Immunomodulatory effects mediated by serotonin.

Preliminary experience using milnacipran in patients with juvenile fibromyalgia: lessons from a clinical trial program. Pediatr Rheumatol Online J (2015) 0.80

Rotavirus and Serotonin Cross-Talk in Diarrhoea. PLoS One (2016) 0.79

Enteric Neuronal Regulation of Intestinal Inflammation. Trends Neurosci (2016) 0.79

Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon. Mediators Inflamm (2016) 0.77

Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients. Oncotarget (2016) 0.76

Alternative Anaphylactic Routes: The Potential Role of Macrophages. Front Immunol (2017) 0.76

Immunomodulatory Effects Mediated by Dopamine. J Immunol Res (2016) 0.75

Dual Role of Endogenous Serotonin in 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis. Front Pharmacol (2016) 0.75

Effect of N-Feruloylserotonin and Methotrexate on Severity of Experimental Arthritis and on Messenger RNA Expression of Key Proinflammatory Markers in Liver. J Immunol Res (2016) 0.75

Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance. Handb Exp Pharmacol (2016) 0.75

Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease. J Diabetes Res (2017) 0.75

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (2002) 49.51

Innate or adaptive immunity? The example of natural killer cells. Science (2011) 8.68

Monocyte-mediated defense against microbial pathogens. Annu Rev Immunol (2008) 7.21

Identification of enteramine, the specific hormone of the enterochromaffin cell system, as 5-hydroxytryptamine. Nature (1952) 6.91

A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol (2008) 6.78

Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol (2009) 5.44

2012 Alzheimer's disease facts and figures. Alzheimers Dement (2012) 5.43

Heterotrimeric G protein activation by G-protein-coupled receptors. Nat Rev Mol Cell Biol (2008) 5.30

Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood (1989) 4.76

The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol (2013) 4.75

The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology (2007) 4.58

Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science (2003) 4.58

Toll-like receptors stimulate human neutrophil function. Blood (2003) 4.29

Recent advances in Cys-loop receptor structure and function. Nature (2006) 4.20

Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase. J Exp Med (2002) 3.97

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels. Nucleic Acids Res (2008) 3.76

Long story short: the serotonin transporter in emotion regulation and social cognition. Nat Neurosci (2007) 3.66

Serotonin content of some mammalian tissues and urine and a method for its determination. Am J Physiol (1953) 3.48

Dendritic cell homeostasis. Blood (2009) 3.18

Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci (2012) 3.11

Crystalline Serotonin. Science (1948) 2.96

Depressive disorders and immunity: 20 years of progress and discovery. Brain Behav Immun (2007) 2.75

Pharmacological actions of synthetic 5-hydroxytryptamine (serotonin, thrombocytin). Nature (1952) 2.72

Endogenous kynurenines as targets for drug discovery and development. Nat Rev Drug Discov (2002) 2.61

Structural features for functional selectivity at serotonin receptors. Science (2013) 2.60

Serotonin receptors. Chem Rev (2008) 2.43

Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation. PLoS Biol (2009) 2.40

A randomized, placebo-controlled, double-blind, flexible-dose study of fluoxetine in the treatment of women with fibromyalgia. Am J Med (2002) 2.34

Kynurenines in the CNS: recent advances and new questions. Nat Rev Drug Discov (2012) 2.29

Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release. Cell (2003) 2.28

A unique central tryptophan hydroxylase isoform. Biochem Pharmacol (2003) 2.23

Rho and Ras GTPases in axon growth, guidance, and branching. Cold Spring Harb Perspect Biol (2010) 2.17

Escitalopram for the prevention of peginterferon-α2a-associated depression in hepatitis C virus-infected patients without previous psychiatric disease: a randomized trial. Ann Intern Med (2012) 2.14

Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes. Eur J Immunol (1999) 1.97

Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice. J Cell Biol (2001) 1.95

Serotonin: a mediator of the brain-gut connection. Am J Gastroenterol (2000) 1.93

Consensus paper of the WFSBP Task Force on Biological Markers: biological markers in depression. World J Biol Psychiatry (2007) 1.93

The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. Mol Cell Biol (2002) 1.87

Structural basis for molecular recognition at serotonin receptors. Science (2013) 1.86

G protein-coupled receptor dimerisation: molecular basis and relevance to function. Biochim Biophys Acta (2006) 1.76

The G protein subunit gene families. Genomics (1999) 1.75

Platelet 3H-imipramine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome. J Rheumatol (1992) 1.74

The 5-HT3 receptor--the relationship between structure and function. Neuropharmacology (2008) 1.70

Role of serotonin in the immune system and in neuroimmune interactions. Brain Behav Immun (1998) 1.69

Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene (2003) 1.67

Serum vasoconstrictor, serotonin; isolation and characterization. J Biol Chem (1948) 1.66

IUPHAR-DB: updated database content and new features. Nucleic Acids Res (2012) 1.66

Rab27b regulates number and secretion of platelet dense granules. Proc Natl Acad Sci U S A (2007) 1.66

Effects of serotonin on platelet activation in whole blood. Blood Coagul Fibrinolysis (1997) 1.63

A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells. Blood (2005) 1.57

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? J Neuroinflammation (2011) 1.56

Evidence for spinal cord hypersensitivity in chronic pain after whiplash injury and in fibromyalgia. Pain (2004) 1.52

Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention. Thorax (2010) 1.52

Atomic force microscopy reveals the stoichiometry and subunit arrangement of 5-HT3 receptors. Proc Natl Acad Sci U S A (2005) 1.52

Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. PLoS Pathog (2014) 1.51

Spinal cord glia: new players in pain. Pain (2001) 1.51

Oligomerization of serotonin transporter and its functional consequences. Proc Natl Acad Sci U S A (2000) 1.49

Melatonin membrane receptors in peripheral tissues: distribution and functions. Mol Cell Endocrinol (2012) 1.47

A new role for an old molecule: serotonin as a mitogen. Am J Physiol (1997) 1.45

The serotoninergic receptors of human dendritic cells: identification and coupling to cytokine release. J Immunol (2004) 1.44

Acute fluoxetine treatment induces slow rolling of leukocytes on endothelium in mice. PLoS One (2014) 1.44

Serotonin control of sleep-wake behavior. Sleep Med Rev (2011) 1.43

SEROTONIN: SYNTHESIS AND RELEASE FROM THE MYENTERIC PLEXUS OF THE MOUSE INTESTINE. Science (1965) 1.43

Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E. Mol Pharmacol (2007) 1.42

Antifungal properties of selective serotonin reuptake inhibitors against Aspergillus species in vitro. J Antimicrob Chemother (2001) 1.42

Serotonin is associated with coronary artery disease and cardiac events. Circulation (1999) 1.41

The kynurenine system and immunoregulation. J Neural Transm (Vienna) (2011) 1.38

Inhibition of serotonin 5-hydroxytryptamine2c receptor function through heterodimerization: receptor dimers bind two molecules of ligand and one G-protein. J Biol Chem (2005) 1.33

Role of serotonin in gastrointestinal motility and irritable bowel syndrome. Clin Chim Acta (2009) 1.33

Control of vesicular trafficking by Rho GTPases. Curr Biol (2003) 1.32

Human microglia convert l-tryptophan into the neurotoxin quinolinic acid. Biochem J (1996) 1.32

The antidepressant sertraline provides a promising therapeutic option for neurotropic cryptococcal infections. Antimicrob Agents Chemother (2012) 1.32

Extrapineal melatonin: sources, regulation, and potential functions. Cell Mol Life Sci (2014) 1.31

5-Hydroxytryptamine modulates cytokine and chemokine production in LPS-primed human monocytes via stimulation of different 5-HTR subtypes. Int Immunol (2005) 1.30

The small GTPase Rab27B regulates amylase release from rat parotid acinar cells. J Cell Sci (2004) 1.30

The complex role of serotonin and 5-HT receptors in chronic pain. Behav Pharmacol (2011) 1.29

Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor. Blood (2006) 1.29

Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies. Brain Res (2006) 1.27

Transglutaminase-dependent RhoA activation and depletion by serotonin in vascular smooth muscle cells. J Biol Chem (2006) 1.27

Rigidity of circulating lymphocytes is primarily conferred by vimentin intermediate filaments. J Immunol (2001) 1.27

Fundamental Ca2+ signaling mechanisms in mouse dendritic cells: CRAC is the major Ca2+ entry pathway. J Immunol (2001) 1.23

Molecular mechanisms of SERT in platelets: regulation of plasma serotonin levels. Mol Interv (2010) 1.23

Cardiovascular responses produced by 5-hydroxytriptamine:a pharmacological update on the receptors/mechanisms involved and therapeutic implications. Naunyn Schmiedebergs Arch Pharmacol (2007) 1.23

Serotonin 5-HT2C receptor homodimer biogenesis in the endoplasmic reticulum: real-time visualization with confocal fluorescence resonance energy transfer. J Biol Chem (2006) 1.22

IDO: a double-edged sword for T(H)1/T(H)2 regulation. Immunol Lett (2008) 1.21

Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid. Biochem J (1992) 1.21

G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient. J Biol Chem (2011) 1.21

Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors. Arthritis Rheum (2010) 1.21

Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. Schizophr Res (2004) 1.21

A dialogue between the immune system and brain, spoken in the language of serotonin. ACS Chem Neurosci (2012) 1.20

Role of serotonin in the hepato-gastroIntestinal tract: an old molecule for new perspectives. Cell Mol Life Sci (2008) 1.18

5-hydroxytryptamine induces mast cell adhesion and migration. J Immunol (2006) 1.17

Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5. Mol Endocrinol (2010) 1.17

Brain serotonin neurotransmission: an overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs. J Clin Psychiatry (1998) 1.16

Serotonin levels, pain threshold, and fibromyalgia symptoms in the general population. J Rheumatol (1997) 1.16

3B but which 3B and that's just one of the questions: the heterogeneity of human 5-HT3 receptors. Trends Pharmacol Sci (2008) 1.14

Serotonylation of vascular proteins important to contraction. PLoS One (2009) 1.14

Basophils are the major producers of IL-4 during primary helminth infection. J Immunol (2011) 1.14

Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages. J Neuroimmunol (2005) 1.14

Origin and metabolism of serotonin. J Cardiovasc Pharmacol (1990) 1.11

Sleep loss as a factor to induce cellular and molecular inflammatory variations. Clin Dev Immunol (2013) 0.92