Published in Gastroenterology on December 01, 2002
Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells. Proc Natl Acad Sci U S A (2003) 1.41
Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis. Cancer Res (2012) 1.17
Integrin signaling, cell survival, and anoikis: distinctions, differences, and differentiation. J Signal Transduct (2011) 1.14
Rapid reversal of human intestinal ischemia-reperfusion induced damage by shedding of injured enterocytes and reepithelialisation. PLoS One (2008) 1.08
Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells. Oncogene (2005) 1.04
p38α MAPK pathway: a key factor in colorectal cancer therapy and chemoresistance. World J Gastroenterol (2014) 1.02
Induced TRPC1 expression sensitizes intestinal epithelial cells to apoptosis by inhibiting NF-kappaB activation through Ca2+ influx. Biochem J (2006) 1.01
Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes. Apoptosis (2012) 0.97
p38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis. Sci Signal (2011) 0.93
Oxidative stress-induced intestinal epithelial cell apoptosis is mediated by p38 MAPK. Biochem Biophys Res Commun (2006) 0.92
Lipid mapping of colonic mucosa by cluster TOF-SIMS imaging and multivariate analysis in cftr knockout mice. J Lipid Res (2010) 0.92
Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research. Am J Physiol Gastrointest Liver Physiol (2014) 0.85
Novel chemo-sensitizing agent, ERW1227B, impairs cellular motility and enhances cell death in glioblastomas. J Neurooncol (2010) 0.85
Suppression of anoikis in human intestinal epithelial cells: differentiation state-selective roles of α2β1, α3β1, α5β1, and α6β4 integrins. BMC Cell Biol (2013) 0.81
Phorbol esters enhance 1α,25-dihydroxyvitamin D3-regulated 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) gene expression through ERK-mediated phosphorylation of specific protein 3 (Sp3) in Caco-2 cells. Mol Cell Endocrinol (2012) 0.81
ErbB2-dependent downregulation of a pro-apoptotic protein Perp is required for oncogenic transformation of breast epithelial cells. Oncogene (2016) 0.78
In vitro organoid culture of primary mouse colon tumors. J Vis Exp (2013) 0.77
Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nat Commun (2016) 0.76
The Ex Vivo Culture and Pattern Recognition Receptor Stimulation of Mouse Intestinal Organoids. J Vis Exp (2016) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science (2009) 9.29
Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell (2005) 9.01
Activation and signaling of the p38 MAP kinase pathway. Cell Res (2005) 5.48
PRAK is essential for ras-induced senescence and tumor suppression. Cell (2007) 4.30
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol (2003) 4.15
MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science (2002) 3.78
Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity (2007) 3.38
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. Immunity (2008) 2.62
Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells (2003) 2.28
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res (2013) 2.26
XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Mol Cell (2007) 2.21
Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction. Biochem J (2009) 2.19
Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels. Neuron (2004) 2.17
Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice. J Clin Invest (2008) 2.15
p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell (2006) 2.06
HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy. J Biol Chem (2007) 2.02
Autophagy contributes to caspase-independent macrophage cell death. J Biol Chem (2006) 1.87
Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. J Biol Chem (2006) 1.86
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science (2012) 1.84
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest (2009) 1.80
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J (2004) 1.79
Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins. Immunity (2010) 1.78
Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation. J Immunol (2008) 1.68
Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase. J Biol Chem (2002) 1.67
The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence. Cancer Res (2010) 1.60
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol (2011) 1.59
Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling. J Biol Chem (2002) 1.59
Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages. Nat Immunol (2007) 1.57
Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein. J Biol Chem (2004) 1.48
Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling. J Biol Chem (2013) 1.48
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J (2006) 1.47
Acute in vivo elevation of intravascular triacylglycerol lipolysis impairs peripheral T cell activation in humans. Am J Clin Nutr (2005) 1.45
Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2. J Biol Chem (2002) 1.44
Deriving uncertainty factors for threshold chemical contaminants in drinking water. J Toxicol Environ Health B Crit Rev (2007) 1.44
Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3. Blood (2005) 1.44
A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Rep (2013) 1.44
MicroRNAs and cardiovascular diseases. FEBS J (2011) 1.41
Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways. J Cell Physiol (2007) 1.39
Calcineurin negatively regulates TLR-mediated activation pathways. J Immunol (2007) 1.33
HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy. Autophagy (2007) 1.33
Distinct chaperone mechanisms can delay the formation of aggresomes by the myopathy-causing R120G alphaB-crystallin mutant. Hum Mol Genet (2003) 1.31
Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease. Gastroenterology (2010) 1.31
Regulation of PRAK subcellular location by p38 MAP kinases. Mol Biol Cell (2003) 1.30
The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition. J Biol Chem (2002) 1.29
TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. J Biol Chem (2005) 1.28
ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells. Am J Physiol Renal Physiol (2006) 1.27
HspB8, a small heat shock protein mutated in human neuromuscular disorders, has in vivo chaperone activity in cultured cells. Hum Mol Genet (2005) 1.27
Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern. J Neurosci (2003) 1.27
Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi. Proc Natl Acad Sci U S A (2010) 1.27
HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2{alpha} phosphorylation. J Biol Chem (2008) 1.27
Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha. J Biol Chem (2002) 1.26
Synergistic activation of NF-kappaB by nontypeable Haemophilus influenzae and tumor necrosis factor alpha. Proc Natl Acad Sci U S A (2004) 1.25
Anthrax lethal toxin paralyzes actin-based motility by blocking Hsp27 phosphorylation. EMBO J (2007) 1.25
Multiple activation mechanisms of p38alpha mitogen-activated protein kinase. J Biol Chem (2006) 1.25
Activation of the p38 signaling pathway by heat shock involves the dissociation of glutathione S-transferase Mu from Ask1. J Biol Chem (2002) 1.24
MAPK signaling in inflammation-associated cancer development. Protein Cell (2010) 1.23
B1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms. Apoptosis (2008) 1.22
TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. J Biol Chem (2002) 1.21
Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes. J Exp Med (2013) 1.21
Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages. J Immunol (2008) 1.20
Multiple death pathways in TNF-treated fibroblasts: RIP3- and RIP1-dependent and independent routes. Cell Res (2011) 1.20
p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity. J Biol Chem (2002) 1.19
Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization. J Biol Chem (2002) 1.19
p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms. J Biol Chem (2009) 1.19
Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha. Biochim Biophys Acta (2007) 1.18
RISC-target interaction: cleavage and translational suppression. Biochim Biophys Acta (2008) 1.18
Disulfide Bond-mediated multimerization of Ask1 and its reduction by thioredoxin-1 regulate H(2)O(2)-induced c-Jun NH(2)-terminal kinase activation and apoptosis. Mol Biol Cell (2007) 1.18
Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death. J Biol Chem (2004) 1.18
A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev Cell (2007) 1.16
Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms. J Biol Chem (2007) 1.14
Rac1-MKK3-p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cells. J Biol Chem (2002) 1.13
Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1. J Cell Biochem (2009) 1.13
Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nat Cell Biol (2009) 1.13
Nod1-dependent control of tumor growth. Proc Natl Acad Sci U S A (2006) 1.13
Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics (2012) 1.13
Human intestinal epithelial cell survival and anoikis. Differentiation state-distinct regulation and roles of protein kinase B/Akt isoforms. J Biol Chem (2004) 1.12
Polymeric binders suppress gliadin-induced toxicity in the intestinal epithelium. Gastroenterology (2008) 1.12
Orphan nuclear receptor Nur77 is involved in caspase-independent macrophage cell death. J Exp Med (2003) 1.11
p38 MAP kinase activation mediates gamma-globin gene induction in erythroid progenitors. Exp Hematol (2003) 1.11
Smad3 mediates transforming growth factor-beta-induced collagenase-3 (matrix metalloproteinase-13) expression in human gingival fibroblasts. Evidence for cross-talk between Smad3 and p38 signaling pathways. J Biol Chem (2002) 1.11
Essential role of p38gamma in K-Ras transformation independent of phosphorylation. J Biol Chem (2005) 1.11
Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor alpha-induced cell death. Mol Cell Biol (2003) 1.10
The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation. J Clin Invest (2014) 1.10
p38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor. J Biol Chem (2004) 1.10
Determinants of public T cell responses. Cell Res (2012) 1.09
Essential role of the NH2-terminal WD/EPF motif in the phosphorylation-activated protective function of mammalian Hsp27. J Biol Chem (2004) 1.09
Down-regulation of the mixed-lineage dual leucine zipper-bearing kinase by heat shock protein 70 and its co-chaperone CHIP. J Biol Chem (2006) 1.09
Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte. Circ Res (2010) 1.08
Inflammatory signaling and cellular senescence. Cell Signal (2008) 1.08
Receptor-interacting protein (RIP) kinase family. Cell Mol Immunol (2010) 1.07
Glucocorticoids synergize with IL-1beta to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells. BMC Mol Biol (2004) 1.07
The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes. Mol Cell Biol (2008) 1.06