Published in Cancer Res on December 22, 2009
Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres. Am J Pathol (2010) 1.86
Remodeling of calcium signaling in tumor progression. J Biomed Sci (2013) 1.19
Digital transcriptome profiling of normal and glioblastoma-derived neural stem cells identifies genes associated with patient survival. Genome Med (2012) 1.11
NFAT gene family in inflammation and cancer. Curr Mol Med (2013) 1.02
High glucose induces podocyte apoptosis by stimulating TRPC6 via elevation of reactive oxygen species. Biochim Biophys Acta (2013) 1.01
TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways. Cell Signal (2014) 0.94
Cancer cell invasion: treatment and monitoring opportunities in nanomedicine. Adv Drug Deliv Rev (2011) 0.93
Cancer as a channelopathy: ion channels and pumps in tumor development and progression. Front Cell Neurosci (2015) 0.92
Genomic profiling of advanced-stage oral cancers reveals chromosome 11q alterations as markers of poor clinical outcome. PLoS One (2011) 0.92
Ionic regulation of cell volume changes and cell death after ischemic stroke. Transl Stroke Res (2013) 0.88
Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca(2+) entry in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol (2014) 0.88
Involvement of tumor acidification in brain cancer pathophysiology. Front Physiol (2013) 0.87
Store-operated Ca2+ entry does not control proliferation in primary cultures of human metastatic renal cellular carcinoma. Biomed Res Int (2014) 0.87
Emerging role of TRP channels in cell migration: from tumor vascularization to metastasis. Front Physiol (2013) 0.87
Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma. J Signal Transduct (2012) 0.87
Emerging roles of canonical TRP channels in neuronal function. Adv Exp Med Biol (2011) 0.87
Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer. PLoS One (2013) 0.87
Permeation, regulation and control of expression of TRP channels by trace metal ions. Pflugers Arch (2014) 0.85
Molecular mechanisms of tumour invasion: regulation by calcium signals. J Physiol (2017) 0.84
The histone variant MacroH2A regulates Ca(2+) influx through TRPC3 and TRPC6 channels. Oncogenesis (2013) 0.83
Cellular functions of transient receptor potential channels. Int J Biochem Cell Biol (2010) 0.83
Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension. Am J Respir Cell Mol Biol (2015) 0.82
WT1/EGR1-mediated control of STIM1 expression and function in cancer cells. Front Biosci (Landmark Ed) (2011) 0.82
The TRPC channel blocker SKF 96365 inhibits glioblastoma cell growth by enhancing reverse mode of the Na(+) /Ca(2+) exchanger and increasing intracellular Ca(2+). Br J Pharmacol (2014) 0.82
Role of ion channels in regulating Ca²⁺ homeostasis during the interplay between immune and cancer cells. Cell Death Dis (2015) 0.81
TRP channels and STIM/ORAI proteins: sensors and effectors of cancer and stroma cell migration. Br J Pharmacol (2014) 0.80
Expression of transient receptor potential channel 6 in cervical cancer. Onco Targets Ther (2012) 0.79
Notch-mediated induction of N-cadherin and α9-integrin confers higher invasive phenotype on rhabdomyosarcoma cells. Br J Cancer (2012) 0.79
Functional properties of ion channels and transporters in tumour vascularization. Philos Trans R Soc Lond B Biol Sci (2014) 0.79
FSH enhances the proliferation of ovarian cancer cells by activating transient receptor potential channel C3. Endocr Relat Cancer (2013) 0.79
A combined gene signature of hypoxia and notch pathway in human glioblastoma and its prognostic relevance. PLoS One (2015) 0.79
Identification of TRPC6 as a possible candidate target gene within an amplicon at 11q21-q22.2 for migratory capacity in head and neck squamous cell carcinomas. BMC Cancer (2013) 0.78
Regulation of Multi-drug Resistance in hepatocellular carcinoma cells is TRPC6/Calcium Dependent. Sci Rep (2016) 0.77
The transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin. J Biol Chem (2011) 0.77
The role of ion channels in the hypoxia-induced aggressiveness of glioblastoma. Front Cell Neurosci (2015) 0.77
SOCE and cancer: Recent progress and new perspectives. Int J Cancer (2015) 0.77
Genome-Wide Loss of Heterozygosity and DNA Copy Number Aberration in HPV-Negative Oral Squamous Cell Carcinoma and Their Associations with Disease-Specific Survival. PLoS One (2015) 0.77
TRPV4 participates in the establishment of trailing adhesions and directional persistence of migrating cells. Pflugers Arch (2015) 0.77
High delta-like ligand 4 (DLL4) is correlated with peritumoral brain edema and predicts poor prognosis in primary glioblastoma. Medicine (Baltimore) (2014) 0.77
Placing ion channels into a signaling network of T cells: from maturing thymocytes to healthy T lymphocytes or leukemic T lymphoblasts. Biomed Res Int (2015) 0.75
Deletion of TRPC6 Attenuates NMDA Receptor-Mediated Ca(2+) Entry and Ca(2+)-Induced Neurotoxicity Following Cerebral Ischemia and Oxygen-Glucose Deprivation. Front Neurosci (2017) 0.75
Enhanced expression of transient receptor potential channel 3 in uterine smooth muscle tissues of lipopolysaccharide-induced preterm delivery mice. Iran J Basic Med Sci (2016) 0.75
Inhibition of TRPC6 reduces non-small cell lung cancer cell proliferation and invasion. Oncotarget (2016) 0.75
TRPC6 channels modulate the response of pancreatic stellate cells to hypoxia. Pflugers Arch (2017) 0.75
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature (2006) 27.91
Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol (2007) 12.62
Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res (2007) 9.21
Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res (2006) 6.77
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell (2009) 5.81
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A (2007) 4.62
Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nat Rev Cancer (2007) 4.54
Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev (2002) 4.30
Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci U S A (2007) 3.91
Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol (2008) 3.84
Integrin alpha 6 regulates glioblastoma stem cells. Cell Stem Cell (2010) 3.82
Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell (2004) 3.63
The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. Cell Cycle (2009) 3.55
Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. Cell (2013) 3.32
Notch promotes radioresistance of glioma stem cells. Stem Cells (2010) 3.07
Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res (2008) 2.97
Recent advances in the treatment of malignant astrocytoma. J Clin Oncol (2006) 2.55
HIF induces human embryonic stem cell markers in cancer cells. Cancer Res (2011) 2.46
Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease. J Neurochem (2002) 2.45
c-Myc is required for maintenance of glioma cancer stem cells. PLoS One (2008) 2.41
Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. Cancer Cell (2013) 2.38
Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. J Clin Oncol (2008) 2.32
Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake. Nat Neurosci (2013) 2.30
Calcium orchestrates apoptosis. Nat Cell Biol (2003) 2.27
Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. J Exp Med (2012) 2.21
Phase II trial of temozolomide in patients with progressive low-grade glioma. J Clin Oncol (2003) 2.16
Toll-like receptors in neurodegeneration. Brain Res Rev (2008) 2.15
Brain cancer stem cells display preferential sensitivity to Akt inhibition. Stem Cells (2008) 2.12
Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer Cell (2011) 2.04
Acute kidney injury leads to inflammation and functional changes in the brain. J Am Soc Nephrol (2008) 2.03
Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron (2004) 1.99
Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem Cells (2009) 1.97
Molecularly targeted therapy for malignant glioma. Cancer (2007) 1.96
Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme. J Clin Oncol (2005) 1.85
Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nat Med (2006) 1.82
Involvement of Notch signaling in hippocampal synaptic plasticity. Proc Natl Acad Sci U S A (2004) 1.77
Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Physiol Rev (2002) 1.77
Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. Cell (2011) 1.77
Neuronal and glial calcium signaling in Alzheimer's disease. Cell Calcium (2003) 1.76
A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth. Mol Carcinog (2007) 1.74
Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. Mol Cancer Ther (2005) 1.66
Biology of glioma cancer stem cells. Mol Cells (2009) 1.64
Cancer stem cells in gliomas: identifying and understanding the apex cell in cancer's hierarchy. Glia (2011) 1.63
Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma. Clin Cancer Res (2006) 1.63
Potential therapeutic implications of cancer stem cells in glioblastoma. Biochem Pharmacol (2010) 1.60
Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma. Neuro Oncol (2010) 1.59
Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal. Exp Neurol (2008) 1.58
beta1 integrin maintains integrity of the embryonic neocortical stem cell niche. PLoS Biol (2009) 1.57
Informed consent in pediatric surgery: Do parents understand the risks? Arch Otolaryngol Head Neck Surg (2010) 1.55
Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. J Clin Oncol (2009) 1.53
Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. J Clin Oncol (2002) 1.50
Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells. Nat Cell Biol (2011) 1.49
Deadly teamwork: neural cancer stem cells and the tumor microenvironment. Cell Stem Cell (2011) 1.49
New treatment strategies for malignant gliomas. Expert Rev Anticancer Ther (2006) 1.47
Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death. Proc Natl Acad Sci U S A (2007) 1.46
Integrins are markers of human neural stem cells. Stem Cells (2006) 1.40
Elevated invasive potential of glioblastoma stem cells. Biochem Biophys Res Commun (2011) 1.39
Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals. J Neurosci (2010) 1.36
Involvement of notch signaling in wound healing. PLoS One (2007) 1.35
Bevacizumab plus irinotecan in recurrent WHO grade 3 malignant gliomas. Clin Cancer Res (2008) 1.35
SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility. Mol Cancer Ther (2004) 1.35
Turning cancer stem cells inside out: an exploration of glioma stem cell signaling pathways. J Biol Chem (2009) 1.33
Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme. Clin Cancer Res (2004) 1.33
Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas. J Clin Oncol (2002) 1.32
Hypoxia and hypoxia inducible factors in cancer stem cell maintenance. Curr Top Microbiol Immunol (2010) 1.32
MET signaling regulates glioblastoma stem cells. Cancer Res (2012) 1.29
Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells. PLoS One (2011) 1.29
Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. Neuromolecular Med (2006) 1.28
Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death. J Biol Chem (2004) 1.28
Designer therapies for glioblastoma multiforme. Ann N Y Acad Sci (2008) 1.28
Inflammation stimulates myelination by transplanted oligodendrocyte precursor cells. Glia (2006) 1.28
Targeting A20 decreases glioma stem cell survival and tumor growth. PLoS Biol (2010) 1.27
Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy. J Neurooncol (2010) 1.26
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A. J Exp Med (2013) 1.21
Phase I trial of irinotecan plus temozolomide in adults with recurrent malignant glioma. Cancer (2005) 1.21
Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain. Neuromolecular Med (2002) 1.17
Best-practice surgical techniques for intrathecal baclofen therapy. J Neurosurg (2006) 1.15
Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity. Genes Dev (2012) 1.15
Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells. J Biol Chem (2006) 1.13
Laminin alpha 2 enables glioblastoma stem cell growth. Ann Neurol (2012) 1.13
Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: phase II study results. J Clin Oncol (2006) 1.12
L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1. EMBO J (2011) 1.10
Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity. Cancer Res (2005) 1.10
Phase II study of imatinib mesylate and hydroxyurea for recurrent grade III malignant gliomas. J Neurooncol (2007) 1.10
Laminin enhances the growth of human neural stem cells in defined culture media. BMC Neurosci (2008) 1.10