Published in J Biol Chem on November 25, 2002
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev (2005) 8.95
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Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol Cell Biol (2005) 2.31
A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax. Genes Dev (2007) 1.97
Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. PLoS One (2011) 1.86
Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria. Proc Natl Acad Sci U S A (2004) 1.85
Bax regulates primary necrosis through mitochondrial dynamics. Proc Natl Acad Sci U S A (2012) 1.80
Conformational control of Bax localization and apoptotic activity by Pro168. J Cell Biol (2004) 1.80
Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2. J Biol Chem (2006) 1.65
Bax dimerizes via a symmetric BH3:groove interface during apoptosis. Cell Death Differ (2011) 1.60
c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL. Mol Cell Biol (2003) 1.59
Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel. Mol Biol Cell (2005) 1.55
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The mitochondrial permeability transition pore and ischemia-reperfusion injury. Basic Res Cardiol (2009) 1.40
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Assembly of the mitochondrial apoptosis-induced channel, MAC. J Biol Chem (2009) 1.35
Oligomerization of the mitochondrial protein voltage-dependent anion channel is coupled to the induction of apoptosis. Mol Cell Biol (2010) 1.30
MAP-1 is a mitochondrial effector of Bax. Proc Natl Acad Sci U S A (2005) 1.30
RNA silencing of Mcl-1 enhances ABT-737-mediated apoptosis in melanoma: role for a caspase-8-dependent pathway. PLoS One (2009) 1.28
Myxoma virus M11L prevents apoptosis through constitutive interaction with Bak. J Virol (2004) 1.27
Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor. J Biol Chem (2010) 1.22
Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy. Proc Natl Acad Sci U S A (2003) 1.16
VDAC1: from structure to cancer therapy. Front Oncol (2012) 1.16
Dynamics of RASSF1A/MOAP-1 association with death receptors. Mol Cell Biol (2008) 1.10
Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak. Mol Cell Biol (2009) 1.09
c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis. EMBO J (2007) 1.08
MEK1/2 inhibitors sensitize Bcr/Abl+ human leukemia cells to the dual Abl/Src inhibitor BMS-354/825. Blood (2007) 1.05
Pseudomonas aeruginosa biofilm-associated homoserine lactone C12 rapidly activates apoptosis in airway epithelia. Cell Microbiol (2012) 1.04
Vinblastine-induced apoptosis is mediated by discrete alterations in subcellular location, oligomeric structure, and activation status of specific Bcl-2 family members. J Biol Chem (2006) 1.03
Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species. Nat Commun (2015) 1.02
Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine. Mol Cancer Ther (2008) 1.00
Cisplatin-induced apoptosis in p53-deficient renal cells via the intrinsic mitochondrial pathway. Am J Physiol Renal Physiol (2009) 0.99
Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check? J Biol Chem (2012) 0.97
Cholesterol effects on BAX pore activation. J Mol Biol (2008) 0.95
TGF-β induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer. Genes Cancer (2014) 0.93
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Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death. J Cell Biochem (2007) 0.89
2,5-hexanedione induced apoptosis in mesenchymal stem cells from rat bone marrow via mitochondria-dependent caspase-3 pathway. Ind Health (2015) 0.88
Deerpox virus encodes an inhibitor of apoptosis that regulates Bak and Bax. J Virol (2010) 0.86
Regulation of caspase-9 activity by differential binding to the apoptosome complex. Front Biosci (2007) 0.86
Identification of subtilase cytotoxin (SubAB) receptors whose signaling, in association with SubAB-induced BiP cleavage, is responsible for apoptosis in HeLa cells. Infect Immun (2010) 0.86
Mitochondrial ion channels as therapeutic targets. FEBS Lett (2010) 0.85
Gating of the mitochondrial permeability transition pore by long chain fatty acyl analogs in vivo. J Biol Chem (2009) 0.85
MAC inhibitors antagonize the pro-apoptotic effects of tBid and disassemble Bax / Bak oligomers. J Bioenerg Biomembr (2015) 0.85
Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo. Breast Cancer Res Treat (2012) 0.83
Pseudomonas aeruginosa homoserine lactone triggers apoptosis and Bak/Bax-independent release of mitochondrial cytochrome C in fibroblasts. Cell Microbiol (2014) 0.82
DAP1, a negative regulator of autophagy, controls SubAB-mediated apoptosis and autophagy. Infect Immun (2014) 0.80
Pore formation by dimeric Bak and Bax: an unusual pore? Philos Trans R Soc Lond B Biol Sci (2017) 0.80
Regulation of subtilase cytotoxin-induced cell death by an RNA-dependent protein kinase-like endoplasmic reticulum kinase-dependent proteasome pathway in HeLa cells. Infect Immun (2012) 0.79
Helicobacter pylori VacA induces apoptosis by accumulation of connexin 43 in autophagic vesicles via a Rac1/ERK-dependent pathway. Cell Death Discov (2015) 0.78
Mutual regulation of Bcl-2 proteins independent of the BH3 domain as shown by the BH3-lacking protein Bcl-x(AK). PLoS One (2012) 0.77
Apoptosis induced by Ginkgo biloba (EGb761) in melanoma cells is Mcl-1-dependent. PLoS One (2015) 0.77
Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway. PLoS One (2011) 0.76
c-FLIP protects T lymphocytes from apoptosis in the intrinsic pathway. J Immunol (2015) 0.76
News about VDAC1 in Hypoxia. Front Oncol (2016) 0.75
Aberrant Apoptotic Response of Colorectal Cancer Cells to Novel Nucleoside Analogues. PLoS One (2015) 0.75
3-MCPD 1-Palmitate Induced Tubular Cell Apoptosis In Vivo via JNK/p53 Pathways. Toxicol Sci (2016) 0.75
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell (2006) 11.79
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Autophagy suppresses tumorigenesis through elimination of p62. Cell (2009) 9.95
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Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev (2011) 7.43
Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev (2007) 7.41
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev (2007) 6.35
Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res (2011) 5.40
DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells. Genes Dev (2003) 3.67
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Ammonia derived from glutaminolysis is a diffusible regulator of autophagy. Sci Signal (2010) 3.38
Acute kidney injury: a springboard for progression in chronic kidney disease. Am J Physiol Renal Physiol (2010) 3.25
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy. Cancer Cell (2005) 3.19
Bax and Bak independently promote cytochrome C release from mitochondria. J Biol Chem (2002) 3.18
A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol (2010) 2.93
Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev (2013) 2.90
Hypoxia and defective apoptosis drive genomic instability and tumorigenesis. Genes Dev (2004) 2.69
BAX and BAK mediate p53-independent suppression of tumorigenesis. Cancer Cell (2002) 2.64
Metabolic catastrophe as a means to cancer cell death. J Cell Sci (2007) 2.58
Viral homologs of BCL-2: role of apoptosis in the regulation of virus infection. Genes Dev (2002) 2.29
The role for autophagy in cancer. J Clin Invest (2015) 2.11
Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night. Curr Opin Genet Dev (2011) 2.09
Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors. Cancer Discov (2013) 2.08
Autophagy-mediated tumor promotion. Cell (2013) 2.08
ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL. EMBO J (2007) 1.90
Tolerance of the human kidney to isolated controlled ischemia. J Am Soc Nephrol (2013) 1.82
Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nat Cell Biol (2010) 1.76
A mouse model system to genetically dissect the molecular mechanisms regulating tumorigenesis. Clin Cancer Res (2006) 1.74
Tumor suppression by autophagy through the management of metabolic stress. Autophagy (2008) 1.71
Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol Syst Biol (2013) 1.56
BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis. Genes Dev (2005) 1.55
NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition. Genes Dev (2007) 1.53
Exploiting different ways to die. Genes Dev (2004) 1.51
Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling. Oncogene (2005) 1.51
Calcium in cell injury and death. Annu Rev Pathol (2006) 1.48
Immortalized mouse epithelial cell models to study the role of apoptosis in cancer. Methods Enzymol (2008) 1.47
Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy. Prostate (2008) 1.45
Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies. Prostate (2010) 1.45
Role of autophagy in cancer prevention. Cancer Prev Res (Phila) (2011) 1.43
Signal transduction pathways in androgen-dependent and -independent prostate cancer cell proliferation. Endocr Relat Cancer (2005) 1.43
Role of autophagy in breast cancer. Autophagy (2007) 1.39
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS One (2012) 1.37
ASAP, a novel protein complex involved in RNA processing and apoptosis. Mol Cell Biol (2003) 1.34
Why sick cells produce tumors: the protective role of autophagy. Autophagy (2007) 1.34
Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer. Cancer Discov (2013) 1.32
Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression. Cancer Res (2008) 1.30
Deleted in breast cancer 1, a novel androgen receptor (AR) coactivator that promotes AR DNA-binding activity. J Biol Chem (2009) 1.30
Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation. J Biol Chem (2006) 1.30
Inhibition of autoregulated TGFbeta signaling simultaneously enhances proliferation and differentiation of kidney epithelium and promotes repair following renal ischemia. Am J Pathol (2009) 1.27
Bak and Bax function to limit adenovirus replication through apoptosis induction. J Virol (2002) 1.24
Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer. J Surg Res (2007) 1.21
Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2. Am J Pathol (2003) 1.14
Autophagic cell death unraveled: Pharmacological inhibition of apoptosis and autophagy enables necrosis. Autophagy (2008) 1.14
Mutational landscape of the essential autophagy gene BECN1 in human cancers. Mol Cancer Res (2014) 1.13
Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism. Anal Chem (2011) 1.13
Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens. Autophagy (2012) 1.12
Production of membrane proteins for NMR studies using the condensed single protein (cSPP) production system. J Struct Funct Genomics (2009) 1.12
Assessing metabolic stress and autophagy status in epithelial tumors. Methods Enzymol (2009) 1.11
Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner. Mol Cell Biol (2013) 1.10
Effect of dual inhibition of apoptosis and autophagy in prostate cancer. Prostate (2012) 1.07
PTEN loss defines a TGF-β-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis. Am J Physiol Renal Physiol (2012) 1.07
Transforming growth factor-beta (TGF-beta)-inducible gene TMEPAI converts TGF-beta from a tumor suppressor to a tumor promoter in breast cancer. Cancer Res (2010) 1.06
Preservation of complex I function during hypoxia-reoxygenation-induced mitochondrial injury in proximal tubules. Am J Physiol Renal Physiol (2003) 1.06
A mouse mammary epithelial cell model to identify molecular mechanisms regulating breast cancer progression. Methods Enzymol (2008) 1.05
Hyperoxia sensing: from molecular mechanisms to significance in disease. J Immunotoxicol (2010) 1.05
Measurement of subcellular texture by optical Gabor-like filtering with a digital micromirror device. Opt Lett (2008) 1.04
Induction of apoptosis by diterpenes from the soft coral Xenia elongata. J Nat Prod (2007) 1.03
Role of apoptosis in hypoxic/ischemic damage in the kidney. Semin Nephrol (2003) 1.03
Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β. Am J Pathol (2012) 1.03
Bcl-2 modulation to activate apoptosis in prostate cancer. Mol Cancer Res (2009) 1.01
E1A sensitizes cells to tumor necrosis factor alpha by downregulating c-FLIP S. J Virol (2003) 1.01
Dual EGFR/HER2 inhibition sensitizes prostate cancer cells to androgen withdrawal by suppressing ErbB3. Clin Cancer Res (2011) 0.99
Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity. J Biol Chem (2005) 0.98
Autophagy regulates keratin 8 homeostasis in mammary epithelial cells and in breast tumors. Mol Cancer Res (2010) 0.96
Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Delta(12,14)-prostaglandin J2. Biochem Biophys Res Commun (2010) 0.93
Regulation of the mitochondrial checkpoint in p53-mediated apoptosis confers resistance to cell death. Oncogene (2002) 0.92
Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia. Biochem J (2002) 0.91
Therapeutic targeting of death pathways in cancer: mechanisms for activating cell death in cancer cells. Adv Exp Med Biol (2008) 0.91
Does control of mutant p53 by Mdm2 complicate cancer therapy? Genes Dev (2008) 0.90
Advanced glycation of type I collagen and fibronectin modifies periodontal cell behavior. J Periodontol (2008) 0.90
A novel proteomic coculture model of prostate cancer cell growth. Proteomics (2004) 0.89
Epothilone induced cytotoxicity is dependent on p53 status in prostate cells. Prostate (2004) 0.89
Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma. Blood (2010) 0.89