Published in Proc Natl Acad Sci U S A on July 16, 2008
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli. Proc Natl Acad Sci U S A (2011) 1.56
The folding of single domain proteins--have we reached a consensus? Curr Opin Struct Biol (2010) 1.42
Complex energy landscape of a giant repeat protein. Structure (2013) 1.41
Frustration in biomolecules. Q Rev Biophys (2014) 1.05
An unusual hydrophobic core confers extreme flexibility to HEAT repeat proteins. Biophys J (2010) 1.02
The capillarity picture and the kinetics of one-dimensional protein folding. Proc Natl Acad Sci U S A (2008) 1.02
Mechanical unfolding of an ankyrin repeat protein. Biophys J (2010) 0.99
Exploring the folding energy landscape of a series of designed consensus tetratricopeptide repeat proteins. Proc Natl Acad Sci U S A (2009) 0.98
Single-molecule chemo-mechanical unfolding reveals multiple transition state barriers in a small single-domain protein. Nat Commun (2015) 0.97
Direct observation of parallel folding pathways revealed using a symmetric repeat protein system. Biophys J (2014) 0.91
Discrete kinetic models from funneled energy landscape simulations. PLoS One (2012) 0.91
Folding kinetics of the cooperatively folded subdomain of the IκBα ankyrin repeat domain. J Mol Biol (2011) 0.90
Structural and Energetic Characterization of the Ankyrin Repeat Protein Family. PLoS Comput Biol (2015) 0.86
Full reconstruction of a vectorial protein folding pathway by atomic force microscopy and molecular dynamics simulations. J Biol Chem (2010) 0.86
The HD-exchange motions of ribosomal protein S6 are insensitive to reversal of the protein-folding pathway. Proc Natl Acad Sci U S A (2009) 0.83
Even with nonnative interactions, the updated folding transition states of the homologs Proteins G & L are extensive and similar. Proc Natl Acad Sci U S A (2015) 0.80
Mechanical anisotropy of ankyrin repeats. Biophys J (2012) 0.78
Mutagenesis of Trichoderma reesei endoglucanase I: impact of expression host on activity and stability at elevated temperatures. BMC Biotechnol (2015) 0.76
Disorder drives cooperative folding in a multidomain protein. Proc Natl Acad Sci U S A (2016) 0.75
Single-molecule FRET reveals hidden complexity in a protein energy landscape. Structure (2015) 0.75
Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. Physiol Rev (2001) 6.31
The FoldX web server: an online force field. Nucleic Acids Res (2005) 6.30
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature (2004) 4.50
Protein repeats: structures, functions, and evolution. J Struct Biol (2001) 3.67
In search of the hair-cell gating spring elastic properties of ankyrin and cadherin repeats. Structure (2005) 3.36
High-affinity binders selected from designed ankyrin repeat protein libraries. Nat Biotechnol (2004) 3.34
Design of stable alpha-helical arrays from an idealized TPR motif. Structure (2003) 3.17
Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins. J Mol Biol (2003) 2.81
Topological characteristics of helical repeat proteins. Curr Opin Struct Biol (1999) 2.75
Crystal structure of a 12 ANK repeat stack from human ankyrinR. EMBO J (2002) 2.27
When protein folding is simplified to protein coiling: the continuum of solenoid protein structures. Trends Biochem Sci (2000) 2.15
Hypothesis: a helix of ankyrin repeats of the NOMPC-TRP ion channel is the gating spring of mechanoreceptors. Curr Biol (2004) 1.93
Transient aggregates in protein folding are easily mistaken for folding intermediates. Proc Natl Acad Sci U S A (1997) 1.86
A designed ankyrin repeat protein evolved to picomolar affinity to Her2. J Mol Biol (2007) 1.71
Parallel protein-unfolding pathways revealed and mapped. Nat Struct Biol (2003) 1.67
Folding and unfolding mechanism of highly stable full-consensus ankyrin repeat proteins. J Mol Biol (2007) 1.67
The energy landscape of modular repeat proteins: topology determines folding mechanism in the ankyrin family. J Mol Biol (2005) 1.60
Stabilizing IkappaBalpha by "consensus" design. J Mol Biol (2006) 1.53
Sequential unfolding of ankyrin repeats in tumor suppressor p16. Structure (2003) 1.43
Designing repeat proteins: modular leucine-rich repeat protein libraries based on the mammalian ribonuclease inhibitor family. J Mol Biol (2003) 1.39
Rational redesign of the folding pathway of a modular protein. Proc Natl Acad Sci U S A (2007) 1.37
The refolding of cis- and trans-peptidylprolyl isomers of barstar. Biochemistry (1993) 1.36
Designed armadillo repeat proteins as general peptide-binding scaffolds: consensus design and computational optimization of the hydrophobic core. J Mol Biol (2007) 1.33
Folding landscapes of ankyrin repeat proteins: experiments meet theory. Curr Opin Struct Biol (2008) 1.31
Conformational plasticity in folding of the split beta-alpha-beta protein S6: evidence for burst-phase disruption of the native state. J Mol Biol (2002) 1.30
Enhancing the stability and folding rate of a repeat protein through the addition of consensus repeats. J Mol Biol (2006) 1.28
The notch ankyrin domain folds via a discrete, centralized pathway. Structure (2006) 1.26
Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein. Proc Natl Acad Sci U S A (2007) 1.25
The energy landscapes of repeat-containing proteins: topology, cooperativity, and the folding funnels of one-dimensional architectures. PLoS Comput Biol (2008) 1.25
Apparent two-state tendamistat folding is a sequential process along a defined route. J Mol Biol (2001) 1.21
Biophysical characterisation of the small ankyrin repeat protein myotrophin. J Mol Biol (2006) 1.17
Experimental characterization of the folding kinetics of the notch ankyrin domain. J Mol Biol (2005) 1.15
The plastic landscape of repeat proteins. Proc Natl Acad Sci U S A (2007) 0.94
Folding of the yeast prion protein Ure2: kinetic evidence for folding and unfolding intermediates. J Mol Biol (2002) 0.88
Movement of the intermediate and rate determining transition state of barnase on the energy landscape with changing temperature. Biochemistry (1998) 0.85
The unfolding story of three-dimensional domain swapping. Structure (2003) 1.89
ATPase site architecture and helicase mechanism of an archaeal MCM. Mol Cell (2007) 1.84
Sequential unfolding of ankyrin repeats in tumor suppressor p16. Structure (2003) 1.43
Complex energy landscape of a giant repeat protein. Structure (2013) 1.41
Rational redesign of the folding pathway of a modular protein. Proc Natl Acad Sci U S A (2007) 1.37
Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein. Proc Natl Acad Sci U S A (2007) 1.25
Three different binding sites of Cks1 are required for p27-ubiquitin ligation. J Biol Chem (2002) 1.20
Biophysical characterisation of the small ankyrin repeat protein myotrophin. J Mol Biol (2006) 1.17
Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils. J Biol Chem (2007) 1.11
Implications of 3D domain swapping for protein folding, misfolding and function. Adv Exp Med Biol (2012) 1.04
Mechanical unfolding of an ankyrin repeat protein. Biophys J (2010) 0.99
Toward classification of BRCA1 missense variants using a biophysical approach. J Biol Chem (2010) 0.97
Crystal structure of the ENT domain of human EMSY. J Mol Biol (2005) 0.97
Intermediates control domain swapping during folding of p13suc1. J Biol Chem (2003) 0.91
Tandem-repeat proteins: regularity plus modularity equals design-ability. Curr Opin Struct Biol (2013) 0.91
Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69. EMBO Rep (2005) 0.90
Folding and fibril formation of the cell cycle protein Cks1. J Biol Chem (2006) 0.89
Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2. Philos Trans R Soc Lond B Biol Sci (2013) 0.87
Domain swapping in p13suc1 results in formation of native-like, cytotoxic aggregates. J Mol Biol (2006) 0.87
Activation of ubiquitin ligase SCF(Skp2) by Cks1: insights from hydrogen exchange mass spectrometry. J Mol Biol (2006) 0.86
Alcohol oxidase (AOX1) from Pichia pastoris is a novel inhibitor of prion propagation and a potential ATPase. Mol Microbiol (2008) 0.84
Role of conformational heterogeneity in domain swapping and adapter function of the Cks proteins. J Biol Chem (2005) 0.82
The structure of the transition state for folding of domain-swapped dimeric p13suc1. Structure (2002) 0.81
Cooperative organization in a macromolecular complex. Nat Struct Biol (2003) 0.81
Characterising the binding specificities of the subunits associated with the KMT2/Set1 histone lysine methyltransferase. J Mol Biol (2010) 0.81
Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis. Protein Sci (2004) 0.81
Folding and association of the human cell cycle regulatory proteins ckshs1 and ckshs2. Biochemistry (2002) 0.80
Effects of ligand binding on the mechanical properties of ankyrin repeat protein gankyrin. PLoS Comput Biol (2013) 0.79
The how's and why's of protein folding intermediates. Arch Biochem Biophys (2012) 0.79
Subdomain architecture and stability of a giant repeat protein. J Phys Chem B (2013) 0.78
Using FlAsH to probe conformational changes in a large HEAT repeat protein. Chembiochem (2012) 0.78
Diffuse transition state structure for the unfolding of a leucine-rich repeat protein. Phys Chem Chem Phys (2014) 0.76
Folding and binding: lingering questions, emerging answers. Curr Opin Struct Biol (2012) 0.75
Accessible high-performance double nanohole tweezers. Opt Express (2022) 0.75