Published in J Biol Chem on January 10, 2003
TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab (2009) 6.91
The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors. Br J Pharmacol (2013) 5.74
Bile acids: regulation of synthesis. J Lipid Res (2009) 4.31
Bile acids as regulatory molecules. J Lipid Res (2009) 3.23
Endocrine functions of bile acids. EMBO J (2006) 3.03
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc Natl Acad Sci U S A (2010) 2.52
Pleiotropic roles of bile acids in metabolism. Cell Metab (2013) 2.25
Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes. Mol Syst Biol (2008) 2.17
TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metab (2011) 2.17
Retracted Deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis. Hepatology (2013) 2.16
Biliary acute pancreatitis in mice is mediated by the G-protein-coupled cell surface bile acid receptor Gpbar1. Gastroenterology (2009) 1.91
Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice. Hepatology (2012) 1.77
Fifty years of advances in bile acid synthesis and metabolism. J Lipid Res (2008) 1.74
The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice. Hepatology (2011) 1.71
Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation. Biochem J (2006) 1.70
The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation. J Hepatol (2010) 1.69
Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. J Biol Chem (2011) 1.62
Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system. Neurogastroenterol Motil (2010) 1.60
Bile acid signaling in metabolic disease and drug therapy. Pharmacol Rev (2014) 1.58
Bile acids are essential for porcine enteric calicivirus replication in association with down-regulation of signal transducer and activator of transcription 1. Proc Natl Acad Sci U S A (2004) 1.57
Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery. Nat Commun (2015) 1.57
Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease. J Lipid Res (2012) 1.55
Bile acids: chemistry, physiology, and pathophysiology. World J Gastroenterol (2009) 1.51
Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion. Br J Pharmacol (2012) 1.48
G Protein-Coupled Bile Acid Receptor TGR5 Activation Inhibits Kidney Disease in Obesity and Diabetes. J Am Soc Nephrol (2015) 1.47
Bile acids and the gut microbiome. Curr Opin Gastroenterol (2014) 1.45
Bile acid metabolism and signaling. Compr Physiol (2013) 1.42
The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling. Mol Endocrinol (2011) 1.39
Bile acids: regulation of apoptosis by ursodeoxycholic acid. J Lipid Res (2009) 1.36
Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes. Hepatology (2011) 1.33
Reverse genetics system for porcine enteric calicivirus, a prototype sapovirus in the Caliciviridae. J Virol (2005) 1.33
Diet-microbiota interactions as moderators of human metabolism. Nature (2016) 1.31
Bile acid metabolism and the pathogenesis of type 2 diabetes. Curr Diab Rep (2011) 1.30
Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels. J Physiol (2010) 1.29
Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model. Diabetes (2010) 1.29
The TGR5 receptor mediates bile acid-induced itch and analgesia. J Clin Invest (2013) 1.27
Hepatic glucose sensing is required to preserve β cell glucose competence. J Clin Invest (2013) 1.27
Roux-en-Y gastric bypass normalizes the blunted postprandial bile acid excursion associated with obesity. Int J Obes (Lond) (2013) 1.24
Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass. Obes Surg (2012) 1.24
TGR5 potentiates GLP-1 secretion in response to anionic exchange resins. Sci Rep (2012) 1.23
The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts. J Biol Chem (2013) 1.23
Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes. Biochem Pharmacol (2009) 1.21
Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes. Endocrinology (2008) 1.20
Review article: the emerging interplay among the gastrointestinal tract, bile acids and incretins in the pathogenesis of diabetes and non-alcoholic fatty liver disease. Aliment Pharmacol Ther (2012) 1.20
Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma. Gut (2009) 1.20
Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway. J Lipid Res (2010) 1.18
Tissue-specific function of farnesoid X receptor in liver and intestine. Pharmacol Res (2011) 1.17
Bile acid-induced arrhythmia is mediated by muscarinic M2 receptors in neonatal rat cardiomyocytes. PLoS One (2010) 1.15
Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters. PLoS One (2011) 1.14
Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling. Mol Pharmacol (2007) 1.14
Bile Acid signaling in liver metabolism and diseases. J Lipids (2011) 1.13
Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease. J Biol Chem (2013) 1.13
TGR5: a novel target for weight maintenance and glucose metabolism. Exp Diabetes Res (2011) 1.12
A novel bile acid-activated vitamin D receptor signaling in human hepatocytes. Mol Endocrinol (2010) 1.12
The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis. PLoS One (2011) 1.11
Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output. Hepatology (2011) 1.11
Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist. Mol Pharmacol (2010) 1.08
Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. PLoS One (2010) 1.07
Plasma bile acids are not associated with energy metabolism in humans. Nutr Metab (Lond) (2010) 1.06
Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration. Mol Endocrinol (2008) 1.05
Nutritional lipidomics: molecular metabolism, analytics, and diagnostics. Mol Nutr Food Res (2013) 1.03
Endocrine and paracrine role of bile acids. World J Gastroenterol (2008) 1.02
Itch mechanisms and circuits. Annu Rev Biophys (2014) 1.01
Specific bile acids inhibit hepatic fatty acid uptake in mice. Hepatology (2012) 1.01
Physiology of cholangiocytes. Compr Physiol (2013) 1.00
Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation. PLoS One (2011) 1.00
The bile acid membrane receptor TGR5: a valuable metabolic target. Dig Dis (2011) 0.99
Bile acid receptors in non-alcoholic fatty liver disease. Biochem Pharmacol (2013) 0.99
Bile acid binding resin improves metabolic control through the induction of energy expenditure. PLoS One (2012) 0.99
Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosis. Hepatology (2010) 0.99
Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades. J Lipid Res (2014) 0.99
Bile acids are nutrient signaling hormones. Steroids (2014) 0.97
Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults. Nutr Metab (Lond) (2011) 0.97
Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Am J Physiol Gastrointest Liver Physiol (2012) 0.96
Bile acid sequestrants for lipid and glucose control. Curr Diab Rep (2010) 0.96
Microbiota-induced obesity requires farnesoid X receptor. Gut (2016) 0.96
Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice. Biochim Biophys Acta (2014) 0.96
Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids. Cancer Res (2014) 0.95
Intestinal bile acid physiology and pathophysiology. World J Gastroenterol (2008) 0.95
Bile acids regulate cardiovascular function. Clin Transl Sci (2011) 0.95
Bile acids, obesity, and the metabolic syndrome. Best Pract Res Clin Gastroenterol (2014) 0.94
Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling. Am J Physiol Gastrointest Liver Physiol (2013) 0.94
Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome. J Biol Chem (2011) 0.94
FXR promotes endothelial cell motility through coordinated regulation of FAK and MMP-9. Arterioscler Thromb Vasc Biol (2009) 0.94
TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease. Immunology (2013) 0.93
Expression of bile acid receptor TGR5 in gastric adenocarcinoma. Am J Physiol Gastrointest Liver Physiol (2012) 0.93
Gustducin couples fatty acid receptors to GLP-1 release in colon. Am J Physiol Endocrinol Metab (2013) 0.93
The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice. Gastroenterology (2014) 0.93
Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs. Anticancer Agents Med Chem (2012) 0.92
Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells. PeerJ (2013) 0.92
Advances in understanding of bile acid diarrhea. Expert Rev Gastroenterol Hepatol (2013) 0.91
Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway. Am J Physiol Gastrointest Liver Physiol (2012) 0.91
GPBA: a GPCR for bile acids and an emerging therapeutic target for disorders of digestion and sensation. Br J Pharmacol (2014) 0.91
The G-protein-coupled bile acid receptor Gpbar1 (TGR5) suppresses gastric cancer cell proliferation and migration through antagonizing STAT3 signaling pathway. Oncotarget (2015) 0.90
Genetic variation in GPBAR1 predisposes to quantitative changes in colonic transit and bile acid excretion. Am J Physiol Gastrointest Liver Physiol (2014) 0.90
Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells. Biochem Biophys Res Commun (2012) 0.90
Association of bile acid receptor TGR5 variation and transit in health and lower functional gastrointestinal disorders. Neurogastroenterol Motil (2011) 0.90
Dual activation of the bile acid nuclear receptor FXR and G-protein-coupled receptor TGR5 protects mice against atherosclerosis. PLoS One (2014) 0.90
Consequences of bile salt biotransformations by intestinal bacteria. Gut Microbes (2016) 0.89
Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature (2003) 6.87
The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol Biol Cell (2008) 6.66
Cadherin switching. J Cell Sci (2008) 3.70
Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb. Development (2005) 2.56
Large scale screening for novel rab effectors reveals unexpected broad Rab binding specificity. Mol Cell Proteomics (2008) 2.10
Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors. Biochem Biophys Res Commun (2002) 2.08
Successful autologous peripheral blood stem cell transplantation with a double-conditioning regimen for recurrent hepatoblastoma after liver transplantation. Pediatr Transplant (2008) 1.99
Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans. J Clin Endocrinol Metab (2003) 1.81
Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis. EMBO J (2008) 1.72
Risk of pleural recurrence after computed tomographic-guided percutaneous needle biopsy in stage I lung cancer patients. Ann Thorac Surg (2011) 1.71
Migration of eosinophils and CCR2-/CD68-double positive cells into the duodenal mucosa of patients with postinfectious functional dyspepsia. Am J Gastroenterol (2010) 1.67
Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans. Mol Biol Cell (2006) 1.61
Apelin is a novel angiogenic factor in retinal endothelial cells. Biochem Biophys Res Commun (2004) 1.59
Validation of pN2 sub-classifications in patients with pathological stage IIIA N2 non-small cell lung cancer. Interact Cardiovasc Thorac Surg (2011) 1.57
Tetraspanin CD151 protects against pulmonary fibrosis by maintaining epithelial integrity. Am J Respir Crit Care Med (2012) 1.55
Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation. J Biol Chem (2008) 1.54
Regulation of the PRL promoter by Akt through cAMP response element binding protein. Endocrinology (2002) 1.51
Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist. Neuropharmacology (2005) 1.47
Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells. Stem Cell Res (2011) 1.45
Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. J Cell Biol (2013) 1.44
Haloquadratum walsbyi gen. nov., sp. nov., the square haloarchaeon of Walsby, isolated from saltern crystallizers in Australia and Spain. Int J Syst Evol Microbiol (2007) 1.41
Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes. Mol Biol Cell (2009) 1.40
Electron tomography reveals diverse conformations of integrin alphaIIbbeta3 in the active state. J Struct Biol (2005) 1.37
Overexpression of the Wilms' tumor gene WT1 in de novo lung cancers. Int J Cancer (2002) 1.32
Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors. Life Sci (2005) 1.32
The Japanese national health screening and intervention program aimed at preventing worsening of the metabolic syndrome. Int Heart J (2008) 1.30
Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway. Am J Respir Crit Care Med (2002) 1.29
Recent advances in mammalian RFamide peptides: the discovery and functional analyses of PrRP, RFRPs and QRFP. Peptides (2006) 1.22
Identification of a G protein-coupled receptor specifically responsive to beta-alanine. J Biol Chem (2004) 1.21
Expression of KiSS-1, a metastasis suppressor gene, in trophoblast giant cells of the rat placenta. Biochim Biophys Acta (2004) 1.18
Development of vaccine strains of H5 and H7 influenza viruses. Jpn J Vet Res (2008) 1.18
A series of ENU-induced single-base substitutions in a long-range cis-element altering Sonic hedgehog expression in the developing mouse limb bud. Genomics (2006) 1.16
Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. J Biol Chem (2002) 1.13
Further refinement of the phylogeny of the Halobacteriaceae based on the full-length RNA polymerase subunit B' (rpoB') gene. Int J Syst Evol Microbiol (2009) 1.13
Small GTPase Rab12 regulates constitutive degradation of transferrin receptor. Traffic (2011) 1.12
A new peptidic ligand and its receptor regulating adrenal function in rats. J Biol Chem (2003) 1.11
Design, synthesis, and biological activity of potent and orally available G protein-coupled receptor 40 agonists. J Med Chem (2011) 1.10
GPR40, a free fatty acid receptor on pancreatic beta cells, regulates insulin secretion. Hepatol Res (2005) 1.10
Therapeutic time window of post-ischemic mild hypothermia and the gene expression associated with the neuroprotection in rat focal cerebral ischemia. Neurosci Res (2007) 1.10
Thermococcus thioreducens sp. nov., a novel hyperthermophilic, obligately sulfur-reducing archaeon from a deep-sea hydrothermal vent. Int J Syst Evol Microbiol (2007) 1.09
Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond to stress. Eur J Neurosci (2005) 1.07
N-Formylated humanin activates both formyl peptide receptor-like 1 and 2. Biochem Biophys Res Commun (2004) 1.06
Impact of positive pleural lavage cytology on survival in patients having lung resection for non-small-cell lung cancer: An international individual patient data meta-analysis. J Thorac Cardiovasc Surg (2009) 1.06
A new method for attenuation coefficient measurement in the liver: comparison with the spectral shift central frequency method. J Ultrasound Med (2002) 1.05
The regulatory or phosphorylation domain of p120 catenin controls E-cadherin dynamics at the plasma membrane. Exp Cell Res (2007) 1.04
Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7. J Biol Chem (2002) 1.04
Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. Genes Cells (2008) 1.04
Slac2-a/melanophilin contains multiple PEST-like sequences that are highly sensitive to proteolysis. J Biol Chem (2004) 1.03
Localization and neuronal response of RFamide related peptides in the rat central nervous system. Brain Res (2003) 1.01
Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex. Autophagy (2011) 1.01
Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain. Biochem Biophys Res Commun (2003) 1.01
Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology. J Cell Sci (2012) 1.00
Archaeal pre-mRNA splicing: a connection to hetero-oligomeric splicing endonuclease. Biochem Biophys Res Commun (2006) 0.99
Molecular properties of endogenous RFamide-related peptide-3 and its interaction with receptors. Biochim Biophys Acta (2003) 0.98
Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1. Glycobiology (2008) 0.97
Functional analysis of slac2-a/melanophilin as a linker protein between Rab27A and myosin Va in melanosome transport. Methods Enzymol (2005) 0.95
FBL2 regulates amyloid precursor protein (APP) metabolism by promoting ubiquitination-dependent APP degradation and inhibition of APP endocytosis. J Neurosci (2012) 0.95
The oncological feasibility and limitations of video-assisted thoracoscopic thymectomy for early-stage thymomas. Eur J Cardiothorac Surg (2013) 0.94
DNA polymerase gamma inhibition by vitamin K3 induces mitochondria-mediated cytotoxicity in human cancer cells. Cancer Sci (2008) 0.94
A novel antidiabetic drug, fasiglifam/TAK-875, acts as an ago-allosteric modulator of FFAR1. PLoS One (2013) 0.93
Novel approach for detection of isolated tumor cells in pulmonary vein using negative selection method: morphological classification and clinical implications. Eur J Cardiothorac Surg (2011) 0.93
F-blast is a useful marker for differentiating hypocellular refractory anemia from aplastic anemia. Int J Hematol (2002) 0.93
Carbohydrate recognition mechanism of HA70 from Clostridium botulinum deduced from X-ray structures in complexes with sialylated oligosaccharides. FEBS Lett (2012) 0.93
A plant phytotoxin, solanapyrone A, is an inhibitor of DNA polymerase beta and lambda. J Biol Chem (2001) 0.93
Endogenous prolactin-releasing peptide regulates food intake in rodents. J Clin Invest (2008) 0.93
Overdosage of Hand2 causes limb and heart defects in the human chromosomal disorder partial trisomy distal 4q. Hum Mol Genet (2013) 0.93
Archaeal diversity in a terrestrial acidic spring field revealed by a novel PCR primer targeting archaeal 16S rRNA genes. FEMS Microbiol Lett (2011) 0.93
Impact of sleep disorders in Japanese patients with functional dyspepsia (FD): nizatidine improves clinical symptoms, gastric emptying and sleep disorders in FD patients. J Gastroenterol Hepatol (2013) 0.92