Published in J Mol Biol on January 10, 2003
Phi-value analysis and the nature of protein-folding transition states. Proc Natl Acad Sci U S A (2004) 2.53
Protein folding thermodynamics and dynamics: where physics, chemistry, and biology meet. Chem Rev (2006) 2.48
Folding versus aggregation: polypeptide conformations on competing pathways. Arch Biochem Biophys (2007) 1.97
Systematically perturbed folding patterns of amyotrophic lateral sclerosis (ALS)-associated SOD1 mutants. Proc Natl Acad Sci U S A (2005) 1.94
Folding of human superoxide dismutase: disulfide reduction prevents dimerization and produces marginally stable monomers. Proc Natl Acad Sci U S A (2004) 1.89
Full distance-resolved folding energy landscape of one single protein molecule. Proc Natl Acad Sci U S A (2010) 1.85
The leucine-rich repeat domain of Internalin B folds along a polarized N-terminal pathway. Structure (2008) 1.63
Experimental evidence for a frustrated energy landscape in a three-helix-bundle protein family. Nature (2010) 1.61
Intermediates: ubiquitous species on folding energy landscapes? Curr Opin Struct Biol (2007) 1.60
Repeat-protein folding: new insights into origins of cooperativity, stability, and topology. Arch Biochem Biophys (2007) 1.51
Early events in protein folding explored by rapid mixing methods. Chem Rev (2006) 1.50
An unlocking/relocking barrier in conformational fluctuations of villin headpiece subdomain. Proc Natl Acad Sci U S A (2010) 1.47
The folding of single domain proteins--have we reached a consensus? Curr Opin Struct Biol (2010) 1.42
Complex energy landscape of a giant repeat protein. Structure (2013) 1.41
Rational redesign of the folding pathway of a modular protein. Proc Natl Acad Sci U S A (2007) 1.37
Determination of an ensemble of structures representing the intermediate state of the bacterial immunity protein Im7. Proc Natl Acad Sci U S A (2005) 1.31
Free-energy landscapes of ion-channel gating are malleable: changes in the number of bound ligands are accompanied by changes in the location of the transition state in acetylcholine-receptor channels. Biochemistry (2003) 1.29
Enhancing the stability and folding rate of a repeat protein through the addition of consensus repeats. J Mol Biol (2006) 1.28
Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation. Proc Natl Acad Sci U S A (2004) 1.21
Exploring subdomain cooperativity in T4 lysozyme II: uncovering the C-terminal subdomain as a hidden intermediate in the kinetic folding pathway. Protein Sci (2007) 1.21
NMR analysis of the conformational properties of the trapped on-pathway folding intermediate of the bacterial immunity protein Im7. J Mol Biol (2006) 1.17
Spectrin R16: broad energy barrier or sequential transition states? Protein Sci (2005) 1.16
Localizing internal friction along the reaction coordinate of protein folding by combining ensemble and single-molecule fluorescence spectroscopy. Nat Commun (2012) 1.13
Intermediates and the folding of proteins L and G. Protein Sci (2004) 1.13
Subdomain competition, cooperativity, and topological frustration in the folding of CheY. J Mol Biol (2008) 1.10
Scattered Hammond plots reveal second level of site-specific information in protein folding: phi' (beta++). Proc Natl Acad Sci U S A (2004) 1.10
A unified mechanism for protein folding: predetermined pathways with optional errors. Protein Sci (2007) 1.09
Early intermediate in human prion protein folding as evidenced by ultrarapid mixing experiments. J Am Chem Soc (2006) 1.09
A PDZ domain recapitulates a unifying mechanism for protein folding. Proc Natl Acad Sci U S A (2006) 1.06
Frustration in biomolecules. Q Rev Biophys (2014) 1.05
Dissecting the mechanical unfolding of ubiquitin. Proc Natl Acad Sci U S A (2005) 1.02
Folding of a LysM domain: entropy-enthalpy compensation in the transition state of an ideal two-state folder. J Mol Biol (2008) 1.00
Plasticity within the obligatory folding nucleus of an immunoglobulin-like domain. J Mol Biol (2007) 0.99
Exploring the folding energy landscape of a series of designed consensus tetratricopeptide repeat proteins. Proc Natl Acad Sci U S A (2009) 0.98
Apparent cooperativity in the folding of multidomain proteins depends on the relative rates of folding of the constituent domains. Proc Natl Acad Sci U S A (2006) 0.97
An intramolecular chaperone inserted in bacteriophage P22 coat protein mediates its chaperonin-independent folding. J Biol Chem (2013) 0.95
Thermodynamics, kinetics, and salt dependence of folding of YopM, a large leucine-rich repeat protein. J Mol Biol (2008) 0.95
The experimental folding landscape of monomeric lactose repressor, a large two-domain protein, involves two kinetic intermediates. Proc Natl Acad Sci U S A (2005) 0.95
The denatured state dictates the topology of two proteins with almost identical sequence but different native structure and function. J Biol Chem (2010) 0.95
GB1 is not a two-state folder: identification and characterization of an on-pathway intermediate. Biophys J (2011) 0.95
Hydration of the folding transition state ensemble of a protein. Biochemistry (2006) 0.93
Separating the effects of internal friction and transition state energy to explain the slow, frustrated folding of spectrin domains. Proc Natl Acad Sci U S A (2012) 0.92
Multiple folding pathways of the SH3 domain. Biophys J (2004) 0.91
What have we learned from the studies of two-state folders, and what are the unanswered questions about two-state protein folding? Phys Biol (2009) 0.91
Discrete kinetic models from funneled energy landscape simulations. PLoS One (2012) 0.91
Chevron behavior and isostable enthalpic barriers in protein folding: successes and limitations of simple Gō-like modeling. Biophys J (2005) 0.90
Efficient maximum likelihood parameterization of continuous-time Markov processes. J Chem Phys (2015) 0.90
Folding kinetics of the cooperatively folded subdomain of the IκBα ankyrin repeat domain. J Mol Biol (2011) 0.90
A simple model predicts experimental folding rates and a hub-like topology. J Phys Chem B (2012) 0.90
The inverted chevron plot measured by NMR relaxation reveals a native-like unfolding intermediate in acyl-CoA binding protein. Proc Natl Acad Sci U S A (2006) 0.90
T-jump infrared study of the folding mechanism of coiled-coil GCN4-p1. Biophys J (2005) 0.90
Molecular dynamics simulations of the native and partially folded states of ubiquitin: influence of methanol cosolvent, pH, and temperature on the protein structure and dynamics. Protein Sci (2007) 0.89
The plastic energy landscape of protein folding: a triangular folding mechanism with an equilibrium intermediate for a small protein domain. J Biol Chem (2010) 0.89
Correspondence between anomalous m- and DeltaCp-values in protein folding. Protein Sci (2004) 0.89
Structural insights into an equilibrium folding intermediate of an archaeal ankyrin repeat protein. Proc Natl Acad Sci U S A (2008) 0.89
The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity. Proc Natl Acad Sci U S A (2008) 0.88
Microsecond folding dynamics of apomyoglobin at acidic pH. J Phys Chem B (2012) 0.87
Hydrogen-exchange stability analysis of Bergerac-Src homology 3 variants allows the characterization of a folding intermediate in equilibrium. Proc Natl Acad Sci U S A (2003) 0.87
Protein folding in high-dimensional spaces: hypergutters and the role of nonnative interactions. Biophys J (2004) 0.87
Topology is the principal determinant in the folding of a complex all-alpha Greek key death domain from human FADD. J Mol Biol (2009) 0.86
Highly polarized C-terminal transition state of the leucine-rich repeat domain of PP32 is governed by local stability. Proc Natl Acad Sci U S A (2015) 0.85
Probing the folding intermediate of Bacillus subtilis RNase P protein by nuclear magnetic resonance. Biochemistry (2010) 0.84
Crosstalk between the protein surface and hydrophobic core in a core-swapped fibronectin type III domain. J Mol Biol (2007) 0.84
Apo-azurin folds via an intermediate that resembles the molten-globule. Protein Sci (2004) 0.84
Solvation of the folding-transition state in Pseudomonas aeruginosa azurin is modulated by metal: Solvation of azurin's folding nucleus. Protein Sci (2006) 0.83
Capture of monomeric refolding intermediate of human muscle creatine kinase. Protein Sci (2006) 0.83
The role of high-dimensional diffusive search, stabilization, and frustration in protein folding. Biophys J (2014) 0.82
Microsecond unfolding kinetics of sheep prion protein reveals an intermediate that correlates with susceptibility to classical scrapie. Biophys J (2011) 0.82
The folding pathway of a single domain in a multidomain protein is not affected by its neighbouring domain. J Mol Biol (2008) 0.81
Probing the folding intermediate of Rd-apocyt b562 by protein engineering and infrared T-jump. Protein Sci (2007) 0.81
Folding mechanism of reduced Cytochrome c: equilibrium and kinetic properties in the presence of carbon monoxide. J Mol Biol (2008) 0.81
Protein folding transition states probed by loop extension. Protein Sci (2008) 0.80
Visualizing transient protein-folding intermediates by tryptophan-scanning mutagenesis. Nat Struct Mol Biol (2012) 0.80
Mechanisms of protein folding. Eur Biophys J (2008) 0.80
Rational design of protein stability: effect of (2S,4R)-4-fluoroproline on the stability and folding pathway of ubiquitin. PLoS One (2011) 0.79
Protein Folding Mechanism of the Dimeric AmphiphysinII/Bin1 N-BAR Domain. PLoS One (2015) 0.77
Complex kinetics and residual structure in the thermal unfolding of yeast triosephosphate isomerase. BMC Biochem (2015) 0.76
Protein folding of the SAP domain, a naturally occurring two-helix bundle. FEBS Lett (2015) 0.75
Evidence for a Shared Mechanism in the Formation of Urea-Induced Kinetic and Equilibrium Intermediates of Horse Apomyoglobin from Ultrarapid Mixing Experiments. PLoS One (2015) 0.75
Human Frataxin Folds Via an Intermediate State. Role of the C-Terminal Region. Sci Rep (2016) 0.75
Perplexing cooperative folding and stability of a low-sequence complexity, polyproline 2 protein lacking a hydrophobic core. Proc Natl Acad Sci U S A (2017) 0.75
Unveiling the folding mechanism of the Bromodomains. Biochem Biophys Rep (2017) 0.75
Dynamics of unfolded polypeptide chains as model for the earliest steps in protein folding. J Mol Biol (2003) 2.56
End-to-end distance distributions and intrachain diffusion constants in unfolded polypeptide chains indicate intramolecular hydrogen bond formation. Proc Natl Acad Sci U S A (2006) 2.23
Hammond behavior versus ground state effects in protein folding: evidence for narrow free energy barriers and residual structure in unfolded states. J Mol Biol (2003) 1.76
Origin of unusual phi-values in protein folding: evidence against specific nucleation sites. J Mol Biol (2003) 1.75
Effect of proline and glycine residues on dynamics and barriers of loop formation in polypeptide chains. J Am Chem Soc (2005) 1.60
Molecular basis for the effect of urea and guanidinium chloride on the dynamics of unfolded polypeptide chains. J Mol Biol (2005) 1.55
An unlocking/relocking barrier in conformational fluctuations of villin headpiece subdomain. Proc Natl Acad Sci U S A (2010) 1.47
Mapping backbone and side-chain interactions in the transition state of a coupled protein folding and binding reaction. Proc Natl Acad Sci U S A (2011) 1.26
Very fast folding and association of a trimerization domain from bacteriophage T4 fibritin. J Mol Biol (2004) 1.18
End-to-end vs interior loop formation kinetics in unfolded polypeptide chains. J Am Chem Soc (2007) 1.18
Local conformational dynamics in alpha-helices measured by fast triplet transfer. Proc Natl Acad Sci U S A (2009) 1.17
Effect of thioxopeptide bonds on alpha-helix structure and stability. J Am Chem Soc (2008) 1.01
Collagen triple-helix formation in all-trans chains proceeds by a nucleation/growth mechanism with a purely entropic barrier. Proc Natl Acad Sci U S A (2005) 0.97
A nearly isosteric photosensitive amide-backbone substitution allows enzyme activity switching in ribonuclease s. J Am Chem Soc (2007) 0.96
Non-linear rate-equilibrium free energy relationships and Hammond behavior in protein folding. Biophys Chem (2003) 0.96
Loop formation in unfolded polypeptide chains on the picoseconds to microseconds time scale. Proc Natl Acad Sci U S A (2007) 0.95
Interpretation of protein folding psi values. J Mol Biol (2005) 0.92
Fast folding of the two-domain semliki forest virus capsid protein explains co-translational proteolytic activity. J Mol Biol (2004) 0.85
Test for cooperativity in the early kinetic intermediate in lysozyme folding. Biophys Chem (2002) 0.85
NMR structure of a monomeric intermediate on the evolutionarily optimized assembly pathway of a small trimerization domain. J Mol Biol (2009) 0.83
Shape of the free energy barriers for protein folding probed by multiple perturbation analysis. J Mol Biol (2006) 0.82
Testing the diffusing boundary model for the helix-coil transition in peptides. Proc Natl Acad Sci U S A (2013) 0.81
Kinetic mechanism and catalysis of a native-state prolyl isomerization reaction. J Mol Biol (2003) 0.81
Transition state and ground state properties of the helix-coil transition in peptides deduced from high-pressure studies. Proc Natl Acad Sci U S A (2013) 0.81
Conserved folding pathways of alpha-lactalbumin and lysozyme revealed by kinetic CD, fluorescence, NMR, and interrupted refolding experiments. J Mol Biol (2008) 0.80
Following the energy transfer in and out of a polyproline-peptide. Biopolymers (2013) 0.75
Using triplet-triplet energy transfer to measure conformational dynamics in polypeptide chains. Methods Mol Biol (2007) 0.75