Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance.

PubWeight™: 1.26‹?› | Rank: Top 10%

🔗 View Article (PMC 2376823)

Published in J Neurosci on May 12, 2004

Authors

Mei Xu1, Michael Petraschka, Jay P McLaughlin, Ruth E Westenbroek, Marc G Caron, Robert J Lefkowitz, Traci A Czyzyk, John E Pintar, Gregory W Terman, Charles Chavkin

Author Affiliations

1: Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195-7280, USA.

Articles citing this

Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria. J Neurosci (2007) 2.51

Dynorphin, stress, and depression. Brain Res (2009) 2.45

Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes. J Biol Chem (2006) 1.97

Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning. Neuropsychopharmacology (2006) 1.81

HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines. Glia (2006) 1.53

Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling. J Clin Invest (2008) 1.41

Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase. J Neurosci (2007) 1.31

Pathobiology of dynorphins in trauma and disease. Front Biosci (2005) 1.17

Inflammatory pain is enhanced in delta opioid receptor-knockout mice. Eur J Neurosci (2008) 1.14

Partial infraorbital nerve ligation as a model of trigeminal nerve injury in the mouse: behavioral, neural, and glial reactions. J Pain (2008) 1.08

Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake. J Neurosci (2012) 1.04

Kappa opioids and the modulation of pain. Psychopharmacology (Berl) (2010) 1.03

Neuropathic plasticity in the opioid and non-opioid actions of dynorphin A fragments and their interactions with bradykinin B2 receptors on neuronal activity in the rat spinal cord. Neuropharmacology (2014) 1.00

Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents. J Clin Invest (2009) 0.96

The role of kappa-opioid receptor activation in mediating antinociception and addiction. Acta Pharmacol Sin (2010) 0.95

The absence of endogenous beta-endorphin selectively blocks phosphorylation and desensitization of mu opioid receptors following partial sciatic nerve ligation. Neuroscience (2007) 0.94

Spinal dynorphin and bradykinin receptors maintain inflammatory hyperalgesia. J Pain (2008) 0.93

Does the kappa opioid receptor system contribute to pain aversion? Front Pharmacol (2014) 0.92

Tyrosine phosphorylation of K(ir)3.1 in spinal cord is induced by acute inflammation, chronic neuropathic pain, and behavioral stress. J Biol Chem (2005) 0.91

Sex differences in kappa opioid pharmacology. Life Sci (2010) 0.90

Trigeminal injury causes kappa opioid-dependent allodynic, glial and immune cell responses in mice. Mol Pain (2010) 0.89

Repeated stress dysregulates κ-opioid receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism. J Neurosci (2012) 0.88

Glial-restricted precursors: patterns of expression of opioid receptors and relationship to human immunodeficiency virus-1 Tat and morphine susceptibility in vitro. Neuroscience (2007) 0.87

Importance of sex to pain and its amelioration; relevance of spinal estrogens and its membrane receptors. Front Neuroendocrinol (2012) 0.87

Endogenous kappa-opioid receptor systems inhibit hyperalgesia associated with localized peripheral inflammation. Pain (2008) 0.87

Tyrosine phosphorylation of Kir3 following kappa-opioid receptor activation of p38 MAPK causes heterologous desensitization. J Biol Chem (2009) 0.86

Pronociceptive actions of dynorphin via bradykinin receptors. Neurosci Lett (2008) 0.85

Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats. Pain (2013) 0.82

Regulation of spinal dynorphin 1-17 release by endogenous pituitary adenylyl cyclase-activating polypeptide in the male rat: relevance of excitation via disinhibition. J Pharmacol Exp Ther (2010) 0.82

Differential effects of inescapable stress on locus coeruleus GRK3, alpha2-adrenoceptor and CRF1 receptor levels in learned helpless and non-helpless rats: a potential link to stress resilience. Behav Brain Res (2011) 0.82

G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses. J Leukoc Biol (2013) 0.80

Kir3 channel signaling complexes: focus on opioid receptor signaling. Front Cell Neurosci (2014) 0.80

Sustained Suppression of Hyperalgesia during Latent Sensitization by μ-, δ-, and κ-opioid receptors and α2A Adrenergic Receptors: Role of Constitutive Activity. J Neurosci (2016) 0.78

An integrated perspective on diabetic, alcoholic, and drug-induced neuropathy, etiology, and treatment in the US. J Pain Res (2017) 0.78

κ-Opioid receptors are not necessary for the antidepressant treatment of neuropathic pain. Br J Pharmacol (2014) 0.76

Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain. Sci Rep (2016) 0.75

Nor-Binaltorphimine Blocks the Adverse Effects of Morphine after Spinal Cord Injury. J Neurotrauma (2016) 0.75

Articles cited by this

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain (1988) 18.17

Ethical guidelines for investigations of experimental pain in conscious animals. Pain (1983) 17.70

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain (1988) 15.15

A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain (1990) 4.51

p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci (2003) 3.72

Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses. J Neurosci (2003) 3.64

Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain (1988) 3.06

Pathobiology of neuropathic pain. Eur J Pharmacol (2001) 2.82

Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Discov (2003) 2.71

Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists. Pain (1989) 2.44

Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin. Pain (2001) 2.05

The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord. J Neurophysiol (1994) 2.04

Light microscope study of the coexistence of GABA-like and glycine-like immunoreactivities in the spinal cord of the rat. J Comp Neurol (1990) 2.02

Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. J Neurosci (2002) 2.00

Extremely long-lasting antagonistic actions of nor-binaltorphimine (nor-BNI) in the mouse tail-flick test. J Pharmacol Exp Ther (1992) 1.88

Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance. J Neurosci (2000) 1.71

Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions. Proc Natl Acad Sci U S A (1999) 1.69

Opioids in chronic pain. Eur J Pharmacol (2001) 1.67

Pronociceptive actions of dynorphin maintain chronic neuropathic pain. J Neurosci (2001) 1.67

Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization. J Biol Chem (2003) 1.58

Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus. Pain (2002) 1.56

G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. J Biol Chem (1997) 1.55

Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance. J Biol Chem (2003) 1.45

Spinal and supraspinal mechanisms of neuropathic pain. Ann N Y Acad Sci (2000) 1.33

Nonopiate effects of dynorphin and des-Tyr-dynorphin. Science (1982) 1.29

The kappa-opioid receptor is primarily postsynaptic: combined immunohistochemical localization of the receptor and endogenous opioids. Proc Natl Acad Sci U S A (1995) 1.25

Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats. Pain (2000) 1.25

Generation of dynorphin knockout mice. Brain Res Mol Brain Res (2001) 1.22

Spinally administered dynorphin A produces long-lasting allodynia: involvement of NMDA but not opioid receptors. Pain (1997) 1.18

Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice. Brain Res (2000) 1.16

Regional, developmental, and cell cycle-dependent differences in mu, delta, and kappa-opioid receptor expression among cultured mouse astrocytes. Glia (1998) 1.14

Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance. Life Sci (2003) 1.05

Dynorphin opioids present in dentate granule cells may function as retrograde inhibitory neurotransmitters. J Neurosci (1994) 1.04

Reorganization of the spinal dorsal horn in models of chronic pain: correlation with behaviour. Neuroscience (1998) 1.04

Dynorphin: friend or foe? Pain (2000) 0.97

Agonist-induced phosphorylation of the kappa-opioid receptor. J Neurochem (1997) 0.94

Dorsal horn synaptosomal content of aspartate, glutamate, glycine and GABA are differentially altered following chronic constriction injury to the rat sciatic nerve. Neurosci Lett (2002) 0.93

Peripheral kappa 1-opioid receptor-mediated analgesia in mice. Eur J Pharmacol (1996) 0.91

Glial ion channels. Curr Opin Neurobiol (1991) 0.87

Evidence for a kappa-opioid receptor on pituitary astrocytes: an autoradiographic study. Neurosci Lett (1985) 0.87

Antagonists of the kappa-opioid receptor enhance allodynia in rats and mice after sciatic nerve ligation. Br J Pharmacol (2003) 0.85

A novel interaction between dynorphin(1-13) and an N-methyl-D-aspartate site. Brain Res (1988) 0.85

Reversal of behavioural and electrophysiological correlates of experimental peripheral neuropathy by the NK1 receptor antagonist GR205171 in rats. Neuropharmacology (1998) 0.84

Spinal kappa receptor-mediated analgesia of E-2078, a systemically active dynorphin analog, in mice. J Pharmacol Exp Ther (1991) 0.83

Effects of traumatic injury on dynorphin immunoreactivity in spinal cord. Neuropeptides (1985) 0.82

Spinal dynorphin immunoreactivity increases bilaterally in a neuropathic pain model. Brain Res (1993) 0.81

kappa-opioid receptor agonists modulate excitatory transmission in substantia gelatinosa neurons of the rat spinal cord. J Neurosci (1995) 0.81

Spinal release of immunoreactive dynorphin A(1-8) with the development of peripheral inflammation in the rat. Brain Res (1996) 0.81

Opioid peptides modulate the response of neurons of the superficial laminae of the rat spinal dorsal horn to GABA. Biochem Biophys Res Commun (2003) 0.80

Articles by these authors

Seven-transmembrane receptors. Nat Rev Mol Cell Biol (2002) 11.50

Beta-arrestins and cell signaling. Annu Rev Physiol (2007) 8.65

Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat Rev Drug Discov (2010) 5.76

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell (2005) 5.60

Seven-transmembrane-spanning receptors and heart function. Nature (2002) 5.38

The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. J Cell Sci (2002) 5.04

Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nat Neurosci (2006) 5.02

beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. J Biol Chem (2005) 4.91

Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron (2005) 4.78

Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci (2003) 4.50

Desensitization of G protein-coupled receptors and neuronal functions. Annu Rev Neurosci (2004) 4.44

Beta-arrestin-biased ligands at seven-transmembrane receptors. Trends Pharmacol Sci (2007) 4.35

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. Proc Natl Acad Sci U S A (2003) 3.99

A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A (2007) 3.82

Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses. J Neurosci (2003) 3.64

Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. Proc Natl Acad Sci U S A (2004) 3.60

The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. J Neurosci (2008) 3.54

Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science (2003) 3.52

Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. Science (2002) 3.46

Food reward in the absence of taste receptor signaling. Neuron (2008) 3.37

GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. Trends Endocrinol Metab (2006) 3.34

Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma. Science (2003) 3.27

Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors. Annu Rev Pharmacol Toxicol (2011) 3.15

Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. J Clin Invest (2007) 3.15

Beta-arrestin-mediated localization of smoothened to the primary cilium. Science (2008) 3.10

Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A (2007) 3.08

Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor. J Biol Chem (2004) 3.07

β-Arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol Sci (2011) 3.02

Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. J Biol Chem (2006) 3.00

A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia. Proc Natl Acad Sci U S A (2004) 3.00

Therapeutic potential of β-arrestin- and G protein-biased agonists. Trends Mol Med (2010) 2.82

Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci (2009) 2.78

Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. Proc Natl Acad Sci U S A (2009) 2.76

Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity. Neuron (2004) 2.76

Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. Prog Neurobiol (2002) 2.76

A beta-arrestin 2 signaling complex mediates lithium action on behavior. Cell (2008) 2.76

Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell (2007) 2.65

Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science (2004) 2.64

Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. Proc Natl Acad Sci U S A (2003) 2.62

Akt/GSK3 signaling in the action of psychotropic drugs. Annu Rev Pharmacol Toxicol (2009) 2.60

Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2. J Neurosci (2003) 2.58

Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Sci Signal (2011) 2.56

Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization. Mol Pharmacol (2003) 2.55

Monoamine transporters: from genes to behavior. Annu Rev Pharmacol Toxicol (2002) 2.54

Trafficking of G protein-coupled receptors. Circ Res (2006) 2.54

Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. Proc Natl Acad Sci U S A (2005) 2.53

Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria. J Neurosci (2007) 2.51

beta-arrestin-biased agonism at the beta2-adrenergic receptor. J Biol Chem (2007) 2.51

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. Trends Biochem Sci (2011) 2.51

An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart. Proc Natl Acad Sci U S A (2002) 2.48

Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. Proc Natl Acad Sci U S A (2005) 2.48

The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation. J Biol Chem (2002) 2.47

Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission. Nature (2012) 2.46

beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. Proc Natl Acad Sci U S A (2003) 2.43

Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharmacol Rev (2013) 2.42

beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation. J Biol Chem (2002) 2.42

Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. Biochem J (2003) 2.42

beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. J Biol Chem (2007) 2.42

GOAT links dietary lipids with the endocrine control of energy balance. Nat Med (2009) 2.42

Building a new conceptual framework for receptor heteromers. Nat Chem Biol (2009) 2.41

Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference. Proc Natl Acad Sci U S A (2003) 2.40

CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proc Natl Acad Sci U S A (2003) 2.34

Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. Science (2003) 2.31

Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. Proc Natl Acad Sci U S A (2002) 2.26

Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science (2007) 2.25

A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. Sci Transl Med (2009) 2.24

Multiple ligand-specific conformations of the β2-adrenergic receptor. Nat Chem Biol (2011) 2.23

Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proc Natl Acad Sci U S A (2008) 2.23

The Akt-GSK-3 signaling cascade in the actions of dopamine. Trends Pharmacol Sci (2007) 2.22

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science (2004) 2.19

Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction. Neuron (2006) 2.19

Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive. Nature (2012) 2.19

Seven-transmembrane receptor signaling through beta-arrestin. Sci STKE (2005) 2.18

Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heart. Circulation (2004) 2.15

Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature (2013) 2.14

Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15. Proc Natl Acad Sci U S A (2003) 2.09

Quantifying ligand bias at seven-transmembrane receptors. Mol Pharmacol (2011) 2.08

Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors. Proc Natl Acad Sci U S A (2008) 2.06

Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. Neuron (2003) 2.03

Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. Proc Natl Acad Sci U S A (2006) 2.01

Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. J Neurosci (2002) 2.01

Distinct domains of the mu-opioid receptor control uncoupling and internalization. Mol Pharmacol (2004) 2.00

MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction. Proc Natl Acad Sci U S A (2009) 2.00

Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition. Neuron (2006) 1.98

Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A (2011) 1.98

Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes. J Biol Chem (2006) 1.97

Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo. J Neurosci (2007) 1.93

Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci (2004) 1.92

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy. J Neurosci (2007) 1.92

beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha. Proc Natl Acad Sci U S A (2004) 1.91

Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase. J Biol Chem (2007) 1.91