Published in Front Immunol on March 13, 2017
A core gut microbiome in obese and lean twins. Nature (2008) 52.30
Pathogen recognition and innate immunity. Cell (2006) 44.14
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 37.15
Microbial ecology: human gut microbes associated with obesity. Nature (2006) 36.98
Toll-like receptor signalling. Nat Rev Immunol (2004) 34.74
Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet (1984) 32.58
Structure, function and diversity of the healthy human microbiome. Nature (2012) 30.40
The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature (1993) 27.07
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A (2007) 20.60
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol (1999) 16.86
Evolving concepts of rheumatoid arthritis. Nature (2003) 14.31
Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol (1989) 12.08
Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Gut (2005) 10.95
Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. BMJ (1991) 9.88
Gut flora in health and disease. Lancet (2003) 9.85
Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol (2005) 9.70
TLR signaling pathways. Semin Immunol (2004) 9.08
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science (1999) 8.63
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature (1999) 8.50
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87
Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem (1999) 7.81
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science (1999) 7.75
Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) J Exp Med (1999) 7.62
Innate immunity. N Engl J Med (2000) 7.03
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A (2004) 5.58
Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res (2011) 5.58
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife (2013) 5.49
A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. Gastroenterology (2010) 5.29
Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses. Nat Rev Immunol (2004) 5.13
Intracellular toll-like receptors. Immunity (2010) 4.66
Homeostasis and inflammation in the intestine. Cell (2010) 4.60
Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev (2009) 4.55
Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med (2004) 4.29
Cross-presentation by dendritic cells. Nat Rev Immunol (2012) 3.95
Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response. Nat Immunol (2006) 3.89
Identification of periodontal pathogens in atheromatous plaques. J Periodontol (2000) 3.45
Role of the microbiota in immunity and inflammation. Cell (2014) 3.43
Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives. Gut (2011) 3.36
Toward defining the autoimmune microbiome for type 1 diabetes. ISME J (2010) 3.03
The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nat Med (2015) 3.01
Molecular analysis of the gut microbiota of identical twins with Crohn's disease. ISME J (2008) 2.96
The microbiome in inflammatory bowel disease: current status and the future ahead. Gastroenterology (2014) 2.73
Cytokines in acute and chronic inflammation. Front Biosci (1997) 2.67
Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum (2010) 2.53
Structural analysis of Francisella tularensis lipopolysaccharide. Eur J Biochem (2002) 2.33
Detection of Chlamydia pneumoniae in coronary arterial fatty streaks and atheromatous plaques. S Afr Med J (1992) 2.28
Variation in lipid A structure in the pathogenic yersiniae. Mol Microbiol (2004) 2.28
Detection of Chlamydia pneumoniae in aortic lesions of atherosclerosis by immunocytochemical stain. Arterioscler Thromb (1993) 2.27
Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum (2012) 2.24
Fecal microbiota composition differs between children with β-cell autoimmunity and those without. Diabetes (2012) 2.22
Gut microbiota. Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation. Science (2015) 2.21
Relationship of periodontal disease to carotid artery intima-media wall thickness: the atherosclerosis risk in communities (ARIC) study. Arterioscler Thromb Vasc Biol (2001) 2.20
Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes. PLoS One (2011) 2.18
Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol (2003) 2.17
Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Arterioscler Thromb Vasc Biol (2005) 2.13
Microbial manipulation of receptor crosstalk in innate immunity. Nat Rev Immunol (2011) 2.01
Novel modification of lipid A of Francisella tularensis. Infect Immun (2004) 1.91
Modification of the structure and activity of lipid A in Yersinia pestis lipopolysaccharide by growth temperature. Infect Immun (2002) 1.88
Immunogenicity and toxicity of lipopolysaccharide from Francisella tularensis LVS. FEMS Microbiol Immunol (1992) 1.82
Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist. J Pharmacol Exp Ther (2003) 1.75
Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens. Immunity (2015) 1.73
Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study. BMC Med (2013) 1.71
Variegation of the immune response with dendritic cells and pathogen recognition receptors. J Immunol (2005) 1.70
Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids. Atherosclerosis (2007) 1.67
Human Toll-like receptor 4 responses to P. gingivalis are regulated by lipid A 1- and 4'-phosphatase activities. Cell Microbiol (2009) 1.66
TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules. Mol Pharmacol (2010) 1.63
Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs. Semin Immunopathol (2007) 1.54
Chlamydia pneumoniae infection accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. J Infect Dis (1999) 1.54
Perspective: alpha-bugs, their microbial partners, and the link to colon cancer. J Infect Dis (2010) 1.53
Toll like receptor 4 in atherosclerosis and plaque destabilization. Atherosclerosis (2009) 1.51
Sensing gram-negative bacterial lipopolysaccharides: a human disease determinant? Infect Immun (2007) 1.50
Structural characterization of the lipid A component of Helicobacter pylori rough- and smooth-form lipopolysaccharides. J Bacteriol (1997) 1.49
Porphyromonas gingivalis lipopolysaccharide lipid A heterogeneity: differential activities of tetra- and penta-acylated lipid A structures on E-selectin expression and TLR4 recognition. Cell Microbiol (2006) 1.48
Lipopolysaccharides from periodontopathic bacteria Porphyromonas gingivalis and Capnocytophaga ochracea are antagonists for human toll-like receptor 4. Infect Immun (2002) 1.46
Review: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways. Mol Oral Microbiol (2010) 1.44
Chapter 12: Human microbiome analysis. PLoS Comput Biol (2012) 1.44
Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling. J Immunol (2006) 1.44
Recognition of lipopolysaccharide pattern by TLR4 complexes. Exp Mol Med (2013) 1.41
Helicobacter pylori versus the host: remodeling of the bacterial outer membrane is required for survival in the gastric mucosa. PLoS Pathog (2011) 1.40
Antibodies to periodontal pathogens are associated with coronary heart disease. Arterioscler Thromb Vasc Biol (2003) 1.38
Toll-like receptor-2 mediates inflammation and matrix degradation in human atherosclerosis. Circulation (2009) 1.38
Porphyromonas gingivalis lipopolysaccharide antagonizes Escherichia coli lipopolysaccharide at toll-like receptor 4 in human endothelial cells. Infect Immun (2003) 1.34
Toll-like receptors confer responsiveness to lipopolysaccharide from Porphyromonas gingivalis in human gingival fibroblasts. Infect Immun (2000) 1.33
Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study. Gut (2012) 1.32
Antagonistic lipopolysaccharides block E. coli lipopolysaccharide function at human TLR4 via interaction with the human MD-2 lipopolysaccharide binding site. Cell Microbiol (2007) 1.29
Toll-like receptors, wound healing, and carcinogenesis. J Mol Med (Berl) (2008) 1.27
Chlamydia pneumoniae and atherosclerosis. Cell Microbiol (2004) 1.23
TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis. J Immunol (2008) 1.22
The intestinal microbiota in inflammatory bowel diseases: time to connect with the host. Curr Opin Gastroenterol (2010) 1.22
The lipid A phosphate position determines differential host Toll-like receptor 4 responses to phylogenetically related symbiotic and pathogenic bacteria. Infect Immun (2010) 1.22
Pathogen-mediated inflammatory atherosclerosis is mediated in part via Toll-like receptor 2-induced inflammatory responses. J Innate Immun (2010) 1.21
Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss. J Immunol (2012) 1.18
Differential activation of human and mouse Toll-like receptor 4 by the adjuvant candidate LpxL1 of Neisseria meningitidis. Infect Immun (2008) 1.16
Detection of Helicobacter pylori in human carotid atherosclerotic plaques. Stroke (2001) 1.16
Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production. Arthritis Rheum (2008) 1.14
TLRs and chronic inflammation. Int J Biochem Cell Biol (2009) 1.14
Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease. Digestion (2016) 1.09
Porphyromonas gingivalis oral infection exacerbates the development and severity of collagen-induced arthritis. Arthritis Res Ther (2013) 1.05
HLA molecules, bacteria and autoimmunity. J Med Microbiol (2000) 1.04