. J Biol Chem (2009) 1.07
Silencing acid-sensing ion channel 1a alters cone-mediated retinal function. J Neurosci (2006) 1.07
How nerve growth factor drives physiological and inflammatory expressions of acid-sensing ion channel 3 in sensory neurons. J Biol Chem (2003) 1.06
FMRFamide-gated sodium channel and ASIC channels: a new class of ionotropic receptors for FMRFamide and related peptides. Peptides (2006) 1.04
Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats. J Vasc Surg (2003) 1.02
Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1. J Biol Chem (2005) 1.00
APETx1, a new toxin from the sea anemone Anthopleura elegantissima, blocks voltage-gated human ether-a-go-go-related gene potassium channels. Mol Pharmacol (2003) 1.00
Acid-sensing ion channel 3 in retinal function and survival. Invest Ophthalmol Vis Sci (2008) 1.00
Up- and down-regulation of the mechano-gated K(2P) channel TREK-1 by PIP (2) and other membrane phospholipids. Pflugers Arch (2007) 0.99
The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons. J Biol Chem (2002) 0.99
Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers. Nat Med (2012) 0.98
Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity. Biochemistry (2003) 0.95
Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach-brainstem axis. Pain (2007) 0.95
Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions. Proc Natl Acad Sci U S A (2012) 0.93
Antipsychotics inhibit TREK but not TRAAK channels. Biochem Biophys Res Commun (2007) 0.92
A novel vasopressin-induced transcript promotes MAP kinase activation and ENaC downregulation. EMBO J (2002) 0.92
Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus. Protein Sci (2004) 0.91
Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels. Toxicon (2013) 0.91
Species diversity and peptide toxins blocking selectivity of ether-a-go-go-related gene subfamily K+ channels in the central nervous system. Mol Pharmacol (2006) 0.90
Membrane potential-regulated transcription of the resting K+ conductance TASK-3 via the calcineurin pathway. J Biol Chem (2006) 0.90
Current perspectives on acid-sensing ion channels: new advances and therapeutic implications. Expert Rev Clin Pharmacol (2010) 0.89
Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity. Biochemistry (2006) 0.89
Sea anemone toxins affecting potassium channels. Prog Mol Subcell Biol (2009) 0.85
Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels. Protein Sci (2005) 0.85
Spinal cord plasticity and acid-sensing ion channels involvement in a rodent model of irritable bowel syndrome. Eur J Pain (2011) 0.82
Secreted phospholipase A2 potentiates glutamate-induced calcium increase and cell death in primary neuronal cultures. J Neurosci Res (2002) 0.82