Published in FASEB J on November 01, 2002
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell (2009) 2.45
WW domains provide a platform for the assembly of multiprotein networks. Mol Cell Biol (2005) 1.97
Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions. Cell Death Differ (2010) 1.77
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels. Proc Natl Acad Sci U S A (2004) 1.23
Regulation of the epithelial sodium channel by accessory proteins. Biochem J (2003) 1.15
Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes. J Biol Chem (2010) 1.13
Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nat Commun (2011) 1.13
Role of the ubiquitin system in regulating ion transport. Pflugers Arch (2010) 1.12
Open probability of the epithelial sodium channel is regulated by intracellular sodium. J Physiol (2006) 1.11
The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism. J Biol Chem (2009) 1.11
Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel. Am J Physiol Renal Physiol (2008) 1.10
WW domain interactions regulate the Hippo tumor suppressor pathway. Cell Death Dis (2011) 1.09
Epithelial Na(+) channel regulation by cytoplasmic and extracellular factors. Exp Cell Res (2012) 1.08
Protein kinase C (PKC)-promoted endocytosis of glutamate transporter GLT-1 requires ubiquitin ligase Nedd4-2-dependent ubiquitination but not phosphorylation. J Biol Chem (2012) 1.06
Protein kinase C-dependent ubiquitination and clathrin-mediated endocytosis of the cationic amino acid transporter CAT-1. J Biol Chem (2011) 1.03
TGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury. Proc Natl Acad Sci U S A (2013) 1.01
Participation of the ubiquitin-conjugating enzyme UBE2E3 in Nedd4-2-dependent regulation of the epithelial Na+ channel. Mol Cell Biol (2004) 0.97
Structural and biochemical basis for ubiquitin ligase recruitment by arrestin-related domain-containing protein-3 (ARRDC3). J Biol Chem (2013) 0.95
Regulation of ENaC-mediated alveolar fluid clearance by insulin via PI3K/Akt pathway in LPS-induced acute lung injury. Respir Res (2012) 0.88
Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition. Pflugers Arch (2006) 0.87
Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D. Neuropharmacology (2013) 0.87
Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation. PLoS One (2010) 0.87
Complete thermodynamic and kinetic characterization of the isomer-specific interaction between Pin1-WW domain and the amyloid precursor protein cytoplasmic tail phosphorylated at Thr668. Biochemistry (2012) 0.86
Regulation of the epithelial Na+ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Galphaq/11. J Biol Chem (2011) 0.82
Regulation of the human ether-a-go-go-related gene (hERG) channel by Rab4 protein through neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2). J Biol Chem (2013) 0.82
Crystallization and preliminary X-ray diffraction studies of the WW4 domain of the Nedd4-2 ubiquitin-protein ligase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.81
Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes. Front Pharmacol (2015) 0.80
Nedd4-2 but not Nedd4-1 is critical for protein kinase C-regulated ubiquitination, expression, and transport activity of human organic anion transporter 1. Am J Physiol Renal Physiol (2016) 0.77
Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver. Sci Rep (2016) 0.77
Differential expression and localisation of WWP1, a Nedd4-like protein, in epithelia. Pflugers Arch (2003) 0.76
The role of Nedd4-1 WW domains in binding and regulating human organic anion transporter 1. Am J Physiol Renal Physiol (2016) 0.75
Regulation of the divalent metal ion transporter via membrane budding. Cell Discov (2016) 0.75
Deletion of Nedd4-2 results in progressive kidney disease in mice. Cell Death Differ (2017) 0.75
PKC/Nedd4-2 Signaling Pathway Regulates the Cell Surface Expression of Drug Transporter hOAT1. Drug Metab Dispos (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Physiological functions of the HECT family of ubiquitin ligases. Nat Rev Mol Cell Biol (2009) 5.43
Pathogenesis of chytridiomycosis, a cause of catastrophic amphibian declines. Science (2009) 4.45
Cooperativity in long-range gene regulation by the lambda CI repressor. Genes Dev (2004) 2.65
Plasmin in nephrotic urine activates the epithelial sodium channel. J Am Soc Nephrol (2008) 2.57
Autophagy, not apoptosis, is essential for midgut cell death in Drosophila. Curr Biol (2009) 2.20
A tumor suppressor function for caspase-2. Proc Natl Acad Sci U S A (2009) 2.15
The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila. Dev Cell (2004) 1.90
Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis. Dev Cell (2004) 1.87
N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. J Biol Chem (2001) 1.84
Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins. Bioessays (2006) 1.83
Transcriptional interference between convergent promoters caused by elongation over the promoter. Mol Cell (2004) 1.79
Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease. Hum Mutat (2009) 1.71
Enhancing DNA vaccine potency by coadministration of DNA encoding antiapoptotic proteins. J Clin Invest (2003) 1.71
Nedd4 controls animal growth by regulating IGF-1 signaling. Sci Signal (2008) 1.67
The role of cytochrome c in caspase activation in Drosophila melanogaster cells. J Cell Biol (2002) 1.67
A mathematical model for transcriptional interference by RNA polymerase traffic in Escherichia coli. J Mol Biol (2004) 1.64
Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: therapeutic implications. Clin Cancer Res (2008) 1.62
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood (2008) 1.62
Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins. J Biol Chem (2008) 1.60
Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese mice. PLoS One (2012) 1.59
A novel Apaf-1-independent putative caspase-2 activation complex. J Cell Biol (2002) 1.58
Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron. Am J Physiol Renal Physiol (2012) 1.58
Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die. J Cell Biol (2004) 1.57
A novel pathway of epithelial sodium channel activation involves a serum- and glucocorticoid-inducible kinase consensus motif in the C terminus of the channel's alpha-subunit. J Biol Chem (2004) 1.55
Revisited gene regulation in bacteriophage lambda. Curr Opin Genet Dev (2005) 1.54
Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC). Pflugers Arch (2009) 1.44
Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. J Biol Chem (2007) 1.41
mTORC2 critically regulates renal potassium handling. J Clin Invest (2016) 1.40
Cleavage in the {gamma}-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels. J Physiol (2008) 1.38
The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells. J Cell Biol (2004) 1.37
Role of prodomain in importin-mediated nuclear localization and activation of caspase-2. J Biol Chem (2002) 1.35
Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects. Biochim Biophys Acta (2013) 1.34
Potent transcriptional interference by pausing of RNA polymerases over a downstream promoter. Mol Cell (2009) 1.31
Cro's role in the CI Cro bistable switch is critical for {lambda}'s transition from lysogeny to lytic development. Genes Dev (2007) 1.31
Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein. J Biol Chem (2002) 1.28
Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2. J Biol Chem (2004) 1.27
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels. Proc Natl Acad Sci U S A (2004) 1.23
The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts. J Biol Chem (2013) 1.23
Stimulation of the epithelial sodium channel (ENaC) by cAMP involves putative ERK phosphorylation sites in the C termini of the channel's beta- and gamma-subunit. J Biol Chem (2006) 1.22
Structure of the Drosophila apoptosome at 6.9 å resolution. Structure (2011) 1.22
The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death. J Cell Biol (2006) 1.22
Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. J Biol Chem (2004) 1.21
Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions. EMBO J (2003) 1.21
N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. J Cell Sci (2004) 1.20
Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons. Proc Natl Acad Sci U S A (2009) 1.20
Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2. J Biol Chem (2007) 1.15
Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex. J Cell Biol (2002) 1.15
The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1. J Am Soc Nephrol (2002) 1.14
Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. J Cell Biol (2012) 1.13
Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nat Commun (2011) 1.13
Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension. J Clin Invest (2013) 1.13
Ecdysone receptor directly binds the promoter of the Drosophila caspase dronc, regulating its expression in specific tissues. J Cell Biol (2004) 1.12
Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice. Proc Natl Acad Sci U S A (2013) 1.12
Transcriptional interference by RNA polymerase pausing and dislodgement of transcription factors. Transcription (2012) 1.11
The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism. J Biol Chem (2009) 1.11
Trypsin can activate the epithelial sodium channel (ENaC) in microdissected mouse distal nephron. Am J Physiol Renal Physiol (2008) 1.11
Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival after acute cortical brain injury. J Neurosci (2006) 1.10
Atomic force microscopy reveals the architecture of the epithelial sodium channel (ENaC). J Biol Chem (2011) 1.10
Death to flies: Drosophila as a model system to study programmed cell death. J Immunol Methods (2002) 1.07
Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells. J Biol Chem (2004) 1.06
Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells. J Biol Chem (2005) 1.06
HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Am J Pathol (2009) 1.06
Basolateral PAR-2 receptors mediate KCl secretion and inhibition of Na+ absorption in the mouse distal colon. J Physiol (2002) 1.05
One-step cloning and chromosomal integration of DNA. ACS Synth Biol (2013) 1.04
Extracellular Na+ removal attenuates rundown of the epithelial Na+-channel (ENaC) by reducing the rate of channel retrieval. Pflugers Arch (2003) 1.03
A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+ self inhibition. J Physiol (2010) 1.01
Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption. Pflugers Arch (2011) 1.00
The structural basis of cooperative regulation at an alternate genetic switch. Mol Cell (2006) 1.00
Additional disruption of the ClC-2 Cl(-) channel does not exacerbate the cystic fibrosis phenotype of cystic fibrosis transmembrane conductance regulator mouse models. J Biol Chem (2004) 0.99
The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities. Int J Biochem Cell Biol (2005) 0.98
Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S. Pflugers Arch (2012) 0.97
Larval midgut destruction in Drosophila: not dependent on caspases but suppressed by the loss of autophagy. Autophagy (2010) 0.97
Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels. Am J Physiol Cell Physiol (2002) 0.96
dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes. J Cell Biol (2008) 0.95
Cholesterol depletion of the plasma membrane prevents activation of the epithelial sodium channel (ENaC) by SGK1. Cell Physiol Biochem (2009) 0.94
An arginine-histone methyltransferase, CARMER, coordinates ecdysone-mediated apoptosis in Drosophila cells. J Biol Chem (2004) 0.94
Modelling transcriptional interference and DNA looping in gene regulation. J Mol Biol (2007) 0.93
NEDD1: function in microtubule nucleation, spindle assembly and beyond. Int J Biochem Cell Biol (2006) 0.93
The delta-subunit of the epithelial sodium channel (ENaC) enhances channel activity and alters proteolytic ENaC activation. J Biol Chem (2009) 0.92
Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis. Blood (2010) 0.92
Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR. Nucleic Acids Res (2011) 0.92
Role of Bcl-2 family of proteins in malignancy. Hematol Oncol (2002) 0.92
cAMP-dependent activation of CFTR inhibits the epithelial sodium channel (ENaC) without affecting its surface expression. Pflugers Arch (2002) 0.92
Enhancer-like long-range transcriptional activation by λ CI-mediated DNA looping. Proc Natl Acad Sci U S A (2013) 0.92
Regulation of epithelial Na+ channels by aldosterone: role of Sgk1. Clin Exp Pharmacol Physiol (2008) 0.91