Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease.

PubWeight™: 0.91‹?›

🔗 View Article (PMID 27230642)

Published in Circ Res on May 27, 2016

Authors

José J Fuster1, Noriyuki Ouchi2, Noyan Gokce2, Kenneth Walsh1

Author Affiliations

1: From the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (J.J.F., N.G., K.W.); and Department of Molecular Cardiology, Nagoya University School of Medicine, Nagoya, Japan (N.O.). jjfuster@bu.edu kxwalsh@bu.edu.
2: From the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (J.J.F., N.G., K.W.); and Department of Molecular Cardiology, Nagoya University School of Medicine, Nagoya, Japan (N.O.).

Articles citing this

The role of perivascular adipose tissue in obesity-induced vascular dysfunction. Br J Pharmacol (2016) 0.82

Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function. Br J Pharmacol (2017) 0.79

Adipocyte-Specific Enhancement of Angiotensin II Type 1 Receptor-Associated Protein Ameliorates Diet-Induced Visceral Obesity and Insulin Resistance. J Am Heart Assoc (2017) 0.77

ATRAP Expression in Brown Adipose Tissue Does Not Influence the Development of Diet-Induced Metabolic Disorders in Mice. Int J Mol Sci (2017) 0.75

Diffuse Optical Spectroscopy and Imaging to Detect and Quantify Adipose Tissue Browning. Sci Rep (2017) 0.75

Effects and Mechanisms of Fruit and Vegetable Juices on Cardiovascular Diseases. Int J Mol Sci (2017) 0.75

The Role of the Growth Hormone/Insulin-Like Growth Factor System in Visceral Adiposity. Biochem Insights (2017) 0.75

Obesity, Diabetes, and Cardiovascular Diseases: A Compendium. Circ Res (2016) 0.75

Exploring the Crosstalk between Adipose Tissue and the Cardiovascular System. Korean Circ J (2017) 0.75

Humans and Mice Display Opposing Patterns of "Browning" Gene Expression in Visceral and Subcutaneous White Adipose Tissue Depots. Front Cardiovasc Med (2017) 0.75

Short-term regular aerobic exercise reduces oxidative stress produced by acute in the adipose microvasculature. Am J Physiol Heart Circ Physiol (2017) 0.75

Perivascular Adipose Tissue Harbors Atheroprotective IgM-Producing B Cells. Front Physiol (2017) 0.75

Articles cited by this

(truncated to the top 100)

Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22

Positional cloning of the mouse obese gene and its human homologue. Nature (1994) 38.85

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01

Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet (2009) 26.09

Identification and importance of brown adipose tissue in adult humans. N Engl J Med (2009) 20.57

Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 20.19

C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med (2000) 18.04

The hormone resistin links obesity to diabetes. Nature (2001) 15.49

Leptin and the regulation of body weight in mammals. Nature (1998) 14.84

Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun (1999) 14.25

Effects of the obese gene product on body weight regulation in ob/ob mice. Science (1995) 13.57

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res (2005) 11.88

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med (2009) 11.28

Elevated C-reactive protein levels in overweight and obese adults. JAMA (1999) 9.94

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature (2003) 9.79

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med (2009) 9.71

Adipokines in inflammation and metabolic disease. Nat Rev Immunol (2011) 8.92

Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature (1994) 8.85

Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest (2007) 8.71

Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation (2000) 8.17

Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med (2009) 8.15

Interleukin-6 and the acute phase response. Biochem J (1990) 7.97

Plasma adiponectin levels and risk of myocardial infarction in men. JAMA (2004) 7.46

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature (1998) 7.36

Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab (1998) 7.05

Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation (2000) 6.96

Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science (2011) 6.83

Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes (2007) 6.81

Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science (1996) 6.70

Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med (2005) 6.04

Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab (1997) 5.84

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med (2011) 5.16

Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab (2008) 5.10

Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation (2007) 5.10

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat Med (2010) 4.96

Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab (2007) 4.94

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87

Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol (2003) 4.86

Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation (2001) 4.82

Evidence for a role of developmental genes in the origin of obesity and body fat distribution. Proc Natl Acad Sci U S A (2006) 4.81

Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem (2002) 4.79

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest (1998) 4.77

Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol (2008) 4.75

Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology (2004) 4.67

Visceral adiposity and risk of type 2 diabetes: a prospective study among Japanese Americans. Diabetes Care (2000) 4.64

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63

Immunoregulatory functions of surfactant proteins. Nat Rev Immunol (2005) 4.55

Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood (2000) 4.46

Pathophysiology of human visceral obesity: an update. Physiol Rev (2013) 4.41

Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem (2003) 4.38

Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev (2009) 4.35

Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review. PLoS Med (2008) 4.34

Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes (2007) 4.28

The science of obesity: what do we really know about what makes us fat? An essay by Gary Taubes. BMJ (2013) 4.25

Trends over 5 decades in U.S. occupation-related physical activity and their associations with obesity. PLoS One (2011) 4.21

Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem (2002) 4.16

Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science (2010) 4.15

Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med (2005) 4.11

Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med (2004) 4.05

Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults. JAMA (2012) 4.04

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med (2009) 3.97

Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol (2009) 3.96

Splanchnic lipolysis in human obesity. J Clin Invest (2004) 3.94

Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat Med (2013) 3.86

Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation (2002) 3.81

Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes (2008) 3.80

Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation (2003) 3.73

A key role of leptin in the control of regulatory T cell proliferation. Immunity (2007) 3.71

Resistin, an adipokine with potent proinflammatory properties. J Immunol (2005) 3.63

Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation (2001) 3.57

Regulation of fasted blood glucose by resistin. Science (2004) 3.54

Resistin is an inflammatory marker of atherosclerosis in humans. Circulation (2005) 3.52

Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol (1996) 3.47

IL-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat Immunol (2000) 3.39

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med (2012) 3.21

Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study. Diabetologia (2005) 3.20

Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ Res (2004) 3.16

Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators. Biochem Biophys Res Commun (2003) 3.16

Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10. Arterioscler Thromb Vasc Biol (2008) 3.13

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol (2014) 3.12

Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Biochem J (2008) 3.10

Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem (2002) 3.05

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice. J Lipid Res (2008) 3.03

Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling. J Biol Chem (2004) 3.01

Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pract (2004) 2.95

Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production. Int J Obes (Lond) (2007) 2.92

Defective inflammatory response in interleukin 6-deficient mice. J Exp Med (1994) 2.92

Adiponectin and coronary heart disease: a prospective study and meta-analysis. Circulation (2006) 2.89

Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes (2002) 2.85

Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects. Arterioscler Thromb Vasc Biol (2008) 2.82

Plasma adiponectin, body mass index, and mortality in patients with chronic heart failure. Circulation (2005) 2.81

Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes (2006) 2.80

Abdominal subcutaneous adipose tissue: a protective fat depot? Diabetes Care (2009) 2.80

In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. J Clin Invest (2008) 2.78

Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity? Br J Nutr (2008) 2.73

Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem (2009) 2.69

Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci U S A (1996) 2.68

Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis. Circ Res (2007) 2.66

Adiponectin and inflammation: consensus and controversy. J Allergy Clin Immunol (2007) 2.63

Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages. Circulation (2004) 2.58