Published in Diabetes on December 01, 2002
Effectiveness of Dapagliflozin for Weight Loss | NCT03968224
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science (2008) 5.28
Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer (2009) 5.02
Adipokines and insulin resistance. Mol Med (2008) 2.97
Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice. J Clin Invest (2009) 2.39
Obesity, inflammation, and liver cancer. J Hepatol (2011) 2.09
Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle. Diabetes (2009) 2.00
Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing (2005) 1.99
Human IL6 enhances leptin action in mice. Diabetologia (2009) 1.98
AMPK inhibition in health and disease. Crit Rev Biochem Mol Biol (2010) 1.93
The major inflammatory mediator interleukin-6 and obesity. Inflamm Res (2009) 1.67
The role of interleukins in insulin resistance and type 2 diabetes mellitus. Nat Rev Endocrinol (2009) 1.66
Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol (2007) 1.61
gp130 receptor ligands as potential therapeutic targets for obesity. J Clin Invest (2007) 1.46
AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease. Clin Sci (Lond) (2009) 1.43
Role of interleukin-6 levels in cardiovascular autonomic dysfunction in type 2 diabetic patients. Eur J Nucl Med Mol Imaging (2008) 1.39
De novo generation of white adipocytes from the myeloid lineage via mesenchymal intermediates is age, adipose depot, and gender specific. Proc Natl Acad Sci U S A (2010) 1.35
Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle. Diabetes (2008) 1.34
Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart. Diabetes (2009) 1.23
The portal theory supported by venous drainage-selective fat transplantation. Diabetes (2010) 1.23
Adipo-myokines: two sides of the same coin--mediators of inflammation and mediators of exercise. Mediators Inflamm (2013) 1.19
Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training. Compr Physiol (2013) 1.17
The ubiquitous interleukin-6: a time for reappraisal. Cardiovasc Diabetol (2010) 1.16
Insulin resistance in patients with chronic kidney disease. J Biomed Biotechnol (2012) 1.15
Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans. J Clin Invest (2005) 1.14
Metabolic syndrome: the danger signal in atherosclerosis. Vasc Health Risk Manag (2006) 1.13
Exercise induced adipokine changes and the metabolic syndrome. J Diabetes Res (2014) 1.12
Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling. Biochim Biophys Acta (2009) 1.09
Diabetes and altered glucose metabolism with aging. Endocrinol Metab Clin North Am (2013) 1.09
Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol (2014) 1.07
Differential white blood cell count and type 2 diabetes: systematic review and meta-analysis of cross-sectional and prospective studies. PLoS One (2010) 1.06
The role of chronic inflammation in obesity-associated cancers. ISRN Oncol (2013) 1.04
Signal transducer and activator of transcription 3 (STAT3) mediates amino acid inhibition of insulin signaling through serine 727 phosphorylation. J Biol Chem (2009) 1.04
Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation. J Inflamm (Lond) (2012) 1.03
Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation. Br J Pharmacol (2010) 1.01
Metabolic syndrome in rheumatic diseases: epidemiology, pathophysiology, and clinical implications. Arthritis Res Ther (2008) 1.01
IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis. PLoS One (2009) 1.01
The adipose cell lineage is not intrinsically insulin resistant in polycystic ovary syndrome. Metabolism (2007) 1.00
Temporal profiling of the transcriptional basis for the development of corticosteroid-induced insulin resistance in rat muscle. J Endocrinol (2005) 1.00
Targeting the Peroxisome Proliferator-Activated Receptor-γ to Counter the Inflammatory Milieu in Obesity. Diabetes Metab J (2013) 0.99
Identification and validation of novel contraction-regulated myokines released from primary human skeletal muscle cells. PLoS One (2013) 0.99
HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance. Nat Commun (2014) 0.97
Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes. Inflammation (2011) 0.95
Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells. Mol Cell Biol (2007) 0.95
Signaling pathways involved in LPS induced TNFalpha production in human adipocytes. J Inflamm (Lond) (2010) 0.94
Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies. Metab Syndr Relat Disord (2015) 0.94
Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns. Arch Med Sci (2015) 0.93
The gp130 receptor cytokine family: regulators of adipocyte development and function. Curr Pharm Des (2011) 0.92
Investigating Susceptibility to Diabetes Using Features of the Adipose Tissue in Response to In Utero Polycyclic Aromatic Hydrocarbons Exposure. Diabetes Metab J (2016) 0.91
Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease. Circ Res (2016) 0.91
Obesity and hepatocellular carcinoma: targeting obesity-related inflammation for chemoprevention of liver carcinogenesis. Semin Immunopathol (2012) 0.90
Role of cytokines in the pathogenesis of non-alcoholic Fatty liver disease. Indian J Clin Biochem (2011) 0.90
The IL-6 Paradox: Context Dependent Interplay of SOCS3 and AMPK. J Diabetes Metab (2013) 0.90
Analysis of inflammatory mediators in type 2 diabetes patients. Int J Endocrinol (2013) 0.90
Differential inflammatory status in rats susceptible or resistant to diet-induced obesity: effects of EPA ethyl ester treatment. Eur J Nutr (2008) 0.90
Exploring pathway interactions in insulin resistant mouse liver. BMC Syst Biol (2011) 0.89
Adipokines and hepatic insulin resistance. J Diabetes Res (2013) 0.88
Low-grade chronic inflammation in the relationship between insulin sensitivity and cardiovascular disease (RISC) population: associations with insulin resistance and cardiometabolic risk profile. Diabetes Care (2009) 0.88
Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design. Nutr J (2011) 0.88
Genetic ablation of cGMP-dependent protein kinase type I causes liver inflammation and fasting hyperglycemia. Diabetes (2011) 0.88
Obesity Is a Positive Modulator of IL-6R and IL-6 Expression in the Subcutaneous Adipose Tissue: Significance for Metabolic Inflammation. PLoS One (2015) 0.88
Insulin and glucose play a role in foam cell formation and function. Cardiovasc Diabetol (2006) 0.87
Serum soluble glycoprotein 130 concentration is inversely related to insulin sensitivity in women with polycystic ovary syndrome. Diabetes (2010) 0.86
Trans fat feeding results in higher serum alanine aminotransferase and increased insulin resistance compared with a standard murine high-fat diet. Am J Physiol Gastrointest Liver Physiol (2009) 0.86
The good, the bad, and the ugly of interleukin-6 signaling. EMBO J (2014) 0.85
Towards a mechanistic understanding of lipodystrophy and seipin functions. Biosci Rep (2014) 0.85
Association of Insulin Resistance with Serum Interleukin-6 and TNF-α Levels During Normal Pregnancy. Biomark Insights (2011) 0.85
Visceral adiposopathy: a vascular perspective. Horm Mol Biol Clin Investig (2015) 0.85
Irisin, a link among fatty liver disease, physical inactivity and insulin resistance. Int J Mol Sci (2014) 0.85
Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice. Dis Model Mech (2015) 0.84
Role of body size on cardiovascular function: can we see the meat through the fat? Hypertension (2009) 0.84
A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. Nat Commun (2015) 0.84
Novel Action of Carotenoids on Non-Alcoholic Fatty Liver Disease: Macrophage Polarization and Liver Homeostasis. Nutrients (2016) 0.84
Involvement of toll-like receptor 4 in alveolar bone loss and glucose homeostasis in experimental periodontitis. J Periodontal Res (2010) 0.83
Interleukin-6 mediates hepatic hypersecretion of apolipoprotein B. Am J Physiol Gastrointest Liver Physiol (2010) 0.83
The influence of EPA and DHA on markers of inflammation in 3T3-L1 cells at different stages of cellular maturation. Lipids Health Dis (2014) 0.83
Suppressive Effects of Insulin on Tumor Necrosis Factor-Dependent Early Osteoarthritic Changes Associated With Obesity and Type 2 Diabetes Mellitus. Arthritis Rheumatol (2016) 0.82
Paradoxical glucose-sensitizing yet proinflammatory effects of acute ASP administration in mice. Mediators Inflamm (2013) 0.82
Maternal diet, bioactive molecules, and exercising as reprogramming tools of metabolic programming. Eur J Nutr (2014) 0.81
Linking obesity with type 2 diabetes: the role of T-bet. Diabetes Metab Syndr Obes (2014) 0.81
Interleukin-6 amplifies glucagon secretion: coordinated control via the brain and pancreas. Am J Physiol Endocrinol Metab (2014) 0.81
Stimulation of incretin secreting cells. Ther Adv Endocrinol Metab (2016) 0.81
Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice. PLoS One (2015) 0.81
Antimicrobial-sensing proteins in obesity and type 2 diabetes: the buffering efficiency hypothesis. Diabetes Care (2011) 0.81
Enhancement of inflammatory protein expression and nuclear factor Κb (NF-Κb) activity by trichostatin A (TSA) in OP9 preadipocytes. PLoS One (2013) 0.80
A single bout of downhill running transiently increases HOMA-IR without altering adipokine response in healthy adult women. Eur J Appl Physiol (2013) 0.80
Activation of the GP130-STAT3 axis and its potential implications in nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol (2015) 0.79
Deletion of interleukin-6 improves pyruvate tolerance without altering hepatic insulin signaling in the leptin receptor-deficient mouse. Metabolism (2011) 0.79
CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPARγ. Am J Physiol Endocrinol Metab (2014) 0.79
Hepatic inflammation and insulin resistance in pre-diabetes - further evidence for the beneficial actions of PPAR-gamma agonists and a role for SOCS-3 modulation. Br J Pharmacol (2010) 0.79
The relationship of metabolic syndrome with disease activity and the functional status in patients with rheumatoid arthritis. J Clin Med Res (2012) 0.79
Epicardial Fat: Physiological, Pathological, and Therapeutic Implications. Cardiol Res Pract (2016) 0.79
Insulin resistance and serum levels of interleukin-17 and interleukin-18 in normal pregnancy. Immune Netw (2014) 0.78
Leptin, IL-6, and suPAR reflect distinct inflammatory changes associated with adiposity, lipodystrophy and low muscle mass in HIV-infected patients and controls. Immun Ageing (2015) 0.78
Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance. Mol Cell Biol (2010) 0.78
Perinatal overnutrition exacerbates adipose tissue inflammation caused by high-fat feeding in C57BL/6J mice. PLoS One (2015) 0.78
Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner. Cell Cycle (2015) 0.78
Yi-Qi-Zeng-Min-Tang, a Chinese medicine, ameliorates insulin resistance in type 2 diabetic rats. World J Gastroenterol (2011) 0.78
Menopause, obesity and inflammation: interactive risk factors for Alzheimer's disease. Front Aging Neurosci (2015) 0.78
MicroRNA-181b regulates endotoxin tolerance by targeting IL-6 in macrophage RAW264.7 cells. J Inflamm (Lond) (2015) 0.78
Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. J Biol Chem (2003) 2.67
Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes (2003) 2.40
Interleukin-6 depletion selectively improves hepatic insulin action in obesity. Endocrinology (2005) 1.68
The ratio of arginine to dimethylarginines is reduced and predicts outcomes in patients with severe sepsis. Crit Care Med (2011) 1.54
Hepatocytes: critical for glucose homeostasis. Int J Biochem Cell Biol (2004) 1.45
Second-trimester maternal serum placental growth factor and vascular endothelial growth factor for predicting severe, early-onset preeclampsia. Obstet Gynecol (2003) 1.40
Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies. J Autism Dev Disord (2003) 1.25
Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis. Sci Transl Med (2011) 1.12
Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling. Biochim Biophys Acta (2009) 1.09
Shear wave dispersion measures liver steatosis. Ultrasound Med Biol (2011) 1.00
Immature mice are more susceptible to the detrimental effects of high fat diet on cancellous bone in the distal femur. Bone (2013) 0.90
Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigma. Can J Physiol Pharmacol (2006) 0.89
Effects of Combined Exposure to Lead and High-Fat Diet on Bone Quality in Juvenile Male Mice. Environ Health Perspect (2015) 0.88
Expression of the leucocyte common antigen-related (LAR) tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes. Biochem J (2002) 0.86
RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance. Arthritis Rheum (2013) 0.85
High-fat diet causes bone loss in young mice by promoting osteoclastogenesis through alteration of the bone marrow environment. Calcif Tissue Int (2015) 0.84
Midtrimester fetal herpes simplex-2 diagnosis by serology, culture and quantitative polymerase chain reaction. Fetal Diagn Ther (2012) 0.82
Altered amino acid levels in sera of a mouse model for juvenile neuronal ceroid lipofuscinoses. Clin Chim Acta (2003) 0.81
Deletion of interleukin-6 improves pyruvate tolerance without altering hepatic insulin signaling in the leptin receptor-deficient mouse. Metabolism (2011) 0.79
Maternal serum alpha-fetoprotein values in type 1 and type 2 diabetic patients. Am J Obstet Gynecol (2008) 0.79
Suppressor of cytokine signaling-3 is a glucagon-inducible inhibitor of PKA activity and gluconeogenic gene expression in hepatocytes. J Biol Chem (2010) 0.77
Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes. Biochim Biophys Acta (2010) 0.77
New developments in prenatal screening for Down syndrome. Am J Clin Pathol (2003) 0.75