Published in Nat Rev Drug Discov on August 01, 2002
Indoleamine 2,3-dioxygenase and tumor-induced tolerance. J Clin Invest (2007) 5.05
An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J Immunol (2010) 3.75
The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation. J Immunol (2008) 2.55
Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia. J Neuroinflammation (2008) 2.53
Two distinct pathways supply anthranilate as a precursor of the Pseudomonas quinolone signal. J Bacteriol (2007) 1.47
IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis. J Immunol (2010) 1.46
Serotonin and blood pressure regulation. Pharmacol Rev (2012) 1.41
Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression. Prog Neurobiol (2010) 1.38
NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab (2015) 1.38
The kynurenine system and immunoregulation. J Neural Transm (Vienna) (2011) 1.38
The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression. J Psychiatry Neurosci (2004) 1.24
Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide. J Neuroinflammation (2010) 1.24
Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation. Proc Natl Acad Sci U S A (2008) 1.22
IDO: a double-edged sword for T(H)1/T(H)2 regulation. Immunol Lett (2008) 1.21
Structure, expression, and function of kynurenine aminotransferases in human and rodent brains. Cell Mol Life Sci (2009) 1.19
Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease. Prog Neurobiol (2009) 1.18
On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. J Neurochem (2009) 1.11
N-Methyl-D-aspartate receptors as a target for improved antipsychotic agents: novel insights and clinical perspectives. Psychopharmacology (Berl) (2005) 1.11
Quinolinic acid selectively induces apoptosis of human astrocytes: potential role in AIDS dementia complex. J Neuroinflammation (2005) 1.10
The concept of depression as a dysfunction of the immune system. Curr Immunol Rev (2010) 1.06
The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders. Br J Pharmacol (2013) 1.04
Immune system dysregulation in adolescent major depressive disorder. J Affect Disord (2008) 1.04
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. Brain (2009) 1.02
Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease. EMBO J (2013) 1.02
Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder. Neuropsychopharmacology (2014) 1.02
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice. Mol Cell Biol (2004) 1.01
Decreased tryptophan metabolism in patients with autism spectrum disorders. Mol Autism (2013) 0.97
Immune and behavioral consequences of microglial reactivity in the aged brain. Integr Comp Biol (2009) 0.95
Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2. Br J Pharmacol (2011) 0.93
Potential biofluid markers and treatment targets for renal cell carcinoma. Nat Rev Urol (2013) 0.91
A simple LC-MS/MS method for determination of kynurenine and tryptophan concentrations in human plasma from HIV-infected patients. Bioanalysis (2013) 0.91
Local expression of indoleamine 2,3 dioxygenase in syngeneic fibroblasts significantly prolongs survival of an engineered three-dimensional islet allograft. Diabetes (2010) 0.90
Tryptophan, Neurodegeneration and HIV-Associated Neurocognitive Disorder. Int J Tryptophan Res (2010) 0.90
Crystal structure of the Anopheles gambiae 3-hydroxykynurenine transaminase. Proc Natl Acad Sci U S A (2006) 0.90
Identification of xanthurenic acid 8-O-beta-D-glucoside and xanthurenic acid 8-O-sulfate as human natriuretic hormones. Proc Natl Acad Sci U S A (2007) 0.90
Gene expression in cortex and hippocampus during acute pneumococcal meningitis. BMC Biol (2006) 0.90
Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K. J Med Chem (2009) 0.89
Cold adaptation shapes the robustness of metabolic networks in Drosophila melanogaster. Evolution (2014) 0.89
Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets. Curr Neuropharmacol (2016) 0.89
Regulation of Th1/Th17 cytokines and IDO gene expression by inhibition of calpain in PBMCs from MS patients. J Neuroimmunol (2010) 0.88
Involvement of kynurenines in Huntington's disease and stroke-induced brain damage. J Neural Transm (Vienna) (2011) 0.88
The tryptophan oxidation pathway in mosquitoes with emphasis on xanthurenic acid biosynthesis. J Insect Physiol (2006) 0.88
Enzyme reactivation by hydrogen peroxide in heme-based tryptophan dioxygenase. J Biol Chem (2011) 0.88
Neuropsychiatric manifestations of depression in multiple sclerosis: neuroinflammatory, neuroendocrine, and neurotrophic mechanisms in the pathogenesis of immune-mediated depression. Dialogues Clin Neurosci (2007) 0.88
The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment. J Neuroinflammation (2011) 0.88
On the Biological Importance of the 3-hydroxyanthranilic Acid: Anthranilic Acid Ratio. Int J Tryptophan Res (2010) 0.88
Dendritic cell modification as a route to inhibiting corneal graft rejection by the indirect pathway of allorecognition. Eur J Immunol (2013) 0.88
Tryptophan degradation in women with breast cancer: a pilot study. BMC Res Notes (2011) 0.87
Kynurenine in combination with probenecid mitigates the stimulation-induced increase of c-fos immunoreactivity of the rat caudal trigeminal nucleus in an experimental migraine model. J Neural Transm (Vienna) (2006) 0.87
EPR and Mössbauer spectroscopy show inequivalent hemes in tryptophan dioxygenase. J Am Chem Soc (2010) 0.87
Effects of Kynurenine Pathway Inhibition on NAD Metabolism and Cell Viability in Human Primary Astrocytes and Neurons. Int J Tryptophan Res (2011) 0.87
Crystal structure of 3-hydroxyanthranilic acid 3,4-dioxygenase from Saccharomyces cerevisiae: a special subgroup of the type III extradiol dioxygenases. Protein Sci (2006) 0.87
Indoleamine 2,3-diooxygenase in periaortic fat: mechanisms of inhibition of contraction. Am J Physiol Heart Circ Physiol (2011) 0.87
Hypoxia and Mucosal Inflammation. Annu Rev Pathol (2016) 0.87
A preliminary study of cytokines in suicidal and nonsuicidal adolescents with major depression. J Child Adolesc Psychopharmacol (2009) 0.87
A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer. Cancer Res (2015) 0.86
A pro-convulsive carbamazepine metabolite: quinolinic acid in drug resistant epileptic human brain. Neurobiol Dis (2012) 0.86
The power of two: arginine 51 and arginine 239* from a neighboring subunit are essential for catalysis in α-amino-β-carboxymuconate-epsilon-semialdehyde decarboxylase. J Biol Chem (2013) 0.86
Immunomodulatory effects mediated by serotonin. J Immunol Res (2015) 0.85
Attention-deficit hyperactivity disorder (ADHD) and glial integrity: an exploration of associations of cytokines and kynurenine metabolites with symptoms and attention. Behav Brain Funct (2010) 0.84
Changes in the immune system in depression and dementia: causal or coincidental effects? Dialogues Clin Neurosci (2006) 0.84
Maternal tryptophan and kynurenine pathway metabolites and risk of preeclampsia. Obstet Gynecol (2012) 0.84
Crystallographic and spectroscopic snapshots reveal a dehydrogenase in action. Nat Commun (2015) 0.84
Adenosine receptor ligands protect against a combination of apoptotic and necrotic cell death in cerebellar granule neurons. Exp Brain Res (2007) 0.84
Anti-tumor immunity: myeloid leukocytes control the immune landscape. Cell Immunol (2012) 0.84
Metabonomics Combined with UPLC-MS Chemical Profile for Discovery of Antidepressant Ingredients of a Traditional Chinese Medicines Formula, Chaihu-Shu-Gan-San. Evid Based Complement Alternat Med (2013) 0.84
Tryptophan-kynurenine pathway is dysregulated in inflammation, and immune activation. Front Biosci (Landmark Ed) (2015) 0.84
Structural insight into the mechanism of substrate specificity of aedes kynurenine aminotransferase. Biochemistry (2008) 0.83
An anti-interleukin-2 receptor drug attenuates T- helper 1 lymphocytes-mediated inflammation in an acute model of endotoxin-induced uveitis. PLoS One (2014) 0.83
Pleural fluid from tuberculous pleurisy inhibits the functions of T cells and the differentiation of Th1 cells via immunosuppressive factors. Cell Mol Immunol (2011) 0.83
Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases. BMC Biochem (2010) 0.82
Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster. Biochem J (2012) 0.82
Association of kynurenine aminotransferase II gene C401T polymorphism with immune response in patients with meningitis. BMC Med Genet (2011) 0.82
Xanthurenic aciduria due to a mutation in KYNU encoding kynureninase. J Inherit Metab Dis (2007) 0.81
Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV. Biosci Rep (2011) 0.81
Evidence for a dual role of an active site histidine in α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase. Biochemistry (2012) 0.81
Human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD): a structural and mechanistic unveiling. Proteins (2014) 0.81
Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons. PLoS One (2012) 0.81
Cysteine and keto acids modulate mosquito kynurenine aminotransferase catalyzed kynurenic acid production. FEBS Lett (2004) 0.81
Indoleamine 2,3-dioxygenase 1 (ido1) is involved in the control of mouse caput epididymis immune environment. PLoS One (2013) 0.81
Pharmacophore-based discovery of inhibitors of a novel drug/proton antiporter in human brain endothelial hCMEC/D3 cell line. Br J Pharmacol (2015) 0.80
Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome. Psychopharmacology (Berl) (2014) 0.80
Apicomplexan parasite, Eimeria falciformis, co-opts host tryptophan catabolism for life cycle progression in mouse. J Biol Chem (2012) 0.80
Kynurenines in Parkinson's disease: therapeutic perspectives. J Neural Transm (Vienna) (2011) 0.80
The involvement of neuroinflammation and kynurenine pathway in Parkinson's disease. Parkinsons Dis (2011) 0.79
The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases. J Allergy Clin Immunol (2015) 0.79
The ACMSD gene, involved in tryptophan metabolism, is mutated in a family with cortical myoclonus, epilepsy, and parkinsonism. J Mol Med (Berl) (2013) 0.79
The aryl hydrocarbon receptor (AhR) mediates resistance to apoptosis induced in breast cancer cells. Pestic Biochem Physiol (2014) 0.79
Elevated kynurenine pathway metabolism during neurodevelopment: Implications for brain and behavior. Neuropharmacology (2016) 0.79
Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. Nutrients (2016) 0.78
Structure of the PLP-Form of the Human Kynurenine Aminotransferase II in a Novel Spacegroup at 1.83 Å Resolution. Int J Mol Sci (2016) 0.78
Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development. Proc Natl Acad Sci U S A (2015) 0.78
Prenatal inhibition of the kynurenine pathway leads to structural changes in the hippocampus of adult rat offspring. Eur J Neurosci (2014) 0.78
What is the tryptophan kynurenine pathway and why is it important to neurotherapeutics? Expert Rev Neurother (2015) 0.77
Renal effects of a novel endogenous natriuretic agent xanthurenic acid 8-o-β-d-glucoside in rats. Physiol Rep (2013) 0.77
Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine. Neuroscience (2015) 0.77
Development of a CZE-ESI-MS assay with a sulfonated capillary for profiling picolinic acid and quinolinic acid formation in multienzyme system. Electrophoresis (2013) 0.77
The Tumor-Selective Cytotoxic Agent β-Lapachone is a Potent Inhibitor of IDO1. Int J Tryptophan Res (2013) 0.77
Concurrent quantification of tryptophan and its major metabolites. Anal Biochem (2013) 0.77
An expanding range of targets for kynurenine metabolites of tryptophan. Trends Pharmacol Sci (2012) 1.29
Tryptophan metabolites and brain disorders. Clin Chem Lab Med (2003) 1.05
The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders. Br J Pharmacol (2013) 1.04
Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin. Br J Clin Pharmacol (2007) 1.00
Kynurenine pathway inhibition as a therapeutic strategy for neuroprotection. FEBS J (2012) 1.00
Kynurenine pathway metabolism in patients with osteoporosis after 2 years of drug treatment. Clin Exp Pharmacol Physiol (2006) 0.98
Levels of purine, kynurenine and lipid peroxidation products in patients with inflammatory bowel disease. Adv Exp Med Biol (2003) 0.94
Involvement of kynurenines in Huntington's disease and stroke-induced brain damage. J Neural Transm (Vienna) (2011) 0.88
Kynurenine metabolites and inflammation markers in depressed patients treated with fluoxetine or counselling. Clin Exp Pharmacol Physiol (2008) 0.86
Kynurenine and neopterin levels in patients with rheumatoid arthritis and osteoporosis during drug treatment. Adv Exp Med Biol (2003) 0.85
Blood levels of kynurenines, interleukin-23 and soluble human leucocyte antigen-G at different stages of Huntington's disease. J Neurochem (2009) 0.84
Kynurenine metabolism predicts cognitive function in patients following cardiac bypass and thoracic surgery. J Neurochem (2011) 0.84
Purine, kynurenine, neopterin and lipid peroxidation levels in inflammatory bowel disease. J Biomed Sci (2002) 0.84
Prenatal inhibition of the tryptophan-kynurenine pathway alters synaptic plasticity and protein expression in the rat hippocampus. Brain Res (2013) 0.82
Adenosine and cytokine levels following treatment of rheumatoid arthritis with dipyridamole. Rheumatol Int (2006) 0.79
Prenatal inhibition of the kynurenine pathway leads to structural changes in the hippocampus of adult rat offspring. Eur J Neurosci (2014) 0.78
Protection by the flavonoids quercetin and luteolin against peroxide- or menadione-induced oxidative stress in MC3T3-E1 osteoblast cells. Nat Prod Res (2014) 0.76
Prenatal activation of maternal TLR3 receptors by viral-mimetic poly(I:C) modifies GluN2B expression in embryos and sonic hedgehog in offspring in the absence of kynurenine pathway activation. Immunopharmacol Immunotoxicol (2013) 0.75
Molecular changes associated with hippocampal long-lasting depression induced by the serine protease subtilisin-A. Eur J Neurosci (2011) 0.75