Oxidative stress, cell cycle, and neurodegeneration.

Nitric oxide and peroxynitrite in health and disease. Physiol Rev (2007) 15.49

Reactive oxygen species: role in the development of cancer and various chronic conditions. J Carcinog (2006) 3.65

AIF deficiency compromises oxidative phosphorylation. EMBO J (2004) 3.19

Redox control of the cell cycle in health and disease. Antioxid Redox Signal (2009) 1.72

Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Mol Cell Biol (2005) 1.58

Redox mechanisms in hepatic chronic wound healing and fibrogenesis. Fibrogenesis Tissue Repair (2008) 1.30

Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death. J Neurol Sci (2009) 1.26

Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal. Proc Natl Acad Sci U S A (2006) 1.24

Preventing oxidative stress: a new role for XBP1. Cell Death Differ (2009) 1.15

Combined use of pregabalin and memantine in fibromyalgia syndrome treatment: a novel analgesic and neuroprotective strategy? Med Hypotheses (2009) 1.12

Differential regulation of Mn-superoxide dismutase in neurons and astroglia by HIV-1 gp120: Implications for HIV-associated dementia. Free Radic Biol Med (2007) 1.08

Reversible and irreversible protein glutathionylation: biological and clinical aspects. Expert Opin Drug Metab Toxicol (2011) 1.07

Towards a pathway definition of Parkinson's disease: a complex disorder with links to cancer, diabetes and inflammation. Neurogenetics (2008) 1.04

Reactive oxygen/nitrogen species and their functional correlations in neurodegenerative diseases. J Neural Transm (Vienna) (2012) 1.04

Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. Neuron (2014) 1.03

Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis. Cold Spring Harb Perspect Biol (2011) 1.02

Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds). Genome Biol (2008) 1.02

Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage. Mol Cell (2014) 0.99

Oxidative stress in genetic mouse models of Parkinson's disease. Oxid Med Cell Longev (2012) 0.98

Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage. Biochem J (2004) 0.98

Genetic networks controlling retinal injury. Mol Vis (2005) 0.97

Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons. Exp Cell Res (2010) 0.97

Transgenic Drosophila models of Alzheimer's disease and tauopathies. Brain Struct Funct (2009) 0.96

Ethanolic extract of fructus Alpinia oxyphylla protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish. Cell Mol Neurobiol (2011) 0.96

SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and induces apoptotic cell death. J Biol Chem (2008) 0.94

Evidence of neurodegeneration in autism spectrum disorder. Transl Neurodegener (2013) 0.94

CHIP has a protective role against oxidative stress-induced cell death through specific regulation of endonuclease G. Cell Death Dis (2013) 0.93

Ethyl acetate extract of germinated brown rice attenuates hydrogen peroxide-induced oxidative stress in human SH-SY5Y neuroblastoma cells: role of anti-apoptotic, pro-survival and antioxidant genes. BMC Complement Altern Med (2013) 0.93

Increased proliferative cells in the medullary thick ascending limb of the loop of Henle in the Dahl salt-sensitive rat. Hypertension (2012) 0.92

Biomarkers in autism. Front Psychiatry (2014) 0.92

Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture. J Neurochem (2014) 0.92

Oxidative damage and defective DNA repair is linked to apoptosis of migrating neurons and progenitors during cerebral cortex development in Ku70-deficient mice. Cereb Cortex (2004) 0.91

Disruption of the nuclear membrane by perinuclear inclusions of mutant huntingtin causes cell-cycle re-entry and striatal cell death in mouse and cell models of Huntington's disease. Hum Mol Genet (2014) 0.90

Adult neurogenesis transiently generates oxidative stress. PLoS One (2012) 0.90

Neuronal cell cycle: the neuron itself and its circumstances. Cell Cycle (2015) 0.90

Oxidative stress impairs the heat stress response and delays unfolded protein recovery. PLoS One (2009) 0.90

The expanding network of redox signaling: new observations, complexities, and perspectives. J Clin Invest (2003) 0.89

Neuroprotective effects of germinated brown rice against hydrogen peroxide induced cell death in human SH-SY5Y cells. Int J Mol Sci (2012) 0.89

Connecting cell-cycle activation to neurodegeneration in Drosophila. Biochim Biophys Acta (2006) 0.87

Thymoquinone prevents β-amyloid neurotoxicity in primary cultured cerebellar granule neurons. Cell Mol Neurobiol (2013) 0.87

Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice. Neurosci Bull (2012) 0.87

Evidence from in vivo 31-phosphorus magnetic resonance spectroscopy phosphodiesters that exhaled ethane is a biomarker of cerebral n-3 polyunsaturated fatty acid peroxidation in humans. BMC Psychiatry (2008) 0.87

Viral vectors for in vivo gene transfer in Parkinson's disease: properties and clinical grade production. Exp Neurol (2007) 0.86

The ubiquitin-proteasome system in spongiform degenerative disorders. Biochim Biophys Acta (2008) 0.86

Oxidative stress in Alzheimer's and Parkinson's diseases: insights from the yeast Saccharomyces cerevisiae. Oxid Med Cell Longev (2012) 0.85

Neuroprotective effects of bikaverin on H2O2-induced oxidative stress mediated neuronal damage in SH-SY5Y cell line. Cell Mol Neurobiol (2014) 0.84

The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease. Mol Neurodegener (2009) 0.84

HIV-1 gp120 and morphine induced oxidative stress: role in cell cycle regulation. Front Microbiol (2015) 0.83

Mechanistic basis for protection of differentiated SH-SY5Y cells by oryzanol-rich fraction against hydrogen peroxide-induced neurotoxicity. BMC Complement Altern Med (2014) 0.82

Neuroprotection of antioxidant enzymes against transient global cerebral ischemia in gerbils. Anat Cell Biol (2014) 0.82

2,4-Di-tert-butylphenol from sweet potato protects against oxidative stress in PC12 cells and in mice. J Med Food (2013) 0.81

Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress. Brain Res (2016) 0.81

Physiological antioxidative network of the bilirubin system in aging and age-related diseases. Front Pharmacol (2012) 0.80

Hydrogen peroxide alters splicing of soluble guanylyl cyclase and selectively modulates expression of splicing regulators in human cancer cells. PLoS One (2012) 0.80

24-Epibrassinolide, a Phytosterol from the Brassinosteroid Family, Protects Dopaminergic Cells against MPP-Induced Oxidative Stress and Apoptosis. J Toxicol (2011) 0.80

Physiological and pathophysiological functions of cell cycle proteins in post-mitotic neurons: implications for Alzheimer's disease. Acta Neuropathol (2015) 0.79

Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges. Immun Ageing (2016) 0.79

The expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer's disease. BMC Neurosci (2014) 0.78

Maximal electroshock induces changes in some markers of oxidative stress in mice. J Neural Transm (Vienna) (2007) 0.77

Delivery of a protein transduction domain-mediated Prdx6 protein ameliorates oxidative stress-induced injury in human and mouse neuronal cells. Am J Physiol Cell Physiol (2015) 0.77

Photoreceptor proliferation and dysregulation of cell cycle genes in early onset inherited retinal degenerations. BMC Genomics (2016) 0.77

ALS-linked SOD1 in glial cells enhances ß-N-Methylamino L-Alanine (BMAA)-induced toxicity in Drosophila. F1000Res (2012) 0.76

Protection of Tong-Sai-Mai Decoction against Apoptosis Induced by H2O2 in PC12 Cells: Mechanisms via Bcl-2-Mitochondria-ROS-INOS Pathway. Evid Based Complement Alternat Med (2014) 0.76

Akt attenuates apoptotic death through phosphorylation of H2A under hydrogen peroxide-induced oxidative stress in PC12 cells and hippocampal neurons. Sci Rep (2016) 0.76

Mulberry extracts alleviate aβ 25-35-induced injury and change the gene expression profile in PC12 cells. Evid Based Complement Alternat Med (2014) 0.76

The ameliorative potential of ethanolic extract of propolis on hematotoxicity and structural neuronal damage in hyperthermia-exposed rats. Iran J Basic Med Sci (2016) 0.75

Distinct regulation of cell cycle and survival in lymphocytes from patients with Alzheimer's disease and amyotrophic lateral sclerosis. Int J Clin Exp Pathol (2008) 0.75

Vitamin C Attenuates Chronic Chlorpyrifos-induced Alteration of Neurobehavioral Parameters in Wistar Rats. Toxicol Int (2012) 0.75

Modulation of Hydrogen Peroxide-Induced Oxidative Stress in Human Neuronal Cells by Thymoquinone-Rich Fraction and Thymoquinone via Transcriptomic Regulation of Antioxidant and Apoptotic Signaling Genes. Oxid Med Cell Longev (2015) 0.75

PEDF Promotes Biosynthesis of a Novel Anti-inflammatory and Anti-apoptotic Mediator NPD1 in Retinal Pigment Epithelial Cells. Ochsner J (2008) 0.75

Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice. Transl Psychiatry (2017) 0.75

Neuroprotective effects of Nigella sativa extract upon the hippocampus in PTU-induced hypothyroidism juvenile rats: A stereological study. Metab Brain Dis (2017) 0.75

Free radicals in the physiological control of cell function. Physiol Rev (2002) 19.62

Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05

Molecular characterization of mitochondrial apoptosis-inducing factor. Nature (1999) 14.41

Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol (2002) 6.68

What's up and down with histone deacetylation and transcription? Cell (1997) 5.99

Sir2 links chromatin silencing, metabolism, and aging. Genes Dev (2000) 5.95

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature (2001) 5.07

Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab (2001) 5.06

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase. Nat Genet (1998) 3.41

The harlequin mouse mutation downregulates apoptosis-inducing factor. Nature (2002) 3.30

Direct coupling of the cell cycle and cell death machinery by E2F. Nat Cell Biol (2002) 3.00

Is NF-kappaB the sensor of oxidative stress? FASEB J (1999) 2.86

NF-kappaB in neuronal plasticity and neurodegenerative disorders. J Clin Invest (2001) 2.78

Rapid accumulation of genome rearrangements in liver but not in brain of old mice. Nat Genet (1997) 2.74

DNA replication precedes neuronal cell death in Alzheimer's disease. J Neurosci (2001) 2.60

Oxidative stress and apoptosis. Pathophysiology (2000) 2.58

An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J Neurosci (2002) 2.54

Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. J Neurosci (1998) 2.42

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proc Natl Acad Sci U S A (1994) 2.39

Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans. Science (2002) 2.36

NADH oxidase activity of mitochondrial apoptosis-inducing factor. J Biol Chem (2001) 2.22

Antioxidant function of thioredoxin and glutaredoxin systems. Antioxid Redox Signal (2000) 2.08

Oxidative stress and the pathogenesis of Parkinson's disease. Neurology (1996) 2.05

Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli. J Cell Biol (2002) 1.90

Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol Cell (2002) 1.90

Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? J Cell Sci (2002) 1.88

Oxidative stress in Alzheimer's disease. Biochim Biophys Acta (2000) 1.84

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease. Am J Pathol (1997) 1.71

UV activates growth factor receptors via reactive oxygen intermediates. J Cell Biol (1996) 1.70

Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr Med Chem (2001) 1.68

Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions. Acta Neuropathol (1997) 1.58

Delayed-onset ataxia in mice lacking alpha -tocopherol transfer protein: model for neuronal degeneration caused by chronic oxidative stress. Proc Natl Acad Sci U S A (2001) 1.57

Oxidative nucleotide damage: consequences and prevention. Oncogene (2002) 1.50

The induction of multiple cell cycle events precedes target-related neuronal death. Development (1995) 1.49

P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis. EMBO J (2002) 1.48

Redox signaling in vascular angiogenesis. Free Radic Biol Med (2002) 1.45

Cyclin-dependent kinases as a therapeutic target for stroke. Proc Natl Acad Sci U S A (2000) 1.45

Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins. Mech Ageing Dev (2001) 1.45

Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease. Biochim Biophys Acta (1997) 1.44

Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease. J Neuropathol Exp Neurol (2000) 1.42

Dueling activities of AIF in cell death versus survival: DNA binding and redox activity. Cell (2002) 1.41

Selective E2F-dependent gene transcription is controlled by histone deacetylase activity during neuronal apoptosis. J Neurochem (2003) 1.37

Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death. J Neurosci (2001) 1.37

The crystal structure of the mouse apoptosis-inducing factor AIF. Nat Struct Biol (2002) 1.36

Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice. Neuron (1992) 1.36

Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts. Biochem J (2000) 1.35

Re-expression of cell cycle proteins induces neuronal cell death during Alzheimer's disease. J Alzheimers Dis (2002) 1.34

The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases. Free Radic Biol Med (2002) 1.32

Alterations in G(1) to S phase cell-cycle regulators during amyotrophic lateral sclerosis. Am J Pathol (2003) 1.27

Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism. J Neurochem (2001) 1.24

Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation. J Biol Chem (2002) 1.21

Mitotic signaling by beta-amyloid causes neuronal death. FASEB J (1999) 1.21

Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis. J Neuropathol Exp Neurol (2001) 1.18

An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration. Brain Res Brain Res Rev (1999) 1.17

Oxidative stress, transcription factors and chromatin remodelling in lung inflammation. Biochem Pharmacol (2002) 1.16

Hydrogen peroxide-mediated phosphorylation of ERK1/2, Akt/PKB and JNK in cortical neurones: dependence on Ca(2+) and PI3-kinase. J Neurochem (2002) 1.14

Cell death and the cell cycle: a relationship between transformation and neurodegeneration? Trends Biochem Sci (1993) 1.14

Genetic and environmental factors in cancer and neurodegenerative diseases. Mutat Res (2002) 1.14

Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease. Neuroscience (2001) 1.08

Radical formation site of cerebral complex I and Parkinson's disease. J Neurosci Res (1995) 1.05

The cell division cycle and the pathophysiology of Alzheimer's disease. Neuroscience (1998) 1.01

Reactive oxygen intermediates regulate cellular response to apoptotic stimuli: an hypothesis. Free Radic Res (1999) 1.00

Reactive oxygen species up-regulates cyclooxygenase-2, p53, and Bax mRNA expression in bovine luteal cells. Biochem Biophys Res Commun (2001) 0.96

Can oxidative DNA damage be used as a biomarker of cancer risk in humans? Problems, resolutions and preliminary results from nutritional supplementation studies. Free Radic Res (1998) 0.96

Activation of oncogenic pathways in degenerating neurons in Alzheimer disease. Int J Dev Neurosci (2000) 0.96

Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress. J Neurosci (1998) 0.95

In vivo viability of postmitotic Purkinje neurons requires pRb family member function. Mol Cell Neurosci (1995) 0.95

Unscheduled re-entry into the cell cycle induced by NGF precedes cell death in nascent retinal neurones. J Cell Sci (2000) 0.94

A cell cycle alteration precedes apoptosis of granule cell precursors in the weaver mouse cerebellum. Am J Pathol (1999) 0.94

The expression of key oxidative stress-handling genes in different brain regions in Alzheimer's disease. J Mol Neurosci (1998) 0.94

Kainic acid-induced apoptosis in cerebellar granule neurons: an attempt at cell cycle re-entry. Neuroreport (2002) 0.92

New insights into progressive supranuclear palsy. Trends Neurosci (2001) 0.91

Beta-amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons. J Neurosci (2002) 0.89

Immunoreactive epidermal growth factor receptors in neuritic plaques from patients with Alzheimer's disease. J Neuropathol Exp Neurol (1988) 0.87

Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons. Neurosci Lett (2002) 0.86

Oxidative stress and neurodegeneration in prion diseases. Ann N Y Acad Sci (2001) 0.85

Expression of cell cycle-related genes during neuronal apoptosis: is there a distinct pattern? Neurochem Res (1998) 0.83

Growth arrest failure, G1 restriction point override, and S phase death of sensory precursor cells in the absence of neurotrophin-3. Neuron (1998) 0.82

Unscheduled DNA replication precedes apoptosis of photoreceptors expressing SV40 T antigen. Exp Eye Res (1997) 0.80

beta-Amyloid induces oxidative DNA damage and cell death through activation of c-Jun N terminal kinase. Ann N Y Acad Sci (2002) 0.80

Mechanisms of neuronal death in Down's syndrome. J Neural Transm Suppl (1999) 0.79

Cell culture models of neuronal degeneration and neuroprotection. Implications for Parkinson's disease. Adv Exp Med Biol (1998) 0.79

Somatic cell mutations: can they provide a link between aging and cancer? Mech Ageing Dev (2000) 0.79

Neurodegeneration: A non-apoptotic role for AIF in the brain. Curr Biol (2003) 0.78

Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration. Nature (2006) 5.07

The harlequin mouse mutation downregulates apoptosis-inducing factor. Nature (2002) 3.30

Endoplasmic reticulum stress in health and disease. Curr Opin Cell Biol (2006) 2.59

Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP. Nat Genet (2005) 1.98

Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies. Gastroenterology (2007) 1.83

Divide and die: cell cycle events as triggers of nerve cell death. J Neurosci (2004) 1.74

The netrin 1 receptors Unc5h3 and Dcc are necessary at multiple choice points for the guidance of corticospinal tract axons. J Neurosci (2002) 1.56

Plexin-A2 and its ligand, Sema6A, control nucleus-centrosome coupling in migrating granule cells. Nat Neurosci (2008) 1.44

Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation. Circ Res (2005) 1.41

Deletion in Catna2, encoding alpha N-catenin, causes cerebellar and hippocampal lamination defects and impaired startle modulation. Nat Genet (2002) 1.34

EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. J Am Coll Cardiol (2006) 1.28

In vivo magnetic resonance imaging and semiautomated image analysis extend the brain phenotype for cdf/cdf mice. J Neurosci (2006) 1.26

Motor axon guidance of the mammalian trochlear and phrenic nerves: dependence on the netrin receptor Unc5c and modifier loci. J Neurosci (2006) 1.16

Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco-Sjögren syndrome. Hum Mol Genet (2010) 1.13

Netrin 1-mediated chemoattraction regulates the migratory pathway of LHRH neurons. Eur J Neurosci (2004) 1.11

An assessment of mechanisms underlying peripheral axonal degeneration caused by aminoacyl-tRNA synthetase mutations. Mol Cell Neurosci (2010) 1.08

A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet (2011) 1.05

Dorsally derived netrin 1 provides an inhibitory cue and elaborates the 'waiting period' for primary sensory axons in the developing spinal cord. Development (2006) 1.05

Mutation of a U2 snRNA gene causes global disruption of alternative splicing and neurodegeneration. Cell (2012) 1.00

The RHOX5 homeodomain protein mediates transcriptional repression of the netrin-1 receptor gene Unc5c. J Biol Chem (2007) 0.95

The UNC5C netrin receptor regulates dorsal guidance of mouse hindbrain axons. J Neurosci (2011) 0.92

Loss of apoptosis-inducing factor results in cell-type-specific neurogenesis defects. J Neurosci (2008) 0.85

The cerebellar deficient folia (cdf) gene acts intrinsically in Purkinje cell migrations. Genesis (2002) 0.85

Notch1-induced brain tumor models the sonic hedgehog subgroup of human medulloblastoma. Cancer Res (2013) 0.83

Cholesterol metabolism and Rett syndrome pathogenesis. Nat Genet (2013) 0.81

CHP1-mediated NHE1 biosynthetic maturation is required for Purkinje cell axon homeostasis. J Neurosci (2013) 0.81

Genomewide two-generation screens for recessive mutations by ES cell mutagenesis. Mamm Genome (2004) 0.78