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1
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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.
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Mol Cell Biol
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2005
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6.44
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2
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Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.
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J Biol Chem
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2004
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5.05
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3
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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
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J Biol Chem
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2002
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3.91
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4
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Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.
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FASEB J
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2002
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3.81
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5
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Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
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Nature
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2002
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3.78
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6
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High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.
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Blood
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2011
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3.00
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7
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Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status.
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J Pathol
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2011
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2.45
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8
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Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
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J Biol Chem
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2002
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2.29
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9
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Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
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Proc Natl Acad Sci U S A
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2006
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1.87
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10
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Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans.
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PLoS Biol
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2004
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1.72
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11
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Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.
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Cell Mol Life Sci
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2009
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1.71
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12
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Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology.
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PLoS Med
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2006
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1.66
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13
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Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.
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Mol Cell Biol
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2008
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1.62
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14
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2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
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Bioorg Med Chem Lett
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2003
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1.59
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15
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Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice.
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J Physiol
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2004
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1.53
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16
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The impact of renin-angiotensin-aldosterone system inhibitors on Type 1 and Type 2 diabetic patients with and without early diabetic nephropathy.
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Kidney Int
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2011
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1.53
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17
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Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.
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Blood
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2013
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1.48
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18
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Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.
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J Clin Invest
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2011
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1.44
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19
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Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors.
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J Biol Chem
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2011
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1.42
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20
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Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.
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Hum Mol Genet
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2010
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1.33
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21
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Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.
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Anticancer Res
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2009
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1.24
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22
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Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
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FEBS Lett
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2004
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1.23
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23
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Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation.
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FASEB J
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2011
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1.14
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24
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The use of dioxygen by HIF prolyl hydroxylase (PHD1).
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Bioorg Med Chem Lett
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2002
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1.11
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25
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Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis.
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Proc Natl Acad Sci U S A
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2002
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1.11
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26
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Regulation of growth differentiation factor 15 expression by intracellular iron.
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Blood
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2008
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1.11
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27
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Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.
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Biochem J
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2004
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1.08
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28
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Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis.
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J Biol Chem
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2010
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1.08
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29
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Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.
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J Biol Chem
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2007
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1.07
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30
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Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis.
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Cancer Res
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2010
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1.05
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31
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Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
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ACS Chem Biol
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2013
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1.04
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32
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Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
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Bioorg Med Chem Lett
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2003
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1.02
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33
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HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
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J Mol Cell Cardiol
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2006
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0.99
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34
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MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).
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Biochem J
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2009
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0.94
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35
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Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.
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J Physiol
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2013
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0.94
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36
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The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.
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FEBS Lett
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2004
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0.94
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37
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The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha.
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Adv Enzyme Regul
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2004
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0.90
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38
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Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation.
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Clin Cancer Res
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2006
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0.89
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39
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Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice.
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J Physiol
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2012
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0.82
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40
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Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.
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Adv Enzyme Regul
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2002
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0.77
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41
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Oxygen sensing.
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Haematologica
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2005
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0.75
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