Published in J Clin Invest on April 24, 2014
Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome. Nat Rev Urol (2015) 1.04
Metabolic reprogramming: the emerging concept and associated therapeutic strategies. J Exp Clin Cancer Res (2015) 1.04
Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer. Trends Pharmacol Sci (2015) 0.96
Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn. Proc Natl Acad Sci U S A (2015) 0.92
The ever-expanding role of HIF in tumour and stromal biology. Nat Cell Biol (2016) 0.89
Beyond indigestion: emerging roles for lysosome-based signaling in human disease. Curr Opin Cell Biol (2015) 0.89
Fnip1 regulates skeletal muscle fiber type specification, fatigue resistance, and susceptibility to muscular dystrophy. Proc Natl Acad Sci U S A (2014) 0.88
SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis. Oncotarget (2016) 0.86
Is 5´-AMP-Activated Protein Kinase Both Jekyll and Hyde in Bladder Cancer? Int Neurourol J (2015) 0.85
Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma. Cell Rep (2015) 0.84
Oncogenes strike a balance between cellular growth and homeostasis. Semin Cell Dev Biol (2015) 0.81
Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells. PLoS One (2014) 0.81
Regulation and function of AMPK in physiology and diseases. Exp Mol Med (2016) 0.80
Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα. Genes Dev (2016) 0.78
Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein. Open Biol (2015) 0.78
FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores. PLoS Genet (2015) 0.78
Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. Proc Natl Acad Sci U S A (2016) 0.77
Clinical Features, Genetics and Potential Therapeutic Approaches for Birt-Hogg-Dubé Syndrome. Expert Opin Orphan Drugs (2014) 0.77
Glycogen: A must have storage to survive stressful emergencies. Worm (2016) 0.76
Tumor Suppressor Folliculin Regulates mTORC1 through Primary Cilia. J Biol Chem (2016) 0.76
Expression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis. BMC Dev Biol (2016) 0.76
AMPKα1 deletion in fibroblasts promotes tumorigenesis in athymic nude mice by p52-mediated elevation of erythropoietin and CDK2. Oncotarget (2016) 0.75
FLCN: A new regulator of AMPK-dependent Warburg metabolic reprogramming. Mol Cell Oncol (2014) 0.75
Sixth BHD Symposium and First International Upstate Kidney Cancer Symposium: latest scientific and clinical discoveries. Oncotarget (2016) 0.75
Prognostic value of plasma levels of HIF-1a and PGC-1a in breast cancer. Oncotarget (2016) 0.75
Control of B lymphocyte development and functions by the mTOR signaling pathways. Cytokine Growth Factor Rev (2017) 0.75
FLCN: The causative gene for Birt-Hogg-Dubé syndrome. Gene (2017) 0.75
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A (2007) 15.88
Regulation of cancer cell metabolism. Nat Rev Cancer (2011) 15.44
Network organization of the human autophagy system. Nature (2010) 11.38
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell (2006) 10.18
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell (2006) 9.80
Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer (2011) 9.68
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A (2007) 8.23
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature (2011) 7.94
Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell (2010) 7.20
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab (2007) 7.07
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev (2004) 6.98
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab (2005) 6.85
Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature (2011) 6.57
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer (2011) 6.32
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab (2005) 5.61
HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev (2009) 5.24
Signal transduction by reactive oxygen species. J Cell Biol (2011) 5.21
The genetic basis of kidney cancer: a metabolic disease. Nat Rev Urol (2010) 5.04
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature (2012) 3.85
How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature (2012) 3.77
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc Natl Acad Sci U S A (2006) 3.51
AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab (2012) 3.35
Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome. Am J Hum Genet (2005) 3.26
Renal tumors in the Birt-Hogg-Dubé syndrome. Am J Surg Pathol (2002) 3.06
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res (2002) 2.97
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell (2013) 2.74
Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr Biol (2010) 2.55
The updated biology of hypoxia-inducible factor. EMBO J (2012) 2.49
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab (2012) 2.43
AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol (2010) 2.11
In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation. Cell Metab (2013) 1.93
Deregulated MYC expression induces dependence upon AMPK-related kinase 5. Nature (2012) 1.88
AMPK: a contextual oncogene or tumor suppressor? Cancer Res (2013) 1.82
The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans. PLoS One (2009) 1.81
Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells. Carcinogenesis (2008) 1.46
AMPK functions as an adenylate charge-regulated protein kinase. Trends Endocrinol Metab (2012) 1.44
PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis. Cancer Res (2011) 1.43
PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells. Proc Natl Acad Sci U S A (2009) 1.38
Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility. Oncogene (2010) 1.33
Elevated mitochondrial reactive oxygen species generation affects the immune response via hypoxia-inducible factor-1alpha in long-lived Mclk1+/- mouse mutants. J Immunol (2009) 1.33
Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling. Mol Cancer (2010) 1.30
SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis. Cancer Res (2012) 1.22
Turn me on: regulating HIF transcriptional activity. Cell Death Differ (2008) 1.21
HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells. Free Radic Biol Med (2011) 1.17
Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN. J Natl Cancer Inst (2012) 1.16
PGC-1-related coactivator and targets are upregulated in thyroid oncocytoma. Biochem Biophys Res Commun (2003) 1.14
The PGC-1/ERR signaling axis in cancer. Oncogene (2012) 1.10
Targeting oxidative phosphorylation: why, when, and how. Cancer Cell (2013) 1.09
Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch. Oncogene (2013) 1.08
Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression. BMC Med Genomics (2010) 1.06
The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer. Semin Cell Dev Biol (2012) 1.02
PGC-1α promotes the growth of ErbB2/Neu-induced mammary tumors by regulating nutrient supply. Cancer Res (2012) 1.01
LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer. Cancer Metab (2013) 0.94
Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway. Biochem Biophys Res Commun (2009) 0.91
Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dubé gene product. FEBS Lett (2010) 0.91
Cell biology: a clean energy programme. Nature (2006) 0.90
Therapeutic targeting the loss of the birt-hogg-dube suppressor gene. Mol Cancer Ther (2011) 0.87
Gene expression and protein array studies of folliculin-regulated pathways. Anticancer Res (2012) 0.82
LKB1-AMPK axis revisited. Cell Res (2012) 0.80
MgcRacGAP, a cytoskeleton regulator, inhibits HIF-1 transcriptional activity by blocking its dimerization. Biochim Biophys Acta (2013) 0.79
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell (2002) 11.65
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31
Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell (2013) 6.30
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol (2004) 5.46
Whole-genome sequencing for optimized patient management. Sci Transl Med (2011) 4.51
The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J Biol Chem (2005) 4.34
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema. Nat Genet (2007) 3.94
Birt-Hogg-Dubé syndrome: diagnosis and management. Lancet Oncol (2009) 3.60
AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab (2012) 3.35
Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning. J Cell Biol (2006) 3.33
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci U S A (2008) 3.13
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science (2010) 3.05
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev (2011) 2.97
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochem J (2003) 2.84
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell (2013) 2.74
Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J Biol Chem (2007) 2.70
Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection. Nat Med (2004) 2.59
Clinical and pathological features of pachyonychia congenita. J Investig Dermatol Symp Proc (2005) 2.45
Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1). Hum Mol Genet (2002) 2.41
Protein ISGylation modulates the JAK-STAT signaling pathway. Genes Dev (2003) 2.24
RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells. Blood (2013) 2.00
A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nat Cell Biol (2013) 1.96
A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension. Hypertension (2009) 1.94
mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action. J Biol Chem (2009) 1.93
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metab (2013) 1.91
CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. Proc Natl Acad Sci U S A (2013) 1.90
Open reduction of irreducible atlantoaxial dislocation by transoral anterior atlantoaxial release and posterior internal fixation. Spine (Phila Pa 1976) (2006) 1.86
Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling. Mol Cell Biol (2006) 1.80
A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension. Circ Res (2012) 1.79
The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites. J Biol Chem (2002) 1.77
Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension. Am J Physiol Renal Physiol (2008) 1.71
AT1 receptors in the collecting duct directly modulate the concentration of urine. J Am Soc Nephrol (2011) 1.63
Hepatitis C virus NS2/3 processing is required for NS3 stability and viral RNA replication. J Biol Chem (2005) 1.63
Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43. Mol Cell Biol (2009) 1.61
Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis. Proc Natl Acad Sci U S A (2003) 1.59
An oxygen-regulated switch in the protein synthesis machinery. Nature (2012) 1.56
The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the beta-actin mRNA in a U-rich-element-dependent manner. Mol Cell Biol (2007) 1.54
Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection. Proc Natl Acad Sci U S A (2010) 1.49
Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies. Hum Mol Genet (2011) 1.47
Hepatitis C therapeutics: current status and emerging strategies. Nat Rev Drug Discov (2002) 1.46
Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential. Blood (2013) 1.46
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc Natl Acad Sci U S A (2002) 1.43
Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia. Blood (2012) 1.42
Enhanced antibacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulating type I IFN signaling. J Immunol (2005) 1.42
Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis. Cancer Res (2006) 1.41
Mutations in KAT6B, encoding a histone acetyltransferase, cause Genitopatellar syndrome. Am J Hum Genet (2012) 1.39
Adherence to current guidelines for chronic obstructive pulmonary disease (COPD) among patients treated with combination of long-acting bronchodilators or inhaled corticosteroids. Int J Chron Obstruct Pulmon Dis (2012) 1.37
The genetic basis of pachyonychia congenita. J Investig Dermatol Symp Proc (2005) 1.34
A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome. Am J Hum Genet (2005) 1.33
Anomalous vertebral artery in craniovertebral junction with occipitalization of the atlas. Spine (Phila Pa 1976) (2009) 1.32
Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis. Nat Genet (2009) 1.31
Cosegregation of C-insertion at position 961 with the A1555G mutation of the mitochondrial 12S rRNA gene in a large Chinese family with maternally inherited hearing loss. Am J Med Genet A (2004) 1.30
Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts. Blood (2007) 1.29
Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition. Cell Signal (2009) 1.29
Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proc Natl Acad Sci U S A (2013) 1.29
Quality assurance of intracellular cytokine staining assays: analysis of multiple rounds of proficiency testing. J Immunol Methods (2010) 1.24
Leucine and mTORC1: a complex relationship. Am J Physiol Endocrinol Metab (2012) 1.24
Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways. Hepatology (2008) 1.24
Biomimetic enzyme nanocomplexes and their use as antidotes and preventive measures for alcohol intoxication. Nat Nanotechnol (2013) 1.23
Diffuse and segmental variants of cutaneous leiomyomatosis: novel mutations in the fumarate hydratase gene and review of the literature. Exp Dermatol (2006) 1.21
Spatial expression and regulation of rice high-affinity nitrate transporters by nitrogen and carbon status. J Exp Bot (2011) 1.21
Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling. J Biol Chem (2012) 1.20
eEF1A is a novel component of the mammalian nuclear protein export machinery. Mol Biol Cell (2008) 1.19
ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding. Autophagy (2011) 1.17
Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation. J Biol Chem (2005) 1.17
PDX-1 acts as a potential molecular target for treatment of human pancreatic cancer. Pancreas (2008) 1.17
The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO. Blood (2007) 1.17
Familial pityriasis rubra pilaris is caused by mutations in CARD14. Am J Hum Genet (2012) 1.16
Mammalian septins are required for phagosome formation. Mol Biol Cell (2008) 1.16
Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis. Proc Natl Acad Sci U S A (2008) 1.14
Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes. Am J Physiol Endocrinol Metab (2009) 1.14
Atlantoaxial transarticular screw fixation with morselized autograft and without additional internal fixation: technical description and report of 57 cases. Spine (Phila Pa 1976) (2007) 1.13
Genetics and epigenetics of cutaneous malignant melanoma: a concert out of tune. Biochim Biophys Acta (2012) 1.13
Treatment of pachyonychia congenita. J Investig Dermatol Symp Proc (2005) 1.13
The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma. BMC Cancer (2009) 1.12
Human intestinal epithelial cell survival and anoikis. Differentiation state-distinct regulation and roles of protein kinase B/Akt isoforms. J Biol Chem (2004) 1.12
Compound heterozygosity for mutations in LMNA causes a progeria syndrome without prelamin A accumulation. Hum Mol Genet (2006) 1.11
Effective and highly stereoselective coupling with vinyldiazomethanes to form symmetrical trienes. J Org Chem (2002) 1.07
Active oxygen and cell death in cereal aleurone cells. J Exp Bot (2002) 1.07
A missense mutation in TGM5 causes acral peeling skin syndrome in a Tunisian family. J Invest Dermatol (2009) 1.07
Differentiation state-selective roles of p38 isoforms in human intestinal epithelial cell anoikis. Gastroenterology (2002) 1.07
PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential. Blood (2012) 1.07
Percutaneous left atrial appendage occlusion (PLAATO) for preventing cardioembolism: first experience in canine model. Circulation (2002) 1.06
Upregulation of a functional form of the beta4 integrin subunit in colorectal cancers correlates with c-Myc expression. Oncogene (2005) 1.06
Telmisartan and amlodipine single-pill combinations vs amlodipine monotherapy for superior blood pressure lowering and improved tolerability in patients with uncontrolled hypertension: results of the TEAMSTA-5 study. J Clin Hypertens (Greenwich) (2011) 1.06
Pathologic evaluation of a spherical polyvinyl alcohol embolic agent in a porcine renal model. J Vasc Interv Radiol (2003) 1.06
Comment on Zhao et al. "Palmoplantar keratoderma of the Gamborg-Nielsen type is caused by mutations in the SLURP1 gene and represents a variant of Mal de Meleda". Acta Derm Venereol (2015) 1.05
Erythropoietin receptor expression in non-small cell lung carcinoma: a question of antibody specificity. Stem Cells (2006) 1.05
Dysregulated miR-363 affects head and neck cancer invasion and metastasis by targeting podoplanin. Int J Biochem Cell Biol (2012) 1.05
Mammalian epididymal proteome. Mol Cell Endocrinol (2009) 1.04
Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17. Cancer Res (2006) 1.04
Birt-Hogg-Dube syndrome is a novel ciliopathy. Hum Mol Genet (2013) 1.04