Published in J Org Chem on January 10, 2003
A catalytic, Brønsted base strategy for intermolecular allylic C-H amination. J Am Chem Soc (2009) 1.10
Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate. J Org Chem (2010) 0.83
The effect of mutation of F87 on the properties of CYP102A1-CYP4C7 chimeras: altered regiospecificity and substrate selectivity. J Biol Inorg Chem (2008) 0.78
Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase. Proc Natl Acad Sci U S A (2002) 2.44
Identification of syn-pimara-7,15-diene synthase reveals functional clustering of terpene synthases involved in rice phytoalexin/allelochemical biosynthesis. Plant Physiol (2004) 2.06
Functional identification of rice syn-copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products. Plant J (2004) 1.85
Functional characterization of the rice kaurene synthase-like gene family. Phytochemistry (2006) 1.79
Structure of limonene synthase, a simple model for terpenoid cyclase catalysis. Proc Natl Acad Sci U S A (2007) 1.64
Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis. Nature (2010) 1.49
Probing the role of the DXDD motif in Class II diterpene cyclases. Chembiochem (2007) 1.39
Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase. Nat Chem Biol (2011) 1.33
Dynamic vaccine blocks relapse to compulsive intake of heroin. Proc Natl Acad Sci U S A (2013) 1.24
16-Aza-ent-beyerane and 16-Aza-ent-trachylobane: potent mechanism-based inhibitors of recombinant ent-kaurene synthase from Arabidopsis thaliana. J Am Chem Soc (2007) 1.23
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. J Med Chem (2002) 1.22
Molecular recognition of the substrate diphosphate group governs product diversity in trichodiene synthase mutants. Biochemistry (2005) 1.20
Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates. J Am Chem Soc (2002) 1.19
Exploring biosynthetic diversity with trichodiene synthase. Arch Biochem Biophys (2007) 1.18
An unexpected diterpene cyclase from rice: functional identification of a stemodene synthase. Arch Biochem Biophys (2005) 1.16
Syn- and anti-selective Prins cyclizations of delta,epsilon-unsaturated ketones to 1,3-halohydrins with Lewis acids. J Org Chem (2006) 1.14
Characterization and inhibition of a class II diterpene cyclase from Mycobacterium tuberculosis: implications for tuberculosis. J Biol Chem (2009) 1.13
Taxadiene synthase-catalyzed cyclization of 6-fluorogeranylgeranyl diphosphate to 7-fluoroverticillenes. J Am Chem Soc (2005) 1.11
X-ray crystallographic studies of substrate binding to aristolochene synthase suggest a metal ion binding sequence for catalysis. J Biol Chem (2008) 1.07
Synthesis of enantiopure 2-C-methyl-D-erythritol 4-phosphate and 2,4-cyclodiphosphate from D-arabitol. Org Lett (2004) 1.06
Characterization of the kaurene oxidase CYP701A3, a multifunctional cytochrome P450 from gibberellin biosynthesis. Biochem J (2010) 1.06
Eremophilane sesquiterpenes from capsidiol. J Org Chem (2004) 1.04
Pharmacophore reassignment for induction of the immunosurveillance cytokine TRAIL. Angew Chem Int Ed Engl (2014) 1.03
Formation of the unusual semivolatile diterpene rhizathalene by the Arabidopsis class I terpene synthase TPS08 in the root stele is involved in defense against belowground herbivory. Plant Cell (2013) 1.02
Kinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenes. J Biol Chem (2004) 1.01
Conformational Analysis of (+)-Germacrene A by Variable Temperature NMR and NOE Spectroscopy. Tetrahedron (2007) 0.99
Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates. J Biol Chem (2007) 0.98
Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates. ACS Chem Biol (2010) 0.96
Scalable, divergent synthesis of meroterpenoids via "borono-sclareolide". J Am Chem Soc (2012) 0.96
Inhibition of monoterpene cyclases by inert analogues of geranyl diphosphate and linalyl diphosphate. Arch Biochem Biophys (2007) 0.95
Stereochemistry and deuterium isotope effects associated with the cyclization-rearrangements catalyzed by tobacco epiaristolochene and hyoscyamus premnaspirodiene synthases, and the chimeric CH4 hybrid cyclase. Arch Biochem Biophys (2005) 0.95
Scope and mechanism of intramolecular aziridination of cyclopent-3-enyl-methylamines to 1-azatricyclo[2.2.1.0(2,6)]heptanes with lead tetraacetate. J Am Chem Soc (2009) 0.91
A single residue switch for Mg(2+)-dependent inhibition characterizes plant class II diterpene cyclases from primary and secondary metabolism. J Biol Chem (2010) 0.90
Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis. J Biol Chem (2012) 0.90
Total synthesis of (+/-)-cameroonan-7alpha-ol and biomimetic rearrangements to related nopsane sesquiterpenes. J Org Chem (2003) 0.89
Stereochemistry of the macrocyclization and elimination steps in taxadiene biosynthesis through deuterium labeling. J Org Chem (2005) 0.88
Structures, biogenetic relationships, and cytotoxicity of pimarane-derived diterpenes from Petalostigma pubescens. Phytochemistry (2005) 0.87
The dioxanone approach to (2S,3R)-2-C-methylerythritol 4-phosphate and 2,4-cyclodiphosphate, and various MEP analogues. J Org Chem (2007) 0.85
Bisabolyl-derived sesquiterpenes from tobacco 5-epi-aristolochene synthase-catalyzed cyclization of (2Z,6E)-farnesyl diphosphate. J Am Chem Soc (2010) 0.85
Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate. Chembiochem (2007) 0.84
Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate. J Org Chem (2010) 0.83
Dissecting paclitaxel-microtubule association: quantitative assessment of the 2'-OH group. Biochemistry (2013) 0.83
Alternative synthesis of the Colorado potato beetle pheromone. J Org Chem (2013) 0.82
Syn stereochemistry of cyclic ether formation in 1,8-cineole biosynthesis catalyzed by recombinant synthase from Salvia officinalis. J Am Chem Soc (2002) 0.80
Surrogate splicing for functional analysis of sesquiterpene synthase genes. Plant Physiol (2005) 0.80
Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-(2)H(1)]farnesyl diphosphate catalyzed by recombinant patchoulol synthase. J Am Chem Soc (2010) 0.79
Specificity of the N-benzoyl transferase responsible for the last step of Taxol biosynthesis. Arch Biochem Biophys (2008) 0.78
2-azapinanes: aza analogues of the enantiomeric pinyl carbocation intermediates in pinene biosynthesis. Org Lett (2011) 0.78
Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase. J Biol Chem (2002) 0.78
Characteristic flavonoids from Acacia burkittii and A. acuminata heartwoods and their differential cytotoxicity to normal and leukemia cells. Nat Prod Commun (2009) 0.75
Synthesis of methylerythritol phosphate analogues and their evaluation as alternate substrates for IspDF and IspE from Agrobacterium tumefaciens. J Org Chem (2014) 0.75
ent-Beyerane diterpenoids from the heartwood of Excoecaria parvifolia. Phytochemistry (2006) 0.75
A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior. Chem Commun (Camb) (2017) 0.75
Stereoselective prins cyclizations of delta, epsilon-unsaturated ketones to cis-3-chlorocyclohexanols with TiCl(4). Angew Chem Int Ed Engl (2002) 0.75
Enantioselective synthesis of alpha-terpineol and nephthenol by intramolecular acyloxazolidinone enolate alkylations. Chem Commun (Camb) (2006) 0.75