Published in Biochemistry on December 03, 2002
ZAP-70: an essential kinase in T-cell signaling. Cold Spring Harb Perspect Biol (2010) 1.88
Tyr130 phosphorylation triggers Syk release from antigen receptor by long-distance conformational uncoupling. Proc Natl Acad Sci U S A (2008) 1.04
3D structure of Syk kinase determined by single-particle electron microscopy. Biochim Biophys Acta (2007) 1.01
Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker. Mol Cell Biol (2013) 0.99
Conformational rearrangements upon Syk auto-phosphorylation. Biochim Biophys Acta (2009) 0.84
Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction. Acta Crystallogr D Biol Crystallogr (2006) 0.79
Molecular mechanism of selective recruitment of Syk kinases by the membrane antigen-receptor complex. J Biol Chem (2011) 0.79
Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. Biochem J (2015) 0.79
Insights into the allosteric regulation of Syk association with receptor ITAM, a multi-state equilibrium. Phys Chem Chem Phys (2016) 0.75
Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration. Mol Cell Proteomics (2015) 0.75
Non-degradative Ubiquitination of Protein Kinases. PLoS Comput Biol (2016) 0.75
Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen. J Biomol Screen (2016) 0.75
Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J Biol Chem (2003) 2.65
Exploitation of structural and regulatory diversity in glutamate racemases. Nature (2007) 1.28
Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3. Bioorg Med Chem Lett (2005) 1.17
Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency. J Med Chem (2007) 1.17
Affinity-based, biophysical methods to detect and analyze ligand binding to recombinant proteins: matching high information content with high throughput. J Struct Biol (2010) 1.05
Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3. Bioorg Med Chem Lett (2005) 1.03
Clavatadine A, a natural product with selective recognition and irreversible inhibition of factor XIa. J Med Chem (2008) 0.99
Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors. Bioorg Med Chem Lett (2004) 0.96
Total synthesis and structural confirmation of chlorodysinosin A. J Am Chem Soc (2006) 0.96
An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes. Curr Top Med Chem (2007) 0.96
Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily. Proc Natl Acad Sci U S A (2013) 0.93
Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas. J Med Chem (2012) 0.91
Discovery of novel potent and highly selective glycogen synthase kinase-3β (GSK3β) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines. J Med Chem (2012) 0.89
Biophysical methods in drug discovery from small molecule to pharmaceutical. Methods Mol Biol (2013) 0.88
Structure-based organic synthesis of unnatural aeruginosin hybrids as potent inhibitors of thrombin. Bioorg Med Chem Lett (2007) 0.85
FAM3B PANDER and FAM3C ILEI represent a distinct class of signaling molecules with a non-cytokine-like fold. Structure (2013) 0.83
Structure-driven HtL: design and synthesis of novel aminoindazole inhibitors of c-Jun N-terminal kinase activity. Bioorg Med Chem Lett (2005) 0.83
Characterization of a small molecule inhibitor of plasminogen activator inhibitor type 1 that accelerates the transition into the latent conformation. J Biol Chem (2012) 0.81
Identification of structural-kinetic and structural-thermodynamic relationships for thrombin inhibitors. Biochemistry (2013) 0.80
Crystal structure of the double azurin mutant Cys3Ser/Ser100Pro from Pseudomonas aeruginosa at 1.8 A resolution: its folding-unfolding energy and unfolding kinetics. Biochim Biophys Acta (2002) 0.77
Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure. Bioorg Med Chem Lett (2005) 0.77
From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs. Bioorg Med Chem Lett (2009) 0.77
Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors. Bioorg Med Chem Lett (2012) 0.76
Drug discovery at the single molecule level: inhibition-in-solution assay of membrane-reconstituted β-secretase using single-molecule imaging. Anal Chem (2015) 0.76
Compounds binding to the S2-S3 pockets of thrombin. J Med Chem (2009) 0.76
Protein preparation, crystallization and preliminary X-ray analysis of the C-terminal domain of human RSK1 serine/threonine protein kinase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.75
Design, synthesis and biological evaluation of thrombin inhibitors based on a pyridine scaffold. Org Biomol Chem (2007) 0.75
Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV. Bioorg Med Chem Lett (2012) 0.75