Published in J Neurochem on February 01, 2003
Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. Neuron (2008) 2.88
Oxidative stress, cell cycle, and neurodegeneration. J Clin Invest (2003) 1.84
HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis. Cell Death Differ (2006) 1.82
Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration. EMBO J (2003) 1.80
HDAC4 inhibits cell-cycle progression and protects neurons from cell death. Dev Neurobiol (2008) 1.56
Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor. PLoS One (2010) 1.40
Neuroprotection by histone deacetylase-related protein. Mol Cell Biol (2006) 1.37
Cell cycle molecules define a pathway required for neuron death in development and disease. Biochim Biophys Acta (2006) 1.35
HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation. EMBO J (2007) 1.31
Putting the 'HAT' back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions. Expert Opin Investig Drugs (2009) 1.28
Histone deacetylase inhibitors induce reactivation of herpes simplex virus type 1 in a latency-associated transcript-independent manner in neuronal cells. J Neurovirol (2005) 1.27
Regulation of neuron survival and death by p130 and associated chromatin modifiers. Genes Dev (2005) 1.25
Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosis. BMC Neurosci (2010) 1.20
HDAC inhibitors and neurodegeneration: at the edge between protection and damage. Pharmacol Res (2010) 1.15
Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo. BMC Cancer (2011) 1.07
Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegeneration. Mol Pharmacol (2010) 1.05
Neuroprotection by histone deacetylase-7 (HDAC7) occurs by inhibition of c-jun expression through a deacetylase-independent mechanism. J Biol Chem (2010) 1.04
ER stress response plays an important role in aggregation of α-synuclein. Mol Neurodegener (2010) 0.99
Histone deacetylase inhibitors sodium butyrate and valproic acid delay spontaneous cell death in purified rat retinal ganglion cells. Mol Vis (2011) 0.98
Chromatin modification of Apaf-1 restricts the apoptotic pathway in mature neurons. J Cell Biol (2007) 0.96
Tip60 HAT activity mediates APP induced lethality and apoptotic cell death in the CNS of a Drosophila Alzheimer's disease model. PLoS One (2012) 0.96
Class IIA HDACs in the regulation of neurodegeneration. Front Biosci (2008) 0.94
Histone deacetylase inhibitors as therapeutic agents for acute central nervous system injuries. Mol Med (2011) 0.93
Unique functional roles for class I and class II histone deacetylases in central nervous system development and function. Int J Dev Neurosci (2013) 0.90
Paraquat induces epigenetic changes by promoting histone acetylation in cell culture models of dopaminergic degeneration. Neurotoxicology (2011) 0.89
Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. J Biol Chem (2014) 0.87
Histone acetylation inhibitors promote axon growth in adult dorsal root ganglia neurons. J Neurosci Res (2015) 0.86
Collapsin response mediator protein 3 deacetylates histone H4 to mediate nuclear condensation and neuronal death. Sci Rep (2013) 0.81
Epigenetics of neural repair following spinal cord injury. Neurotherapeutics (2013) 0.81
Chromatin modifications associated with DNA double-strand breaks repair as potential targets for neurological diseases. Neurotherapeutics (2013) 0.81
Mechanisms of Histone Deacetylase Inhibitor-Regulated Gene Expression in Cancer Cells. Antioxid Redox Signal (2014) 0.80
Histone deacetylase inhibition and the regulation of cell growth with particular reference to liver pathobiology. J Cell Mol Med (2009) 0.80
A proapoptotic effect of valproic acid on progenitors of embryonic stem cell-derived glutamatergic neurons. Cell Death Dis (2013) 0.79
Inhibitors of histone deacetylases enhance neurotoxicity of DNA damage. Neuromolecular Med (2014) 0.79
Matters of life and death: the role of chromatin remodeling proteins in retinal neuron survival. J Ocul Biol Dis Infor (2012) 0.79
Inhibition of Plk1 and Cyclin B1 expression results in panobinostat-induced G₂ delay and mitotic defects. Sci Rep (2013) 0.77
Epigenetic regulation in the brain after spinal cord injury : a comparative study. J Korean Neurosurg Soc (2013) 0.75
The Molecular Basis of Toxins' Interactions with Intracellular Signaling via Discrete Portals. Toxins (Basel) (2017) 0.75
Transcriptional landscapes at the intersection of neuronal apoptosis and substance P-induced survival: exploring pathways and drug targets. Cell Death Discov (2016) 0.75
The Modulation of Neurotrophin and Epigenetic Regulators: Implication for Astrocyte Proliferation and Neuronal Cell Apoptosis After Spinal Cord Injury. Ann Rehabil Med (2016) 0.75
Muscle Nogo-A expression is a prognostic marker in lower motor neuron syndromes. Ann Neurol (2007) 2.37
Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse model. Proc Natl Acad Sci U S A (2004) 2.26
Guidelines for preclinical animal research in ALS/MND: A consensus meeting. Amyotroph Lateral Scler (2010) 2.14
Energy metabolism in amyotrophic lateral sclerosis. Lancet Neurol (2010) 2.00
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J (2007) 1.99
Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration. EMBO J (2003) 1.80
Nogo-A, -B, and -C are found on the cell surface and interact together in many different cell types. J Biol Chem (2005) 1.61
Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription. Nucleic Acids Res (2005) 1.61
Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model. J Neurosci (2007) 1.52
Neuromuscular junction destruction during amyotrophic lateral sclerosis: insights from transgenic models. Curr Opin Pharmacol (2009) 1.47
Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons. PLoS One (2009) 1.45
Gene profiling of skeletal muscle in an amyotrophic lateral sclerosis mouse model. Physiol Genomics (2007) 1.31
HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation. EMBO J (2007) 1.31
Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy in neurological disorders. Biochem Pharmacol (2004) 1.22
Spatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus. Neuropsychopharmacology (2010) 1.21
Impaired glucose tolerance in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler (2010) 1.20
Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis. Neurobiol Dis (2002) 1.17
Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain. Ann Neurol (2012) 1.12
Up-regulation of mitochondrial uncoupling protein 3 reveals an early muscular metabolic defect in amyotrophic lateral sclerosis. FASEB J (2003) 1.11
Nogo expression in muscle correlates with amyotrophic lateral sclerosis severity. Ann Neurol (2005) 1.11
Increased peripheral lipid clearance in an animal model of amyotrophic lateral sclerosis. J Lipid Res (2007) 1.09
The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model. EMBO Rep (2006) 1.09
A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons. Hum Mol Genet (2010) 1.09
Mitochondria in amyotrophic lateral sclerosis: a trigger and a target. Neurodegener Dis (2004) 1.07
A ruthenium-containing organometallic compound reduces tumor growth through induction of the endoplasmic reticulum stress gene CHOP. Cancer Res (2009) 1.06
Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73. J Biol Chem (2003) 1.05
Mice with a mutation in the dynein heavy chain 1 gene display sensory neuropathy but lack motor neuron disease. Exp Neurol (2008) 1.05
Enhancement of p53 activity and inhibition of neural cell proliferation by glucocorticoid receptor activation. FASEB J (2002) 1.04
Constitutive repression of E2F1 transcriptional activity through HDAC proteins is essential for neuronal survival. Ann N Y Acad Sci (2002) 1.00
Amyotrophic lateral sclerosis: all roads lead to Rome. J Neurochem (2007) 0.99
Diffusion-weighted MRI of denervated muscle: a clinical and experimental study. Skeletal Radiol (2008) 0.96
Dynein mutations associated with hereditary motor neuropathies impair mitochondrial morphology and function with age. Neurobiol Dis (2013) 0.96
Muscular mitochondrial function in amyotrophic lateral sclerosis is progressively altered as the disease develops: a temporal study in man. Exp Neurol (2005) 0.93
BBS-induced ciliary defect enhances adipogenesis, causing paradoxical higher-insulin sensitivity, glucose usage, and decreased inflammatory response. Cell Metab (2012) 0.93
Oxidative stress in skeletal muscle stimulates early expression of Rad in a mouse model of amyotrophic lateral sclerosis. Free Radic Biol Med (2010) 0.93
Nogo receptor antagonizes p75NTR-dependent motor neuron death. Proc Natl Acad Sci U S A (2008) 0.91
Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway. J Biol Chem (2002) 0.91
Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity. Biochem Pharmacol (2012) 0.91
Investigating the contribution of VAPB/ALS8 loss of function in amyotrophic lateral sclerosis. Hum Mol Genet (2013) 0.89
P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis. Neurosci Lett (2010) 0.88
The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1. Mol Cancer Res (2009) 0.88
Muscle gene expression is a marker of amyotrophic lateral sclerosis severity. Neurodegener Dis (2011) 0.88
Detection of histone acetylation levels in the dorsal hippocampus reveals early tagging on specific residues of H2B and H4 histones in response to learning. PLoS One (2013) 0.87
The metabolic hypothesis in amyotrophic lateral sclerosis: insights from mutant Cu/Zn-superoxide dismutase mice. Biomed Pharmacother (2005) 0.87
Tissue specificity and regulation of the N-terminal diversity of reticulon 3. Biochem J (2005) 0.86
Mutations in cytoplasmic dynein lead to a Huntington's disease-like defect in energy metabolism of brown and white adipose tissues. Biochim Biophys Acta (2010) 0.85
Elevated levels of amyloid precursor protein in muscle of patients with amyotrophic lateral sclerosis and a mouse model of the disease. Muscle Nerve (2006) 0.85
The beta-amyloid precursor protein controls a store-operated Ca2+ entry in cortical neurons. Eur J Neurosci (2004) 0.84
Platelet serotonin level predicts survival in amyotrophic lateral sclerosis. PLoS One (2010) 0.82
Degeneration of serotonergic neurons in amyotrophic lateral sclerosis: a link to spasticity. Brain (2012) 0.82
Fatting the brain: a brief of recent research. Front Cell Neurosci (2013) 0.82
Mitochondrial dysfunction in amyotrophic lateral sclerosis also affects skeletal muscle. Muscle Nerve (2006) 0.81
Loss of prion protein in a transgenic model of amyotrophic lateral sclerosis. Mol Cell Neurosci (2002) 0.81
HDAC-3 participates in the repression of e2f-dependent gene transcription in primary differentiated neurons. Ann N Y Acad Sci (2004) 0.81
The Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctions. PLoS One (2012) 0.80
Reticulons as markers of neurological diseases: focus on amyotrophic lateral sclerosis. Neurodegener Dis (2005) 0.80
Complex regulation of p73 isoforms after alteration of amyloid precursor polypeptide (APP) function and DNA damage in neurons. J Biol Chem (2011) 0.79
Electrophysiological studies in a mouse model of Schwartz-Jampel syndrome demonstrate muscle fiber hyperactivity of peripheral nerve origin. Muscle Nerve (2009) 0.79
Antibody-bound beta-amyloid precursor protein stimulates the production of tumor necrosis factor-alpha and monocyte chemoattractant protein-1 by cortical neurons. Neurobiol Dis (2005) 0.79
Systemic down-regulation of delta-9 desaturase promotes muscle oxidative metabolism and accelerates muscle function recovery following nerve injury. PLoS One (2013) 0.79
A mutation in the dynein heavy chain gene compensates for energy deficit of mutant SOD1 mice and increases potentially neuroprotective IGF-1. Mol Neurodegener (2011) 0.78
Early activation of antioxidant mechanisms in muscle of mutant Cu/Zn-superoxide dismutase-linked amyotrophic lateral sclerosis mice. Ann N Y Acad Sci (2003) 0.78
Neuroendocrinology of neurodegenerative diseases. Insights from transgenic mouse models. Neuroendocrinology (2003) 0.78
Sp3 and sp4 transcription factor levels are increased in brains of patients with Alzheimer's disease. Neurodegener Dis (2007) 0.78
[Amyotrophic lateral sclerosis: role of energy deficiency in neuromuscular junction dismantlement]. Med Sci (Paris) (2008) 0.76
Full-length PGC-1α salvages the phenotype of a mouse model of human neuropathy through mitochondrial proliferation. Hum Mol Genet (2013) 0.75
Lesions and genes: on the edge of improved isomorphic models for Alzheimer's disease? Neurodegener Dis (2008) 0.75
Denervation is not a primary cause of prion protein down-regulation occurring in the spinal cord of a transgenic model of amyotrophic lateral sclerosis. Ann N Y Acad Sci (2002) 0.75
[Cellular prion protein: more than what beyond spongiform encephalopathies]. Med Sci (Paris) (2003) 0.75