Published in Eur J Biochem on December 01, 2002
Lipid A modification systems in gram-negative bacteria. Annu Rev Biochem (2007) 8.60
Francisella tularensis: taxonomy, genetics, and Immunopathogenesis of a potential agent of biowarfare. Annu Rev Microbiol (2006) 2.68
Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors. Infect Immun (2006) 2.18
Toll-like receptor 2 is required for control of pulmonary infection with Francisella tularensis. Infect Immun (2006) 2.12
Francisella tularensis enters macrophages via a novel process involving pseudopod loops. Infect Immun (2005) 1.95
Novel modification of lipid A of Francisella tularensis. Infect Immun (2004) 1.91
MsbA transporter-dependent lipid A 1-dephosphorylation on the periplasmic surface of the inner membrane: topography of francisella novicida LpxE expressed in Escherichia coli. J Biol Chem (2004) 1.73
Characterization of the receptor-ligand pathways important for entry and survival of Francisella tularensis in human macrophages. Infect Immun (2006) 1.68
Expression cloning and periplasmic orientation of the Francisella novicida lipid A 4'-phosphatase LpxF. J Biol Chem (2006) 1.67
The structure and function of Francisella lipopolysaccharide. Ann N Y Acad Sci (2007) 1.64
Attenuated virulence of a Francisella mutant lacking the lipid A 4'-phosphatase. Proc Natl Acad Sci U S A (2007) 1.64
Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development. Microbiol Mol Biol Rev (2009) 1.59
Neisseria meningitidis lipooligosaccharide structure-dependent activation of the macrophage CD14/Toll-like receptor 4 pathway. Infect Immun (2004) 1.59
Characterization of Francisella tularensis outer membrane proteins. J Bacteriol (2006) 1.59
Discovery of new biosynthetic pathways: the lipid A story. J Lipid Res (2008) 1.58
A Francisella mutant in lipid A carbohydrate modification elicits protective immunity. PLoS Pathog (2008) 1.58
Role of the wbt locus of Francisella tularensis in lipopolysaccharide O-antigen biogenesis and pathogenicity. Infect Immun (2006) 1.53
Structure and biosynthesis of free lipid A molecules that replace lipopolysaccharide in Francisella tularensis subsp. novicida. Biochemistry (2006) 1.47
An outer membrane enzyme encoded by Salmonella typhimurium lpxR that removes the 3'-acyloxyacyl moiety of lipid A. J Biol Chem (2006) 1.39
Structural heterogeneity and environmentally regulated remodeling of Francisella tularensis subspecies novicida lipid A characterized by tandem mass spectrometry. J Am Soc Mass Spectrom (2007) 1.37
The lipid A 1-phosphatase of Helicobacter pylori is required for resistance to the antimicrobial peptide polymyxin. J Bacteriol (2006) 1.33
A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity. Infect Immun (2007) 1.27
Intranasal vaccination with a defined attenuated Francisella novicida strain induces gamma interferon-dependent antibody-mediated protection against tularemia. Infect Immun (2006) 1.27
Francisella tularensis infection-derived monoclonal antibodies provide detection, protection, and therapy. Clin Vaccine Immunol (2009) 1.20
Expression cloning and biochemical characterization of a Rhizobium leguminosarum lipid A 1-phosphatase. J Biol Chem (2003) 1.19
Basis for the failure of Francisella tularensis lipopolysaccharide to prime human polymorphonuclear leukocytes. Infect Immun (2006) 1.17
Contribution of Porphyromonas gingivalis lipopolysaccharide to periodontitis. Periodontol 2000 (2010) 1.17
Comparative review of Francisella tularensis and Francisella novicida. Front Cell Infect Microbiol (2014) 1.16
Structural Modifications of Bacterial Lipopolysaccharide that Facilitate Gram-Negative Bacteria Evasion of Host Innate Immunity. Front Immunol (2013) 1.03
Vaccination with a defined Francisella tularensis subsp. novicida pathogenicity island mutant (DeltaiglB) induces protective immunity against homotypic and heterotypic challenge. Vaccine (2009) 1.03
A cross-disciplinary perspective on the innate immune responses to bacterial lipopolysaccharide. Mol Cell (2014) 1.03
Identification of undecaprenyl phosphate-beta-D-galactosamine in Francisella novicida and its function in lipid A modification. Biochemistry (2009) 1.01
A typical preparation of Francisella tularensis O-antigen yields a mixture of three types of saccharides. Biochemistry (2011) 0.98
Characterization of the O-antigen polymerase (Wzy) of Francisella tularensis. J Biol Chem (2010) 0.98
Versatile set of orthogonal protecting groups for the preparation of highly branched oligosaccharides. Org Lett (2010) 0.96
Structural Relationship of the Lipid A Acyl Groups to Activation of Murine Toll-Like Receptor 4 by Lipopolysaccharides from Pathogenic Strains of Burkholderia mallei, Acinetobacter baumannii, and Pseudomonas aeruginosa. Front Immunol (2015) 0.96
Structure of compositionally simple lipopolysaccharide from marine synechococcus. J Bacteriol (2009) 0.94
A two-component Kdo hydrolase in the inner membrane of Francisella novicida. Mol Microbiol (2010) 0.93
Identification of LpxL, a late acyltransferase of Francisella tularensis. Infect Immun (2007) 0.93
Host Defense and the Airway Epithelium: Frontline Responses That Protect against Bacterial Invasion and Pneumonia. J Pathog (2011) 0.92
A galU mutant of Francisella tularensis is attenuated for virulence in a murine pulmonary model of tularemia. BMC Microbiol (2011) 0.91
Mechanisms of Antimicrobial Peptide Resistance in Gram-Negative Bacteria. Antibiotics (Basel) (2015) 0.90
NaxD is a deacetylase required for lipid A modification and Francisella pathogenesis. Mol Microbiol (2012) 0.90
WaaA of the hyperthermophilic bacterium Aquifex aeolicus is a monofunctional 3-deoxy-D-manno-oct-2-ulosonic acid transferase involved in lipopolysaccharide biosynthesis. J Biol Chem (2009) 0.90
GroEL and lipopolysaccharide from Francisella tularensis live vaccine strain synergistically activate human macrophages. Infect Immun (2010) 0.90
A conserved and immunodominant lipoprotein of Francisella tularensis is proinflammatory but not essential for virulence. Microb Pathog (2008) 0.90
Uncovering the components of the Francisella tularensis virulence stealth strategy. Front Cell Infect Microbiol (2014) 0.90
Chemical synthesis and immunological evaluation of the inner core oligosaccharide of Francisella tularensis. J Am Chem Soc (2012) 0.89
A variety of novel lipid A structures obtained from Francisella tularensis live vaccine strain. Innate Immun (2011) 0.89
Altered lipid A structures and polymyxin hypersensitivity of Rhizobium etli mutants lacking the LpxE and LpxF phosphatases. Biochim Biophys Acta (2010) 0.89
3-Deoxy-D-manno-octulosonic acid (Kdo) hydrolase identified in Francisella tularensis, Helicobacter pylori, and Legionella pneumophila. J Biol Chem (2010) 0.89
Biosynthesis of undecaprenyl phosphate-galactosamine and undecaprenyl phosphate-glucose in Francisella novicida. Biochemistry (2009) 0.89
Purification and characterization of the lipid A 1-phosphatase LpxE of Rhizobium leguminosarum. J Biol Chem (2008) 0.88
A mannosyl transferase required for lipopolysaccharide inner core assembly in Rhizobium leguminosarum. Purification, substrate specificity, and expression in Salmonella waaC mutants. J Biol Chem (2003) 0.87
Host-pathogen interactions and immune evasion strategies in Francisella tularensis pathogenicity. Infect Drug Resist (2014) 0.87
O-antigen-deficient Francisella tularensis Live Vaccine Strain mutants are ingested via an aberrant form of looping phagocytosis and show altered kinetics of intracellular trafficking in human macrophages. Infect Immun (2011) 0.87
Francisella tularensis blue-gray phase variation involves structural modifications of lipopolysaccharide o-antigen, core and lipid a and affects intramacrophage survival and vaccine efficacy. Front Microbiol (2010) 0.87
Kdo hydrolase is required for Francisella tularensis virulence and evasion of TLR2-mediated innate immunity. MBio (2013) 0.86
Evasion of IFN-γ signaling by Francisella novicida is dependent upon Francisella outer membrane protein C. PLoS One (2011) 0.86
NMR-based structural analysis of the complete rough-type lipopolysaccharide isolated from Capnocytophaga canimorsus. J Biol Chem (2014) 0.86
From the Outside-In: The Francisella tularensis Envelope and Virulence. Front Cell Infect Microbiol (2015) 0.85
Francisella tularensis Schu S4 lipopolysaccharide core sugar and O-antigen mutants are attenuated in a mouse model of tularemia. Infect Immun (2014) 0.84
Metabolic labeling to characterize the overall composition of Francisella lipid A and LPS grown in broth and in human phagocytes. Innate Immun (2013) 0.83
Kinetics of the immune response associated with tularemia: comparison of an enzyme-linked immunosorbent assay, a tube agglutination test, and a novel whole-blood lymphocyte stimulation test. Clin Vaccine Immunol (2008) 0.83
Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria. Immunity (2015) 0.82
Detoxified endotoxin vaccine (J5dLPS/OMP) protects mice against lethal respiratory challenge with Francisella tularensis SchuS4. Vaccine (2010) 0.82
A MyD88-dependent IFNγR-CCR2 signaling circuit is required for mobilization of monocytes and host defense against systemic bacterial challenge. Cell Res (2011) 0.82
The atypical lipopolysaccharide of Francisella. Carbohydr Res (2013) 0.81
Characterization of Francisella tularensis Schu S4 mutants identified from a transposon library screened for O-antigen and capsule deficiencies. Front Microbiol (2015) 0.81
Immunomodulatory effects of Yersinia pestis lipopolysaccharides on human macrophages. Clin Vaccine Immunol (2009) 0.80
IKKβ in myeloid cells controls the host response to lethal and sublethal Francisella tularensis LVS infection. PLoS One (2013) 0.80
TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB. Front Immunol (2014) 0.78
Inflammasome priming is similar for francisella species that differentially induce inflammasome activation. PLoS One (2015) 0.76
Roles for wbtC, wbtI, and kdtA Genes in Lipopolysaccharide Biosynthesis, Protein Glycosylation, Virulence, and Immunogenicity in Francisella tularensis2 Strain SCHU S4. Pathogens (2012) 0.76
Microbiota, Immune Subversion, and Chronic Inflammation. Front Immunol (2017) 0.75
Neutrophils play an important role in host resistance to respiratory infection with Acinetobacter baumannii in mice. Infect Immun (2007) 1.77
Susceptibility of immunodeficient mice to aerosol and systemic infection with virulent strains of Francisella tularensis. Microb Pathog (2004) 1.50
Poly-N-acetylglucosamine mediates biofilm formation and antibiotic resistance in Actinobacillus pleuropneumoniae. Microb Pathog (2007) 1.49
Characterization of the lipopolysaccharide O-antigen of Francisella novicida (U112). Carbohydr Res (2004) 1.29
Virulence comparison in mice of distinct isolates of type A Francisella tularensis. Microb Pathog (2006) 1.28
A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity. Infect Immun (2007) 1.27
Oral immunization of mice with the live vaccine strain (LVS) of Francisella tularensis protects mice against respiratory challenge with virulent type A F. tularensis. Vaccine (2007) 1.24
Poly-N-acetylglucosamine mediates biofilm formation and detergent resistance in Aggregatibacter actinomycetemcomitans. Microb Pathog (2007) 1.22
Toll-like receptor 4 (TLR4) does not confer a resistance advantage on mice against low-dose aerosol infection with virulent type A Francisella tularensis. Microb Pathog (2004) 1.15
Toll-like receptor 4 (TLR4) plays a relatively minor role in murine defense against primary intradermal infection with Francisella tularensis LVS. Immunol Lett (2005) 1.14
Low dose aerosol infection of mice with virulent type A Francisella tularensis induces severe thymus atrophy and CD4+CD8+ thymocyte depletion. Microb Pathog (2005) 1.12
Mice sublethally infected with Francisella novicida U112 develop only marginal protective immunity against systemic or aerosol challenge with virulent type A or B strains of F. tularensis. Microb Pathog (2004) 1.04
Cellular and humoral immunity are synergistic in protection against types A and B Francisella tularensis. Vaccine (2008) 1.04
Francisella tularensis proteome: low levels of ASB-14 facilitate the visualization of membrane proteins in total protein extracts. J Proteome Res (2005) 1.01
Structural analysis of the lipopolysaccharide derived core oligosaccharides of Actinobacillus pleuropneumoniae serotypes 1, 2, 5a and the genome strain 5b. Carbohydr Res (2004) 0.99
Immunoproteomic analysis of the murine antibody response to successful and failed immunization with live anti-Francisella vaccines. Biochem Biophys Res Commun (2006) 0.99
A rapid, small-scale procedure for the structural characterization of lipid A applied to Citrobacter and Bordetella strains: discovery of a new structural element. J Lipid Res (2007) 0.98
Role of neutrophils and NADPH phagocyte oxidase in host defense against respiratory infection with virulent Francisella tularensis in mice. Microbes Infect (2011) 0.97
Structure of a novel lipid A obtained from the lipopolysaccharide of Caulobacter crescentus. Innate Immun (2008) 0.93
Measurement of macrophage-mediated killing of intracellular bacteria, including Francisella and mycobacteria. Curr Protoc Immunol (2011) 0.93
Immunoproteomics analysis of the murine antibody response to vaccination with an improved Francisella tularensis live vaccine strain (LVS). PLoS One (2010) 0.92
Differential susceptibility of Sprague-Dawley and Fischer 344 rats to infection by Francisella tularensis. Microb Pathog (2009) 0.90
Characterisation of the core part of the lipopolysaccharide O-antigen of Francisella novicida (U112). Carbohydr Res (2004) 0.90
Characterization of the O-antigen in the lipopolysaccharide of Cronobacter (Enterobacter) malonaticus 3267. Biochem Cell Biol (2009) 0.87
Characterization of the antigenic lipopolysaccharide O chain and the capsular polysaccharide produced by Actinobacillus pleuropneumoniae serotype 13. Infect Immun (2004) 0.87
The structure of the O-antigen in the endotoxin of the emerging food pathogen Cronobacter (Enterobacter) muytjensii strain 3270. Carbohydr Res (2009) 0.87
Study of matrix additives for sensitive analysis of lipid A by matrix-assisted laser desorption ionization mass spectrometry. Appl Environ Microbiol (2010) 0.87
Francisella tularensis blue-gray phase variation involves structural modifications of lipopolysaccharide o-antigen, core and lipid a and affects intramacrophage survival and vaccine efficacy. Front Microbiol (2010) 0.87
The structure of the O-antigen of Cronobacter sakazakii HPB 2855 isolate involved in a neonatal infection. Carbohydr Res (2010) 0.84
Structure of the antigenic repeating pentasaccharide unit of the LPS O-polysaccharide of Cronobacter sakazakii implicated in the Tennessee outbreak. Biochem Cell Biol (2009) 0.84
Identification of a D-glycero-D-manno-heptosyltransferase gene from Helicobacter pylori. J Bacteriol (2005) 0.83
Structural characterization of Bordetella parapertussis lipid A. J Lipid Res (2008) 0.82
Structural characterization of the lipopolysaccharide O-polysaccharide antigen produced by Flavobacterium columnare ATCC 43622. Eur J Biochem (2003) 0.82
Characterization of the lipopolysaccharide and beta-glucan of the fish pathogen Francisella victoria. FEBS J (2006) 0.82
Structure of the polysaccharide chain of the lipopolysaccharide from Flexibacter maritimus. Eur J Biochem (2003) 0.81
Characterization of the lipopolysaccharide O-antigen of Cronobacter turicensis HPB3287 as a polysaccharide containing a 5,7-diacetamido-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid (legionaminic acid) residue. Carbohydr Res (2011) 0.81
Francisella tularensis: a red-blooded pathogen. J Infect Dis (2011) 0.81
The structure of the polysaccharide of the lipopolysaccharide produced by Taylorella equigenitalis type strain (ATCC 35865). Carbohydr Res (2008) 0.80
The structure of the polysaccharide O-chain of the LPS from Acinetobacter baumannii strain ATCC 17961. Carbohydr Res (2009) 0.80
Structural elucidation of the novel core oligosaccharide from LPS of Burkholderia cepacia serogroup O4. Glycobiology (2009) 0.80
Structural characterization of the O-chain polysaccharide isolated from Bordetella avium ATCC 5086: variation on a theme(1). FEBS Lett (2003) 0.79
Lymphotoxin-alpha plays only a minor role in host resistance to respiratory infection with virulent type A Francisella tularensis in mice. Mediators Inflamm (2008) 0.78
The structure of the glycopeptides from the fish pathogen Flavobacterium columnare. Carbohydr Res (2003) 0.78
The structure of the carbohydrate backbone of the LPS from Myxococcus xanthus strain DK1622. Carbohydr Res (2007) 0.78
The structure and biological characteristics of the Spirochaeta aurantia outer membrane glycolipid LGLB. Eur J Biochem (2004) 0.78
Lipopolysaccharide O-antigen antibody-based detection of the fish pathogen Flavobacterium psychrophilum. J Mol Microbiol Biotechnol (2003) 0.77
The structure of the antigenic O-polysaccharide of the lipopolysaccharide of Edwardsiella ictaluri strain MT104. Carbohydr Res (2005) 0.77
The structure of the antigenic O-polysaccharide in the lipopolysaccharide of enterohaemorrhagic Escherichia coli serotype O71:H12. Biochem Cell Biol (2010) 0.77
A new rapid and micro-scale hydrolysis, using triethylamine citrate, for lipopolysaccharide characterization by mass spectrometry. Rapid Commun Mass Spectrom (2011) 0.77
Structural elucidation of the O-antigenic polysaccharide from enterohemorrhagic (EHEC) Escherichia coli O48:H21. Carbohydr Res (2006) 0.77
Identification and differentiation of Taylorella equigenitalis and Taylorella asinigenitalis by lipopolysaccharide O-antigen serology using monoclonal antibodies. Can J Vet Res (2010) 0.77
Structure of the O-polysaccharide of the lipopolysaccharide produced by Taylorella asinigenitalis type strain (ATCC 700933). Biochem Cell Biol (2008) 0.77
Structure of the O-antigen polysaccharide present in the lipopolysaccharide of Cronobacter dublinensis (subspecies lactaridi or lausannensis) HPB 3169. Can J Microbiol (2012) 0.76
Structural characterization of the O-polysaccharide antigen of Edwardsiella tarda MT 108. Carbohydr Res (2005) 0.76
Characterization of the antigenic O-polysaccharide produced by Escherichia coli serotype O:70. Carbohydr Res (2009) 0.75
The structural characterization of the O-polysaccharide antigen of the lipopolysaccharide of Escherichiacoli serotype O118 and its relation to the O-antigens of Escherichiacoli O151 and Salmonellaenterica O47. Carbohydr Res (2010) 0.75
Structural determination of the O-antigenic polysaccharide of enteropathogenic Escherichia coli O103:H2. Can J Microbiol (2010) 0.75