Published in Proc Natl Acad Sci U S A on December 23, 2002
Conformational selection and induced fit mechanism underlie specificity in noncovalent interactions with ubiquitin. Proc Natl Acad Sci U S A (2009) 1.60
Computer-aided antibody design. Protein Eng Des Sel (2012) 1.44
Structure and kinetics of a transient antibody binding intermediate reveal a kinetic discrimination mechanism in antigen recognition. Proc Natl Acad Sci U S A (2005) 1.29
Molecular evolution of affinity and flexibility in the immune system. Proc Natl Acad Sci U S A (2007) 1.26
Cross-domain inhibition of TACE ectodomain. Proc Natl Acad Sci U S A (2011) 1.26
Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics. Proc Natl Acad Sci U S A (2006) 1.26
Protein dynamics and the immunological evolution of molecular recognition. Proc Natl Acad Sci U S A (2004) 1.24
Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques. PLoS Pathog (2015) 1.11
Conformational proofreading: the impact of conformational changes on the specificity of molecular recognition. PLoS One (2007) 1.06
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Human germline antibody gene segments encode polyspecific antibodies. PLoS Comput Biol (2013) 0.89
Protein dynamics and the diversity of an antibody response. J Biol Chem (2012) 0.89
Effect of protein binding on ultrafast DNA dynamics: characterization of a DNA:APE1 complex. Biophys J (2005) 0.85
A single intermolecular contact mediates intramolecular stabilization of both RNA and protein. Proc Natl Acad Sci U S A (2005) 0.82
Effect of lesions on the dynamics of DNA on the picosecond and nanosecond timescales using a polarity sensitive probe. Nucleic Acids Res (2004) 0.81
The Fundamental Role of Flexibility on the Strength of Molecular Binding. Soft Matter (2012) 0.81
Discriminating binding mechanisms of an intrinsically disordered protein via a multi-state coarse-grained model. J Chem Phys (2014) 0.79
Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee. EBioMedicine (2015) 0.78
Structure-Based Reverse Vaccinology Failed in the Case of HIV Because it Disregarded Accepted Immunological Theory. Int J Mol Sci (2016) 0.75
Thermodynamic mechanism for the evasion of antibody neutralization in flaviviruses. J Am Chem Soc (2014) 0.75
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Structural insights into the evolution of an antibody combining site. Science (1997) 3.92
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Protein fluctuations are sensed by stimulated infrared echoes of the vibrations of carbon monoxide and azide probes. Proc Natl Acad Sci U S A (1998) 1.56
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Spectral properties of fluorescein in solvent-water mixtures: applications as a probe of hydrogen bonding environments in biological systems. Photochem Photobiol (1998) 1.09
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Inhibition of mutation and combating the evolution of antibiotic resistance. PLoS Biol (2005) 3.47
Combating bacteria and drug resistance by inhibiting mechanisms of persistence and adaptation. Nat Chem Biol (2007) 2.01
Beyond A, C, G and T: augmenting nature's alphabet. Curr Opin Chem Biol (2003) 1.99
Discovery, characterization, and optimization of an unnatural base pair for expansion of the genetic alphabet. J Am Chem Soc (2008) 1.91
Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. J Bacteriol (2006) 1.85
Complete and SOS-mediated response of Staphylococcus aureus to the antibiotic ciprofloxacin. J Bacteriol (2006) 1.73
Optimization of an unnatural base pair toward natural-like replication. J Am Chem Soc (2009) 1.66
Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast. Proc Natl Acad Sci U S A (2002) 1.61
Efficient and sequence-independent replication of DNA containing a third base pair establishes a functional six-letter genetic alphabet. Proc Natl Acad Sci U S A (2012) 1.57
Efforts to expand the genetic alphabet: identification of a replicable unnatural DNA self-pair. J Am Chem Soc (2004) 1.41
Transcription of an expanded genetic alphabet. J Am Chem Soc (2009) 1.41
PCR with an expanded genetic alphabet. J Am Chem Soc (2009) 1.35
Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage. Proc Natl Acad Sci U S A (2007) 1.32
Determinants of unnatural nucleobase stability and polymerase recognition. J Am Chem Soc (2003) 1.30
Polymerase recognition of unnatural base pairs. Angew Chem Int Ed Engl (2002) 1.27
Directed evolution of novel polymerase activities: mutation of a DNA polymerase into an efficient RNA polymerase. Proc Natl Acad Sci U S A (2002) 1.26
Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics. Proc Natl Acad Sci U S A (2006) 1.26
Efforts toward expansion of the genetic alphabet: structure and replication of unnatural base pairs. J Am Chem Soc (2007) 1.25
Protein dynamics and the immunological evolution of molecular recognition. Proc Natl Acad Sci U S A (2004) 1.24
KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry. Nat Chem Biol (2012) 1.24
Induction and inhibition of ciprofloxacin resistance-conferring mutations in hypermutator bacteria. Antimicrob Agents Chemother (2006) 1.24
Minor groove hydrogen bonds and the replication of unnatural base pairs. J Am Chem Soc (2007) 1.23
Expanding the substrate repertoire of a DNA polymerase by directed evolution. J Am Chem Soc (2004) 1.22
Phosphatases, DNA damage checkpoints and checkpoint deactivation. Cell Cycle (2007) 1.21
Esc4/Rtt107 and the control of recombination during replication. DNA Repair (Amst) (2006) 1.19
Site-specific labeling of DNA and RNA using an efficiently replicated and transcribed class of unnatural base pairs. J Am Chem Soc (2011) 1.19
Solution structure, mechanism of replication, and optimization of an unnatural base pair. Chemistry (2010) 1.17
Major groove substituents and polymerase recognition of a class of predominantly hydrophobic unnatural base pairs. Chemistry (2011) 1.16
Structural insights into DNA replication without hydrogen bonds. J Am Chem Soc (2013) 1.15
AID-initiated purposeful mutations in immunoglobulin genes. Adv Immunol (2007) 1.15
Efforts towards expansion of the genetic alphabet: pyridone and methyl pyridone nucleobases. Angew Chem Int Ed Engl (2006) 1.15
Unnatural substrate repertoire of A, B, and X family DNA polymerases. J Am Chem Soc (2008) 1.13
Broad-spectrum antibiotic activity of the arylomycin natural products is masked by natural target mutations. Chem Biol (2010) 1.13
The effect of minor-groove hydrogen-bond acceptors and donors on the stability and replication of four unnatural base pairs. J Am Chem Soc (2003) 1.12
Through-space interactions between parallel-offset arenes at the van der Waals distance: 1,8-diarylbiphenylene syntheses, structure and QM computations. Phys Chem Chem Phys (2008) 1.11
Optimization of unnatural base pair packing for polymerase recognition. J Am Chem Soc (2006) 1.11
Stability and polymerase recognition of pyridine nucleobase analogues: role of minor-groove H-bond acceptors. Angew Chem Int Ed Engl (2006) 1.10
Structural and initial biological analysis of synthetic arylomycin A2. J Am Chem Soc (2007) 1.09
Optimization of interstrand hydrophobic packing interactions within unnatural DNA base pairs. J Am Chem Soc (2004) 1.09
Secretion of the chlamydial virulence factor CPAF requires the Sec-dependent pathway. Microbiology (2010) 1.08
Isochorismate pyruvate lyase: a pericyclic reaction mechanism? J Am Chem Soc (2005) 1.06
Natural-like replication of an unnatural base pair for the expansion of the genetic alphabet and biotechnology applications. J Am Chem Soc (2013) 1.05
Controlling mutation: intervening in evolution as a therapeutic strategy. Crit Rev Biochem Mol Biol (2007) 1.05
Substituent effects on the pairing and polymerase recognition of simple unnatural base pairs. Nucleic Acids Res (2006) 1.04
Role of Doa1 in the Saccharomyces cerevisiae DNA damage response. Mol Cell Biol (2006) 1.04
Carbon-deuterium bonds as probes of dihydrofolate reductase. J Am Chem Soc (2008) 1.02
Type I signal peptidase and protein secretion in Staphylococcus aureus. J Bacteriol (2012) 1.01
Type I signal peptidase and protein secretion in Staphylococcus epidermidis. J Bacteriol (2010) 0.99
The evolution of DNA polymerases with novel activities. Curr Opin Biotechnol (2005) 0.99
Enzymatic phosphorylation of unnatural nucleosides. J Am Chem Soc (2002) 0.97
SOS regulatory elements are essential for UPEC pathogenesis. Microbes Infect (2010) 0.97
Synthesis of 2,6-diarylphenyldimethylsilyl cations: polar-pi distribution of cation character. Angew Chem Int Ed Engl (2008) 0.97
An efficiently extended class of unnatural base pairs. J Am Chem Soc (2006) 0.97
In vitro activities of arylomycin natural-product antibiotics against Staphylococcus epidermidis and other coagulase-negative staphylococci. Antimicrob Agents Chemother (2010) 0.96
A high-resolution probe of protein folding. J Am Chem Soc (2004) 0.94
Protein dynamics and cytochrome c: correlations between ligand vibrations and redox activity. J Am Chem Soc (2002) 0.94
A simple model system for the study of carbohydrate--aromatic interactions. J Am Chem Soc (2007) 0.93
Molecular description of flexibility in an antibody combining site. J Phys Chem B (2010) 0.93
Exploring biomolecular machines: energy landscape control of biological reactions. Philos Trans R Soc Lond B Biol Sci (2006) 0.92
Exploring the energy landscape of antibody-antigen complexes: protein dynamics, flexibility, and molecular recognition. Biochemistry (2008) 0.92
Major groove derivatization of an unnatural base pair. Chembiochem (2009) 0.92
Characterization of alkaline transitions in ferricytochrome c using carbon-deuterium infrared probes. Biochemistry (2008) 0.92
Expanding the scope of replicable unnatural DNA: stepwise optimization of a predominantly hydrophobic base pair. J Am Chem Soc (2013) 0.91
Differential solvation and tautomer stability of a model base pair within the minor and major grooves of DNA. J Am Chem Soc (2005) 0.91
Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response. Nucleic Acids Res (2004) 0.91
Infrared line shape of an alpha-carbon deuterium-labeled amino acid. J Am Chem Soc (2006) 0.91
Experimental and computational investigation of the uncatalyzed rearrangement and elimination reactions of isochorismate. J Am Chem Soc (2006) 0.90
Polymerase evolution: efforts toward expansion of the genetic code. J Am Chem Soc (2005) 0.90
Cyano groups as probes of protein microenvironments and dynamics. Angew Chem Int Ed Engl (2011) 0.90
Initial efforts toward the optimization of arylomycins for antibiotic activity. J Med Chem (2011) 0.90
Multiethynyl corannulenes: synthesis, structure, and properties. J Am Chem Soc (2008) 0.89
Protein dynamics and the diversity of an antibody response. J Biol Chem (2012) 0.89
Efforts toward developing direct probes of protein dynamics. J Am Chem Soc (2006) 0.88
Synthesis and characterization of the arylomycin lipoglycopeptide antibiotics and the crystallographic analysis of their complex with signal peptidase. J Am Chem Soc (2011) 0.88
The folding energy landscape and free energy excitations of cytochrome c. Acc Chem Res (2010) 0.88
Identification of pathways controlling DNA damage induced mutation in Saccharomyces cerevisiae. DNA Repair (Amst) (2008) 0.88
Stability and selectivity of unnatural DNA with five-membered-ring nucleobase analogues. J Am Chem Soc (2002) 0.87
Mechanism of action of the arylomycin antibiotics and effects of signal peptidase I inhibition. Antimicrob Agents Chemother (2012) 0.87
Through-space interactions between face-to-face, center-to-edge oriented arenes: importance of polar-pi effects. Org Biomol Chem (2003) 0.85
Proton-catalyzed, silane-fueled Friedel-Crafts coupling of fluoroarenes. Science (2011) 0.85
The effects of unnatural base pairs and mispairs on DNA duplex stability and solvation. Nucleic Acids Res (2009) 0.85
Molecular spur gears comprising triptycene rotators and bibenzimidazole-based stators. J Am Chem Soc (2012) 0.85
Functional endothelial progenitor cells selectively recruit neurovascular protective monocyte-derived F4/80(+) /Ly6c(+) macrophages in a mouse model of retinal degeneration. Stem Cells (2013) 0.85
Redox-coupled dynamics and folding in cytochrome c. J Am Chem Soc (2006) 0.85
Polymerase recognition and stability of fluoro-substituted pyridone nucleobase analogues. Chembiochem (2007) 0.85
Efforts toward the direct experimental characterization of enzyme microenvironments: tyrosine100 in dihydrofolate reductase. Angew Chem Int Ed Engl (2009) 0.85
Optimization of the pyridyl nucleobase scaffold for polymerase recognition and unnatural base pair replication. Chembiochem (2008) 0.84
Synthesis and properties of sym-pentasubstituted derivatives of corannulene. Org Lett (2003) 0.84
Direct and high resolution characterization of cytochrome c equilibrium folding. J Am Chem Soc (2006) 0.84
Evidence of an unusual N-H···N hydrogen bond in proteins. J Am Chem Soc (2014) 0.84
Directed evolution of novel polymerases. Biomol Eng (2005) 0.83
Efficient discovery of fluorescent chemosensors based on a biarylpyridine scaffold. Org Lett (2010) 0.83
C-D modes of deuterated side chain of leucine as structural reporters via dual-frequency two-dimensional infrared spectroscopy. J Phys Chem B (2009) 0.82
Directed evolution of DNA polymerases for next-generation sequencing. Angew Chem Int Ed Engl (2010) 0.82
Synthesis and biological characterization of arylomycin B antibiotics. J Nat Prod (2011) 0.82
Thermodynamic and computational studies on the binding of p53-derived peptides and peptidomimetic inhibitors to HDM2. Chembiochem (2009) 0.81
On the origins of non-radiative excited state relaxation in aryl sulfoxides relevant to fluorescent chemosensing. J Am Chem Soc (2016) 0.81
Axinellamines as broad-spectrum antibacterial agents: scalable synthesis and biology. J Am Chem Soc (2014) 0.81
Side effects may include evolution. Nat Med (2006) 0.81