PubRank

Sic L Chan

Author PubWeight™ 54.67‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A 2007 4.62
2 Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease. J Neurochem 2002 2.45
3 Calcium orchestrates apoptosis. Nat Cell Biol 2003 2.27
4 Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron 2004 1.99
5 Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nat Med 2006 1.82
6 Involvement of Notch signaling in hippocampal synaptic plasticity. Proc Natl Acad Sci U S A 2004 1.77
7 Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Physiol Rev 2002 1.77
8 Neuronal and glial calcium signaling in Alzheimer's disease. Cell Calcium 2003 1.76
9 Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. J Neurosci 2004 1.57
10 Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death. Proc Natl Acad Sci U S A 2007 1.46
11 Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. Neuromolecular Med 2006 1.28
12 Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness. Cancer Res 2009 1.18
13 Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain. Neuromolecular Med 2002 1.17
14 Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesis. J Biol Chem 2008 1.08
15 Involvement of Gadd153 in the pathogenic action of presenilin-1 mutations. J Neurochem 2002 1.05
16 Neuroprotective and neurorestorative signal transduction mechanisms in brain aging: modification by genes, diet and behavior. Neurobiol Aging 2002 1.04
17 Evidence that gamma-secretase-mediated Notch signaling induces neuronal cell death via the nuclear factor-kappaB-Bcl-2-interacting mediator of cell death pathway in ischemic stroke. Mol Pharmacol 2011 1.04
18 New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists. Ann N Y Acad Sci 2004 1.03
19 p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults. Neuromolecular Med 2003 1.01
20 Notch activation enhances the microglia-mediated inflammatory response associated with focal cerebral ischemia. Stroke 2011 1.01
21 Neuroprotective actions of a histidine analogue in models of ischemic stroke. J Neurochem 2007 0.99
22 Involvement of mitochondrial K+ release and cellular efflux in ischemic and apoptotic neuronal death. J Neurochem 2003 0.98
23 The homocysteine-inducible endoplasmic reticulum stress protein counteracts calcium store depletion and induction of CCAAT enhancer-binding protein homologous protein in a neurotoxin model of Parkinson disease. J Biol Chem 2009 0.96
24 The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins. Hum Mol Genet 2011 0.94
25 TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein-binding ability. FASEB J 2003 0.92
26 The lipid peroxidation product 4-hydroxynonenal facilitates opening of voltage-dependent Ca2+ channels in neurons by increasing protein tyrosine phosphorylation. J Biol Chem 2002 0.91
27 Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways. J Neurochem 2012 0.89
28 Presenilin-1 mutation sensitizes oligodendrocytes to glutamate and amyloid toxicities, and exacerbates white matter damage and memory impairment in mice. Neuromolecular Med 2003 0.89
29 Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease. Aging Cell 2012 0.88
30 Lifelong running reduces oxidative stress and degenerative changes in the testes of mice. J Endocrinol 2008 0.88
31 Expression of aquaporin 1 and 4 in a congenital hydrocephalus rat model. Neurosurgery 2011 0.88
32 Numb isoforms containing a short PTB domain promote neurotrophic factor-induced differentiation and neurotrophic factor withdrawal-induced death of PC12 Cells. J Neurochem 2002 0.86
33 Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel. J Biol Chem 2009 0.86
34 Interferon-gamma is up-regulated in the hippocampus in response to intermittent fasting and protects hippocampal neurons against excitotoxicity. J Neurosci Res 2006 0.83
35 A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78. J Neurochem 2002 0.83
36 Electroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice. Hum Mol Genet 2010 0.83
37 Evidence for altered Numb isoform levels in Alzheimer's disease patients and a triple transgenic mouse model. J Alzheimers Dis 2011 0.81
38 Chronic nicotine administration impairs activation of cyclic AMP-response element binding protein and survival of newborn cells in the dentate gyrus. Stem Cells Dev 2011 0.81
39 Pivotal role for beta-1 integrin in neurovascular remodelling after ischemic stroke. Exp Neurol 2009 0.81
40 A synthetic uric acid analog accelerates cutaneous wound healing in mice. PLoS One 2010 0.81
41 Electrophysiological and cerebrovascular effects of the alpha-secretase-derived form of amyloid precursor protein in young and middle-aged rats. Brain Res 2006 0.80
42 The brain uncoupling protein UCP4 attenuates mitochondrial toxin-induced cell death: role of extracellular signal-regulated kinases in bioenergetics adaptation and cell survival. Neurotox Res 2009 0.80
43 Homocysteine and folate deficiency sensitize oligodendrocytes to the cell death-promoting effects of a presenilin-1 mutation and amyloid beta-peptide. Neuromolecular Med 2003 0.79
44 Good and bad amyloid antibodies. Science 2003 0.79
45 Effect of acetazolamide on aquaporin-1 and fluid flow in cultured choroid plexus. Acta Neurochir Suppl 2012 0.78
46 Defects of immune regulation in the presenilin-1 mutant knockin mouse. Neuromolecular Med 2007 0.78
47 Phenformin suppresses calcium responses to glutamate and protects hippocampal neurons against excitotoxicity. Exp Neurol 2002 0.77