Published in J Biol Chem on November 12, 2002
The search for endogenous activators of the aryl hydrocarbon receptor. Chem Res Toxicol (2007) 3.68
The aryl hydrocarbon receptor complex and the control of gene expression. Crit Rev Eukaryot Gene Expr (2008) 3.06
The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways. Biochem Pharmacol (2008) 1.90
Ah receptor represses acute-phase response gene expression without binding to its cognate response element. Lab Invest (2009) 1.37
Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters. Biochem Pharmacol (2012) 1.31
Over-expression of AhR (aryl hydrocarbon receptor) induces neural differentiation of Neuro2a cells: neurotoxicology study. Environ Health (2006) 1.07
Roles of coactivator proteins in dioxin induction of CYP1A1 and CYP1B1 in human breast cancer cells. Toxicol Sci (2008) 1.01
Role of the Per/Arnt/Sim domains in ligand-dependent transformation of the aryl hydrocarbon receptor. J Biol Chem (2008) 1.01
Knockdown of aberrantly upregulated aryl hydrocarbon receptor reduces tumor growth and metastasis of MDA-MB-231 human breast cancer cell line. Int J Cancer (2013) 0.94
Identification of the Ah-receptor structural determinants for ligand preferences. Toxicol Sci (2012) 0.89
Interaction networks in yeast define and enumerate the signaling steps of the vertebrate aryl hydrocarbon receptor. PLoS Biol (2004) 0.87
Repression of Ah receptor and induction of transforming growth factor-beta genes in DEN-induced mouse liver tumors. Toxicology (2008) 0.85
G-protein signalling negatively regulates the stability of aryl hydrocarbon receptor. EMBO Rep (2009) 0.81
Differential suppression of the aryl hydrocarbon receptor nuclear translocator-dependent function by an aryl hydrocarbon receptor PAS-A-derived inhibitory molecule. Biochem Pharmacol (2014) 0.80
p23 co-chaperone protects the aryl hydrocarbon receptor from degradation in mouse and human cell lines. Biochem Pharmacol (2012) 0.79
Beta tubulin affects the aryl hydrocarbon receptor function via an Arnt-mediated mechanism. Biochem Pharmacol (2009) 0.78
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the mortality and growth of two amphibian species (Xenopus laevis and Pseudacris triseriata). Int J Environ Res Public Health (2008) 0.77
Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon. J Biol Chem (2015) 0.77
Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science (2010) 5.50
The aryl hydrocarbon receptor complex and the control of gene expression. Crit Rev Eukaryot Gene Expr (2008) 3.06
Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling. Toxicol Sci (2010) 1.91
The role of chaperone proteins in the aryl hydrocarbon receptor core complex. Chem Biol Interact (2002) 1.70
Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice. Mol Pharmacol (2009) 1.47
Quantitative expression patterns of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) protein in mice. Biochem Biophys Res Commun (2008) 1.47
Aryl hydrocarbon receptor ligands in cancer: friend and foe. Nat Rev Cancer (2014) 1.46
ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription. J Biol Chem (2005) 1.41
Ah receptor represses acute-phase response gene expression without binding to its cognate response element. Lab Invest (2009) 1.37
Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation. Environ Health Perspect (2015) 1.34
Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity. J Biol Chem (2005) 1.34
The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor. Biochemistry (2010) 1.32
Use of 2-azido-3-[125I]iodo-7,8-dibromodibenzo-p-dioxin as a probe to determine the relative ligand affinity of human versus mouse aryl hydrocarbon receptor in cultured cells. Mol Pharmacol (2004) 1.31
Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities. Toxicol Sci (2010) 1.29
Mechanistic insights into the events that lead to synergistic induction of interleukin 6 transcription upon activation of the aryl hydrocarbon receptor and inflammatory signaling. J Biol Chem (2010) 1.27
Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells. Cancer Res (2008) 1.19
A dynamic role for the Ah receptor in cell signaling? Insights from a diverse group of Ah receptor interacting proteins. J Biochem Mol Toxicol (2002) 1.19
Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity. Mol Pharmacol (2009) 1.18
Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. J Biol Chem (2002) 1.16
Evidence for an aryl hydrocarbon receptor-mediated cytochrome p450 autoregulatory pathway. Mol Pharmacol (2007) 1.15
Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism. J Pharmacol Exp Ther (2011) 1.15
Role of the aryl hydrocarbon receptor in drug metabolism. Expert Opin Drug Metab Toxicol (2005) 1.12
Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity. Biochemistry (2003) 1.11
The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axis. Mol Endocrinol (2011) 1.10
Omeprazole stimulates the induction of human insulin-like growth factor binding protein-1 through aryl hydrocarbon receptor activation. J Pharmacol Exp Ther (2007) 1.08
Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression. Toxicol Sci (2008) 1.07
Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties. Chem Res Toxicol (2010) 1.06
Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner. Hepatology (2012) 1.05
Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone. Mol Pharmacol (2010) 1.04
The mouse and human Ah receptor differ in recognition of LXXLL motifs. Arch Biochem Biophys (2008) 1.03
Leukotriene A4 metabolites are endogenous ligands for the Ah receptor. Biochemistry (2008) 1.03
Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone. J Pharmacol Exp Ther (2009) 1.02
Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787. Mol Pharmacol (2010) 1.02
Differential gene regulation by the human and mouse aryl hydrocarbon receptor. Toxicol Sci (2009) 1.01
The aryl hydrocarbon receptor directly regulates expression of the potent mitogen epiregulin. Toxicol Sci (2005) 0.99
Evidence that ligand binding is a key determinant of Ah receptor-mediated transcriptional activity. Arch Biochem Biophys (2005) 0.97
Ah receptor antagonism inhibits constitutive and cytokine inducible IL6 production in head and neck tumor cell lines. Mol Carcinog (2010) 0.97
Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver. Hepatology (2007) 0.96
Carboxyl terminus of hsc70-interacting protein (CHIP) can remodel mature aryl hydrocarbon receptor (AhR) complexes and mediate ubiquitination of both the AhR and the 90 kDa heat-shock protein (hsp90) in vitro. Biochemistry (2007) 0.95
12(R)-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid [12(R)-HETE], an arachidonic acid derivative, is an activator of the aryl hydrocarbon receptor. Mol Pharmacol (2008) 0.94
Role of GAC63 in transcriptional activation mediated by the aryl hydrocarbon receptor. J Biol Chem (2006) 0.93
The aryl hydrocarbon (Ah) receptor transcriptional regulator hepatitis B virus X-associated protein 2 antagonizes p23 binding to Ah receptor-Hsp90 complexes and is dispensable for receptor function. J Biol Chem (2004) 0.92
NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways. Cell Metab (2011) 0.91
The subdomains of the transactivation domain of the aryl hydrocarbon receptor (AhR) inhibit AhR and estrogen receptor transcriptional activity. Arch Biochem Biophys (2002) 0.90
Divergent roles of hepatitis B virus X-associated protein 2 (XAP2) in human versus mouse Ah receptor complexes. Biochemistry (2004) 0.90
Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes. Ann Rheum Dis (2013) 0.89
Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors. Mol Cell Biol (2014) 0.89
Ah receptor antagonism represses head and neck tumor cell aggressive phenotype. Mol Cancer Res (2012) 0.88
Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver. Toxicol Sci (2012) 0.88
The transactivation domain of the Ah receptor is a key determinant of cellular localization and ligand-independent nucleocytoplasmic shuttling properties. Biochemistry (2005) 0.88
Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines. PLoS One (2012) 0.85
Endogenous hepatic expression of the hepatitis B virus X-associated protein 2 is adequate for maximal association with aryl hydrocarbon receptor-90-kDa heat shock protein complexes. Mol Pharmacol (2006) 0.84
Characterization of the antiallergic drugs 3-[2-(2-phenylethyl) benzoimidazole-4-yl]-3-hydroxypropanoic acid and ethyl 3-hydroxy-3-[2-(2-phenylethyl)benzoimidazol-4-yl]propanoate as full aryl hydrocarbon receptor agonists. Chem Res Toxicol (2008) 0.84
Transgenic Humanized AHR Mouse Reveals Differences between Human and Mouse AHR Ligand Selectivity. Mol Cell Pharmacol (2009) 0.84
Regulation of peroxisome proliferator-activated receptor alpha by protein kinase C. Biochemistry (2005) 0.84
The Ah receptor regulates growth factor expression in head and neck squamous cell carcinoma cell lines. Mol Carcinog (2013) 0.83
Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Pharmacol Exp Ther (2013) 0.81
In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract. Br J Pharmacol (2014) 0.81
Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure. J Pharmacol Exp Ther (2012) 0.81
The Aryl-hydrocarbon receptor does not require the p23 co-chaperone for ligand binding and target gene expression in vivo. Toxicol Lett (2009) 0.80
Protein function analysis: rapid, cell-based siRNA-mediated ablation of endogenous expression with simultaneous ectopic replacement. Cytotechnology (2010) 0.80
Family members CREB and CREM control thyrotropin-releasing hormone (TRH) expression in the hypothalamus. Mol Cell Endocrinol (2012) 0.79
Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway. J Clin Invest (2014) 0.78
Characterization of the phosphorylation status of the hepatitis B virus X-associated protein 2. Arch Biochem Biophys (2002) 0.76
Use of [125I]4'-iodoflavone as a tool to characterize ligand-dependent differences in Ah receptor behavior. J Biochem Mol Toxicol (2002) 0.75