Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization.

A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nat Med (2008) 3.98

The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology. Br J Pharmacol (2004) 2.70

Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. Proc Natl Acad Sci U S A (2005) 2.53

Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. Proc Natl Acad Sci U S A (2005) 2.48

G-protein signaling: back to the future. Cell Mol Life Sci (2005) 2.38

Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets. CNS Neurol Disord Drug Targets (2006) 1.97

Kinase cascades and ligand-directed signaling at the kappa opioid receptor. Psychopharmacology (Berl) (2010) 1.90

Identification of a novel extracellular cation-sensing G-protein-coupled receptor. J Biol Chem (2005) 1.86

Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. Dev Cell (2009) 1.83

Role of CRF receptor signaling in stress vulnerability, anxiety, and depression. Ann N Y Acad Sci (2009) 1.59

Clinical and genetic modifiers of long-term survival in heart failure. J Am Coll Cardiol (2009) 1.42

G-protein-coupled receptors: past, present and future. Br J Pharmacol (2006) 1.41

Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. EMBO J (2006) 1.39

The regulator of G-protein signaling proteins involved in sugar and abscisic acid signaling in Arabidopsis seed germination. Plant Physiol (2005) 1.31

When 7 transmembrane receptors are not G protein-coupled receptors. J Clin Invest (2005) 1.24

Endocytosis of the seven-transmembrane RGS1 protein activates G-protein-coupled signalling in Arabidopsis. Nat Cell Biol (2012) 1.18

Fluorogen-activating proteins as biosensors of cell-surface proteins in living cells. Cytometry A (2010) 1.17

Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2. J Biol Chem (2008) 1.14

Olfactory receptor surface expression is driven by association with the beta2-adrenergic receptor. Proc Natl Acad Sci U S A (2004) 1.14

G protein coupled receptor kinases as therapeutic targets in cardiovascular disease. Circ Res (2011) 1.14

Carboxyl-terminal and intracellular loop sites for CRF1 receptor phosphorylation and beta-arrestin-2 recruitment: a mechanism regulating stress and anxiety responses. Am J Physiol Regul Integr Comp Physiol (2007) 1.12

The role of phosphorylation in D1 dopamine receptor desensitization: evidence for a novel mechanism of arrestin association. J Biol Chem (2003) 1.12

Lysophosphatidylcholine-induced surface redistribution regulates signaling of the murine G protein-coupled receptor G2A. Mol Biol Cell (2005) 1.10

GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation. EMBO J (2004) 1.10

Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation. Am J Physiol Endocrinol Metab (2010) 1.09

Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3. Proc Natl Acad Sci U S A (2003) 1.08

Roles of GRK and PDE4 activities in the regulation of beta2 adrenergic signaling. J Gen Physiol (2008) 1.08

Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylation. Biochemistry (2009) 1.05

Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure. Environ Health Perspect (2004) 1.04

Herkinorin analogues with differential beta-arrestin-2 interactions. J Med Chem (2008) 1.03

The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Proc Natl Acad Sci U S A (2007) 1.03

The information highways of a biotechnological workhorse--signal transduction in Hypocrea jecorina. BMC Genomics (2008) 1.03

Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo. J Clin Invest (2014) 1.03

Cardiac hypertrophy in neonatal nephrectomized rats: the role of the sympathetic nervous system. Pediatr Nephrol (2008) 1.03

The succinate receptor as a novel therapeutic target for oxidative and metabolic stress-related conditions. Front Endocrinol (Lausanne) (2012) 1.01

EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation. Mol Biol Cell (2008) 1.01

Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development. Proc Natl Acad Sci U S A (2009) 1.01

Therapeutic potential for novel drugs targeting the type 1 cholecystokinin receptor. Br J Pharmacol (2009) 0.99

Zinc released from injured cells is acting via the Zn2+-sensing receptor, ZnR, to trigger signaling leading to epithelial repair. J Biol Chem (2010) 0.98

Kinetic diversity in G-protein-coupled receptor signalling. Biochem J (2007) 0.96

Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). Clin Immunol (2008) 0.96

Neural Mechanisms and Information Processing in Recognition Systems. Insects (2014) 0.95

Requirements for recruitment of a G protein-coupled receptor to clathrin-coated pits in budding yeast. Mol Biol Cell (2009) 0.94

Gravin orchestrates protein kinase A and β2-adrenergic receptor signaling critical for synaptic plasticity and memory. J Neurosci (2012) 0.94

Differential temporal and spatial regulation of somatostatin receptor phosphorylation and dephosphorylation. J Biol Chem (2011) 0.93

Metabotropic P2Y receptors inhibit P2X3 receptor-channels via G protein-dependent facilitation of their desensitization. Br J Pharmacol (2007) 0.93

G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei--serpentine gateways to neuroendocrine homeostasis. Front Neuroendocrinol (2011) 0.92

Influence of agonist intrinsic activity on the desensitisation of beta2-adrenoceptor-mediated responses in mast cells. Br J Pharmacol (2004) 0.92

Adrenergic-pathway gene variants influence beta-blocker-related outcomes after acute coronary syndrome in a race-specific manner. J Am Coll Cardiol (2012) 0.92

Sex-biased stress signaling: the corticotropin-releasing factor receptor as a model. Mol Pharmacol (2012) 0.91

The long-acting beta-adrenoceptor agonist, indacaterol, inhibits IgE-dependent responses of human lung mast cells. Br J Pharmacol (2009) 0.91

Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes. Biochem J (2006) 0.91

GRK5 promotes F-actin bundling and targets bundles to membrane structures to control neuronal morphogenesis. J Cell Biol (2011) 0.90

Rhodopsin kinase activity modulates the amplitude of the visual response in Drosophila. Proc Natl Acad Sci U S A (2004) 0.90

Emerging concepts and approaches for chemokine-receptor drug discovery. Expert Opin Drug Discov (2010) 0.89

Unconventional homologous internalization of the angiotensin II type-1 receptor induced by G-protein-independent signals. Hypertension (2005) 0.89

Quantitative modeling of GRK-mediated beta2AR regulation. PLoS Comput Biol (2010) 0.88

GRK2 protein-mediated transphosphorylation contributes to loss of function of μ-opioid receptors induced by neuropeptide FF (NPFF2) receptors. J Biol Chem (2012) 0.88

Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalization. J Biol Chem (2009) 0.88

Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation. Mol Pharmacol (2010) 0.87

Region-specific roles of the corticotropin-releasing factor-urocortin system in stress. Nat Rev Neurosci (2016) 0.85

Extra-long Gαs variant XLαs protein escapes activation-induced subcellular redistribution and is able to provide sustained signaling. J Biol Chem (2011) 0.85

Mechanisms of homologous and heterologous phosphorylation of FFA receptor 4 (GPR120): GRK6 and PKC mediate phosphorylation of Thr³⁴⁷, Ser³⁵⁰, and Ser³⁵⁷ in the C-terminal tail. Biochem Pharmacol (2014) 0.85

Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2). Mol Endocrinol (2009) 0.85

Differential development of tolerance to the functional and behavioral effects of repeated baclofen treatment in rats. Pharmacol Biochem Behav (2013) 0.84

Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis. Nat Commun (2014) 0.84

GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization. J Biol Chem (2009) 0.84

Role of nuclear factor kappa B (NF-kappaB) in oxidative stress-induced defective dopamine D1 receptor signaling in the renal proximal tubules of Sprague-Dawley rats. Free Radic Biol Med (2006) 0.84

Pharmacogenetics in chronic heart failure: new developments and current challenges. Curr Heart Fail Rep (2012) 0.84

Identification of serine 348 on the apelin receptor as a novel regulatory phosphorylation site in apelin-13-induced G protein-independent biased signaling. J Biol Chem (2014) 0.84

GRK5 deficiency exaggerates inflammatory changes in TgAPPsw mice. J Neuroinflammation (2008) 0.84

Effect of CCR5 receptor antagonists on endocytosis of the human CCR5 receptor in CHO-K1 cells. Br J Pharmacol (2008) 0.83

De novo transcriptomes of olfactory epithelium reveal the genes and pathways for spawning migration in japanese grenadier anchovy (Coilia nasus). PLoS One (2014) 0.82

Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. PLoS One (2012) 0.82

Omega-3 Fatty Acids and FFAR4. Front Endocrinol (Lausanne) (2014) 0.82

The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels. J Biol Chem (2015) 0.81

Searching for transcriptional regulators of Ang II-induced vascular pathology. J Clin Invest (2005) 0.81

GRK5 deficiency accelerates {beta}-amyloid accumulation in Tg2576 mice via impaired cholinergic activity. J Biol Chem (2010) 0.80

G protein-coupled estrogen receptor-1 is involved in the protective effect of protocatechuic aldehyde against endothelial dysfunction. PLoS One (2014) 0.80

Proctolin in the post-genomic era: new insights and challenges. Invert Neurosci (2004) 0.79

Mapping the putative G protein-coupled receptor (GPCR) docking site on GPCR kinase 2: insights from intact cell phosphorylation and recruitment assays. J Biol Chem (2014) 0.79

G protein-coupled receptors and adipogenesis: a focus on adenosine receptors. J Cell Physiol (2014) 0.78

Desensitization of human CRF2(a) receptor signaling governed by agonist potency and βarrestin2 recruitment. Regul Pept (2013) 0.78

Structure-activity relationships of fatty acid amide ligands in activating and desensitizing G protein-coupled receptor 119. Eur J Pharmacol (2013) 0.78

Structural and functional interactions between six-transmembrane μ-opioid receptors and β2-adrenoreceptors modulate opioid signaling. Sci Rep (2015) 0.78

GRK-6 mediates FSH action synergistically enhanced by estrogen and the oocyte in rat granulosa cells. Biochem Biophys Res Commun (2013) 0.78

α1 -Adrenoceptor activation of PKC-ε causes heterologous desensitization of thromboxane receptors in the aorta of spontaneously hypertensive rats. Br J Pharmacol (2015) 0.77

Effects of GRK5 and ADRB1 polymorphisms influence on systolic heart failure. J Transl Med (2015) 0.77

Cerebral artery signal transduction mechanisms: developmental changes in dynamics and Ca2+ sensitivity. Curr Vasc Pharmacol (2013) 0.77

Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells. PLoS One (2013) 0.77

Downregulation of propranolol-sensitive beta-adrenoceptor signaling after inhibition of nitric oxide synthesis. Br J Pharmacol (2006) 0.77

Evidence for the role of corticotropin-releasing factor in major depressive disorder. Neurosci Biobehav Rev (2015) 0.77

The Camerino symposium series (1978-2013): a privileged observatory of receptorology development. In Silico Pharmacol (2013) 0.77

Emerging clinical applications in cardiovascular pharmacogenomics. Wiley Interdiscip Rev Syst Biol Med (2010) 0.77

GRK5 Deficiency Leads to Selective Basal Forebrain Cholinergic Neuronal Vulnerability. Sci Rep (2016) 0.77

Neurotransmitter signaling through heterotrimeric G proteins: insights from studies in C. elegans. WormBook (2016) 0.76

Chronic baclofen desensitizes GABAB-mediated G-protein activation and stimulates phosphorylation of kinases in mesocorticolimbic rat brain. Neuropharmacology (2015) 0.75

Osteogenesis Is Improved by Low Tumor Necrosis Factor Alpha Concentration through the Modulation of Gs-Coupled Receptor Signals. Mol Cell Biol (2017) 0.75

Maintenance of homeostasis in the aging hypothalamus: the central and peripheral roles of succinate. Front Endocrinol (Lausanne) (2015) 0.75

G Protein-coupled Receptor Biased Agonism. J Cardiovasc Pharmacol (2016) 0.75

Seven-transmembrane receptors. Nat Rev Mol Cell Biol (2002) 11.50

Beta-arrestins and cell signaling. Annu Rev Physiol (2007) 8.65

Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat Rev Drug Discov (2010) 5.76

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell (2005) 5.60

Seven-transmembrane-spanning receptors and heart function. Nature (2002) 5.38

The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. J Cell Sci (2002) 5.04

beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. J Biol Chem (2005) 4.91

Desensitization of G protein-coupled receptors and neuronal functions. Annu Rev Neurosci (2004) 4.44

Beta-arrestin-biased ligands at seven-transmembrane receptors. Trends Pharmacol Sci (2007) 4.35

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. Proc Natl Acad Sci U S A (2003) 3.99

A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A (2007) 3.82

Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science (2003) 3.52

Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. Science (2002) 3.46

GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. Trends Endocrinol Metab (2006) 3.34

Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma. Science (2003) 3.27

Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors. Annu Rev Pharmacol Toxicol (2011) 3.15

Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. J Clin Invest (2007) 3.15

Beta-arrestin-mediated localization of smoothened to the primary cilium. Science (2008) 3.10

Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A (2007) 3.08

Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor. J Biol Chem (2004) 3.07

β-Arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol Sci (2011) 3.02

Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. J Biol Chem (2006) 3.00

Therapeutic potential of β-arrestin- and G protein-biased agonists. Trends Mol Med (2010) 2.82

Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. Proc Natl Acad Sci U S A (2009) 2.76

Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. Prog Neurobiol (2002) 2.76

A beta-arrestin 2 signaling complex mediates lithium action on behavior. Cell (2008) 2.76

Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell (2007) 2.65

Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Sci Signal (2011) 2.56

Trafficking of G protein-coupled receptors. Circ Res (2006) 2.54

Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. Proc Natl Acad Sci U S A (2005) 2.53

beta-arrestin-biased agonism at the beta2-adrenergic receptor. J Biol Chem (2007) 2.51

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. Trends Biochem Sci (2011) 2.51

Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. Proc Natl Acad Sci U S A (2005) 2.48

The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation. J Biol Chem (2002) 2.47

beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. Proc Natl Acad Sci U S A (2003) 2.43

beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation. J Biol Chem (2002) 2.42

beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. J Biol Chem (2007) 2.42

Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. Biochem J (2003) 2.42

Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference. Proc Natl Acad Sci U S A (2003) 2.40

Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. Science (2003) 2.31

Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. Proc Natl Acad Sci U S A (2002) 2.26

Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science (2007) 2.25

A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. Sci Transl Med (2009) 2.24

Multiple ligand-specific conformations of the β2-adrenergic receptor. Nat Chem Biol (2011) 2.23

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science (2004) 2.19

Seven-transmembrane receptor signaling through beta-arrestin. Sci STKE (2005) 2.18

Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature (2013) 2.14

Quantifying ligand bias at seven-transmembrane receptors. Mol Pharmacol (2011) 2.08

Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors. Proc Natl Acad Sci U S A (2008) 2.06

Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. Neuron (2003) 2.03

Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. Proc Natl Acad Sci U S A (2006) 2.01

Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. J Neurosci (2002) 2.01

beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha. Proc Natl Acad Sci U S A (2004) 1.91

Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. J Biol Chem (2003) 1.90

Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2. J Biol Chem (2004) 1.86

Beta-arrestin-2 regulates the development of allergic asthma. J Clin Invest (2003) 1.85

Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proc Natl Acad Sci U S A (2009) 1.84

Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. Dev Cell (2009) 1.83

beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. J Clin Invest (2009) 1.79

Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis. J Biol Chem (2003) 1.76

Activation-dependent conformational changes in {beta}-arrestin 2. J Biol Chem (2004) 1.76

Regulation of G protein-coupled receptor signaling by scaffold proteins. Circ Res (2002) 1.75

beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J Biol Chem (2004) 1.75

G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. J Biol Chem (2006) 1.73

beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation. J Biol Chem (2001) 1.70

Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways. J Biol Chem (2003) 1.66

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. Sci Signal (2009) 1.66

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Nature (2011) 1.64

Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci U S A (2010) 1.64

S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking. Mol Cell (2008) 1.63

{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. J Biol Chem (2009) 1.59

Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. J Biol Chem (2009) 1.57

Arresting developments in heptahelical receptor signaling and regulation. Trends Cell Biol (2002) 1.55

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature (2016) 1.55

Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science (2004) 1.52

Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system. J Biol Chem (2002) 1.50

Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination. J Biol Chem (2003) 1.50

Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. J Neurosci (2003) 1.49

Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proc Natl Acad Sci U S A (2009) 1.49

Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. J Biol Chem (2005) 1.47

Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance. J Biol Chem (2003) 1.45

Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2. J Biol Chem (2004) 1.41

The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2. J Biol Chem (2007) 1.41

beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6. J Biol Chem (2004) 1.39

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Mol Cell Biol (2006) 1.38

Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. Circ Res (2008) 1.37

Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression. J Biol Chem (2007) 1.36

Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation. J Biol Chem (2007) 1.34

Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. Mol Pharmacol (2005) 1.33

{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J Biol Chem (2005) 1.31

Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance. J Neurosci (2004) 1.26

Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors. Biochemistry (2002) 1.24

When 7 transmembrane receptors are not G protein-coupled receptors. J Clin Invest (2005) 1.24

Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. J Biol Chem (2002) 1.24

G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal. Br J Pharmacol (2003) 1.23

N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. J Biol Chem (2003) 1.23

The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels. Proc Natl Acad Sci U S A (2004) 1.23

G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR. J Biol Chem (2003) 1.20

GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. J Biol Chem (2003) 1.20