Published in Proc Natl Acad Sci U S A on June 25, 2008
Fibril fragmentation enhances amyloid cytotoxicity. J Biol Chem (2009) 2.13
Amyloid β-protein aggregation produces highly reproducible kinetic data and occurs by a two-phase process. ACS Chem Neurosci (2009) 1.75
The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity. Biochemistry (2010) 1.63
Critical nucleus size for disease-related polyglutamine aggregation is repeat-length dependent. Nat Struct Mol Biol (2011) 1.60
Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments. J Chem Phys (2011) 1.52
Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity. Proc Natl Acad Sci U S A (2010) 1.42
Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant. Proc Natl Acad Sci U S A (2011) 1.38
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation. Proc Natl Acad Sci U S A (2014) 1.31
Magic angle spinning NMR analysis of beta2-microglobulin amyloid fibrils in two distinct morphologies. J Am Chem Soc (2010) 1.30
Elongated oligomers in beta2-microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometry. Proc Natl Acad Sci U S A (2010) 1.29
Direct three-dimensional visualization of membrane disruption by amyloid fibrils. Proc Natl Acad Sci U S A (2012) 1.24
Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations. J Chem Phys (2011) 1.23
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation. Nat Chem Biol (2015) 1.22
Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils. J Mol Biol (2009) 1.21
Pathway complexity in supramolecular polymerization. Nature (2012) 1.21
Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet. Proc Natl Acad Sci U S A (2013) 1.20
Replica exchange simulations of the thermodynamics of Abeta fibril growth. Biophys J (2009) 1.18
Intermolecular alignment in β2-microglobulin amyloid fibrils. J Am Chem Soc (2010) 1.18
Stacked sets of parallel, in-register beta-strands of beta2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labeling. J Biol Chem (2010) 1.17
Dynamics of locking of peptides onto growing amyloid fibrils. Proc Natl Acad Sci U S A (2009) 1.15
Effect of dehydration on the aggregation kinetics of two amyloid peptides. J Phys Chem B (2009) 1.14
Dual effect of amino modified polystyrene nanoparticles on amyloid β protein fibrillation. ACS Chem Neurosci (2010) 1.14
Glimpses of the molecular mechanisms of beta2-microglobulin fibril formation in vitro: aggregation on a complex energy landscape. FEBS Lett (2009) 1.13
Assessing the contribution of heterogeneous distributions of oligomers to aggregation mechanisms of polyglutamine peptides. Biophys Chem (2011) 1.13
An efficient kinetic model for assemblies of amyloid fibrils and its application to polyglutamine aggregation. PLoS One (2012) 1.12
Differences in prion strain conformations result from non-native interactions in a nucleus. Nat Chem Biol (2010) 1.08
Fibril fragmentation in amyloid assembly and cytotoxicity: when size matters. Prion (2010) 1.06
Observation of spatial propagation of amyloid assembly from single nuclei. Proc Natl Acad Sci U S A (2011) 1.04
Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17. Proc Natl Acad Sci U S A (2010) 1.03
Intrinsic fibrillation of fast-acting insulin analogs. J Diabetes Sci Technol (2012) 1.03
Direct observation of heterogeneous amyloid fibril growth kinetics via two-color super-resolution microscopy. Nano Lett (2013) 1.02
Model discrimination and mechanistic interpretation of kinetic data in protein aggregation studies. Biophys J (2009) 1.02
Competition between intramolecular and intermolecular interactions in an amyloid-forming protein. J Mol Biol (2009) 1.02
Ligand binding to distinct states diverts aggregation of an amyloid-forming protein. Nat Chem Biol (2011) 1.01
Crowded cell-like environment accelerates the nucleation step of amyloidogenic protein misfolding. J Biol Chem (2009) 1.01
Sensitivity of amyloid formation by human islet amyloid polypeptide to mutations at residue 20. J Mol Biol (2011) 1.00
Fibrillation precursor of superoxide dismutase 1 revealed by gradual tuning of the protein-folding equilibrium. Proc Natl Acad Sci U S A (2012) 0.98
Amyloid fibril length distribution quantified by atomic force microscopy single-particle image analysis. Protein Eng Des Sel (2009) 0.96
A label-free, quantitative assay of amyloid fibril growth based on intrinsic fluorescence. Chembiochem (2013) 0.95
The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro. Cell Stress Chaperones (2012) 0.95
Self-assembly of functional, amphipathic amyloid monolayers by the fungal hydrophobin EAS. Proc Natl Acad Sci U S A (2012) 0.94
Advances in ion mobility spectrometry-mass spectrometry reveal key insights into amyloid assembly. Biochim Biophys Acta (2012) 0.94
Bacterial curli protein promotes the conversion of PAP248-286 into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences. PeerJ (2013) 0.93
Visualization of transient protein-protein interactions that promote or inhibit amyloid assembly. Mol Cell (2014) 0.93
An imaging and systems modeling approach to fibril breakage enables prediction of amyloid behavior. Biophys J (2013) 0.92
Quaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics. PLoS Pathog (2013) 0.90
Nonamyloid aggregates arising from mature copper/zinc superoxide dismutases resemble those observed in amyotrophic lateral sclerosis. J Biol Chem (2010) 0.89
Structure and dynamics of oligomeric intermediates in β2-microglobulin self-assembly. Biophys J (2011) 0.88
The role of conformational flexibility in β2-microglobulin amyloid fibril formation at neutral pH. Rapid Commun Mass Spectrom (2012) 0.88
Residue-specific fluorescent probes of α-synuclein: detection of early events at the N- and C-termini during fibril assembly. Biochemistry (2011) 0.88
A generic crystallization-like model that describes the kinetics of amyloid fibril formation. J Biol Chem (2012) 0.88
Arresting amyloid with coulomb's law: acetylation of ALS-linked SOD1 by aspirin impedes aggregation. Biophys J (2015) 0.88
Simultaneous measurement of amyloid fibril formation by dynamic light scattering and fluorescence reveals complex aggregation kinetics. PLoS One (2013) 0.87
Mechanistic and environmental control of the prevalence and lifetime of amyloid oligomers. Nat Commun (2013) 0.86
Amyloid-like fibril elongation follows michaelis-menten kinetics. PLoS One (2013) 0.85
Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway. J Biol Chem (2012) 0.85
Relationship between prion propensity and the rates of individual molecular steps of fibril assembly. J Biol Chem (2011) 0.85
The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic. Biochemistry (2009) 0.85
Assembly pathway of a designed alpha-helical protein fiber. Biophys J (2010) 0.84
Controlling the aggregation and rate of release in order to improve insulin formulation: molecular dynamics study of full-length insulin amyloid oligomer models. J Mol Model (2011) 0.84
SOD1 aggregation in ALS mice shows simplistic test tube behavior. Proc Natl Acad Sci U S A (2015) 0.83
Chemical and biophysical insights into the propagation of prion strains. HFSP J (2008) 0.83
Mapping the conformational dynamics and pathways of spontaneous steric zipper Peptide oligomerization. PLoS One (2011) 0.82
Rationally designed turn promoting mutation in the amyloid-β peptide sequence stabilizes oligomers in solution. PLoS One (2011) 0.82
Dissecting the kinetic process of amyloid fiber formation through asymptotic analysis. J Phys Chem B (2011) 0.82
Fibrillization propensity for short designed hexapeptides predicted by computer simulation. J Mol Biol (2011) 0.82
Insights into the disparate action of osmolytes and macromolecular crowders on amyloid formation. Prion (2012) 0.81
Effects of macromolecular crowding on amyloid beta (16-22) aggregation using coarse-grained simulations. J Phys Chem B (2014) 0.81
Binding, conformational transition and dimerization of amyloid-β peptide on GM1-containing ternary membrane: insights from molecular dynamics simulation. PLoS One (2013) 0.81
Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis. Protein Sci (2013) 0.81
Evolutionary, physicochemical, and functional mechanisms of protein homooligomerization. Prog Mol Biol Transl Sci (2013) 0.81
A mechanistic model for amorphous protein aggregation of immunoglobulin-like domains. J Am Chem Soc (2013) 0.81
Measurement of amyloid formation by turbidity assay-seeing through the cloud. Biophys Rev (2016) 0.81
β2-Microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pH. PLoS One (2014) 0.81
Protein Polymerization into Fibrils from the Viewpoint of Nucleation Theory. Biophys J (2015) 0.81
Proper calibration of ultrasonic power enabled the quantitative analysis of the ultrasonication-induced amyloid formation process. Protein Sci (2011) 0.80
Mechanisms of amyloid formation revealed by solution NMR. Prog Nucl Magn Reson Spectrosc (2015) 0.80
Microscopic factors that control beta-sheet registry in amyloid fibrils formed by fragment 11-25 of amyloid beta peptide: insights from computer simulations. J Mol Biol (2009) 0.80
Nucleobindin 1 caps human islet amyloid polypeptide protofibrils to prevent amyloid fibril formation. J Mol Biol (2012) 0.79
Kinetics of amyloid aggregation: a study of the GNNQQNY prion sequence. PLoS Comput Biol (2012) 0.79
A brief overview of amyloids and Alzheimer's disease. Protein Sci (2014) 0.79
Simple moment-closure model for the self-assembly of breakable amyloid filaments. Biophys J (2013) 0.79
Computational modeling of the relationship between amyloid and disease. Biophys Rev (2012) 0.79
Structural Conversion of Aβ17-42 Peptides from Disordered Oligomers to U-Shape Protofilaments via Multiple Kinetic Pathways. PLoS Comput Biol (2015) 0.79
Competition between primary nucleation and autocatalysis in amyloid fibril self-assembly. Biophys J (2015) 0.78
Kinetic profile of amyloid formation in the presence of an aromatic inhibitor by nuclear magnetic resonance. ACS Med Chem Lett (2012) 0.78
Unlocked concanavalin A forms amyloid-like fibrils from coagulation of long-lived "crinkled" intermediates. PLoS One (2013) 0.78
An equilibrium model for linear and closed-loop amyloid fibril formation. J Mol Biol (2012) 0.78
Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation. R Soc Open Sci (2017) 0.78
Differences in protein concentration dependence for nucleation and elongation in light chain amyloid formation. Biochemistry (2017) 0.77
Human beta-synuclein rendered fibrillogenic by designed mutations. J Biol Chem (2010) 0.77
Tracking the heterogeneous distribution of amyloid spherulites and their population balance with free fibrils. Eur Phys J E Soft Matter (2010) 0.77
Design of multi-phase dynamic chemical networks. Nat Chem (2017) 0.77
Cellular mechanism of fibril formation from serum amyloid A1 protein. EMBO Rep (2017) 0.76
Analysis of Toxic Amyloid Fibril Interactions at Natively Derived Membranes by Ellipsometry. PLoS One (2015) 0.76
Comparison of the aggregation of homologous β2-microglobulin variants reveals protein solubility as a key determinant of amyloid formation. J Mol Biol (2016) 0.76
Insights into Kinetics of Agitation-Induced Aggregation of Hen Lysozyme under Heat and Acidic Conditions from Various Spectroscopic Methods. PLoS One (2015) 0.76
Monomeric Aβ(1-40) and Aβ(1-42) Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil. Biochemistry (2016) 0.76
Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin. Amyloid (2016) 0.76
Distinguishing closely related amyloid precursors using an RNA aptamer. J Biol Chem (2014) 0.76
Protein misfolding, functional amyloid, and human disease. Annu Rev Biochem (2006) 22.87
A specific amyloid-beta protein assembly in the brain impairs memory. Nature (2006) 16.19
Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils. Biochemistry (2006) 6.54
The physical basis of how prion conformations determine strain phenotypes. Nature (2006) 4.77
Analysis of protein aggregation kinetics. Methods Enzymol (1999) 3.97
Mechanism of prion propagation: amyloid growth occurs by monomer addition. PLoS Biol (2004) 3.75
Kinetics of sickle hemoglobin polymerization. II. A double nucleation mechanism. J Mol Biol (1985) 3.74
Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation. Proc Natl Acad Sci U S A (2002) 3.56
Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism. Biochemistry (2001) 3.47
Kinetic theory of fibrillogenesis of amyloid beta-protein. Proc Natl Acad Sci U S A (1997) 3.40
Characterization of the nanoscale properties of individual amyloid fibrils. Proc Natl Acad Sci U S A (2006) 2.46
Islet amyloid: phase partitioning and secondary nucleation are central to the mechanism of fibrillogenesis. Biochemistry (2002) 2.44
Competing pathways determine fibril morphology in the self-assembly of beta2-microglobulin into amyloid. J Mol Biol (2005) 2.10
Folding versus aggregation: polypeptide conformations on competing pathways. Arch Biochem Biophys (2007) 1.97
Solid-state NMR study of amyloid nanocrystals and fibrils formed by the peptide GNNQQNY from yeast prion protein Sup35p. J Am Chem Soc (2007) 1.96
The kinetics of nucleated polymerizations at high concentrations: amyloid fibril formation near and above the "supercritical concentration". Biophys J (2006) 1.82
Fiber-dependent amyloid formation as catalysis of an existing reaction pathway. Proc Natl Acad Sci U S A (2007) 1.75
The aggregation kinetics of Alzheimer's beta-amyloid peptide is controlled by stochastic nucleation. Protein Sci (2005) 1.74
Kinetics of nucleation-controlled polymerization. A perturbation treatment for use with a secondary pathway. Biophys J (1984) 1.69
Direct observation of oligomeric species formed in the early stages of amyloid fibril formation using electrospray ionisation mass spectrometry. J Mol Biol (2006) 1.60
Kinetics of self-assembling microtubules: an "inverse problem" in biochemistry. Proc Natl Acad Sci U S A (1996) 1.59
Interpreting the aggregation kinetics of amyloid peptides. J Mol Biol (2006) 1.58
Kinetics of sickle hemoglobin polymerization. III. Nucleation rates determined from stochastic fluctuations in polymerization progress curves. J Mol Biol (1986) 1.55
Beta(2)-microglobulin and its deamidated variant, N17D form amyloid fibrils with a range of morphologies in vitro. J Mol Biol (2001) 1.51
Dynamics in the unfolded state of beta2-microglobulin studied by NMR. J Mol Biol (2004) 1.41
Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Abeta fibril formation pathway. Protein Sci (2007) 1.41
Cooperative polymerization reactions. Analytical approximations, numerical examples, and experimental strategy. Biophys J (1986) 1.38
Mechanisms of ataxin-3 misfolding and fibril formation: kinetic analysis of a disease-associated polyglutamine protein. J Mol Biol (2007) 1.29
Aggregation of a slow-folding mutant of a beta-clam protein proceeds through a monomeric nucleus. Biochemistry (2005) 1.29
Nucleation: the connections between equilibrium and kinetic behavior. Methods Enzymol (2006) 1.17
Influence of the N-terminal domain on the aggregation properties of the prion protein. Protein Sci (2005) 1.16
Nucleation of protein fibrillation by nanoparticles. Proc Natl Acad Sci U S A (2007) 3.23
Pulling geometry defines the mechanical resistance of a beta-sheet protein. Nat Struct Biol (2003) 3.21
Im7 folding mechanism: misfolding on a path to the native state. Nat Struct Biol (2002) 3.15
Amyloid formation under physiological conditions proceeds via a native-like folding intermediate. Nat Struct Mol Biol (2006) 2.82
Structural properties of an amyloid precursor of beta(2)-microglobulin. Nat Struct Biol (2002) 2.21
Optimizing protein stability in vivo. Mol Cell (2009) 2.15
Fibril fragmentation enhances amyloid cytotoxicity. J Biol Chem (2009) 2.13
Competing pathways determine fibril morphology in the self-assembly of beta2-microglobulin into amyloid. J Mol Biol (2005) 2.10
Folding versus aggregation: polypeptide conformations on competing pathways. Arch Biochem Biophys (2007) 1.97
Perspectives on NMR in drug discovery: a technique comes of age. Nat Rev Drug Discov (2008) 1.95
Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins. Protein Sci (2005) 1.91
Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism. Mol Cell (2006) 1.81
A diversity of assembly mechanisms of a generic amyloid fold. Mol Cell (2011) 1.80
The Yin and Yang of protein folding. FEBS J (2005) 1.68
Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties. Proc Natl Acad Sci U S A (2002) 1.66
Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid. Proc Natl Acad Sci U S A (2012) 1.62
Intermediates: ubiquitous species on folding energy landscapes? Curr Opin Struct Biol (2007) 1.60
Direct observation of oligomeric species formed in the early stages of amyloid fibril formation using electrospray ionisation mass spectrometry. J Mol Biol (2006) 1.60
Mechanically unfolding the small, topologically simple protein L. Biophys J (2005) 1.57
Structural analysis of the rate-limiting transition states in the folding of Im7 and Im9: similarities and differences in the folding of homologous proteins. J Mol Biol (2003) 1.52
A force-activated trip switch triggers rapid dissociation of a colicin from its immunity protein. PLoS Biol (2013) 1.48
Amyloid-forming peptides from beta2-microglobulin-Insights into the mechanism of fibril formation in vitro. J Mol Biol (2003) 1.44
An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms. Nat Struct Mol Biol (2009) 1.43
Dynamics in the unfolded state of beta2-microglobulin studied by NMR. J Mol Biol (2004) 1.41
Mechanically unfolding proteins: the effect of unfolding history and the supramolecular scaffold. Protein Sci (2002) 1.39
Conformational conversion during amyloid formation at atomic resolution. Mol Cell (2011) 1.39
Hierarchical assembly of beta2-microglobulin amyloid in vitro revealed by atomic force microscopy. J Mol Biol (2003) 1.39
Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fiber diffraction. J Am Chem Soc (2008) 1.38
The transition state for folding of an outer membrane protein. Proc Natl Acad Sci U S A (2010) 1.37
The effect of core destabilization on the mechanical resistance of I27. Biophys J (2002) 1.36
A systematic study of the effect of physiological factors on beta2-microglobulin amyloid formation at neutral pH. Biochemistry (2006) 1.33
pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases. J Am Chem Soc (2003) 1.32
The yeast prion Ure2p retains its native alpha-helical conformation upon assembly into protein fibrils in vitro. EMBO J (2002) 1.31
Determination of an ensemble of structures representing the intermediate state of the bacterial immunity protein Im7. Proc Natl Acad Sci U S A (2005) 1.31
Magic angle spinning NMR analysis of beta2-microglobulin amyloid fibrils in two distinct morphologies. J Am Chem Soc (2010) 1.30
Elongated oligomers in beta2-microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometry. Proc Natl Acad Sci U S A (2010) 1.29
Trapping the on-pathway folding intermediate of Im7 at equilibrium. J Mol Biol (2004) 1.29
A systematic investigation into the effect of protein destabilisation on beta 2-microglobulin amyloid formation. J Mol Biol (2003) 1.28
A generic mechanism of beta2-microglobulin amyloid assembly at neutral pH involving a specific proline switch. J Mol Biol (2009) 1.26
The mechanism of folding of Im7 reveals competition between functional and kinetic evolutionary constraints. Nat Struct Mol Biol (2009) 1.26
Van der Waals interactions dominate ligand-protein association in a protein binding site occluded from solvent water. J Am Chem Soc (2005) 1.24
Direct three-dimensional visualization of membrane disruption by amyloid fibrils. Proc Natl Acad Sci U S A (2012) 1.24
Fibril growth kinetics reveal a region of beta2-microglobulin important for nucleation and elongation of aggregation. J Mol Biol (2008) 1.23
Switching two-state to three-state kinetics in the helical protein Im9 via the optimisation of stabilising non-native interactions by design. J Mol Biol (2004) 1.23
Monitoring copopulated conformational states during protein folding events using electrospray ionization-ion mobility spectrometry-mass spectrometry. J Am Soc Mass Spectrom (2007) 1.22
Poxvirus K7 protein adopts a Bcl-2 fold: biochemical mapping of its interactions with human DEAD box RNA helicase DDX3. J Mol Biol (2008) 1.22
Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils. J Mol Biol (2009) 1.21
Strong solute-solute dispersive interactions in a protein-ligand complex. J Am Chem Soc (2005) 1.19
Intermolecular alignment in β2-microglobulin amyloid fibrils. J Am Chem Soc (2010) 1.18
Tuning the elastic modulus of hydrated collagen fibrils. Biophys J (2009) 1.17
NMR analysis of the conformational properties of the trapped on-pathway folding intermediate of the bacterial immunity protein Im7. J Mol Biol (2006) 1.17
Stacked sets of parallel, in-register beta-strands of beta2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labeling. J Biol Chem (2010) 1.17
Microsecond folding dynamics of the F13W G29A mutant of the B domain of staphylococcal protein A by laser-induced temperature jump. Proc Natl Acad Sci U S A (2004) 1.16
A common beta-sheet architecture underlies in vitro and in vivo beta2-microglobulin amyloid fibrils. J Biol Chem (2008) 1.14
Unraveling the molecular basis of subunit specificity in P pilus assembly by mass spectrometry. Proc Natl Acad Sci U S A (2008) 1.14
The N-terminal helix is a post-assembly clamp in the bacterial outer membrane protein PagP. J Mol Biol (2007) 1.13
Glimpses of the molecular mechanisms of beta2-microglobulin fibril formation in vitro: aggregation on a complex energy landscape. FEBS Lett (2009) 1.13
Thermodynamics of binding of 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the major urinary protein. J Am Chem Soc (2004) 1.13
Urea-induced unfolding of the immunity protein Im9 monitored by spFRET. Biophys J (2006) 1.11
Dissecting the cholera toxin-ganglioside GM1 interaction by isothermal titration calorimetry. J Am Chem Soc (2004) 1.10
Viscoelastic measurements of single molecules on a millisecond time scale by magnetically driven oscillation of an atomic force microscope cantilever. Langmuir (2005) 1.10
Mechanical resistance of proteins explained using simple molecular models. Biophys J (2005) 1.10
The oligomeric state and arrangement of the active bacterial translocon. J Biol Chem (2010) 1.09
Understanding the complex mechanisms of β2-microglobulin amyloid assembly. FEBS J (2011) 1.09
Investigation into the role of macrophages in the formation and degradation of beta2-microglobulin amyloid fibrils. J Biol Chem (2007) 1.09
Fibril fragmentation in amyloid assembly and cytotoxicity: when size matters. Prion (2010) 1.06
Ion mobility spectrometry-mass spectrometry defines the oligomeric intermediates in amylin amyloid formation and the mode of action of inhibitors. J Am Chem Soc (2013) 1.06
Equilibrium hydrogen exchange reveals extensive hydrogen bonded secondary structure in the on-pathway intermediate of Im7. J Mol Biol (2004) 1.05
Competition between intramolecular and intermolecular interactions in an amyloid-forming protein. J Mol Biol (2009) 1.02
Ligand binding to distinct states diverts aggregation of an amyloid-forming protein. Nat Chem Biol (2011) 1.01
Viscoelastic study of the mechanical unfolding of a protein by AFM. Biophys J (2006) 1.01
N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer. Protein Sci (2012) 1.01
Perturbing the folding energy landscape of the bacterial immunity protein Im7 by site-specific N-linked glycosylation. Proc Natl Acad Sci U S A (2010) 1.00
Separation of beta2-microglobulin conformers by high-field asymmetric waveform ion mobility spectrometry (FAIMS) coupled to electrospray ionisation mass spectrometry. Rapid Commun Mass Spectrom (2004) 0.99
Investigating the structural properties of amyloid-like fibrils formed in vitro from beta2-microglobulin using limited proteolysis and electrospray ionisation mass spectrometry. Rapid Commun Mass Spectrom (2006) 0.99
Beta edge strands in protein structure prediction and aggregation. Protein Sci (2003) 0.98
Viscoelastic properties of single polysaccharide molecules determined by analysis of thermally driven oscillations of an atomic force microscope cantilever. Langmuir (2004) 0.98
Quantifying heterogeneity and conformational dynamics from single molecule FRET of diffusing molecules: recurrence analysis of single particles (RASP). Phys Chem Chem Phys (2011) 0.98
Structural plasticity and noncovalent substrate binding in the GroEL apical domain. A study using electrospay ionization mass spectrometry and fluorescence binding studies. J Biol Chem (2002) 0.98
Global changes in local protein dynamics reduce the entropic cost of carbohydrate binding in the arabinose-binding protein. J Mol Biol (2007) 0.98
Identification of a mechanical rheostat in the hydrophobic core of protein L. J Mol Biol (2009) 0.97
Donor-strand exchange in chaperone-assisted pilus assembly revealed in atomic detail by molecular dynamics. J Mol Biol (2007) 0.97
Semisynthesis of a glycosylated Im7 analogue for protein folding studies. J Am Chem Soc (2005) 0.97
Internal friction of single polypeptide chains at high stretch. Faraday Discuss (2008) 0.97
Amyloid fibril length distribution quantified by atomic force microscopy single-particle image analysis. Protein Eng Des Sel (2009) 0.96
Co-populated conformational ensembles of beta2-microglobulin uncovered quantitatively by electrospray ionization mass spectrometry. J Biol Chem (2004) 0.96
The effect of increasing the stability of non-native interactions on the folding landscape of the bacterial immunity protein Im9. J Mol Biol (2007) 0.95
Thermodynamic description of polymorphism in Q- and N-rich peptide aggregates revealed by atomistic simulation. Biophys J (2009) 0.95
HDX-ESI-MS reveals enhanced conformational dynamics of the amyloidogenic protein beta(2)-microglobulin upon release from the MHC-1. J Am Soc Mass Spectrom (2008) 0.94
Ultraviolet resonance Raman studies reveal the environment of tryptophan and tyrosine residues in the native and partially folded states of the E colicin-binding immunity protein Im7. Biochemistry (2005) 0.93
Role of the N and C-terminal strands of beta 2-microglobulin in amyloid formation at neutral pH. J Mol Biol (2003) 0.93
The effect of protein complexation on the mechanical stability of Im9. Biophys J (2007) 0.92