Published in Bioorg Med Chem Lett on January 20, 2003
TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature (2008) 8.40
Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1. J Neurophysiol (2008) 2.99
TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase. J Neurosci (2007) 2.69
Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila. J Neurosci (2004) 2.66
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci (2012) 2.28
Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia. Proc Natl Acad Sci U S A (2002) 1.94
Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding. J Biol Chem (2003) 1.68
Dynamic modulation of ANO1/TMEM16A HCO3(-) permeability by Ca2+/calmodulin. Proc Natl Acad Sci U S A (2012) 1.63
Peripheral mechanisms of pain and analgesia. Brain Res Rev (2008) 1.55
A tarantula spider toxin, GsMTx4, reduces mechanical and neuropathic pain. Pain (2008) 1.52
Mechanosensitive ion channels in cultured sensory neurons of neonatal rats. J Neurosci (2002) 1.44
Histamine-induced itch and its relationship with pain. Mol Pain (2008) 1.34
Histamine-induced Ca(2+) influx via the PLA(2)/lipoxygenase/TRPV1 pathway in rat sensory neurons. Neurosci Lett (2004) 1.33
Cartoon distraction alleviates anxiety in children during induction of anesthesia. Anesth Analg (2012) 1.28
Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction. Circ Res (2004) 1.24
A novel mechanosensitive channel identified in sensory neurons. Eur J Neurosci (2006) 1.23
Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha. J Biol Chem (2001) 1.21
Minimally invasive management of ureteral injuries recognized late after obstetric and gynaecologic surgery. Injury (2003) 1.19
Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons. Eur J Neurosci (2007) 1.16
Agonist recognition sites in the cytosolic tails of vanilloid receptor 1. J Biol Chem (2002) 1.14
Distribution of serum prostate-specific antigen in healthy Korean men: influence of ethnicity. Urology (2002) 1.09
Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice. Neurobiol Aging (2003) 1.08
A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion. PLoS Pathog (2013) 1.05
Conformationally constrained analogues of diacylglycerol. 24. Asymmetric synthesis of a chiral (R)-DAG-lactone template as a versatile precursor for highly functionalized DAG-lactones. Org Lett (2004) 1.05
Calcium-dependent and independent mechanisms of capsaicin receptor (TRPV1)-mediated cytokine production and cell death in human bronchial epithelial cells. J Biochem Mol Toxicol (2005) 1.05
2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: structure activity relationships of the 2-oxy pyridine C-region. Eur J Med Chem (2013) 1.05
Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities. J Med Chem (2008) 1.04
TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation. EMBO J (2006) 1.03
Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents. J Med Chem (2005) 1.02
Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1. Life Sci (2005) 1.01
TRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery. J Dermatol Sci (2010) 1.01
High affinity antagonists of the vanilloid receptor. Mol Pharmacol (2002) 1.00
N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor. J Med Chem (2003) 0.99
Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies. J Comput Aided Mol Des (2011) 0.99
Transient receptor potential vanilloid subtype 1 mediates microglial cell death in vivo and in vitro via Ca2+-mediated mitochondrial damage and cytochrome c release. J Immunol (2006) 0.98
Activation and activators of TRPV1 and their pharmaceutical implication. Curr Pharm Des (2005) 0.98
Painful channels in sensory neurons. Mol Cells (2005) 0.98
Midazolam anesthesia during rigid and flexible cystoscopy. Urol Res (2007) 0.98
Inhibition of mouse skin tumor promotion by anti-inflammatory diarylheptanoids derived from Alpinia oxyphylla Miquel (Zingiberaceae). Oncol Res (2002) 0.97
Quantitative analysis of TRP channel genes in mouse organs. Arch Pharm Res (2012) 0.97
Intracellular amyloid-β accumulation in calcium-binding protein-deficient neurons leads to amyloid-β plaque formation in animal model of Alzheimer's disease. J Alzheimers Dis (2012) 0.97
Lipoxygenase inhibitors suppressed carrageenan-induced Fos-expression and inflammatory pain responses in the rat. Mol Cells (2009) 0.96
TRPV1 recapitulates native capsaicin receptor in sensory neurons in association with Fas-associated factor 1. J Neurosci (2006) 0.95
Sensitization of vanilloid receptor involves an increase in the phosphorylated form of the channel. Arch Pharm Res (2005) 0.94
TRPM4b channel suppresses store-operated Ca2+ entry by a novel protein-protein interaction with the TRPC3 channel. Biochem Biophys Res Commun (2008) 0.93
Arthroscopic excision of dorsal wrist ganglion: factors related to recurrence and postoperative residual pain. Arthroscopy (2013) 0.92
Transient receptor potential vanilloid-1 (TRPV1) is a mediator of lung toxicity for coal fly ash particulate material. Mol Pharmacol (2011) 0.92
Highly efficient hybrid light-emitting device using complex of CdSe/ZnS quantum dots embedded in co-polymer as an active layer. Opt Express (2010) 0.92
High-affinity partial agonists of the vanilloid receptor. Mol Pharmacol (2003) 0.91
Stereospecific high-affinity TRPV1 antagonists: chiral N-(2-benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues. J Med Chem (2007) 0.91
Hot channels in airways: pharmacology of the vanilloid receptor. Curr Opin Pharmacol (2002) 0.91
Kinetics of penetration influence the apparent potency of vanilloids on TRPV1. Mol Pharmacol (2006) 0.89
Synthesis and evaluation of fluorine-substituted 1H-pyrrolo[2,3-b]pyridine derivatives for dopamine D4 receptor imaging. Bioorg Med Chem (2004) 0.89
Phytosphingosine stimulates the differentiation of human keratinocytes and inhibits TPA-induced inflammatory epidermal hyperplasia in hairless mouse skin. Mol Med (2006) 0.88
Structure-activity relationship of capsaicin analogs and transient receptor potential vanilloid 1-mediated human lung epithelial cell toxicity. J Pharmacol Exp Ther (2011) 0.88
TRPM2 mediates the lysophosphatidic acid-induced neurite retraction in the developing brain. Pflugers Arch (2014) 0.88
Axonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth. J Biol Chem (2011) 0.87
Endogenous lipid-derived ligands for sensory TRP ion channels and their pain modulation. Arch Pharm Res (2010) 0.87
2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. Eur J Med Chem (2008) 0.87
Comparison of long-term results according to the primary mode of management and type of injury for posterior urethral injuries. Urol Int (2002) 0.87
Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.86
Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain. J Med Chem (2003) 0.86
Calcium-activated cationic channel in rat sensory neurons. Eur J Neurosci (2003) 0.86
Ablation of Ca2+ channel beta3 subunit leads to enhanced N-methyl-D-aspartate receptor-dependent long term potentiation and improved long term memory. J Biol Chem (2008) 0.86
Alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists. Bioorg Med Chem (2007) 0.85
Characterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytes. J Biol Chem (2012) 0.85
Hypoxia-mediated retinal neovascularization and vascular leakage in diabetic retina is suppressed by HIF-1α destabilization by SH-1242 and SH-1280, novel hsp90 inhibitors. J Mol Med (Berl) (2014) 0.85
Essential role of mitochondrial permeability transition in vanilloid receptor 1-dependent cell death of sensory neurons. Mol Cell Neurosci (2003) 0.84
Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina. PLoS One (2013) 0.84
Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury. Am J Physiol Lung Cell Mol Physiol (2011) 0.84
TRPM8 mediates cold and menthol allergies associated with mast cell activation. Cell Calcium (2010) 0.84
Phosphoiodyns A and B, unique phosphorus-containing iodinated polyacetylenes from a Korean sponge Placospongia sp. Org Lett (2012) 0.83
Highly enantioselective epoxidation of 2,4-diarylenones by using dimeric cinchona phase-transfer catalysts: enhancement of enantioselectivity by surfactants. Angew Chem Int Ed Engl (2005) 0.83
Thimerosal decreases TRPV1 activity by oxidation of extracellular sulfhydryl residues. Neurosci Lett (2004) 0.83
Mutation of Drosophila focal adhesion kinase induces bang-sensitive behavior and disrupts glial function, axonal conduction and synaptic transmission. Eur J Neurosci (2008) 0.83
Overexpression, crystallization and preliminary X-ray crystallographic analysis of the C-terminal cytosolic domain of mouse anoctamin 1. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.83
Emphysematous pyelonephritis recovered by ureteral stenting in a functionally solitary kidney. Urol Int (2002) 0.83
New polyunsaturated fatty acid amides isolated from the seeds of Zanthoxylum piperitum. Arch Pharm Res (2008) 0.82
20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginseng, inhibits colon cancer growth by targeting TRPC channel-mediated calcium influx. J Nutr Biochem (2013) 0.82
Ghrelin receptor is activated by naringin and naringenin, constituents of a prokinetic agent Poncirus fructus. J Ethnopharmacol (2013) 0.82
In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives. J Med Chem (2004) 0.81
Oncostatin M induces growth arrest of skeletal muscle cells in G1 phase by regulating cyclin D1 protein level. Cell Signal (2007) 0.81
TRPV1 activation is not an all-or-none event: TRPV1 partial agonism/antagonism and its regulatory modulation. Curr Top Med Chem (2011) 0.81
Ligand-based design, synthesis, and biological evaluation of 2-aminopyrimidines, a novel series of receptor for advanced glycation end products (RAGE) inhibitors. J Med Chem (2012) 0.81
Na(+)/Ca(2+) exchanger 2 is neuroprotective by exporting Ca(2+) during a transient focal cerebral ischemia in the mouse. Cell Calcium (2007) 0.81
A prodrug approach to COX-2 inhibitors with methylsulfone. Bioorg Med Chem Lett (2004) 0.81
N-4-t-Butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the A-region. Bioorg Med Chem (2011) 0.81
Pharmacophore-based virtual screening: the discovery of novel methionyl-tRNA synthetase inhibitors. Bioorg Med Chem Lett (2006) 0.81
Aminopropyl carbazole analogues as potent enhancers of neurogenesis. Bioorg Med Chem (2013) 0.81
Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics. Bioorg Med Chem (2002) 0.81
Non-vanillyl resiniferatoxin analogues as potent and metabolically stable transient receptor potential vanilloid 1 agonists. Bioorg Med Chem (2008) 0.81
Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template. Bioorg Med Chem (2013) 0.81
3D-QSAR analysis of conformationally constrained diacylglycerol (DAG) analogues as potent protein kinase C (PK-C) ligands. Bioorg Med Chem (2004) 0.80
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Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects. Bioorg Med Chem Lett (2003) 0.80
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