Rhodocetin antagonizes stromal tumor invasion in vitro and other alpha2beta1 integrin-mediated cell functions.

PubWeight™: 1.57‹?› | Rank: Top 4%

🔗 View Article (PMID 12475639)

Published in Matrix Biol on November 01, 2002

Authors

Johannes A Eble1, Stephan Niland, André Dennes, Alletta Schmidt-Hederich, Peter Bruckner, Georg Brunner

Author Affiliations

1: Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Waldeyerstrasse 15, 48149, Münster, Germany. eble@uni-muenster.de

Articles citing this

Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling. Hum Mol Genet (2006) 1.48

A key role for the integrin alpha2beta1 in experimental and developmental angiogenesis. Am J Pathol (2009) 1.07

Antitumoral activity of snake venom proteins: new trends in cancer therapy. Biomed Res Int (2014) 0.89

Disintegrins from snake venoms and their applications in cancer research and therapy. Curr Protein Pept Sci (2015) 0.83

Emerging putative biomarkers: the role of alpha 2 and 6 integrins in susceptibility, treatment, and prognosis. Prostate Cancer (2012) 0.83

The collagen-binding integrin α2β1 is a novel interaction partner of the Trimeresurus flavoviridis venom protein flavocetin-A. J Biol Chem (2012) 0.80

Loss of the α2β1 integrin alters human papilloma virus-induced squamous carcinoma progression in vivo and in vitro. PLoS One (2011) 0.80

Fibrotic remodeling of the extracellular matrix through a novel (engineered, dual-function) antibody reactive to a cryptic epitope on the N-terminal 30 kDa fragment of fibronectin. PLoS One (2013) 0.80

Integrin-mediated cell-matrix interaction in physiological and pathological blood vessel formation. J Oncol (2011) 0.79

Effects of Animal Venoms and Toxins on Hallmarks of Cancer. J Cancer (2016) 0.79

Plumieribetin, a fish lectin homologous to mannose-binding B-type lectins, inhibits the collagen-binding alpha1beta1 integrin. J Biol Chem (2009) 0.79

Vixapatin (VP12), a c-type lectin-protein from Vipera xantina palestinae venom: characterization as a novel anti-angiogenic compound. Toxins (Basel) (2012) 0.78

Molecular mechanical understanding of how integrins work as bi-directional communication devices between cells and surrounding extracellular matrix. Matrix Biol (2002) 0.77

A review on the Scorpaena plumieri fish venom and its bioactive compounds. J Venom Anim Toxins Incl Trop Dis (2016) 0.75

Dramatic and concerted conformational changes enable rhodocetin to block α2β1 integrin selectively. PLoS Biol (2017) 0.75

Articles by these authors

Exome sequencing-based copy-number variation and loss of heterozygosity detection: ExomeCNV. Bioinformatics (2011) 5.45

Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem (2009) 2.12

Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. Mol Cell Biol (2007) 1.70

Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction. Am J Pathol (2002) 1.52

Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures and is antagonistically regulated by endogenous transforming growth factor-beta and interleukin-1. Am J Pathol (2004) 1.39

Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma. Eur J Cancer (2002) 1.38

Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function. EMBO J (2003) 1.34

The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis. FEBS J (2007) 1.31

Collagenous transmembrane proteins: recent insights into biology and pathology. J Biol Chem (2004) 1.29

Supramolecular interactions in the dermo-epidermal junction zone: anchoring fibril-collagen VII tightly binds to banded collagen fibrils. J Biol Chem (2008) 1.26

CEACAM1 expression in cutaneous malignant melanoma predicts the development of metastatic disease. J Clin Oncol (2002) 1.21

Gab2-mediated signaling promotes melanoma metastasis. Am J Pathol (2009) 1.21

Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of alpha2beta1 integrin activity. J Biol Chem (2008) 1.20

Altered integration of matrilin-3 into cartilage extracellular matrix in the absence of collagen IX. Mol Cell Biol (2005) 1.19

The extracellular matrix of blood vessels. Curr Pharm Des (2009) 1.18

Pro-MMP-9 is a specific macrophage product and is activated by osteoarthritic chondrocytes via MMP-3 or a MT1-MMP/MMP-13 cascade. Exp Cell Res (2004) 1.14

Collagen XII interacts with avian tenascin-X through its NC3 domain. J Biol Chem (2006) 1.10

Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils. Matrix Biol (2003) 1.10

SC1/hevin. An extracellular calcium-modulated protein that binds collagen I. J Biol Chem (2003) 1.09

Type XXVII collagen at the transition of cartilage to bone during skeletogenesis. Bone (2007) 1.09

Latent TGF-beta1 activation by platelets. J Cell Physiol (2004) 1.08

The epidermal basement membrane is a composite of separate laminin- or collagen IV-containing networks connected by aggregated perlecan, but not by nidogens. J Biol Chem (2012) 1.04

Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity. J Biol Chem (2007) 1.03

A novel marker of tissue junctions, collagen XXII. J Biol Chem (2004) 1.03

Collagen IX-deficiency seriously compromises growth cartilage development in mice. Matrix Biol (2008) 0.98

GAB2 amplifications refine molecular classification of melanoma. Clin Cancer Res (2009) 0.97

Integrins as antimetastatic targets of RGD-independent snake venom components in liver metastasis [corrected]. Neoplasia (2008) 0.97

Macromolecular specificity of collagen fibrillogenesis: fibrils of collagens I and XI contain a heterotypic alloyed core and a collagen I sheath. J Biol Chem (2003) 0.96

The anchorless adhesin Eap (extracellular adherence protein) from Staphylococcus aureus selectively recognizes extracellular matrix aggregates but binds promiscuously to monomeric matrix macromolecules. Matrix Biol (2006) 0.94

Inactivation of active and latent transforming growth factor beta by free thiols: potential redox regulation of biological action. Int J Biochem Cell Biol (2006) 0.93

WARP is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan. J Biol Chem (2006) 0.92

Recombinant human laminin-5 domains. Effects of heterotrimerization, proteolytic processing, and N-glycosylation on alpha3beta1 integrin binding. J Biol Chem (2003) 0.92

Analysis of novel over- and under-sulfated glycosaminoglycan sequences by enzyme cleavage and multiple stage MS. Proteomics (2009) 0.91

Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts - role of TGFβ1 levels and RhoA activity. J Cell Sci (2010) 0.90

The developmentally regulated neural crest-associated glycotope HNK-1 predicts metastasis in cutaneous malignant melanoma. J Pathol (2004) 0.89

Aberrations of dermal connective tissue in patients with cervical artery dissection (sCAD). J Neurol (2008) 0.88

Unilateral nephrectomy leads to up-regulation of syndecan-2- and TGF-beta-mediated glomerulosclerosis in syndecan-4 deficient male mice. Matrix Biol (2007) 0.85

GPI-specific phospholipase D mRNA expression in tumor cells of different malignancy. Clin Exp Metastasis (2002) 0.85

Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains. J Biol Chem (2006) 0.85

Syndecan 4 supports bone fracture repair, but not fetal skeletal development, in mice. Arthritis Rheum (2013) 0.85

Terminal differentiation of chick embryo chondrocytes requires shedding of a cell surface protein that binds 1,25-dihydroxyvitamin D3. J Biol Chem (2007) 0.84

The early vertebrate Danio rerio Mr 46000 mannose-6-phosphate receptor: biochemical and functional characterisation. Dev Genes Evol (2005) 0.84

Vipera lebetina venom contains two disintegrins inhibiting laminin-binding beta1 integrins. J Biol Chem (2003) 0.84

The alpha2beta1 integrin-specific antagonist rhodocetin is a cruciform, heterotetrameric molecule. FASEB J (2009) 0.84

Glycoconjugate profiling of primary melanoma and its sentinel node and distant metastases: implications for diagnosis and pathophysiology of metastases. Cancer Lett (2006) 0.83

Collagen XXIII, novel ligand for integrin alpha2beta1 in the epidermis. J Biol Chem (2011) 0.83

Cerebral aneurysms: formation, progression, and developmental chronology. Transl Stroke Res (2013) 0.83

Integrin α7β1 is a redox-regulated target of hydrogen peroxide in vascular smooth muscle cell adhesion. Free Radic Biol Med (2012) 0.82

A secreted variant of cartilage oligomeric matrix protein carrying a chondrodysplasia-causing mutation (p.H587R) disrupts collagen fibrillogenesis. Arthritis Rheum (2011) 0.81

Exploring the age of intracranial aneurysms using carbon birth dating: preliminary results. Stroke (2013) 0.80

WARP interacts with collagen VI-containing microfibrils in the pericellular matrix of human chondrocytes. PLoS One (2012) 0.80

Molecular structure and interaction of recombinant human type XVI collagen. J Mol Biol (2004) 0.80

Lateral growth limitation of corneal fibrils and their lamellar stacking depend on covalent collagen cross-linking by transglutaminase-2 and lysyl oxidases, respectively. J Biol Chem (2013) 0.80

Plumieribetin, a fish lectin homologous to mannose-binding B-type lectins, inhibits the collagen-binding alpha1beta1 integrin. J Biol Chem (2009) 0.79

Cyclic mechanical stress downregulates endothelin-1 and its responsive genes independently of TGFβ1 in dermal fibroblasts. Exp Dermatol (2012) 0.78

Impact of thrombolysis on stroke outcome at 12 months in a population: the Bern stroke project. Stroke (2012) 0.78

Cyclic mechanical strain induces TGFβ1-signalling in dermal fibroblasts embedded in a 3D collagen lattice. Arch Dermatol Res (2014) 0.77

Collagen IX is indispensable for timely maturation of cartilage during fracture repair in mice. Matrix Biol (2006) 0.77

Chloroplast fructose 1,6-bisphosphatase with changed redox modulation: comparison of the Galdieria enzyme with cysteine mutants from spinach. Biochim Biophys Acta (2003) 0.77

Theme issue: Wound healing mechanisms. Thromb Haemost (2003) 0.76

The integrin beta1 subunit cytoplasmic tail forms oligomers: a potential role in beta1 integrin clustering. Biol Cell (2002) 0.76

Increased level of circulating U2 small nuclear RNA fragments indicates metastasis in melanoma patients. Clin Chem Lab Med (2015) 0.75

A melanoma subtype: uveal melanoma. J Am Acad Dermatol (2011) 0.75

Correction: Dramatic and concerted conformational changes enable rhodocetin to block α2β1 integrin selectively. PLoS Biol (2017) 0.75

Transcriptional dissection of melanoma identifies a high-risk subtype underlying TP53 family genes and epigenome deregulation. JCI Insight (2017) 0.75

Dr. Jekyll and Mr. Hyde: the many faces of wound healing regulators. Thromb Haemost (2004) 0.75