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1
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Structural insights into inhibition of sterol 14alpha-demethylase in the human pathogen Trypanosoma cruzi.
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J Biol Chem
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2010
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1.71
|
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2
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"Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target.
|
Structure
|
2005
|
1.63
|
|
3
|
Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.
|
J Biol Chem
|
2009
|
1.60
|
|
4
|
Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway.
|
Proc Natl Acad Sci U S A
|
2003
|
1.45
|
|
5
|
Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity.
|
J Virol
|
2004
|
1.40
|
|
6
|
Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14alpha-demethylase (CYP51) from Leishmania infantum.
|
J Biol Chem
|
2011
|
1.29
|
|
7
|
Antitrypanosomal lead discovery: identification of a ligand-efficient inhibitor of Trypanosoma cruzi CYP51 and parasite growth.
|
J Med Chem
|
2013
|
1.19
|
|
8
|
Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity.
|
J Biol Chem
|
2013
|
1.18
|
|
9
|
Covalent incorporation of selenium into oligonucleotides for X-ray crystal structure determination via MAD: proof of principle. Multiwavelength anomalous dispersion.
|
Biochimie
|
2002
|
1.15
|
|
10
|
Selenium-assisted nucleic acid crystallography: use of phosphoroselenoates for MAD phasing of a DNA structure.
|
J Am Chem Soc
|
2002
|
1.11
|
|
11
|
Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Delta7-24, 25-dihydrolanosterol.
|
J Lipid Res
|
2011
|
1.04
|
|
12
|
Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants.
|
Acta Crystallogr D Biol Crystallogr
|
2011
|
1.04
|
|
13
|
Crystal structure of a luteoviral RNA pseudoknot and model for a minimal ribosomal frameshifting motif.
|
Biochemistry
|
2005
|
1.01
|
|
14
|
2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H.
|
Biochemistry
|
2006
|
1.00
|
|
15
|
Structure of the two-subsite beta-d-xylosidase from Selenomonas ruminantium in complex with 1,3-bis[tris(hydroxymethyl)methylamino]propane.
|
Arch Biochem Biophys
|
2008
|
1.00
|
|
16
|
Structure and DNA binding of alkylation response protein AidB.
|
Proc Natl Acad Sci U S A
|
2008
|
0.94
|
|
17
|
Crystal structure of a B-form DNA duplex containing (L)-alpha-threofuranosyl (3'-->2') nucleosides: a four-carbon sugar is easily accommodated into the backbone of DNA.
|
J Am Chem Soc
|
2002
|
0.91
|
|
18
|
Supramolecular allosteric cofacial porphyrin complexes.
|
J Am Chem Soc
|
2006
|
0.89
|
|
19
|
Why does TNA cross-pair more strongly with RNA than with DNA? an answer from X-ray analysis.
|
Angew Chem Int Ed Engl
|
2003
|
0.87
|
|
20
|
Structural basis for rational design of inhibitors targeting Trypanosoma cruzi sterol 14α-demethylase: two regions of the enzyme molecule potentiate its inhibition.
|
J Med Chem
|
2014
|
0.85
|
|
21
|
Basis of miscoding of the DNA adduct N2,3-ethenoguanine by human Y-family DNA polymerases.
|
J Biol Chem
|
2012
|
0.84
|
|
22
|
Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles.
|
Chem Commun (Camb)
|
2007
|
0.83
|
|
23
|
Crystallization and preliminary crystallographic analysis of endonuclease VIII in its uncomplexed form.
|
Acta Crystallogr D Biol Crystallogr
|
2004
|
0.82
|
|
24
|
Structure and activity of the NAD(P)+-dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium.
|
Proteins
|
2013
|
0.81
|
|
25
|
A convergent coordination chemistry-based approach to dissymmetric macrocyclic cofacial porphyrin complexes.
|
Inorg Chem
|
2007
|
0.78
|
|
26
|
Three-dimensional structure of homodimeric cholesterol esterase-ligand complex at 1.4 A resolution.
|
Acta Crystallogr D Biol Crystallogr
|
2002
|
0.77
|
|
27
|
Kinetic and structural mechanisms of (5'S)-8,5'-cyclo-2'-deoxyguanosine-induced dna replication stalling.
|
Biochemistry
|
2015
|
0.76
|
|
28
|
Type III effector NleH2 from Escherichia coli O157:H7 str. Sakai features an atypical protein kinase domain.
|
Biochemistry
|
2014
|
0.76
|
|
29
|
Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuni.
|
J Struct Funct Genomics
|
2012
|
0.76
|
|
30
|
Recognition of O6-benzyl-2'-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction.
|
Nucleic Acids Res
|
2013
|
0.76
|
|
31
|
Retraction: Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus.
|
Nat Commun
|
2017
|
0.75
|