Published in Protein Sci on December 01, 2002
The unfolding kinetics of ubiquitin captured with single-molecule force-clamp techniques. Proc Natl Acad Sci U S A (2004) 3.18
Anisotropic deformation response of single protein molecules. Proc Natl Acad Sci U S A (2006) 2.28
Mechanically unfolding the small, topologically simple protein L. Biophys J (2005) 1.57
Single-molecule force spectroscopy reveals a mechanically stable protein fold and the rational tuning of its mechanical stability. Proc Natl Acad Sci U S A (2007) 1.22
The effects of macromolecular crowding on the mechanical stability of protein molecules. Protein Sci (2008) 1.12
Mechanical resistance of proteins explained using simple molecular models. Biophys J (2005) 1.10
Viscoelastic study of the mechanical unfolding of a protein by AFM. Biophys J (2006) 1.01
Identification of a mechanical rheostat in the hydrophobic core of protein L. J Mol Biol (2009) 0.97
Analyzing forced unfolding of protein tandems by ordered variates, 1: Independent unfolding times. Biophys J (2007) 0.91
Order statistics theory of unfolding of multimeric proteins. Biophys J (2010) 0.88
The effect of temperature on mechanical resistance of the native and intermediate states of I27. Biophys J (2008) 0.86
Dynamics of the coiled-coil unfolding transition of myosin rod probed by dissipation force spectrum. Biophys J (2010) 0.84
Stable single α-helices are constant force springs in proteins. J Biol Chem (2014) 0.84
Altered mechanical properties of titin immunoglobulin domain 27 in the presence of calcium. Eur Biophys J (2012) 0.84
Analyzing forced unfolding of protein tandems by ordered variates, 2: dependent unfolding times. Biophys J (2007) 0.83
A theoretical model for the mechanical unfolding of repeat proteins. Biophys J (2009) 0.83
Unequivocal single-molecule force spectroscopy of proteins by AFM using pFS vectors. Biophys J (2012) 0.81
Monte Carlo simulation of mechanical unfolding of proteins based on a simple two-state model. Int J Biol Macromol (2009) 0.80
Effects of ligand binding on the mechanical properties of ankyrin repeat protein gankyrin. PLoS Comput Biol (2013) 0.79
Mechanical properties of β-catenin revealed by single-molecule experiments. Biophys J (2012) 0.78
Nonkinetic modeling of the mechanical unfolding of multimodular proteins: theory and experiments. Biophys J (2011) 0.77
Mechanically unfolding protein L using a laser-feedback-controlled cantilever. Biophys J (2011) 0.76
Prying open single GroES ring complexes by force reveals cooperativity across domains. Biophys J (2012) 0.75
Models for the specific adhesion of cells to cells. Science (1978) 28.03
Reversible unfolding of individual titin immunoglobulin domains by AFM. Science (1997) 19.62
Dynamic strength of molecular adhesion bonds. Biophys J (1997) 14.93
Energy landscapes of receptor-ligand bonds explored with dynamic force spectroscopy. Nature (1999) 10.45
Folding-unfolding transitions in single titin molecules characterized with laser tweezers. Science (1997) 10.17
Mechanical and chemical unfolding of a single protein: a comparison. Proc Natl Acad Sci U S A (1999) 7.74
Elasticity and unfolding of single molecules of the giant muscle protein titin. Nature (1997) 7.61
Titins: giant proteins in charge of muscle ultrastructure and elasticity. Science (1995) 6.67
Single molecule force spectroscopy of spectrin repeats: low unfolding forces in helix bundles. J Mol Biol (1999) 4.04
Strength of a weak bond connecting flexible polymer chains. Biophys J (1999) 3.88
Reverse engineering of the giant muscle protein titin. Nature (2002) 3.54
Force-mediated kinetics of single P-selectin/ligand complexes observed by atomic force microscopy. Proc Natl Acad Sci U S A (1998) 3.21
Atomic force microscopy reveals the mechanical design of a modular protein. Proc Natl Acad Sci U S A (2000) 3.04
Can non-mechanical proteins withstand force? Stretching barnase by atomic force microscopy and molecular dynamics simulation. Biophys J (2001) 2.25
Solid-state synthesis and mechanical unfolding of polymers of T4 lysozyme. Proc Natl Acad Sci U S A (2000) 2.25
Multiple conformations of PEVK proteins detected by single-molecule techniques. Proc Natl Acad Sci U S A (2001) 2.22
Towards a molecular understanding of the elasticity of titin. J Mol Biol (1996) 2.12
Mechanical unfolding of a titin Ig domain: structure of unfolding intermediate revealed by combining AFM, molecular dynamics simulations, NMR and protein engineering. J Mol Biol (2002) 2.00
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A simple method for probing the mechanical unfolding pathway of proteins in detail. Proc Natl Acad Sci U S A (2002) 1.39
The effect of core destabilization on the mechanical resistance of I27. Biophys J (2002) 1.36
Mechanical unfolding of alpha2-macroglobulin molecules with atomic force microscope. FEBS Lett (1996) 1.23
Nucleation of protein fibrillation by nanoparticles. Proc Natl Acad Sci U S A (2007) 3.23
Pulling geometry defines the mechanical resistance of a beta-sheet protein. Nat Struct Biol (2003) 3.21
Im7 folding mechanism: misfolding on a path to the native state. Nat Struct Biol (2002) 3.15
Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly. Proc Natl Acad Sci U S A (2008) 2.90
Amyloid formation under physiological conditions proceeds via a native-like folding intermediate. Nat Struct Mol Biol (2006) 2.82
Structural properties of an amyloid precursor of beta(2)-microglobulin. Nat Struct Biol (2002) 2.21
Optimizing protein stability in vivo. Mol Cell (2009) 2.15
Fibril fragmentation enhances amyloid cytotoxicity. J Biol Chem (2009) 2.13
Competing pathways determine fibril morphology in the self-assembly of beta2-microglobulin into amyloid. J Mol Biol (2005) 2.10
Folding versus aggregation: polypeptide conformations on competing pathways. Arch Biochem Biophys (2007) 1.97
Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins. Protein Sci (2005) 1.91
Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism. Mol Cell (2006) 1.81
A diversity of assembly mechanisms of a generic amyloid fold. Mol Cell (2011) 1.80
The Yin and Yang of protein folding. FEBS J (2005) 1.68
Carbohydrate-binding modules promote the enzymatic deconstruction of intact plant cell walls by targeting and proximity effects. Proc Natl Acad Sci U S A (2010) 1.68
Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties. Proc Natl Acad Sci U S A (2002) 1.66
Intermediates: ubiquitous species on folding energy landscapes? Curr Opin Struct Biol (2007) 1.60
Direct observation of oligomeric species formed in the early stages of amyloid fibril formation using electrospray ionisation mass spectrometry. J Mol Biol (2006) 1.60
Mechanically unfolding the small, topologically simple protein L. Biophys J (2005) 1.57
Restricted access of proteins to mannan polysaccharides in intact plant cell walls. Plant J (2010) 1.54
Structural analysis of the rate-limiting transition states in the folding of Im7 and Im9: similarities and differences in the folding of homologous proteins. J Mol Biol (2003) 1.52
A force-activated trip switch triggers rapid dissociation of a colicin from its immunity protein. PLoS Biol (2013) 1.48
Amyloid-forming peptides from beta2-microglobulin-Insights into the mechanism of fibril formation in vitro. J Mol Biol (2003) 1.44
Accurate analysis of fluorescence decays from single molecules in photon counting experiments. Anal Chem (2003) 1.43
An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms. Nat Struct Mol Biol (2009) 1.43
Dynamics in the unfolded state of beta2-microglobulin studied by NMR. J Mol Biol (2004) 1.41
Conformational conversion during amyloid formation at atomic resolution. Mol Cell (2011) 1.39
Hierarchical assembly of beta2-microglobulin amyloid in vitro revealed by atomic force microscopy. J Mol Biol (2003) 1.39
Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fiber diffraction. J Am Chem Soc (2008) 1.38
Differential recognition of plant cell walls by microbial xylan-specific carbohydrate-binding modules. Proc Natl Acad Sci U S A (2006) 1.37
The transition state for folding of an outer membrane protein. Proc Natl Acad Sci U S A (2010) 1.37
The effect of core destabilization on the mechanical resistance of I27. Biophys J (2002) 1.36
A systematic study of the effect of physiological factors on beta2-microglobulin amyloid formation at neutral pH. Biochemistry (2006) 1.33
pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases. J Am Chem Soc (2003) 1.32
The yeast prion Ure2p retains its native alpha-helical conformation upon assembly into protein fibrils in vitro. EMBO J (2002) 1.31
Determination of an ensemble of structures representing the intermediate state of the bacterial immunity protein Im7. Proc Natl Acad Sci U S A (2005) 1.31
Magic angle spinning NMR analysis of beta2-microglobulin amyloid fibrils in two distinct morphologies. J Am Chem Soc (2010) 1.30
Elongated oligomers in beta2-microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometry. Proc Natl Acad Sci U S A (2010) 1.29
Trapping the on-pathway folding intermediate of Im7 at equilibrium. J Mol Biol (2004) 1.29
A systematic investigation into the effect of protein destabilisation on beta 2-microglobulin amyloid formation. J Mol Biol (2003) 1.28
A generic mechanism of beta2-microglobulin amyloid assembly at neutral pH involving a specific proline switch. J Mol Biol (2009) 1.26
The mechanism of folding of Im7 reveals competition between functional and kinetic evolutionary constraints. Nat Struct Mol Biol (2009) 1.26
Direct three-dimensional visualization of membrane disruption by amyloid fibrils. Proc Natl Acad Sci U S A (2012) 1.24
Fibril growth kinetics reveal a region of beta2-microglobulin important for nucleation and elongation of aggregation. J Mol Biol (2008) 1.23
Switching two-state to three-state kinetics in the helical protein Im9 via the optimisation of stabilising non-native interactions by design. J Mol Biol (2004) 1.23
Monitoring copopulated conformational states during protein folding events using electrospray ionization-ion mobility spectrometry-mass spectrometry. J Am Soc Mass Spectrom (2007) 1.22
Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils. J Mol Biol (2009) 1.21
Affinity of molecular interactions in the bacteriophage phi29 DNA packaging motor. Nucleic Acids Res (2006) 1.19
Intermolecular alignment in β2-microglobulin amyloid fibrils. J Am Chem Soc (2010) 1.18
Tuning the elastic modulus of hydrated collagen fibrils. Biophys J (2009) 1.17
NMR analysis of the conformational properties of the trapped on-pathway folding intermediate of the bacterial immunity protein Im7. J Mol Biol (2006) 1.17
Stacked sets of parallel, in-register beta-strands of beta2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labeling. J Biol Chem (2010) 1.17
Microsecond folding dynamics of the F13W G29A mutant of the B domain of staphylococcal protein A by laser-induced temperature jump. Proc Natl Acad Sci U S A (2004) 1.16
A common beta-sheet architecture underlies in vitro and in vivo beta2-microglobulin amyloid fibrils. J Biol Chem (2008) 1.14
Unraveling the molecular basis of subunit specificity in P pilus assembly by mass spectrometry. Proc Natl Acad Sci U S A (2008) 1.14
The N-terminal helix is a post-assembly clamp in the bacterial outer membrane protein PagP. J Mol Biol (2007) 1.13
Glimpses of the molecular mechanisms of beta2-microglobulin fibril formation in vitro: aggregation on a complex energy landscape. FEBS Lett (2009) 1.13
Urea-induced unfolding of the immunity protein Im9 monitored by spFRET. Biophys J (2006) 1.11
Mechanical resistance of proteins explained using simple molecular models. Biophys J (2005) 1.10
Viscoelastic measurements of single molecules on a millisecond time scale by magnetically driven oscillation of an atomic force microscope cantilever. Langmuir (2005) 1.10
The oligomeric state and arrangement of the active bacterial translocon. J Biol Chem (2010) 1.09
Understanding the complex mechanisms of β2-microglobulin amyloid assembly. FEBS J (2011) 1.09
Investigation into the role of macrophages in the formation and degradation of beta2-microglobulin amyloid fibrils. J Biol Chem (2007) 1.09
Visualization of detergent solubilization of membranes: implications for the isolation of rafts. Biophys J (2007) 1.09
Unravelling the design principles for single protein mechanical strength. Curr Opin Struct Biol (2010) 1.09
Fibril fragmentation in amyloid assembly and cytotoxicity: when size matters. Prion (2010) 1.06
Ion mobility spectrometry-mass spectrometry defines the oligomeric intermediates in amylin amyloid formation and the mode of action of inhibitors. J Am Chem Soc (2013) 1.06
Equilibrium hydrogen exchange reveals extensive hydrogen bonded secondary structure in the on-pathway intermediate of Im7. J Mol Biol (2004) 1.05
Competition between intramolecular and intermolecular interactions in an amyloid-forming protein. J Mol Biol (2009) 1.02
Mechanical unfolding revisited through a simple but realistic model. J Chem Phys (2006) 1.02
Viscoelastic study of the mechanical unfolding of a protein by AFM. Biophys J (2006) 1.01
Ligand binding to distinct states diverts aggregation of an amyloid-forming protein. Nat Chem Biol (2011) 1.01
N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer. Protein Sci (2012) 1.01