Published in Cancer Res on March 01, 2005
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Human mitochondrial DNA polymerase γ exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers. J Biol Chem (2011) 0.94
Mitochondrial DNA mutations in renal cell carcinomas revealed no general impact on energy metabolism. Br J Cancer (2006) 0.93
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The role of the mitochondrial genome in ageing and carcinogenesis. J Aging Res (2011) 0.90
Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions. Cell Rep (2016) 0.90
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Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression. World J Gastroenterol (2014) 0.82
Silencing of IkBβ mRNA causes disruption of mitochondrial retrograde signaling and suppression of tumor growth in vivo. Carcinogenesis (2012) 0.81
Understanding structure, function, and mutations in the mitochondrial ATP synthase. Microb Cell (2015) 0.81
Mitochondria and cancer. Virchows Arch (2009) 0.81
Electric field driven torque in ATP synthase. PLoS One (2013) 0.80
Alterations in c-Myc phenotypes resulting from dynamin-related protein 1 (Drp1)-mediated mitochondrial fission. Cell Death Dis (2013) 0.80
Cancer cell growth and survival as a system-level property sustained by enhanced glycolysis and mitochondrial metabolic remodeling. Front Physiol (2012) 0.80
Mitochondrial D310 mutation as clonal marker for solid tumors. Virchows Arch (2015) 0.79
mtDNA Mutations and Their Role in Aging, Diseases and Forensic Sciences. Aging Dis (2013) 0.79
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KRas, ROS and the initiation of pancreatic cancer. Small GTPases (2016) 0.78
Mitochondrial DNA mutations in human tumor cells. Oncol Lett (2012) 0.78
Regular moderate or intense exercise prevents depression-like behavior without change of hippocampal tryptophan content in chronically tryptophan-deficient and stressed mice. PLoS One (2013) 0.78
The role of mitochondria in the development and progression of lung cancer. Comput Struct Biotechnol J (2013) 0.78
Roles of Mitochondrial DNA Changes on Cancer Initiation and Progression. Cell Biol (Henderson, NV) (2012) 0.77
Role of mitochondrial dysfunction in cancer progression. Exp Biol Med (Maywood) (2016) 0.77
Nuclear expression of a mitochondrial DNA gene: mitochondrial targeting of allotopically expressed mutant ATP6 in transgenic mice. J Biomed Biotechnol (2012) 0.77
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Radon-induced reduced apoptosis in human bronchial epithelial cells with knockdown of mitochondria DNA. J Toxicol Environ Health A (2012) 0.77
The mitochondrial DNA Northeast Asia CZD haplogroup is associated with good disease-free survival among male oral squamous cell carcinoma patients. PLoS One (2012) 0.77
Analysis of mtDNA sequence variants in colorectal adenomatous polyps. Diagn Pathol (2010) 0.77
Reduced mitochondrial properties in putative progenitor/stem cells of human keratinocytes. Ann Dermatol (2009) 0.77
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Decoding Warburg's hypothesis: tumor-related mutations in the mitochondrial respiratory chain. Oncotarget (2015) 0.76
Effects of Tributyltin Chloride on Cybrids with or without an ATP Synthase Pathologic Mutation. Environ Health Perspect (2016) 0.75
Formation of Mitochondrial Genome Concatemers as an Alternative Mechanism Promoting Oncogenic Transformation of Lymphoid Cells. Biosci Hypotheses (2009) 0.75
Cisplatin selects short forms of the mitochondrial DNA OriB variant (16184-16193 poly-cytosine tract), which confer resistance to cisplatin. Sci Rep (2017) 0.75
Mitochondria and familial predisposition to breast cancer. Curr Genomics (2013) 0.75
Mitochondrial Respiratory Dysfunction Induces Claudin-1 Expression via Reactive Oxygen Species-mediated Heat Shock Factor 1 Activation, Leading to Hepatoma Cell Invasiveness. J Biol Chem (2015) 0.75
Hepatic mitochondrial bioenergetics in aged C57BL/6 mice exhibit delayed recovery from severe burn injury. Biochim Biophys Acta (2017) 0.75
Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome. Semin Cancer Biol (2017) 0.75
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med (2007) 7.27
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature (2009) 3.80
Mitochondrial genome variation in eastern Asia and the peopling of Japan. Genome Res (2004) 3.34
FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest (2008) 3.25
Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice. J Biol Chem (2002) 2.68
Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell Metab (2009) 2.45
Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun (2007) 2.27
Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus. Nat Genet (2002) 2.20
Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy. Ann Neurol (2002) 2.13
Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells. Proc Natl Acad Sci U S A (2010) 2.10
Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun (2008) 2.04
Neuronal degeneration and mitochondrial dysfunction. J Clin Invest (2003) 2.00
Mitochondrial dysfunction and amyotrophic lateral sclerosis. Muscle Nerve (2006) 1.95
Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes. Cell (2002) 1.82
Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice. J Neurosci (2005) 1.79
Protein synthesis by pure translation systems. Methods (2005) 1.79
Assay of mitochondrial ATP synthesis in animal cells and tissues. Methods Cell Biol (2007) 1.76
Pathology of encapsulating peritoneal sclerosis. Perit Dial Int (2005) 1.75
Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett (2008) 1.71
Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice. J Neurochem (2006) 1.64
Tom40 protein import channel binds to non-native proteins and prevents their aggregation. Nat Struct Biol (2003) 1.62
The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells. J Biol Chem (2008) 1.61
Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology. Proc Natl Acad Sci U S A (2007) 1.60
Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology (2008) 1.55
Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol (2009) 1.54
Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci Lett (2009) 1.54
The role of mitochondria in inherited neurodegenerative diseases. J Neurochem (2006) 1.53
Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease. Proc Natl Acad Sci U S A (2004) 1.47
Taurine ameliorates impaired the mitochondrial function and prevents stroke-like episodes in patients with MELAS. Intern Med (2012) 1.46
Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients. J Neurochem (2002) 1.42
The mtDNA T8993G (NARP) mutation results in an impairment of oxidative phosphorylation that can be improved by antioxidants. Hum Mol Genet (2004) 1.40
Transduction of the anti-apoptotic PTD-FNK protein improves the efficiency of transplantation of bone marrow mononuclear cells. J Mol Cell Cardiol (2007) 1.40
Different regulation of wild-type and mutant Cu,Zn superoxide dismutase localization in mammalian mitochondria. Hum Mol Genet (2008) 1.35
Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. Circ Res (2009) 1.31
Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia. J Exp Med (2004) 1.31
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease. PLoS One (2009) 1.30
Mitochondrial dysfunction and intracellular calcium dysregulation in ALS. Mech Ageing Dev (2010) 1.30
Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities. Hum Mol Genet (2009) 1.30
Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation. Cell Metab (2011) 1.29
Histologic criteria for diagnosing encapsulating peritoneal sclerosis in continuous ambulatory peritoneal dialysis patients. Adv Perit Dial (2003) 1.29
Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. Elife (2013) 1.28
The mitochondrial respiratory chain is a modulator of apoptosis. J Cell Biol (2007) 1.28
The role of memantine in the treatment of psychiatric disorders other than the dementias: a review of current preclinical and clinical evidence. CNS Drugs (2012) 1.26
Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis. J Neurochem (2006) 1.26
Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physiol Lung Cell Mol Physiol (2011) 1.25
Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochem Biophys Res Commun (2008) 1.24
Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission. Proc Natl Acad Sci U S A (2011) 1.24
Heterologous mitochondrial DNA recombination in human cells. Hum Mol Genet (2004) 1.23
Respiratory chain supercomplexes set the threshold for respiration defects in human mtDNA mutant cybrids. Hum Mol Genet (2006) 1.22
Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2. Hum Mol Genet (2010) 1.21
SOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse. Brain (2010) 1.21
Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons. J Neurosci (2012) 1.19
Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models. Hum Mol Genet (2013) 1.19
Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells. J Neurochem (2003) 1.19
Modulation of mitochondrial protein phosphorylation by soluble adenylyl cyclase ameliorates cytochrome oxidase defects. EMBO Mol Med (2009) 1.17
Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity (Silver Spring) (2011) 1.17
Mechanisms, models and biomarkers in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener (2013) 1.16
Recruitment of a species-specific translational arrest module to monitor different cellular processes. Proc Natl Acad Sci U S A (2011) 1.16
Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1. J Biol Chem (2009) 1.15
MTG1 codes for a conserved protein required for mitochondrial translation. Mol Biol Cell (2003) 1.15
Dok-1 and Dok-2 are negative regulators of T cell receptor signaling. Int Immunol (2007) 1.14
Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci (2009) 1.13
Import, maturation, and function of SOD1 and its copper chaperone CCS in the mitochondrial intermembrane space. Antioxid Redox Signal (2010) 1.12
Mitochondrial function, morphology, and axonal transport in amyotrophic lateral sclerosis. Antioxid Redox Signal (2009) 1.12
Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. J Neurosci (2008) 1.12
Protection against ischemic brain injury by protein therapeutics. Proc Natl Acad Sci U S A (2002) 1.11
Prognostic significance of the immunohistochemical index of survivin in glioma: a comparative study with the MIB-1 index. J Neurooncol (2005) 1.09
A chemical enucleation method for the transfer of mitochondrial DNA to rho(o) cells. Nucleic Acids Res (2003) 1.08
Host-residual invariant NK T cells attenuate graft-versus-host immunity. J Immunol (2005) 1.08
MIDAS/GPP34, a nuclear gene product, regulates total mitochondrial mass in response to mitochondrial dysfunction. J Cell Sci (2005) 1.07
A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. J Biol Chem (2011) 1.07
cAMP and mitochondria. Physiology (Bethesda) (2013) 1.07
An assembled complex IV maintains the stability and activity of complex I in mammalian mitochondria. J Biol Chem (2007) 1.07
Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy. Hum Mol Genet (2011) 1.06
Barth syndrome: cellular compensation of mitochondrial dysfunction and apoptosis inhibition due to changes in cardiolipin remodeling linked to tafazzin (TAZ) gene mutation. Biochim Biophys Acta (2013) 1.06
Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. J Nutr Biochem (2009) 1.06
Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma. Lab Invest (2010) 1.06
Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain. Circ Res (2011) 1.05
Global analysis of chaperone effects using a reconstituted cell-free translation system. Proc Natl Acad Sci U S A (2012) 1.05
Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial. Mov Disord (2013) 1.04
Enhanced ROS production and antioxidant defenses in cybrids harbouring mutations in mtDNA. Neurosci Lett (2005) 1.04
Mitochondrial protein import. Requirement of presequence elements and tom components for precursor binding to the TOM complex. J Biol Chem (2004) 1.03
Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? FEBS Lett (2009) 1.02
New insights into the bioenergetics of mitochondrial disorders using intracellular ATP reporters. Mol Biol Cell (2003) 1.02
Haploinsufficiency of akt1 prolongs the lifespan of mice. PLoS One (2013) 1.02
Histological heterogeneity of glomerular segmental lesions in focal segmental glomerulosclerosis. Int Urol Nephrol (2011) 1.01
A new method for analysis of mitochondrial DNA point mutations and assess levels of heteroplasmy. Biochem Biophys Res Commun (2006) 1.00
Periventricular white matter hyperintensities as predictors of suicide attempts in bipolar disorders and unipolar depression. Prog Neuropsychopharmacol Biol Psychiatry (2008) 1.00
Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects. Neurobiol Dis (2010) 0.99
Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria. J Biol Chem (2008) 0.98
Depletion of mitochondrial fission factor DRP1 causes increased apoptosis in human colon cancer cells. Biochem Biophys Res Commun (2012) 0.97
Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis. FASEB J (2009) 0.97
A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model. Dev Biol (2010) 0.96
Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases. FEBS Lett (2005) 0.95
Neutral solution low in glucose degradation products is associated with less peritoneal fibrosis and vascular sclerosis in patients receiving peritoneal dialysis. Perit Dial Int (2012) 0.95
Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China. Jpn J Cancer Res (2002) 0.95