Published in J Biol Chem on December 10, 2002
The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem J (2004) 4.85
Characterization of cytoplasmic caspase-2 activation by induced proximity. Mol Cell (2009) 2.18
A tumor suppressor function for caspase-2. Proc Natl Acad Sci U S A (2009) 2.15
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more? Nat Rev Cancer (2009) 1.84
The enigma of caspase-2: the laymen's view. Cell Death Differ (2008) 1.63
Caspase-dependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosis. Mol Biol Cell (2004) 1.51
Retracted DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance. Cell (2009) 1.37
Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability. Cell Death Differ (2012) 1.33
HIV-1 integrase is capable of targeting DNA to the nucleus via an importin alpha/beta-dependent mechanism. Biochem J (2006) 1.24
Caspase-2 as a tumour suppressor. Cell Death Differ (2013) 1.19
Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation. EMBO Rep (2010) 1.17
SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage. J Biol Chem (2008) 0.99
The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells. Mol Cell Biol (2004) 0.99
Rhinovirus 3C protease can localize in the nucleus and alter active and passive nucleocytoplasmic transport. J Virol (2009) 0.95
The role of caspase-2 in stress-induced apoptosis. J Cell Mol Med (2010) 0.91
Mechanism of microtubule-facilitated "fast track" nuclear import. J Biol Chem (2011) 0.91
Calmodulin-dependent nuclear import of HMG-box family nuclear factors: importance of the role of SRY in sex reversal. Biochem J (2010) 0.89
A novel nuclear trafficking module regulates the nucleocytoplasmic localization of the rabies virus interferon antagonist, P protein. J Biol Chem (2012) 0.87
Regulation of immune pathways by the NOD-like receptor NLRC5. Immunobiology (2011) 0.87
The PIDDosome, DNA-damage-induced apoptosis and beyond. Cell Death Differ (2011) 0.85
Binding of p110 retinoblastoma protein inhibits nuclear import of simian virus SV40 large tumor antigen. J Biol Chem (2010) 0.80
70-kDa heat shock cognate protein hsc70 mediates calmodulin-dependent nuclear import of the sex-determining factor SRY. J Biol Chem (2012) 0.80
Caspase-2 promotes cytoskeleton protein degradation during apoptotic cell death. Cell Death Dis (2013) 0.78
Nuclear import of β-dystroglycan is facilitated by ezrin-mediated cytoskeleton reorganization. PLoS One (2014) 0.78
A novel cell lysis approach reveals that caspase-2 rapidly translocates from the nucleus to the cytoplasm in response to apoptotic stimuli. PLoS One (2013) 0.77
Putative functions of caspase-2. F1000 Biol Rep (2009) 0.77
Detection of a secreted metalloprotease within the nuclei of liver cells. Mol Biosyst (2011) 0.76
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Physiological functions of the HECT family of ubiquitin ligases. Nat Rev Mol Cell Biol (2009) 5.43
Regulation of nuclear transport: central role in development and transformation? Traffic (2005) 2.51
An efficient system for high-level expression and easy purification of authentic recombinant proteins. Protein Sci (2004) 2.31
Towards safe, non-viral therapeutic gene expression in humans. Nat Rev Genet (2005) 2.28
Autophagy, not apoptosis, is essential for midgut cell death in Drosophila. Curr Biol (2009) 2.20
A tumor suppressor function for caspase-2. Proc Natl Acad Sci U S A (2009) 2.15
The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65. PLoS Pathog (2010) 2.03
The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila. Dev Cell (2004) 1.90
Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis. Dev Cell (2004) 1.87
N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. J Biol Chem (2001) 1.84
Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins. Bioessays (2006) 1.83
Enhancing DNA vaccine potency by coadministration of DNA encoding antiapoptotic proteins. J Clin Invest (2003) 1.71
The role of cytochrome c in caspase activation in Drosophila melanogaster cells. J Cell Biol (2002) 1.67
Nedd4 controls animal growth by regulating IGF-1 signaling. Sci Signal (2008) 1.67
Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: therapeutic implications. Clin Cancer Res (2008) 1.62
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood (2008) 1.62
Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins. J Biol Chem (2008) 1.60
A novel Apaf-1-independent putative caspase-2 activation complex. J Cell Biol (2002) 1.58
Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die. J Cell Biol (2004) 1.57
Trafficking and signaling pathways of nuclear localizing protein ligands and their receptors. Bioessays (2004) 1.42
Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. J Biol Chem (2007) 1.41
Importins and beyond: non-conventional nuclear transport mechanisms. Traffic (2009) 1.41
Nuclear localization of dengue virus nonstructural protein 5 through its importin alpha/beta-recognized nuclear localization sequences is integral to viral infection. Traffic (2007) 1.41
Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations. Proc Natl Acad Sci U S A (2003) 1.40
The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells. J Cell Biol (2004) 1.37
Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus. Biochem J (2012) 1.36
Apoptin nuclear accumulation is modulated by a CRM1-recognized nuclear export signal that is active in normal but not in tumor cells. Cancer Res (2005) 1.36
Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects. Biochim Biophys Acta (2013) 1.34
Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-alpha. Biochem J (2003) 1.34
EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. J Biol Chem (2002) 1.34
The interdomain region of dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin beta 1 and importin alpha/beta-recognized nuclear localization signals. J Biol Chem (2002) 1.31
The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. FASEB J (2002) 1.30
Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein. J Biol Chem (2002) 1.28
Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2. J Biol Chem (2004) 1.27
HIV-1 integrase is capable of targeting DNA to the nucleus via an importin alpha/beta-dependent mechanism. Biochem J (2006) 1.24
Targeted delivery to the nucleus. Adv Drug Deliv Rev (2007) 1.24
Heterologous protein production in the yeast Kluyveromyces lactis. FEMS Yeast Res (2006) 1.24
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels. Proc Natl Acad Sci U S A (2004) 1.23
A microtubule-facilitated nuclear import pathway for cancer regulatory proteins. Traffic (2007) 1.22
The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death. J Cell Biol (2006) 1.22
Structure of the Drosophila apoptosome at 6.9 å resolution. Structure (2011) 1.22
Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. J Biol Chem (2004) 1.21
Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions. EMBO J (2003) 1.21
Association of respiratory syncytial virus M protein with viral nucleocapsids is mediated by the M2-1 protein. J Virol (2008) 1.21
N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. J Cell Sci (2004) 1.20
Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons. Proc Natl Acad Sci U S A (2009) 1.20
Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-alpha using oriented peptide library screening. J Biol Chem (2010) 1.18
Importin alpha mRNAs have distinct expression profiles during spermatogenesis. Dev Dyn (2006) 1.17
Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules. Mol Endocrinol (2002) 1.17
Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2. J Biol Chem (2007) 1.15
Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex. J Cell Biol (2002) 1.15
Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha. Biochemistry (2005) 1.14
Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. J Cell Biol (2012) 1.13
Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nat Commun (2011) 1.13
Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension. J Clin Invest (2013) 1.13
Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice. Proc Natl Acad Sci U S A (2013) 1.12
Ecdysone receptor directly binds the promoter of the Drosophila caspase dronc, regulating its expression in specific tissues. J Cell Biol (2004) 1.12
The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism. J Biol Chem (2009) 1.11
Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival after acute cortical brain injury. J Neurosci (2006) 1.10
The N-terminal basic domain of the HIV-1 matrix protein does not contain a conventional nuclear localization sequence but is required for DNA binding and protein self-association. Biochemistry (2008) 1.10
Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association. J Biol Chem (2005) 1.09
Dynein light chain association sequences can facilitate nuclear protein import. Mol Biol Cell (2007) 1.08
Protein transduction: cell penetrating peptides and their therapeutic applications. Curr Med Chem (2006) 1.08
Death to flies: Drosophila as a model system to study programmed cell death. J Immunol Methods (2002) 1.07
Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells. J Biol Chem (2004) 1.06
Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells. J Biol Chem (2005) 1.06
Dual modes of rabies P-protein association with microtubules: a novel strategy to suppress the antiviral response. J Cell Sci (2009) 1.06
Intramolecular masking of nuclear localization signals: analysis of importin binding using a novel AlphaScreen-based method. Anal Biochem (2005) 1.06
The respiratory syncytial virus matrix protein possesses a Crm1-mediated nuclear export mechanism. J Virol (2009) 1.06
HIV-1 infection induces changes in expression of cellular splicing factors that regulate alternative viral splicing and virus production in macrophages. Retrovirology (2008) 1.05
CRM1-mediated nuclear export of dengue virus RNA polymerase NS5 modulates interleukin-8 induction and virus production. J Biol Chem (2009) 1.05
A protein kinase CK2 site flanking the nuclear targeting signal enhances nuclear transport of human cytomegalovirus ppUL44. Traffic (2005) 1.04
Recombinant modular transporters for cell-specific nuclear delivery of locally acting drugs enhance photosensitizer activity. FASEB J (2003) 1.03
Role of interferon antagonist activity of rabies virus phosphoprotein in viral pathogenicity. J Virol (2010) 1.03
A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death. J Cell Biol (2003) 1.02
Bovine ephemeral fever rhabdovirus α1 protein has viroporin-like properties and binds importin β1 and importin 7. J Virol (2013) 1.02
A SOX9 defect of calmodulin-dependent nuclear import in campomelic dysplasia/autosomal sex reversal. J Biol Chem (2003) 1.01
Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis. Proc Natl Acad Sci U S A (2007) 1.00
Central role of the respiratory syncytial virus matrix protein in infection. FEMS Microbiol Rev (2006) 0.99
The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities. Int J Biochem Cell Biol (2005) 0.98
Nucleocytoplasmic distribution of rabies virus P-protein is regulated by phosphorylation adjacent to C-terminal nuclear import and export signals. Biochemistry (2007) 0.98
Arginine methylation increases the stability of human immunodeficiency virus type 1 Tat. J Virol (2009) 0.97
The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins. Mol Biol Cell (2006) 0.97
Larval midgut destruction in Drosophila: not dependent on caspases but suppressed by the loss of autophagy. Autophagy (2010) 0.97
Nuclear import pathway of the telomere elongation suppressor TRF1: inhibition by importin alpha. Biochemistry (2002) 0.96
Regulation of nucleocytoplasmic trafficking of viral proteins: an integral role in pathogenesis? Biochim Biophys Acta (2011) 0.96
dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes. J Cell Biol (2008) 0.95
The biarsenical dye Lumio exhibits a reduced ability to specifically detect tetracysteine-containing proteins within live cells. J Fluoresc (2007) 0.95
Regulating the functions of the HIV-1 matrix protein. AIDS Res Hum Retroviruses (2007) 0.95
Rhinovirus 3C protease can localize in the nucleus and alter active and passive nucleocytoplasmic transport. J Virol (2009) 0.95
Myb-binding protein 1a is a nucleocytoplasmic shuttling protein that utilizes CRM1-dependent and independent nuclear export pathways. Exp Cell Res (2003) 0.94
Using nuclear targeting signals to enhance non-viral gene transfer. Immunol Cell Biol (2002) 0.94
Expression of nuclear transport importins beta 1 and beta 3 is regulated during rodent spermatogenesis. Biol Reprod (2005) 0.94
Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes. Biochem J (2012) 0.94
An arginine-histone methyltransferase, CARMER, coordinates ecdysone-mediated apoptosis in Drosophila cells. J Biol Chem (2004) 0.94
Towards delineation of a developmental α-importome in the mammalian male germline. Biochim Biophys Acta (2012) 0.93