Published in Diabetes Care on January 01, 2003
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med (2007) 7.27
Mitochondrial genome variation in eastern Asia and the peopling of Japan. Genome Res (2004) 3.34
FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest (2008) 3.25
Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes (2002) 3.04
Cilostazol for prevention of secondary stroke (CSPS 2): an aspirin-controlled, double-blind, randomised non-inferiority trial. Lancet Neurol (2010) 2.99
Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun (2007) 2.27
Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population. Clin Sci (Lond) (2002) 2.26
Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial. Diabetes Care (2006) 2.06
Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun (2008) 2.04
Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis. Cancer Res (2005) 1.90
Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett (2008) 1.71
Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis. J Clin Endocrinol Metab (2007) 1.57
PPAR(gamma)2 gene Pro12Ala polymorphism may influence serum level of an adipocyte-derived protein, adiponectin, in the Japanese population. Metabolism (2002) 1.56
Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology (2008) 1.55
Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol (2009) 1.54
Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci Lett (2009) 1.54
Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease. Proc Natl Acad Sci U S A (2004) 1.47
Taurine ameliorates impaired the mitochondrial function and prevents stroke-like episodes in patients with MELAS. Intern Med (2012) 1.46
Transduction of the anti-apoptotic PTD-FNK protein improves the efficiency of transplantation of bone marrow mononuclear cells. J Mol Cell Cardiol (2007) 1.40
A case of painless thyroiditis in a very early stage of pregnancy. Intern Med (2012) 1.39
Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. Circ Res (2009) 1.31
Adiponectin and renal function, and implication as a risk of cardiovascular disease. Am J Cardiol (2006) 1.30
Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physiol Lung Cell Mol Physiol (2011) 1.25
Decrease in serum adiponectin level due to obesity and visceral fat accumulation in children. Obes Res (2003) 1.24
Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochem Biophys Res Commun (2008) 1.24
Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice. Carcinogenesis (2002) 1.21
Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells. J Neurochem (2003) 1.19
Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes. Metabolism (2002) 1.18
Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity (Silver Spring) (2011) 1.17
Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1. J Biol Chem (2009) 1.15
Localization of Ang-1, -2, Tie-2, and VEGF expression at endothelial-pericyte interdigitation in rat angiogenesis. Lab Invest (2006) 1.15
Correlation between the adiponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes. Metabolism (2005) 1.14
Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci (2009) 1.13
Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. J Neurosci (2008) 1.12
Protection against ischemic brain injury by protein therapeutics. Proc Natl Acad Sci U S A (2002) 1.11
Prognostic significance of the immunohistochemical index of survivin in glioma: a comparative study with the MIB-1 index. J Neurooncol (2005) 1.09
Changes in nerve root motion and intraradicular blood flow during an intraoperative straight-leg-raising test. Spine (Phila Pa 1976) (2003) 1.08
MIDAS/GPP34, a nuclear gene product, regulates total mitochondrial mass in response to mitochondrial dysfunction. J Cell Sci (2005) 1.07
Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. J Nutr Biochem (2009) 1.06
Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain. Circ Res (2011) 1.05
Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial. Mov Disord (2013) 1.04
Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? FEBS Lett (2009) 1.02
Association of a C/T single-nucleotide polymorphism in the 5' untranslated region of the CD40 gene with Graves' disease in Japanese. Thyroid (2006) 1.02
Haploinsufficiency of akt1 prolongs the lifespan of mice. PLoS One (2013) 1.02
Nuclear survivin expression predicts poorer prognosis in glioblastoma. J Neurooncol (2008) 1.00
Higher pAkt expression predicts a significant worse prognosis in glioblastomas. J Radiat Res (2010) 1.00
Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects. Neurobiol Dis (2010) 0.99
Association of a CTLA-4 3' untranslated region (CT60) single nucleotide polymorphism with autoimmune thyroid disease in the Japanese population. Autoimmunity (2005) 0.97
Adiponectin and inflammatory markers in peripheral arterial occlusive disease. Atherosclerosis (2006) 0.97
H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model. J Am Heart Assoc (2012) 0.95
Effect of mechanical compression on the lumbar nerve root: localization and changes of intraradicular inflammatory cytokines, nitric oxide, and cyclooxygenase. Spine (Phila Pa 1976) (2005) 0.95
Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases. FEBS Lett (2005) 0.95
Prognosis of glioma patients by combined immunostaining for survivin, Ki-67 and epidermal growth factor receptor. J Clin Neurosci (2008) 0.94
Suppression of endoplasmic reticulum stress-induced caspase activation and cell death by the overexpression of Bcl-xL or Bcl-2. J Biochem (2007) 0.92
The codon 620 single nucleotide polymorphism of the protein tyrosine phosphatase-22 gene does not contribute to autoimmune thyroid disease susceptibility in the Japanese. Thyroid (2005) 0.92
Prevention of chemotherapy-induced alopecia by the anti-death FNK protein. Life Sci (2007) 0.91
Association of a thyroglobulin gene polymorphism with Hashimoto's thyroiditis in the Japanese population. Clin Endocrinol (Oxf) (2004) 0.91
ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes. Alcohol Clin Exp Res (2004) 0.91
Increased electronegative charge of serum low-density lipoprotein in patients with diabetes mellitus. Clin Chim Acta (2004) 0.90
Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide. Med Gas Res (2011) 0.90
Association studies of the IL-23R gene in autoimmune thyroid disease in the Japanese population. Autoimmunity (2009) 0.89
Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females. J Hum Genet (2003) 0.89
Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density of the femoral neck in elderly Japanese women. J Mol Med (Berl) (2002) 0.89
Accumulation of somatic mutation in mitochondrial DNA and atherosclerosis in diabetic patients. Ann N Y Acad Sci (2004) 0.88
Preventive effects of Chlorella on cognitive decline in age-dependent dementia model mice. Neurosci Lett (2009) 0.88
Low birth weight and development of type 2 diabetes in a Japanese population. Diabetes Care (2003) 0.87
Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis. J Bone Miner Res (2012) 0.87
Overexpression of KLF15 transcription factor in adipocytes of mice results in down-regulation of SCD1 protein expression in adipocytes and consequent enhancement of glucose-induced insulin secretion. J Biol Chem (2011) 0.87
Plasma adrenomedullin as an independent predictor of future cardiovascular events in high-risk patients: comparison with C-reactive protein and adiponectin. Peptides (2007) 0.87
Interleukin-6 as an independent predictor of future cardiovascular events in high-risk Japanese patients: comparison with C-reactive protein. Cytokine (2010) 0.87
Transduction of anti-apoptotic proteins into chondrocytes in cartilage slice culture. Biochem Biophys Res Commun (2004) 0.87
Effect of Bisphenol A on non-specific immunodefenses against non-pathogenic Escherichia coli. Toxicol Lett (2003) 0.86
Effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on the susceptibility to Listeria infection. Biosci Biotechnol Biochem (2003) 0.86
Regular voluntary exercise cures stress-induced impairment of cognitive function and cell proliferation accompanied by increases in cerebral IGF-1 and GST activity in mice. Behav Brain Res (2010) 0.86
Therapeutic benefits of intrathecal protein therapy in a mouse model of amyotrophic lateral sclerosis. J Neurosci Res (2008) 0.85
PTD-mediated delivery of anti-cell death proteins/peptides and therapeutic enzymes. Adv Drug Deliv Rev (2007) 0.84
Changes in nerve root motion and intraradicular blood flow during intraoperative femoral nerve stretch test. Report of four cases. J Neurosurg (2003) 0.84
Anti-apoptotic PTD-FNK protein suppresses lipopolysaccharide-induced acute lung injury in rats. Exp Mol Pathol (2007) 0.84
The replication of the association of the rs9355610 within 6p27 with Graves' disease. Autoimmunity (2013) 0.83
A mitochondrial DNA variant associated with left ventricular hypertrophy in diabetes. Biochem Biophys Res Commun (2003) 0.83
Lipoma and opthalmoplegia in mitochondrial diabetes associated with small heteroplasmy level of 3243 tRNA(Leu(UUR)) mutation. Diabetes Res Clin Pract (2004) 0.83
Association of cholecystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese population. Alcohol Alcohol (2003) 0.83
Benefit of cilostazol in patients with high risk of bleeding: subanalysis of cilostazol stroke prevention study 2. Cerebrovasc Dis (2014) 0.83
Combination therapy with transductive anti-death FNK protein and FK506 ameliorates brain damage with focal transient ischemia in rat. J Neurochem (2008) 0.82
Cyclin D1/cdk4, estrogen receptors α and β, in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric carcinogenesis: immunohistochemical study. J Toxicol Sci (2011) 0.82
Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impairment of spatial memory. Behav Brain Res (2009) 0.82
A new preventive strategy for hypoglycemia incorporating added food diet in patients with type 2 diabetes who received sitagliptin therapy. Endocr Res (2012) 0.81
Association of alcohol dehydrogenase 2*1 allele with liver damage and insulin concentration in the Japanese. J Hum Genet (2005) 0.81
Cytoprotective role of mitochondrial amyloid beta peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde. Neurobiol Aging (2007) 0.81
Mutations in the mitochondrial genome confer resistance of cancer cells to anticancer drugs. Cancer Sci (2009) 0.81
Hepatotoxicity and cutaneous reactions after antithyroid drug administration. Clin Endocrinol (Oxf) (2012) 0.81
Wobble modification defect suppresses translational activity of tRNAs with MERRF and MELAS mutations. Mitochondrion (2002) 0.81
[Hydrogen gas and hydrogen water act as a therapeutic and preventive antioxidant with a novel concept]. Nihon Ronen Igakkai Zasshi (2008) 0.80
Association of the protein tyrosine phosphatase nonreceptor 22 haplotypes with autoimmune thyroid disease in the Japanese population. Thyroid (2010) 0.80
A Filipino patient with fulminant type 1 diabetes. Diabetes Care (2004) 0.80