Protein complexes gain momentum.

Structural basis for protein-protein interactions in the 14-3-3 protein family. Proc Natl Acad Sci U S A (2006) 1.95

Polydispersity of a mammalian chaperone: mass spectrometry reveals the population of oligomers in alphaB-crystallin. Proc Natl Acad Sci U S A (2003) 1.76

Subunit architecture of multimeric complexes isolated directly from cells. EMBO Rep (2006) 1.75

Receiver domains control the active-state stoichiometry of Aquifex aeolicus sigma54 activator NtrC4, as revealed by electrospray ionization mass spectrometry. J Mol Biol (2009) 1.01

Native electrospray mass spectrometry reveals the nature and stoichiometry of pigments in the FMO photosynthetic antenna protein. Biochemistry (2011) 0.98

Surface-induced dissociation of small molecules, peptides, and non-covalent protein complexes. J Am Soc Mass Spectrom (2007) 0.97

Nature's molecular sponges: small heat shock proteins grow into their chaperone roles. Proc Natl Acad Sci U S A (2010) 0.90

Integral membrane proteins and bilayer proteomics. Anal Chem (2013) 0.90

Structural basis for PPARγ transactivation by endocrine-disrupting organotin compounds. Sci Rep (2015) 0.89

The centaurin gamma-1 GTPase-like domain functions as an NTPase. Biochem J (2007) 0.89

High-performance liquid chromatography separation and intact mass analysis of detergent-solubilized integral membrane proteins. Anal Biochem (2010) 0.87

Inter-ring communication allows the GroEL chaperonin complex to distinguish between different substrates. Protein Sci (2007) 0.87

Characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75NTR. J Biol Chem (2005) 0.85

An Ion Mobility-Mass Spectrometry Investigation of Monocyte Chemoattractant Protein-1. Int J Mass Spectrom (2009) 0.81

A competitive binding study of chemokine, sulfated receptor, and glycosaminoglycan interactions by nano-electrospray ionization mass spectrometry. Anal Biochem (2010) 0.81

Monitoring enzyme catalysis in the multimeric state: direct observation of Arthrobacter 4-hydroxybenzoyl-coenzyme A thioesterase catalytic complexes using time-resolved electrospray ionization mass spectrometry. Anal Biochem (2009) 0.80

Characterization of a noncovalent lipocalin complex by liquid chromatography/electrospray ionization mass spectrometry. J Biomol Tech (2004) 0.79

Native Liquid Extraction Surface Analysis Mass Spectrometry: Analysis of Noncovalent Protein Complexes Directly from Dried Substrates. J Am Soc Mass Spectrom (2015) 0.78

Unfolding and Folding of the Three-Helix Bundle Protein KIX in the Absence of Solvent. J Am Soc Mass Spectrom (2016) 0.77

Mechanism of auxin perception by the TIR1 ubiquitin ligase. Nature (2007) 8.21

The protofilament structure of insulin amyloid fibrils. Proc Natl Acad Sci U S A (2002) 4.08

Targeting C-reactive protein for the treatment of cardiovascular disease. Nature (2006) 4.07

A tandem mass spectrometer for improved transmission and analysis of large macromolecular assemblies. Anal Chem (2002) 3.83

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease. Nat Chem (2009) 3.66

Determining the stoichiometry and interactions of macromolecular assemblies from mass spectrometry. Nat Protoc (2007) 3.64

Ion mobility-mass spectrometry analysis of large protein complexes. Nat Protoc (2008) 3.51

In vitro reconstitution of the human RISC-loading complex. Proc Natl Acad Sci U S A (2008) 3.43

Evidence for macromolecular protein rings in the absence of bulk water. Science (2005) 3.26

Structures of SAS-6 suggest its organization in centrioles. Science (2011) 2.67

Structure of an Hsp90-Cdc37-Cdk4 complex. Mol Cell (2006) 2.62

Collision cross sections of proteins and their complexes: a calibration framework and database for gas-phase structural biology. Anal Chem (2010) 2.62

Protein complexes in the gas phase: technology for structural genomics and proteomics. Chem Rev (2007) 2.57

Structural organization of the 19S proteasome lid: insights from MS of intact complexes. PLoS Biol (2006) 2.56

Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. Proc Natl Acad Sci U S A (2008) 2.50

Micelles protect membrane complexes from solution to vacuum. Science (2008) 2.40

Molecular recycling within amyloid fibrils. Nature (2005) 2.39

The role of mass spectrometry in structure elucidation of dynamic protein complexes. Annu Rev Biochem (2007) 2.39

Mass measurements of increased accuracy resolve heterogeneous populations of intact ribosomes. J Am Chem Soc (2006) 2.31

Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Structure (2009) 2.30

Assembly reflects evolution of protein complexes. Nature (2008) 2.27

The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat Struct Mol Biol (2010) 2.08

Structural insights into the activity of enhancer-binding proteins. Science (2005) 2.04

Tandem mass spectrometry reveals the quaternary organization of macromolecular assemblies. Chem Biol (2006) 1.96

Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function. Protein Sci (2010) 1.95

Structural basis for protein-protein interactions in the 14-3-3 protein family. Proc Natl Acad Sci U S A (2006) 1.95

An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4. J Biol Chem (2009) 1.85

Structural basis for the subunit assembly of the anaphase-promoting complex. Nature (2011) 1.80

Recognition of a signal peptide by the signal recognition particle. Nature (2010) 1.77

Polydispersity of a mammalian chaperone: mass spectrometry reveals the population of oligomers in alphaB-crystallin. Proc Natl Acad Sci U S A (2003) 1.76

Subunit architecture of multimeric complexes isolated directly from cells. EMBO Rep (2006) 1.75

The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins. J Mol Biol (2005) 1.74

Structure of the CRISPR interference complex CSM reveals key similarities with cascade. Mol Cell (2013) 1.74

Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Mol Cell Proteomics (2007) 1.71

Protein complexes of the Escherichia coli cell envelope. J Biol Chem (2005) 1.69

A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme. Nature (2003) 1.66

Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme. Nat Struct Biol (2002) 1.64

Quaternary dynamics and plasticity underlie small heat shock protein chaperone function. Proc Natl Acad Sci U S A (2010) 1.63

Mass spectrometry of macromolecular assemblies: preservation and dissociation. Curr Opin Struct Biol (2006) 1.62

Aspects of native proteins are retained in vacuum. Curr Opin Chem Biol (2006) 1.61

Studies of the RNA degradosome-organizing domain of the Escherichia coli ribonuclease RNase E. J Mol Biol (2004) 1.60

Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions. Nat Methods (2009) 1.51

Structural characterization of drug-like compounds by ion mobility mass spectrometry: comparison of theoretical and experimentally derived nitrogen collision cross sections. Anal Chem (2011) 1.51

Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication. J Cell Biol (2006) 1.51

Subunit exchange of multimeric protein complexes. Real-time monitoring of subunit exchange between small heat shock proteins by using electrospray mass spectrometry. J Biol Chem (2002) 1.50

Structural basis for the inhibition of activin signalling by follistatin. EMBO J (2006) 1.49

αB-crystallin polydispersity is a consequence of unbiased quaternary dynamics. J Mol Biol (2011) 1.48

Defining the mechanism of polymerization in the serpinopathies. Proc Natl Acad Sci U S A (2010) 1.48

Ion mobility-mass spectrometry reveals long-lived, unfolded intermediates in the dissociation of protein complexes. Angew Chem Int Ed Engl (2007) 1.47

Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proc Natl Acad Sci U S A (2009) 1.46

Observation of sequence specificity in the seeding of protein amyloid fibrils. Protein Sci (2004) 1.44

Mass spectrometry of intact membrane protein complexes. Nat Protoc (2013) 1.41

Phosphorylation of alphaB-crystallin alters chaperone function through loss of dimeric substructure. J Biol Chem (2004) 1.41

Subunit architecture of intact protein complexes from mass spectrometry and homology modeling. Acc Chem Res (2008) 1.38

Ion mobility mass spectrometry of peptide ions: effects of drift gas and calibration strategies. Anal Chem (2012) 1.37

Class I HDACs share a common mechanism of regulation by inositol phosphates. Mol Cell (2013) 1.37

Mimicking phosphorylation of alphaB-crystallin affects its chaperone activity. Biochem J (2007) 1.34

How to switch off a histidine kinase: crystal structure of Geobacillus stearothermophilus KinB with the inhibitor Sda. J Mol Biol (2008) 1.33

Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity. J Mol Biol (2004) 1.32

Heteronuclear NMR investigations of dynamic regions of intact Escherichia coli ribosomes. Proc Natl Acad Sci U S A (2004) 1.31

Charge-state dependent compaction and dissociation of protein complexes: insights from ion mobility and molecular dynamics. J Am Chem Soc (2012) 1.30

Advances in the mass spectrometry of membrane proteins: from individual proteins to intact complexes. Annu Rev Biochem (2011) 1.30

Thermal dissociation of multimeric protein complexes by using nanoelectrospray mass spectrometry. Anal Chem (2003) 1.28

Gas-phase unfolding and disassembly reveals stability differences in ligand-bound multiprotein complexes. Chem Biol (2009) 1.27

Comparative cross-linking and mass spectrometry of an intact F-type ATPase suggest a role for phosphorylation. Nat Commun (2013) 1.26

Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin. Nat Struct Mol Biol (2010) 1.26

Biochemical and structural studies of the interaction of Cdc37 with Hsp90. J Mol Biol (2004) 1.25

Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis. J Biol Chem (2005) 1.24

Massign: an assignment strategy for maximizing information from the mass spectra of heterogeneous protein assemblies. Anal Chem (2012) 1.23

The structure and biochemical properties of the human spliceosomal protein U1C. J Mol Biol (2004) 1.23

Structure of the TatC core of the twin-arginine protein transport system. Nature (2012) 1.23

Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex. Proc Natl Acad Sci U S A (2011) 1.23

Integrating ion mobility mass spectrometry with molecular modelling to determine the architecture of multiprotein complexes. PLoS One (2010) 1.22

Structural insights into the p97-Ufd1-Npl4 complex. Proc Natl Acad Sci U S A (2007) 1.22

Tandem mass spectrometry of intact GroEL-substrate complexes reveals substrate-specific conformational changes in the trans ring. J Am Chem Soc (2006) 1.22

Three-dimensional structures of translating ribosomes by Cryo-EM. Mol Cell (2004) 1.21

Heptameric (L12)6/L10 rather than canonical pentameric complexes are found by tandem MS of intact ribosomes from thermophilic bacteria. Proc Natl Acad Sci U S A (2005) 1.21

Reduced global cooperativity is a common feature underlying the amyloidogenicity of pathogenic lysozyme mutations. J Mol Biol (2004) 1.21

Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation. Proc Natl Acad Sci U S A (2009) 1.21

Twenty years of gas phase structural biology. Structure (2013) 1.20

20S proteasomes have the potential to keep substrates in store for continual degradation. J Biol Chem (2006) 1.20

Subunit architecture of multiprotein assemblies determined using restraints from gas-phase measurements. Structure (2009) 1.20

Do charge state signatures guarantee protein conformations? J Am Soc Mass Spectrom (2012) 1.20

Alternate dissociation pathways identified in charge-reduced protein complex ions. Anal Chem (2010) 1.20

Polypyrimidine tract binding protein stabilizes the encephalomyocarditis virus IRES structure via binding multiple sites in a unique orientation. Mol Cell (2009) 1.19

Structural basis for DNA recognition and loading into a viral packaging motor. Proc Natl Acad Sci U S A (2011) 1.19

A new window into the molecular physiology of membrane proteins. J Physiol (2014) 1.18

Small heat shock protein activity is regulated by variable oligomeric substructure. J Biol Chem (2008) 1.17

The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle. Mol Cell (2011) 1.17

Conformational dynamics of the molecular chaperone Hsp90 in complexes with a co-chaperone and anticancer drugs. J Mol Biol (2007) 1.17

Subunit exchange of polydisperse proteins: mass spectrometry reveals consequences of alphaA-crystallin truncation. J Biol Chem (2005) 1.16

Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration. Proc Natl Acad Sci U S A (2011) 1.16

MacB ABC transporter is a dimer whose ATPase activity and macrolide-binding capacity are regulated by the membrane fusion protein MacA. J Biol Chem (2008) 1.16

Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump. Proc Natl Acad Sci U S A (2013) 1.15

Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online. Angew Chem Int Ed Engl (2009) 1.15

Advancing cell biology through proteomics in space and time (PROSPECTS). Mol Cell Proteomics (2012) 1.15

Tandem mass spectrometry defines the stoichiometry and quaternary structural arrangement of tryptophan molecules in the multiprotein complex TRAP. J Am Chem Soc (2004) 1.14

Detergent-free mass spectrometry of membrane protein complexes. Nat Methods (2013) 1.14

Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)-FGF receptor-heparin complex. J Mol Biol (2004) 1.14

Aβ40 and Aβ42 amyloid fibrils exhibit distinct molecular recycling properties. J Am Chem Soc (2011) 1.13