Published in Structure on January 01, 2003
The ankyrin repeat as molecular architecture for protein recognition. Protein Sci (2004) 5.07
The leucine-rich repeat domain of Internalin B folds along a polarized N-terminal pathway. Structure (2008) 1.63
Repeat-protein folding: new insights into origins of cooperativity, stability, and topology. Arch Biochem Biophys (2007) 1.51
Complex energy landscape of a giant repeat protein. Structure (2013) 1.41
Rational redesign of the folding pathway of a modular protein. Proc Natl Acad Sci U S A (2007) 1.37
Folding landscapes of ankyrin repeat proteins: experiments meet theory. Curr Opin Struct Biol (2008) 1.31
Local and long-range stability in tandemly arrayed tetratricopeptide repeats. Proc Natl Acad Sci U S A (2005) 1.28
The energy landscapes of repeat-containing proteins: topology, cooperativity, and the folding funnels of one-dimensional architectures. PLoS Comput Biol (2008) 1.25
Folding of a designed simple ankyrin repeat protein. Protein Sci (2004) 1.20
Stepwise unfolding of ankyrin repeats in a single protein revealed by atomic force microscopy. Biophys J (2005) 1.20
Shifting transition states in the unfolding of a large ankyrin repeat protein. Proc Natl Acad Sci U S A (2008) 1.08
Rerouting the folding pathway of the Notch ankyrin domain by reshaping the energy landscape. J Am Chem Soc (2008) 1.08
Potential responders to FOLFOX therapy for colorectal cancer by Random Forests analysis. Br J Cancer (2011) 1.06
The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold. Protein Sci (2005) 1.04
Mechanical unfolding of an ankyrin repeat protein. Biophys J (2010) 0.99
What lessons can be learned from studying the folding of homologous proteins? Methods (2010) 0.97
The plastic landscape of repeat proteins. Proc Natl Acad Sci U S A (2007) 0.94
Discrete kinetic models from funneled energy landscape simulations. PLoS One (2012) 0.91
Direct observation of parallel folding pathways revealed using a symmetric repeat protein system. Biophys J (2014) 0.91
What have we learned from the studies of two-state folders, and what are the unanswered questions about two-state protein folding? Phys Biol (2009) 0.91
Folding kinetics of the cooperatively folded subdomain of the IκBα ankyrin repeat domain. J Mol Biol (2011) 0.90
Ankyrin domains across the Tree of Life. PeerJ (2014) 0.88
Structural and Energetic Characterization of the Ankyrin Repeat Protein Family. PLoS Comput Biol (2015) 0.86
Full reconstruction of a vectorial protein folding pathway by atomic force microscopy and molecular dynamics simulations. J Biol Chem (2010) 0.86
Highly polarized C-terminal transition state of the leucine-rich repeat domain of PP32 is governed by local stability. Proc Natl Acad Sci U S A (2015) 0.85
Transcriptomics and identification of the chemoreceptor superfamily of the pupal parasitoid of the oriental fruit fly, Spalangia endius Walker (Hymenoptera: Pteromalidae). PLoS One (2014) 0.83
Chimeras of p14ARF and p16: functional hybrids with the ability to arrest growth. PLoS One (2014) 0.80
Diffuse transition state structure for the unfolding of a leucine-rich repeat protein. Phys Chem Chem Phys (2014) 0.76
Disorder drives cooperative folding in a multidomain protein. Proc Natl Acad Sci U S A (2016) 0.75
Inferring repeat-protein energetics from evolutionary information. PLoS Comput Biol (2017) 0.75
Awakening guardian angels: drugging the p53 pathway. Nat Rev Cancer (2009) 5.12
The complete folding pathway of a protein from nanoseconds to microseconds. Nature (2003) 3.61
The crystal structure of human CD1d with and without alpha-galactosylceramide. Nat Immunol (2005) 3.53
Structural biology of the tumor suppressor p53. Annu Rev Biochem (2008) 3.36
Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A (2006) 3.35
A transient and low-populated protein-folding intermediate at atomic resolution. Science (2010) 3.08
Is there a unifying mechanism for protein folding? Trends Biochem Sci (2003) 2.63
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A (2008) 2.30
Cooperative binding of tetrameric p53 to DNA. J Mol Biol (2004) 2.26
Unifying features in protein-folding mechanisms. Proc Natl Acad Sci U S A (2003) 2.24
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. Proc Natl Acad Sci U S A (2008) 2.14
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. Proc Natl Acad Sci U S A (2007) 2.09
PRIMA-1 reactivates mutant p53 by covalent binding to the core domain. Cancer Cell (2009) 2.09
Molecular mechanism of the interaction between MDM2 and p53. J Mol Biol (2002) 2.03
Comparative binding of p53 to its promoter and DNA recognition elements. J Mol Biol (2005) 1.96
Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem (2003) 1.94
The unfolding story of three-dimensional domain swapping. Structure (2003) 1.89
Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53. Proc Natl Acad Sci U S A (2007) 1.86
ATPase site architecture and helicase mechanism of an archaeal MCM. Mol Cell (2007) 1.84
General structural motifs of amyloid protofilaments. Proc Natl Acad Sci U S A (2006) 1.72
Tumor suppressor p53 slides on DNA with low friction and high stability. Biophys J (2008) 1.70
Testing protein-folding simulations by experiment: B domain of protein A. Proc Natl Acad Sci U S A (2004) 1.70
Kinetic instability of p53 core domain mutants: implications for rescue by small molecules. J Biol Chem (2003) 1.68
Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations. J Biol Chem (2005) 1.67
The central region of HDM2 provides a second binding site for p53. Proc Natl Acad Sci U S A (2006) 1.67
Direct observation of barrier-limited folding of BBL by single-molecule fluorescence resonance energy transfer. Proc Natl Acad Sci U S A (2009) 1.65
The tumor suppressor p53: from structures to drug discovery. Cold Spring Harb Perspect Biol (2010) 1.64
The crystal structure of human CD1b with a bound bacterial glycolipid. J Immunol (2004) 1.64
Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains. J Biol Chem (2006) 1.61
Core domain interactions in full-length p53 in solution. Proc Natl Acad Sci U S A (2006) 1.59
A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants. Proc Natl Acad Sci U S A (2002) 1.58
Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA. Nucleic Acids Res (2008) 1.58
Solution structure of p53 core domain: structural basis for its instability. Proc Natl Acad Sci U S A (2006) 1.53
Phi-analysis at the experimental limits: mechanism of beta-hairpin formation. J Mol Biol (2006) 1.53
Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor. Proc Natl Acad Sci U S A (2005) 1.52
Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family. J Mol Biol (2005) 1.52
The denatured state of Engrailed Homeodomain under denaturing and native conditions. J Mol Biol (2003) 1.51
Characterization of the p53-rescue drug CP-31398 in vitro and in living cells. Oncogene (2002) 1.51
Halogen-enriched fragment libraries as leads for drug rescue of mutant p53. J Am Chem Soc (2012) 1.50
Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proc Natl Acad Sci U S A (2009) 1.46
A single-molecule characterization of p53 search on DNA. Proc Natl Acad Sci U S A (2010) 1.43
Complex energy landscape of a giant repeat protein. Structure (2013) 1.41
Direct observation of ultrafast folding and denatured state dynamics in single protein molecules. Proc Natl Acad Sci U S A (2009) 1.39
Rational redesign of the folding pathway of a modular protein. Proc Natl Acad Sci U S A (2007) 1.37
14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers. Nucleic Acids Res (2008) 1.36
Distinguishing between cooperative and unimodal downhill protein folding. Proc Natl Acad Sci U S A (2007) 1.35
Rapid amyloid fiber formation from the fast-folding WW domain FBP28. Proc Natl Acad Sci U S A (2003) 1.33
Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53. J Biol Chem (2004) 1.31
Early events in protein folding. Curr Opin Struct Biol (2003) 1.28
Correlation of levels of folded recombinant p53 in escherichia coli with thermodynamic stability in vitro. J Mol Biol (2007) 1.27
Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant. Chem Biol (2010) 1.27
Simulation and experiment conspire to reveal cryptic intermediates and a slide from the nucleation-condensation to framework mechanism of folding. J Mol Biol (2005) 1.27
Modulation of the oligomerization state of p53 by differential binding of proteins of the S100 family to p53 monomers and tetramers. J Biol Chem (2009) 1.25
Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein. Proc Natl Acad Sci U S A (2007) 1.25
Small molecule induced reactivation of mutant p53 in cancer cells. Nucleic Acids Res (2013) 1.24
One-state downhill versus conventional protein folding. J Mol Biol (2004) 1.24
The helix-turn-helix motif as an ultrafast independently folding domain: the pathway of folding of Engrailed homeodomain. Proc Natl Acad Sci U S A (2007) 1.23
Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL. J Biol Chem (2007) 1.23
Recognition of DNA by p53 core domain and location of intermolecular contacts of cooperative binding. J Mol Biol (2002) 1.22
Regulation of DNA binding of p53 by its C-terminal domain. J Mol Biol (2004) 1.22
Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation. Proc Natl Acad Sci U S A (2004) 1.21
Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition. Proc Natl Acad Sci U S A (2012) 1.21
Three different binding sites of Cks1 are required for p27-ubiquitin ligation. J Biol Chem (2002) 1.20
Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53. Nucleic Acids Res (2010) 1.20
Carboxyl pK(a) values and acid denaturation of BBL. J Mol Biol (2010) 1.20
Binding of natively unfolded HIF-1alpha ODD domain to p53. Mol Cell (2005) 1.18
Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53. Proc Natl Acad Sci U S A (2002) 1.18
Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53. Nucleic Acids Res (2008) 1.18
CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90. Proc Natl Acad Sci U S A (2002) 1.17
Biophysical characterisation of the small ankyrin repeat protein myotrophin. J Mol Biol (2006) 1.17
Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration. Proc Natl Acad Sci U S A (2011) 1.16
Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer. Proc Natl Acad Sci U S A (2009) 1.13
Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53. Nucleic Acids Res (2009) 1.13
Conformational entropy of alanine versus glycine in protein denatured states. Proc Natl Acad Sci U S A (2007) 1.13
Sequence-dependent sliding kinetics of p53. Proc Natl Acad Sci U S A (2012) 1.13
Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils. J Biol Chem (2007) 1.11
A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase. Acta Crystallogr D Biol Crystallogr (2002) 1.10
The structure of the major transition state for folding of an FF domain from experiment and simulation. J Mol Biol (2005) 1.10
The kinetic pathway of folding of barnase. J Mol Biol (2003) 1.09
Shifting transition states in the unfolding of a large ankyrin repeat protein. Proc Natl Acad Sci U S A (2008) 1.08
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. Proc Natl Acad Sci U S A (2010) 1.08
Structural biology of the tumor suppressor p53 and cancer-associated mutants. Adv Cancer Res (2007) 1.07
Ultraslow oligomerization equilibria of p53 and its implications. Proc Natl Acad Sci U S A (2009) 1.07
Structural biology: analysis of 'downhill' protein folding. Nature (2007) 1.07
Modulation of binding of DNA to the C-terminal domain of p53 by acetylation. Structure (2005) 1.06
Solution structure of the C4 zinc finger domain of HDM2. Protein Sci (2005) 1.06
First-order rate-determining aggregation mechanism of p53 and its implications. Proc Natl Acad Sci U S A (2012) 1.06
Simulation and experiment at high temperatures: ultrafast folding of a thermophilic protein by nucleation-condensation. J Mol Biol (2005) 1.06
Phi-analysis of the folding of the B domain of protein A using multiple optical probes. J Mol Biol (2006) 1.06
Mimicking natural evolution in vitro: an N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activity. Proc Natl Acad Sci U S A (2003) 1.05
The role of the turn in beta-hairpin formation during WW domain folding. Protein Sci (2007) 1.05
Determination of the folding transition states of barnase by using PhiI-value-restrained simulations validated by double mutant PhiIJ-values. Proc Natl Acad Sci U S A (2005) 1.05
Interaction of the p53 DNA-binding domain with its n-terminal extension modulates the stability of the p53 tetramer. J Mol Biol (2011) 1.04
Implications of 3D domain swapping for protein folding, misfolding and function. Adv Exp Med Biol (2012) 1.04
Effects of oncogenic mutations and DNA response elements on the binding of p53 to p53-binding protein 2 (53BP2). J Biol Chem (2006) 1.04
Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide. Proc Natl Acad Sci U S A (2003) 1.04
Interaction between the transactivation domain of p53 and PC4 exemplifies acidic activation domains as single-stranded DNA mimics. J Biol Chem (2009) 1.04
Members of the S100 family bind p53 in two distinct ways. Protein Sci (2008) 1.03
Don't waste good methods on bad buffers and ambiguous data. Proc Natl Acad Sci U S A (2013) 1.03