Published in J Biol Chem on December 18, 2002
Neuroinflammatory responses in diabetic retinopathy. J Neuroinflammation (2015) 0.91
Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo. Arthritis Res Ther (2013) 0.87
The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes. Arthritis Res Ther (2004) 0.86
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is increased in osteoarthritis and regulates chondrocyte catabolic and anabolic activities. Osteoarthritis Cartilage (2015) 0.83
P38 mitogen-activated protein kinase promotes dedifferentiation of primary articular chondrocytes in monolayer culture. J Cell Mol Med (2013) 0.83
ErbB1 receptor ligands attenuate the expression of synaptic scaffolding proteins, GRIP1 and SAP97, in developing neocortex. Neuroscience (2005) 0.81
KRAS, EGFR, PDGFR-α, KIT and COX-2 status in carcinoma showing thymus-like elements (CASTLE). Diagn Pathol (2014) 0.78
Population PK-PD Model for Tolerance Evaluation to the p38 MAP Kinase Inhibitor BCT197. CPT Pharmacometrics Syst Pharmacol (2015) 0.75
PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes. Redox Biol (2017) 0.75
Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Nat Med (2010) 3.55
Regulation of the chondrocyte phenotype by beta-catenin. Development (2002) 1.63
ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status. J Biol Chem (2001) 1.50
Maintenance of differentiated phenotype of articular chondrocytes by protein kinase C and extracellular signal-regulated protein kinase. J Biol Chem (2001) 1.38
Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells. J Biol Chem (2007) 1.23
Signaling mechanisms leading to the regulation of differentiation and apoptosis of articular chondrocytes by insulin-like growth factor-1. J Biol Chem (2003) 1.22
Opposing roles of WNT-5A and WNT-11 in interleukin-1beta regulation of type II collagen expression in articular chondrocytes. J Biol Chem (2006) 1.22
p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent transcription and stabilization by serine 15 phosphorylation. J Biol Chem (2002) 1.21
Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase. J Biol Chem (2009) 1.20
Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms. J Biol Chem (2004) 1.20
RGD peptides released from beta ig-h3, a TGF-beta-induced cell-adhesive molecule, mediate apoptosis. Oncogene (2003) 1.19
Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice. Arthritis Rheum (2011) 1.19
Wnt-3a regulates chondrocyte differentiation via c-Jun/AP-1 pathway. FEBS Lett (2005) 1.13
Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model. PLoS One (2011) 1.11
Esophageal cancer related gene 4 (ECRG4) is a marker of articular chondrocyte differentiation and cartilage destruction. Gene (2009) 1.11
Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice. Arthritis Rheum (2012) 1.11
Regulation of beta-catenin signaling and maintenance of chondrocyte differentiation by ubiquitin-independent proteasomal degradation of alpha-catenin. J Biol Chem (2005) 1.10
Leukotriene B(4) stimulates Rac-ERK cascade to generate reactive oxygen species that mediates chemotaxis. J Biol Chem (2001) 1.10
alpha-Melanocyte-stimulating hormone inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production in leukocytes by modulating protein kinase A, p38 kinase, and nuclear factor kappa B signaling pathways. J Biol Chem (2003) 1.09
Regulation of type II collagen expression by histone deacetylase in articular chondrocytes. J Biol Chem (2007) 1.08
A water-soluble extract from Cucurbita moschata shows anti-obesity effects by controlling lipid metabolism in a high fat diet-induced obesity mouse model. Biochem Biophys Res Commun (2007) 1.07
WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase. FEBS Lett (2004) 1.06
Cytokine-like 1 knock-out mice (Cytl1-/-) show normal cartilage and bone development but exhibit augmented osteoarthritic cartilage destruction. J Biol Chem (2011) 0.99
Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2- and p38 kinase-dependent activation of AP-1. J Cell Biochem (2007) 0.98
A hydrophobic ligand-binding protein of the Taenia solium metacestode mediates uptake of the host lipid: implication for the maintenance of parasitic cellular homeostasis. Proteomics (2007) 0.97
Critical roles for excretory-secretory cysteine proteases during tissue invasion of Paragonimus westermani newly excysted metacercariae. Cell Microbiol (2006) 0.95
Modulation of the immune response using dendritic cell-derived exosomes. Methods Mol Biol (2007) 0.94
Plasma-derived MHC class II+ exosomes from tumor-bearing mice suppress tumor antigen-specific immune responses. Eur J Immunol (2012) 0.93
Swiprosin-1 is expressed in mast cells and up-regulated through the protein kinase C beta I/eta pathway. J Cell Biochem (2009) 0.93
Crystal structure of Helicobacter pylori MinE, a cell division topological specificity factor. Mol Microbiol (2010) 0.93
Nicotinamide phosphoribosyltransferase is essential for interleukin-1beta-mediated dedifferentiation of articular chondrocytes via SIRT1 and extracellular signal-regulated kinase (ERK) complex signaling. J Biol Chem (2011) 0.93
Inactivation of NADP(+)-dependent isocitrate dehydrogenase by nitric oxide. Free Radic Biol Med (2002) 0.91
ADAM10 mediates N-cadherin ectodomain shedding during retinal ganglion cell differentiation in primary cultured retinal cells from the developing chick retina. J Cell Biochem (2013) 0.90
Modulation of the conductance-voltage relationship of the BK(Ca) channel by shortening the cytosolic loop connecting two RCK domains. Biophys J (2009) 0.90
c-Jun/activator protein-1 mediates interleukin-1beta-induced dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes. J Biol Chem (2005) 0.90
p38 kinase-dependent and -independent Inhibition of protein kinase C zeta and -alpha regulates nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes. J Biol Chem (2002) 0.90
Non-steroidal anti-inflammatory drugs inhibit nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes independent of cyclooxygenase activity. J Biol Chem (2003) 0.89
Eupatilin inhibits T-cell activation by modulation of intracellular calcium flux and NF-kappaB and NF-AT activity. J Cell Biochem (2009) 0.88
Distribution of TGF-beta isoforms and signaling intermediates in corneal fibrotic wound repair. J Cell Biochem (2009) 0.88
Protein kinase C alpha and zeta regulate nitric oxide-induced NF-kappa B activation that mediates cyclooxygenase-2 expression and apoptosis but not dedifferentiation in articular chondrocytes. Biochem Biophys Res Commun (2003) 0.86
p38 kinase and c-Jun N-terminal kinase oppositely regulates tumor necrosis factor alpha-induced vascular cell adhesion molecule-1 expression and cell adhesion in chondrosarcoma cells. IUBMB Life (2002) 0.86
Foxp3 induces IL-4 gene silencing by affecting nuclear translocation of NFkappaB and chromatin structure. Mol Immunol (2008) 0.86
Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4. PLoS Negl Trop Dis (2010) 0.86
A recombinant chimeric antigen toward a standardized serodiagnosis of Taenia solium neurocysticercosis. Proteomics Clin Appl (2008) 0.86
Chondrogenesis induced by actin cytoskeleton disruption is regulated via protein kinase C-dependent p38 mitogen-activated protein kinase signaling. J Cell Biochem (2003) 0.85
Vitellocyte-specific expression of phospholipid hydroperoxide glutathione peroxidases in Clonorchis sinensis. Int J Parasitol (2008) 0.85
Wnt-5a is involved in TGF-beta3-stimulated chondrogenic differentiation of chick wing bud mesenchymal cells. Int J Biochem Cell Biol (2005) 0.84
Cellular defense against UVB-induced phototoxicity by cytosolic NADP(+)-dependent isocitrate dehydrogenase. Biochem Biophys Res Commun (2002) 0.84
Resveratrol Inhibits Nitric Oxide-Induced Apoptosis via the NF-Kappa B Pathway in Rabbit Articular Chondrocytes. Biomol Ther (Seoul) (2013) 0.83
Paragonimus westermani: biochemical and immunological characterizations of paramyosin. Exp Parasitol (2006) 0.83
Anti-proliferative effect of polysaccharides from Salicornia herbacea on induction of G2/M arrest and apoptosis in human colon cancer cells. J Microbiol Biotechnol (2009) 0.83
Erythropoietin exerts cell protective effect by activating PI3K/Akt and MAPK pathways in C6 Cells. Neurol Res (2014) 0.82
Production of reactive oxygen species by withaferin A causes loss of type collagen expression and COX-2 expression through the PI3K/Akt, p38, and JNK pathways in rabbit articular chondrocytes. Exp Cell Res (2013) 0.82
Control of growth cone motility and neurite outgrowth by SPIN90. Exp Cell Res (2011) 0.82
Regulation of type II collagen expression by cyclin-dependent kinase 6, cyclin D1, and p21 in articular chondrocytes. IUBMB Life (2007) 0.82
Identification of immunodominant excretory-secretory cysteine proteases of adult Paragonimus westermani by proteome analysis. Proteomics (2006) 0.82
PwRn1, a novel Ty3/gypsy-like retrotransposon of Paragonimus westermani: molecular characters and its differentially preserved mobile potential according to host chromosomal polyploidy. BMC Genomics (2008) 0.82
Under-sulfation by PAPS synthetase inhibition modulates the expression of ECM molecules during chondrogenesis. Biochem Biophys Res Commun (2004) 0.81
Thymoquinone-induced reactive oxygen species causes apoptosis of chondrocytes via PI3K/Akt and p38kinase pathway. Exp Biol Med (Maywood) (2013) 0.81
Synergistic effect of combined growth factors in porcine intervertebral disc degeneration. Connect Tissue Res (2013) 0.81
Retinoic acid inhibits chondrogenesis of mesenchymal cells by sustaining expression of N-cadherin and its associated proteins. J Cell Biochem (2003) 0.81
Activation of protein kinase Czeta mediates luteinizing hormone- or forskolin-induced NGFI-B expression in preovulatory granulosa cells of rat ovary. Mol Cell Endocrinol (2007) 0.80
In vitro chondrocyte culture in a heparin-based hydrogel for cartilage regeneration. Tissue Eng Part C Methods (2010) 0.80
Gallotannin causes differentiation and inflammation via ERK‑1/‑2 and p38 kinase pathways in rabbit articular chondrocytes. Mol Med Rep (2012) 0.80
SPIN90-IRSp53 complex participates in Rac-induced membrane ruffling. Exp Cell Res (2009) 0.80
Induction of G₂/M Arrest by Berberine via Activation of PI3K/Akt and p38 in Human Chondrosarcoma Cell Line. Oncol Res (2015) 0.80
Matrix metalloproteinase (MMP)-12 regulates MMP-9 expression in interleukin-1beta-treated articular chondrocytes. J Cell Biochem (2008) 0.80
Misexpression of Dickkopf-1 in endothelial cells, but not in chondrocytes or hypertrophic chondrocytes, causes defects in endochondral ossification. J Bone Miner Res (2012) 0.80
Dehydrodiconiferyl alcohol isolated from Cucurbita moschata shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. J Biol Chem (2012) 0.79
Characterization of Plasmodium vivax heat shock protein 70 and evaluation of its value for serodiagnosis of tertian malaria. Clin Vaccine Immunol (2007) 0.79
Modular evolution of glutathione peroxidase genes in association with different biochemical properties of their encoded proteins in invertebrate animals. BMC Evol Biol (2009) 0.79
Cellular localization of integrin isoforms in phenylephrine-induced hypertrophic cardiac myocytes. Cell Biochem Funct (2003) 0.79
PG201 downregulates the production of nitrite by upregulating heme oxygenase-1 expression through the control of phosphatidylinositol 3-kinase and NF-E2-related factor 2. Nitric Oxide (2013) 0.79
Overexpression of microRNA-25 by withaferin A induces cyclooxygenase-2 expression in rabbit articular chondrocytes. J Pharmacol Sci (2014) 0.79
A membrane-associated metalloprotease of Taenia solium metacestode structurally related to the FACE-1/Ste24p protease family. Int J Parasitol (2006) 0.79
Identification and characterization of arginase II as a chondrocyte phenotype-specific gene. IUBMB Life (2006) 0.78
α-Catenin inhibits β-catenin-T-cell factor/lymphoid enhancing factor transcriptional activity and collagen type II expression in articular chondrocytes through formation of Gli3R.α-catenin.β-catenin ternary complex. J Biol Chem (2012) 0.78
Ameliorating effects of HX106N, a water-soluble botanical formulation, on Aβ25-35-induced memory impairment and oxidative stress in mice. Biol Pharm Bull (2014) 0.78
Differential activation of diverse glutathione transferases of Clonorchis sinensis in response to the host bile and oxidative stressors. PLoS Negl Trop Dis (2013) 0.78
2-Deoxy-D-glucose regulates dedifferentiation through beta-catenin pathway in rabbit articular chondrocytes. Exp Mol Med (2010) 0.78
Identification of proteins differentially expressed during chondrogenesis of mesenchymal cells. FEBS Lett (2004) 0.77
Modulation of Thr phosphorylation of integrin beta1 during muscle differentiation. J Biol Chem (2003) 0.77
Low-density lipoprotein receptor-related protein 5 governs Wnt-mediated osteoarthritic cartilage destruction. Arthritis Res Ther (2014) 0.77
Toxic effects of carbendazim and n-butyl isocyanate, metabolites of the fungicide benomyl, on early development in the African clawed frog, Xenopus laevis. Environ Toxicol (2008) 0.77
Expression pattern and substrate specificity of Clonorchis sinensis tyrosinases. Int J Parasitol (2013) 0.77
Bioactive molecules of Taenia solium metacestode, a causative agent of neurocysticercosis. Expert Rev Proteomics (2010) 0.77
Differential expression of Paragonimus westermani eggshell proteins during the developmental stages. Int J Parasitol (2006) 0.76
SOCS3 suppresses the expression of IL-4 cytokine by inhibiting the phosphorylation of c-Jun through the ERK signaling pathway in rat mast cell line RBL-2H3. Mol Immunol (2010) 0.76
Suppressive effects of PG201, an antiarthritic botanical formulation, on lipopolysaccharide-induced inflammatory mediators in Raw264.7 cells. Exp Biol Med (Maywood) (2012) 0.76
15-deoxy-Delta 12,14-ProstaglandinJ2 regulates dedifferentiation through peroxisome proliferator-activated receptor-gamma-dependent pathway but not COX-2 expression in articular chondrocytes. J Korean Med Sci (2007) 0.76