Published in ACS Chem Biol on June 12, 2013
Hypoxia as a therapy for mitochondrial disease. Science (2016) 2.24
Tumour hypoxia causes DNA hypermethylation by reducing TET activity. Nature (2016) 1.67
Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature (2014) 1.01
HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond. Nat Rev Nephrol (2015) 0.92
Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of γ-butyrobetaine hydroxylase. Chem Sci (2014) 0.84
Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. Nucleic Acids Res (2014) 0.83
Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult. Pflugers Arch (2015) 0.80
Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nat Commun (2016) 0.78
Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells. J Biol Chem (2015) 0.78
Pharmacological inhibition of FTO. PLoS One (2015) 0.77
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. PLoS One (2015) 0.77
Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases. Structure (2015) 0.77
Affinity-Based Fluorescence Polarization Assay for High-Throughput Screening of Prolyl Hydroxylase 2 Inhibitors. ACS Med Chem Lett (2015) 0.77
PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat Cell Biol (2016) 0.77
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun (2016) 0.76
Proteomic analysis reveals diverse proline hydroxylation-mediated oxygen-sensing cellular pathways in cancer cells. Oncotarget (2016) 0.75
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases. J Biol Chem (2016) 0.75
A Genetically Encoded FRET Sensor for Hypoxia and Prolyl Hydroxylases. ACS Chem Biol (2016) 0.75
Normal tissue radioprotection by amifostine via Warburg-type effects. Sci Rep (2016) 0.75
Control of the heart rate of rat embryos during the organogenic period. Hypoxia (Auckl) (2016) 0.75
Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions. Chem Sci (2017) 0.75
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell (2008) 13.49
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol (2004) 9.05
Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med (2003) 8.54
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol (2005) 6.44
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell (2005) 5.47
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem (2004) 5.05
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep (2011) 4.89
HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Cancer Cell (2002) 4.82
Expanding chemical biology of 2-oxoglutarate oxygenases. Nat Chem Biol (2008) 4.52
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature (2012) 4.08
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J Biol Chem (2002) 3.91
Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors. Biochem J (2008) 3.86
Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J (2002) 3.81
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature (2002) 3.78
Efficient target-selected mutagenesis in zebrafish. Genome Res (2003) 3.61
A systematic genome-wide analysis of zebrafish protein-coding gene function. Nature (2013) 3.52
Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. J Biol Chem (2006) 3.43
Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. J Am Soc Nephrol (2002) 3.34
Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts. J Biol Chem (2009) 3.23
Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. J Inorg Biochem (2006) 3.08
Dynamic regulatory network controlling TH17 cell differentiation. Nature (2013) 3.07
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature (2007) 3.05
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer Cell (2011) 3.00
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. Blood (2011) 3.00
The HIF pathway as a therapeutic target. Drug Discov Today (2004) 2.98
Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. Cancer Res (2003) 2.93
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet (2009) 2.68
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases. Structure (2009) 2.59
Signalling hypoxia by HIF hydroxylases. Biochem Biophys Res Commun (2005) 2.50
Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status. J Pathol (2011) 2.45
Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Science (2009) 2.37
First United Kingdom Heart and Renal Protection (UK-HARP-I) study: biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease. Am J Kidney Dis (2005) 2.36
Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation. Cancer Res (2002) 2.31
Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. Genome Res (2011) 2.29
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha. J Biol Chem (2002) 2.29
Oxygenase catalyzed 5-methylcytosine hydroxylation. Chem Biol (2009) 2.28
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression. Nat Genet (2012) 2.25
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). Proc Natl Acad Sci U S A (2006) 2.17
Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases. Trends Biochem Sci (2010) 2.12
Prepatterning of developmental gene expression by modified histones before zygotic genome activation. Dev Cell (2011) 2.05
Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. Cancer Res (2003) 1.99
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands. Elife (2012) 1.99
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. Biochem J (2008) 1.95
Inhibition of 2-oxoglutarate dependent oxygenases. Chem Soc Rev (2011) 1.90
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci U S A (2006) 1.87
Elimination of Rhodnius prolixus in Central America. Parasit Vectors (2012) 1.87
Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J Biol Chem (2007) 1.84
Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar. Mol Cell Biol (2002) 1.83
Oxygen sensors and angiogenesis. Semin Cell Dev Biol (2002) 1.82
Structure and mechanism of anthocyanidin synthase from Arabidopsis thaliana. Structure (2002) 1.82
Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates. J Biol Chem (2006) 1.75
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J Med Chem (2008) 1.74
Structural studies on human 2-oxoglutarate dependent oxygenases. Curr Opin Struct Biol (2010) 1.72
Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans. PLoS Biol (2004) 1.72
Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing. Cell Mol Life Sci (2009) 1.71
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS One (2010) 1.71
Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. PLoS Med (2006) 1.66
Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia. J Appl Physiol (1985) (2013) 1.64
HLA has strongest association with IgA nephropathy in genome-wide analysis. J Am Soc Nephrol (2010) 1.64