Published in Osteoarthritis Cartilage on February 01, 2003
Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis (2005) 3.25
The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol (2010) 3.14
Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis. Rheumatology (Oxford) (2010) 1.74
Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis. Nat Rev Rheumatol (2012) 1.62
Increased interleukin-1β gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis. Arthritis Rheum (2011) 1.16
Osteoarthritis: can anti-cytokine therapy play a role in treatment? Clin Rheumatol (2010) 1.02
New findings in osteoarthritis pathogenesis: therapeutic implications. Ther Adv Chronic Dis (2013) 1.00
Matrix metalloproteases and tissue inhibitors of metalloproteinases in medial plica and pannus-like tissue contribute to knee osteoarthritis progression. PLoS One (2013) 0.86
Differences in Mammalian target of rapamycin gene expression in the peripheral blood and articular cartilages of osteoarthritic patients and disease activity. Arthritis (2013) 0.85
Targeting the synovial angiogenesis as a novel treatment approach to osteoarthritis. Ther Adv Musculoskelet Dis (2014) 0.82
Efficacy and safety of piascledine 300 versus chondroitin sulfate in a 6 months treatment plus 2 months observation in patients with osteoarthritis of the knee. Clin Rheumatol (2010) 0.79
Luteolin Inhibits the Activity, Secretion and Gene Expression of MMP-3 in Cultured Articular Chondrocytes and Production of MMP-3 in the Rat Knee. Biomol Ther (Seoul) (2014) 0.78
Immunohistochemical characterization of reparative tissue present in human osteoarthritic tissue. Virchows Arch (2010) 0.78
The concentration of thiobarbituric acid reactive substances (TBARS) and paraoxonase activity in blood of patients with osteoarthrosis after endoprosthesis implantation. Med Sci Monit (2011) 0.76
Post-operative rehabilitation in osteoarthritis. F1000Res (2014) 0.76
Nutraceutical Supplements in the Management and Prevention of Osteoarthritis. Int J Mol Sci (2016) 0.75
Inhibitory effects of EGb761 on the expression of matrix metalloproteinases (MMPs) and cartilage matrix destruction. Cell Stress Chaperones (2015) 0.75
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
In vitro hemolytic characteristic of Vibrio parahaemolyticus: its close correlation with human pathogenicity. J Bacteriol (1969) 8.04
Positional cloning of the mouse circadian clock gene. Cell (1997) 7.79
Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell (1994) 7.23
The rate of loss of weight in skeletal muscle after nerve section with some observations on the effect of stimulation and other treatment. J Physiol (1915) 6.49
Cooperation between mDia1 and ROCK in Rho-induced actin reorganization. Nat Cell Biol (1999) 5.84
Calcium induced release of calcium from the sarcoplasmic reticulum of skinned skeletal muscle fibres. Nature (1970) 5.65
Isolation and characterization of mutants of Escherichia coli deficient in induction of mutations by ultraviolet light. Mol Gen Genet (1977) 5.61
Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators. Anticancer Drugs (1996) 5.45
The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16. Nature (1989) 5.43
Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose. The Funagata Diabetes Study. Diabetes Care (1999) 5.37
Studies on the enteropathogenic, facultatively halophilic bacterium, Vibrio parahaemolyticus. 3. Enteropathogenicity. Jpn J Med Sci Biol (1968) 5.35
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet (2000) 5.26
Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell (1999) 4.98
Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti. DNA Res (2000) 4.94
Identification of CRE1 as a cytokinin receptor from Arabidopsis. Nature (2001) 4.77
Antimicrobial activity of DU-6859, a new potent fluoroquinolone, against clinical isolates. Antimicrob Agents Chemother (1992) 4.43
The physiological action of physostigmine and its action on denervated skeletal muscle. J Physiol (1915) 4.37
RecA protein-dependent cleavage of UmuD protein and SOS mutagenesis. Proc Natl Acad Sci U S A (1988) 4.12
A novel method for phosphorylation of nucleosides to 5'-nucleotides. Tetrahedron Lett (1967) 4.11
Identification of the heme compound copurified with deoxyribonucleic acid (DNA) from bloodstains, a major inhibitor of polymerase chain reaction (PCR) amplification. J Forensic Sci (1994) 4.02
Arabidopsis NPL1: a phototropin homolog controlling the chloroplast high-light avoidance response. Science (2001) 3.93
Regulation of drought tolerance by gene manipulation of 9-cis-epoxycarotenoid dioxygenase, a key enzyme in abscisic acid biosynthesis in Arabidopsis. Plant J (2001) 3.92
Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Neuroimage (2002) 3.88
Coding of modified body schema during tool use by macaque postcentral neurones. Neuroreport (1996) 3.78
Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices. Cell (1994) 3.74
Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet (1989) 3.69
Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression. J Biol Chem (1999) 3.67
Identification of toxin A-negative, toxin B-positive Clostridium difficile by PCR. J Clin Microbiol (1998) 3.34
TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell (1997) 3.30
Corneal neovascularization. Curr Opin Ophthalmol (2001) 3.22
Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation (1995) 3.18
Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res (2001) 3.18
Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus. Exp Cell Res (1986) 3.17
Determination of the ID50 values of antibacterial agents in agar. J Antibiot (Tokyo) (1978) 3.08
Base-change mutagenesis and prophage induction in strains of Escherichia coli with different DNA repair capacities. Genetics (1970) 3.05
Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet (1998) 3.01
Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis. J Biol Chem (1991) 2.89
Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan. J Clin Microbiol (1997) 2.89
Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease. Proc Natl Acad Sci U S A (1996) 2.88
Genetic evidence for female host-specific races of the common cuckoo. Nature (2000) 2.84
Familial gastrointestinal stromal tumours with germline mutation of the KIT gene. Nat Genet (1998) 2.80
Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res (1995) 2.79
Human Fas ligand: gene structure, chromosomal location and species specificity. Int Immunol (1994) 2.74
Cupric oxide as an induced-multiferroic with high-TC. Nat Mater (2008) 2.67
Preoperative probability model for predicting overall survival after resection of pulmonary metastases from colorectal cancer. Br J Surg (2004) 2.62
Induction of erythroid differentiation in murine virus infected eythroleukemia cells by highly polar compounds. Proc Natl Acad Sci U S A (1975) 2.60
Rapid identification of dengue virus serotypes by using polymerase chain reaction. J Clin Microbiol (1991) 2.60
Hyperammonaemia and Helicobacter pylori. Lancet (1995) 2.59
Mitochondrial genotype associated with longevity. Lancet (1998) 2.58
Uterine sutures at prior caesarean section and placenta accreta in subsequent pregnancy: a case-control study. BJOG (2014) 2.56
Atomic structure of the RuvC resolvase: a holliday junction-specific endonuclease from E. coli. Cell (1994) 2.55
ARR1, a transcription factor for genes immediately responsive to cytokinins. Science (2001) 2.50
Can endoscopic papillary balloon dilation really preserve sphincter of Oddi function? Gut (2001) 2.49
Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: roles of transforming growth factor (TGF)-beta and bone morphogenetic protein (BMP). Anat Rec (2000) 2.44
Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J Clin Invest (1997) 2.44
Activation of protein kinase C by tyrosine phosphorylation in response to H2O2. Proc Natl Acad Sci U S A (1997) 2.42
Genetic evidence that the endodermis is essential for shoot gravitropism in Arabidopsis thaliana. Plant J (1998) 2.41
Spectrodensitometric determination of trichothecene mycotoxins with 4-(p-nitrobenzyl)pyridine on silica gel thin-layer chromatograms. J Chromatogr (1979) 2.38
Genetic and molecular characteristics of X-ray-sensitive mutants of Escherichia coli defective in repair synthesis. J Bacteriol (1970) 2.37
Treatment of hemoptysis patients by thrombin and fibrinogen-thrombin infusion therapy using a fiberoptic bronchoscope. Chest (1989) 2.36
The human amygdala plays an important role in gaze monitoring. A PET study. Brain (1999) 2.33
Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor. J Clin Invest (1992) 2.33
Norfloxacin resistance in a clinical isolate of Escherichia coli. Antimicrob Agents Chemother (1987) 2.33
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis. Ann Rheum Dis (2000) 2.32
A TBP complex essential for transcription from TATA-less but not TATA-containing RNA polymerase III promoters is part of the TFIIIB fraction. Cell (1992) 2.32
Structural analysis of the umu operon required for inducible mutagenesis in Escherichia coli. Proc Natl Acad Sci U S A (1985) 2.30
Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene. EMBO J (1997) 2.28
Acriflavine-binding capacity of Escherichia coli in relation to acriflavine sensitivity and metabolic activity. J Bacteriol (1966) 2.28
Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1. Nat Cell Biol (2001) 2.27
MID1, a novel Saccharomyces cerevisiae gene encoding a plasma membrane protein, is required for Ca2+ influx and mating. Mol Cell Biol (1994) 2.25
Fc epsilon receptor, a specific differentiation marker transiently expressed on mature B cells before isotype switching. J Exp Med (1986) 2.25
Solution structure of a DNA-binding unit of Myb: a helix-turn-helix-related motif with conserved tryptophans forming a hydrophobic core. Proc Natl Acad Sci U S A (1992) 2.23
Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease. Biochem Biophys Res Commun (1989) 2.23
An enzymatic cycling method for nicotinamide-adenine dinucleotide with malic and alcohol dehydrogenases. Anal Biochem (1973) 2.22
Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat Genet (1997) 2.20
Interaction of endostatin with integrins implicated in angiogenesis. Proc Natl Acad Sci U S A (2001) 2.19
Diffusion-weighted imaging of metastatic brain tumors: comparison with histologic type and tumor cellularity. AJNR Am J Neuroradiol (2006) 2.17
Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Nature (2000) 2.17
Crazy-paving appearance at thin-section CT: spectrum of disease and pathologic findings. Radiology (1999) 2.16
Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Nature (2000) 2.16
Suppression of the heterotrimeric G protein causes abnormal morphology, including dwarfism, in rice. Proc Natl Acad Sci U S A (1999) 2.15
Six chloroplast genes (ndhA-F) homologous to human mitochondrial genes encoding components of the respiratory chain NADH dehydrogenase are actively expressed: determination of the splice sites in ndhA and ndhB pre-mRNAs. Mol Gen Genet (1987) 2.14
Function of Light in the Light-induced Geotropic Response in Zea Roots. Plant Physiol (1981) 2.13
N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest (2000) 2.13
Erythromycin reduces neutrophils and neutrophil-derived elastolytic-like activity in the lower respiratory tract of bronchiolitis patients. Am Rev Respir Dis (1992) 2.12
Genetic determination of resistance to acriflavine, phenethyl alcohol, and sodium dodecyl sulfate in Escherichia coli. J Bacteriol (1968) 2.11
Subtractive cDNA cloning using oligo(dT)30-latex and PCR: isolation of cDNA clones specific to undifferentiated human embryonal carcinoma cells. Nucleic Acids Res (1991) 2.08
Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer. Cancer Res (1998) 2.08
A gene controlling the synthesis of non specific alkaline phosphatase in Saccharomyces cerevisiae. Biochim Biophys Acta (1976) 2.04
Poly(L-proline)-binding proteins from chick embryos are a profilin and a profilactin. Eur J Biochem (1985) 2.01
Diffusion-weighted single-shot echoplanar MR imaging for liver disease. AJR Am J Roentgenol (1999) 2.00
The internal biliary fistula--reappraisal of incidence, type, diagnosis and management of 33 consecutive cases. HPB Surg (1997) 2.00
Idiopathic interstitial pneumonias: diagnostic accuracy of thin-section CT in 129 patients. Radiology (1999) 1.99
Symptomatic myopathy associated with interferon therapy for chronic hepatitis C. Lancet (1995) 1.99
Erythroid cell differentiation: murine erythroleukemia cell variant with unique pattern of induction by polar compounds. Proc Natl Acad Sci U S A (1976) 1.99
Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB. J Biol Chem (1999) 1.99
Mitochondrial mutation in fatal infantile cardiomyopathy. Lancet (1990) 1.98
The endodermis and shoot gravitropism Trends Plant Sci (1999) 1.98